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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of insulin receptor signaling pathway
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Accession:GO:0046627 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
Synonyms:exact_synonym: down regulation of insulin receptor signaling pathway;   downregulation of insulin receptor signaling pathway;   negative regulation of insulin receptor signalling pathway
 narrow_synonym: inhibition of insulin receptor signaling pathway


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negative regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein IDA RGD PMID:2766355 RGD:632173 NCBI chr11:81,711,269...81,717,594 JBrowse link
G Ankrd26 ankyrin repeat domain 26 ISO MGI:MGI:3774418 (MGI:MGI:5297321|PMID:21842266) RGD PMID:21842266 MGI:MGI:5297321 NCBI chr 4:150,548,656...150,616,928
Ensembl chr 4:150,547,467...150,616,895
JBrowse link
G Enho energy homeostasis associated ISO MGI:MGI:5781010 (MGI:MGI:5693224|PMID:22318315) RGD PMID:22318315 MGI:MGI:5693224 NCBI chr 5:58,018,039...58,019,836
Ensembl chr 5:58,018,039...58,019,836
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO
IEA
(PMID:17849011), (PMID:7830796)
GO_REF:0000107
RGD
Ensembl
PMID:7830796, PMID:17849011 GO_REF:0000107 NCBI chr 1:21,748,201...21,813,205
Ensembl chr 1:21,748,261...21,813,371
JBrowse link
G Gpr21 G protein-coupled receptor 21 ISO MGI:MGI:5314799 (MGI:MGI:5448902|PMID:22653059) RGD PMID:22653059 MGI:MGI:5448902 NCBI chr 3:21,764,377...21,767,300
Ensembl chr 3:21,764,377...21,767,300
JBrowse link
G Grb10 growth factor receptor bound protein 10 ISO
IBA
IEA
(MGI:MGI:3847873|PMID:15664450)
PMID:21873635
GO_REF:0000002
GO_REF:0000107
RGD
InterPro
Ensembl
PMID:15664450, PMID:21873635 GO_REF:0000002, GO_REF:0000107, MGI:MGI:3847873, RGD:13792537 NCBI chr14:92,021,851...92,122,249
Ensembl chr14:92,021,851...92,117,923
JBrowse link
G Grb14 growth factor receptor bound protein 14 IDA
IBA
ISO
IEA
IMP
PMID:21873635
(PMID:16246733)
GO_REF:0000107
RGD
Ensembl
PMID:16246733, PMID:9748281, PMID:21873635, PMID:18657188 GO_REF:0000107, RGD:61620, RGD:13792537, RGD:2307023 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Grb7 growth factor receptor bound protein 7 NOT IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,393,186...86,408,893
Ensembl chr10:86,399,827...86,409,348
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO (PMID:17569761) RGD PMID:17569761 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Il1b interleukin 1 beta ISO
IEA
(MGI:MGI:3828398|PMID:16865359)
GO_REF:0000107
RGD
Ensembl
PMID:16865359 GO_REF:0000107, MGI:MGI:3828398 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F NAS PMID:26908121 ParkinsonsUK-UCL PMID:26908121 RGD:11059577 NCBI chr 1:200,037,749...200,116,524
Ensembl chr 1:200,037,749...200,116,524
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K ISO
IBA
(PMID:12556481)
PMID:21873635
(MGI:MGI:5294535|PMID:19250614)
RGD PMID:12556481, PMID:19250614, PMID:21873635 MGI:MGI:5294535, RGD:13792537 NCBI chr10:63,775,639...63,796,879
Ensembl chr10:63,776,378...63,795,899
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:11692174 RGD:2312443 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524
JBrowse link
G Irs1 insulin receptor substrate 1 IMP PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 ISO (PMID:18458160) RGD PMID:18458160 NCBI chr 1:243,201,073...243,398,531
Ensembl chr 1:243,276,403...243,398,536
JBrowse link
G Lmbrd1 LMBR1 domain containing 1 ISO MGI:MGI:5559223 (MGI:MGI:5543853|PMID:24078630) RGD PMID:24078630 MGI:MGI:5543853 NCBI chr 9:30,939,555...31,038,381
Ensembl chr 9:30,939,555...31,038,379
JBrowse link
