FOXC2 (forkhead box C2) - Rat Genome Database

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Gene: FOXC2 (forkhead box C2) Canis lupus familiaris
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Symbol: FOXC2
Name: forkhead box C2
RGD ID: 12410126
Description: ENCODES a protein that exhibits chromatin DNA binding (ortholog); DNA binding (ortholog); DNA-binding transcription activator activity (ortholog); INVOLVED IN artery morphogenesis (ortholog); blood vessel development (ortholog); blood vessel diameter maintenance (ortholog); ASSOCIATED WITH Cardiovascular Abnormalities (ortholog); congenital diaphragmatic hernia (ortholog); congestive heart failure (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: forkhead box C2 (MFH-1, mesenchyme forkhead 1); forkhead box protein C2; LOC102153219; uncharacterized LOC102153219
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1566,234,336 - 66,296,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl566,294,176 - 66,295,693 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha566,246,461 - 66,254,587 (-)NCBI
ROS_Cfam_1.0566,455,805 - 66,464,138 (-)NCBI
UMICH_Zoey_3.1566,479,102 - 66,487,010 (-)NCBI
UNSW_CanFamBas_1.0566,314,300 - 66,322,205 (-)NCBI
UU_Cfam_GSD_1.0566,727,335 - 66,735,464 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
artery morphogenesis  (ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
blood vessel remodeling  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
cardiac muscle cell proliferation  (ISO)
cell population proliferation  (ISO)
collagen fibril organization  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic heart tube development  (ISO)
embryonic skeletal system morphogenesis  (ISO)
embryonic viscerocranium morphogenesis  (ISO)
glomerular endothelium development  (ISO)
glomerular mesangial cell development  (ISO)
glomerular visceral epithelial cell differentiation  (ISO)
heart development  (ISO)
heart morphogenesis  (ISO)
insulin receptor signaling pathway  (ISO)
kidney development  (ISO)
lymph vessel development  (ISO)
lymphangiogenesis  (ISO)
metanephros development  (ISO)
negative regulation of apoptotic process involved in outflow tract morphogenesis  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
neural crest cell development  (ISO)
Notch signaling pathway  (ISO)
ossification  (ISO)
paraxial mesoderm formation  (ISO)
paraxial mesodermal cell fate commitment  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of vascular wound healing  (ISO)
regulation of organ growth  (ISO)
response to hormone  (ISO)
skeletal system development  (ISO)
somitogenesis  (ISO)
ureteric bud development  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)
ventricular cardiac muscle tissue morphogenesis  (ISO)

Cellular Component
nuclear body  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

