PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2) - Rat Genome Database

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Gene: PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2) Canis lupus familiaris
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Symbol: PIK3R2
Name: phosphoinositide-3-kinase regulatory subunit 2
RGD ID: 12109547
Description: ENCODES a protein that exhibits 1-phosphatidylinositol-3-kinase regulator activity (inferred); phosphatidylinositol 3-kinase regulatory subunit binding (inferred); phosphotyrosine residue binding (inferred); INVOLVED IN negative regulation of cell migration involved in sprouting angiogenesis (ortholog); positive regulation of cell adhesion (ortholog); regulation of actin filament polymerization (ortholog); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; ASSOCIATED WITH colon cancer (ortholog); Colonic Neoplasms (ortholog); Developmental Disabilities (ortholog); FOUND IN phosphatidylinositol 3-kinase complex, class IA (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: phosphatidylinositol 3-kinase regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,826,037 - 44,838,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,826,339 - 44,836,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,739,520 - 44,751,946 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,311,340 - 45,323,770 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,311,351 - 45,321,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,548,506 - 44,560,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,958,996 - 44,971,420 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,234,496 - 45,247,145 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PIK3R2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,826,037 - 44,838,449 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,826,339 - 44,836,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,739,520 - 44,751,946 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,311,340 - 45,323,770 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,311,351 - 45,321,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,548,506 - 44,560,928 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,958,996 - 44,971,420 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,234,496 - 45,247,145 (-)NCBIUU_Cfam_GSD_1.0
PIK3R2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,153,163 - 18,170,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,153,163 - 18,170,532 (+)EnsemblGRCh38hg38GRCh38
GRCh371918,263,973 - 18,281,342 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,125,016 - 18,142,343 (+)NCBINCBI36Build 36hg18NCBI36
Build 341918,125,015 - 18,142,343NCBI
Celera1918,165,735 - 18,183,085 (+)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,827,466 - 17,844,856 (+)NCBIHuRef
CHM1_11918,263,528 - 18,280,901 (+)NCBICHM1_1
T2T-CHM13v2.01918,287,263 - 18,304,664 (+)NCBIT2T-CHM13v2.0
Pik3r2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,220,820 - 71,229,356 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,220,820 - 71,229,357 (-)EnsemblGRCm39 Ensembl
GRCm38870,768,176 - 70,776,712 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,768,176 - 70,776,713 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,292,080 - 73,300,611 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,697,168 - 73,705,670 (-)NCBIMGSCv36mm8
Celera873,329,482 - 73,338,028 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Pik3r2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,699,389 - 18,708,045 (+)NCBIGRCr8
mRatBN7.21618,665,517 - 18,674,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,665,457 - 18,674,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,707,923 - 18,716,460 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,840,602 - 19,849,140 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,760,867 - 18,769,404 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,415,109 - 20,424,982 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,416,432 - 20,424,980 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,273,500 - 20,282,051 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,171,101 - 19,179,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,171,098 - 19,179,648 (+)NCBI
Celera1618,857,756 - 18,866,282 (+)NCBICelera
Cytogenetic Map16p14NCBI
Pik3r2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,234,111 - 3,241,173 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,234,111 - 3,241,445 (-)NCBIChiLan1.0ChiLan1.0
PIK3R2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,013,784 - 23,031,178 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,022,130 - 22,039,523 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,632,265 - 17,649,664 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,608,470 - 18,624,185 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,611,179 - 18,624,177 (+)Ensemblpanpan1.1panPan2
Pik3r2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,461,387 - 203,472,734 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365963,010,488 - 3,021,920 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365963,010,526 - 3,021,848 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3R2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,637,371 - 59,652,073 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,637,363 - 59,652,075 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,195,762 - 59,210,463 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,620,673 - 16,637,511 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,621,606 - 16,636,937 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,738,902 - 2,757,694 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3r2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,513,969 - 1,523,295 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,513,916 - 1,523,723 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PIK3R2
123 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 4 6 12 10 2
Low 5 6 6 2 6 6 8 4
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000023779   ⟹   ENSCAFP00000022072
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2044,826,339 - 44,836,558 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000071027   ⟹   ENSCAFP00000056489
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2044,829,408 - 44,836,558 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845041427   ⟹   ENSCAFP00845032484
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2045,311,351 - 45,321,865 (-)Ensembl
RefSeq Acc Id: XM_038428186   ⟹   XP_038284114
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02045,311,340 - 45,323,770 (-)NCBI
RefSeq Acc Id: XM_038503845   ⟹   XP_038359773
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12044,548,506 - 44,560,928 (-)NCBI
RefSeq Acc Id: XM_038566856   ⟹   XP_038422784
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02045,234,496 - 45,247,145 (-)NCBI
RefSeq Acc Id: XM_038631009   ⟹   XP_038486937
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02044,958,996 - 44,971,420 (-)NCBI
RefSeq Acc Id: XM_847313   ⟹   XP_852406
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12044,826,037 - 44,838,449 (-)NCBI
Dog10K_Boxer_Tasha2044,739,520 - 44,751,946 (-)NCBI
Sequence:
RefSeq Acc Id: XP_852406   ⟸   XM_847313
- UniProtKB: A0A8C0NQ20 (UniProtKB/TrEMBL),   A0A8I3S3N2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000022072   ⟸   ENSCAFT00000023779
RefSeq Acc Id: ENSCAFP00000056489   ⟸   ENSCAFT00000071027
RefSeq Acc Id: XP_038359773   ⟸   XM_038503845
RefSeq Acc Id: XP_038486937   ⟸   XM_038631009
RefSeq Acc Id: XP_038284114   ⟸   XM_038428186
- UniProtKB: A0A8C0NQ20 (UniProtKB/TrEMBL),   A0A8I3S3N2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038422784   ⟸   XM_038566856
- UniProtKB: A0A8C0NQ20 (UniProtKB/TrEMBL),   A0A8I3S3N2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845032484   ⟸   ENSCAFT00845041427
Protein Domains
Rho-GAP   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014978 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030017194 UniProtKB/TrEMBL
  ENSCAFG00040008912 UniProtKB/TrEMBL
  ENSCAFG00845023471 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000023779.6 UniProtKB/TrEMBL
  ENSCAFT00030031953.1 UniProtKB/TrEMBL
  ENSCAFT00030032050.1 UniProtKB/TrEMBL
  ENSCAFT00040016582.1 UniProtKB/TrEMBL
  ENSCAFT00040016671.1 UniProtKB/TrEMBL
  ENSCAFT00845041427 ENTREZGENE
  ENSCAFT00845041427.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.1490 UniProtKB/TrEMBL
  1.10.555.10 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro PI3K_P85_iSH2 UniProtKB/TrEMBL
  PI3K_p85beta_SH3 UniProtKB/TrEMBL
  PI3kinase_P85_cSH2 UniProtKB/TrEMBL
  PI3kinase_P85_nSH2 UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report cfa:609956 UniProtKB/TrEMBL
NCBI Gene PIK3R2 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/TrEMBL
  PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA UniProtKB/TrEMBL
  PI3K21B, ISOFORM B UniProtKB/TrEMBL
Pfam PI3K_P85_iSH2 UniProtKB/TrEMBL
  RhoGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS PI3KINASEP85 UniProtKB/TrEMBL
  SH2DOMAIN UniProtKB/TrEMBL
PROSITE RHOGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART RhoGAP UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF48350 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8C0NQ20 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0S1H1_CANLF UniProtKB/TrEMBL
  A0A8I3S3N2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:81919 ENTREZGENE