References

Genomics

Comparative Map Data
FOXC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1566,234,336 - 66,296,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl566,294,176 - 66,295,693 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha566,246,461 - 66,254,587 (-)NCBI
ROS_Cfam_1.0566,455,805 - 66,464,138 (-)NCBI
UMICH_Zoey_3.1566,479,102 - 66,487,010 (-)NCBI
UNSW_CanFamBas_1.0566,314,300 - 66,322,205 (-)NCBI
UU_Cfam_GSD_1.0566,727,335 - 66,735,464 (-)NCBI
FOXC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1686,566,829 - 86,569,728 (+)EnsemblGRCh38hg38GRCh38
GRCh381686,566,829 - 86,569,728 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371686,600,435 - 86,603,334 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361685,158,443 - 85,159,948 (+)NCBINCBI36hg18NCBI36
Build 341685,158,442 - 85,159,948NCBI
Celera1670,901,820 - 70,903,503 (+)NCBI
Cytogenetic Map16q24.1NCBI
HuRef1672,340,749 - 72,342,345 (+)NCBIHuRef
CHM1_11688,012,585 - 88,014,267 (+)NCBICHM1_1
Foxc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398121,842,910 - 121,845,634 (+)NCBIGRCm39mm39
GRCm39 Ensembl8121,842,910 - 121,845,634 (+)Ensembl
GRCm388121,116,171 - 121,118,895 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,116,171 - 121,118,895 (+)EnsemblGRCm38mm10GRCm38
MGSCv378123,640,071 - 123,642,795 (+)NCBIGRCm37mm9NCBIm37
MGSCv368124,002,560 - 124,004,872 (+)NCBImm8
Celera8125,334,251 - 125,336,975 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.33NCBI
Foxc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21949,186,034 - 49,188,736 (+)NCBI
Rnor_6.0 Ensembl1953,044,379 - 53,047,081 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01953,044,379 - 53,047,081 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01963,788,037 - 63,790,739 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11228,513,040 - 228,513,088 (-)NCBI
Celera1948,432,333 - 48,435,035 (+)NCBICelera
Cytogenetic Map19q12NCBI
FOXC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11686,569,509 - 86,571,878 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01667,237,476 - 67,239,545 (+)NCBIMhudiblu_PPA_v0panPan3
Foxc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934926,482,456 - 26,485,324 (-)NCBI
SpeTri2.0NW_0049366412,236,224 - 2,238,501 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl62,552,862 - 2,554,367 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.162,552,141 - 2,555,041 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.262,756,138 - 2,761,356 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1571,951,980 - 71,955,021 (+)NCBI
ChlSab1.1 Ensembl571,952,632 - 71,954,134 (+)Ensembl
Vero_WHO_p1.0NW_0236660473,750,917 - 3,753,843 (-)NCBI
Foxc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247462,632,547 - 2,634,867 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1
Low 4 5 15 6 6 2 11 7 10 6
Below cutoff 1 6 6 6 4 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014113959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022419103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022419104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002626945 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002626946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005326501 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005326502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005358928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005393408 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005393409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005426535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005426536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_292349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000031684   ⟹   ENSCAFP00000029498
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl566,294,176 - 66,295,693 (-)Ensembl
RefSeq Acc Id: XM_014113959   ⟹   XP_013969434
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1566,287,436 - 66,296,007 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022419103   ⟹   XP_022274811
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1566,287,436 - 66,296,007 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022419104   ⟹   XP_022274812
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1566,234,340 - 66,296,007 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002626945
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1566,234,336 - 66,242,556 (-)NCBI
Dog10K_Boxer_Tasha566,246,461 - 66,254,573 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002626946
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1566,234,711 - 66,242,576 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005326501
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1566,479,102 - 66,487,010 (-)NCBI
RefSeq Acc Id: XR_005326502
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1566,479,102 - 66,486,996 (-)NCBI
RefSeq Acc Id: XR_005358927
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0566,727,335 - 66,735,464 (-)NCBI
RefSeq Acc Id: XR_005358928
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0566,727,335 - 66,735,450 (-)NCBI
RefSeq Acc Id: XR_005393408
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0566,314,300 - 66,322,205 (-)NCBI
RefSeq Acc Id: XR_005393409
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0566,314,300 - 66,322,191 (-)NCBI
RefSeq Acc Id: XR_005426535
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0566,455,805 - 66,464,138 (-)NCBI
RefSeq Acc Id: XR_005426536
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0566,455,805 - 66,464,124 (-)NCBI
RefSeq Acc Id: XR_292349
RefSeq Status:
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1566,234,751 - 66,242,571 (-)NCBI
Dog10K_Boxer_Tasha566,246,461 - 66,254,587 (-)NCBI
Sequence:
Protein Sequences
Reference Sequences
RefSeq Acc Id: XP_022274812   ⟸   XM_022419104
- Sequence:
RefSeq Acc Id: XP_022274811   ⟸   XM_022419103
- Sequence:
RefSeq Acc Id: XP_013969434   ⟸   XM_014113959
- Sequence:
RefSeq Acc Id: ENSCAFP00000029498   ⟸   ENSCAFT00000031684
Protein Domains
Fork-head

Promoters
RGD ID:13683408
Promoter ID:EPDNEW_C1475
Type:multiple initiation site
Name:FOXC2_1
Description:forkhead box C2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1566,295,765 - 66,295,825EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019916 Ensembl, ENTREZGENE
NCBI Gene LOC102153219 ENTREZGENE
VGNC ID VGNC:40948 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-21 FOXC2  forkhead box C2  FOXC2  forkhead box C2  Data Merged 737654 PROVISIONAL
2017-09-12 FOXC2  forkhead box C2  LOC102153219  uncharacterized LOC102153219  Symbol and/or name change 5135510 APPROVED