G Mir143 microRNA 143 ISO (MGI:MGI:5289772|PMID:21441927) RGD PMID:21441927 MGI:MGI:5289772 NCBI chr18:56,971,273...56,971,377
Ensembl chr18:56,971,273...56,971,377
JBrowse link
G Mstn myostatin ISO (MGI:MGI:3604221|PMID:16182246) RGD PMID:16182246 MGI:MGI:3604221 NCBI chr 9:53,310,977...53,315,804
Ensembl chr 9:53,309,598...53,315,915
JBrowse link
G Nck1 NCK adaptor protein 1 ISO (PMID:21707536) RGD PMID:21707536 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Ncoa5 nuclear receptor coactivator 5 ISO MGI:MGI:5581698 (MGI:MGI:5559256|PMID:24332041) RGD PMID:24332041 MGI:MGI:5559256 NCBI chr 3:161,465,733...161,498,951
Ensembl chr 3:161,465,743...161,498,951
JBrowse link
G Nucb2 nucleobindin 2 IDA RGD PMID:22486620 RGD:9831186 NCBI chr 1:185,106,773...185,143,278
Ensembl chr 1:185,104,656...185,143,272
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 ISO (PMID:19079291) RGD PMID:19079291 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IMP RGD PMID:20501641 RGD:6484547 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkca protein kinase C, alpha ISO MGI:MGI:2679305 (MGI:MGI:2677557|PMID:11923480) RGD PMID:11923480 MGI:MGI:2677557 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta IDA PMID:11714718 UniProt PMID:11714718 RGD:8553365 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta ISO
IEA
(MGI:MGI:3836105|PMID:18285345)
GO_REF:0000107
RGD
Ensembl
PMID:18285345 GO_REF:0000107, MGI:MGI:3836105 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcq protein kinase C, theta IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:15364919)
Ensembl
UniProt
RGD
PMID:15364919 GO_REF:0000024, GO_REF:0000107 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
G Prkcz protein kinase C, zeta ISO (PMID:15069075) RGD PMID:15069075 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISS
ISO
GO_REF:0000024
(MGI:MGI:4941441|PMID:20484139), (MGI:MGI:5488890|PMID:12612081)
UniProt
RGD
PMID:12612081, PMID:20484139 GO_REF:0000024, MGI:MGI:4941441, MGI:MGI:5488890 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E IDA
ISO
PMID:15738637
(MGI:MGI:3772995|PMID:18006633)
RGD PMID:18006633, PMID:15738637 MGI:MGI:3772995, RGD:8553759 NCBI chr 1:207,820,719...207,987,123
Ensembl chr 1:207,887,209...207,987,136
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J ISO (MGI:MGI:6379079|PMID:26063811) RGD PMID:26063811 MGI:MGI:6379079 NCBI chr 3:79,233,519...79,390,956
Ensembl chr 3:79,233,525...79,390,956
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IMP RGD PMID:18073321 RGD:2298860 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 IMP
ISO
PMID:18952604
(PMID:18952604)
RGD PMID:18952604, PMID:18952604 RGD:8554230 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO
IEA
(MGI:MGI:3045683|PMID:15169905)
GO_REF:0000107
RGD
Ensembl
PMID:15169905 GO_REF:0000107, MGI:MGI:3045683 NCBI chr10:4,956,795...4,958,472
Ensembl chr10:4,957,326...4,958,461
JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO
IEA
(MGI:MGI:3045683|PMID:15169905)
GO_REF:0000107
RGD
Ensembl
PMID:15169905 GO_REF:0000107, MGI:MGI:3045683 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Tns2 tensin 2 ISO (PMID:23401856) RGD PMID:23401856 NCBI chr 7:143,702,623...143,720,995
Ensembl chr 7:143,707,237...143,720,595
JBrowse link
G Trim72 tripartite motif containing 72 ISO (MGI:MGI:5602876|PMID:23965929) RGD PMID:23965929 MGI:MGI:5602876 NCBI chr 1:199,450,042...199,457,902
Ensembl chr 1:199,449,973...199,457,895
JBrowse link
G Tsc1 TSC complex subunit 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:7,219,955...7,269,063
Ensembl chr 3:7,237,192...7,265,145
JBrowse link
G Tsc2 TSC complex subunit 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,962,006...13,996,684
Ensembl chr10:13,961,947...13,996,584
JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Ybx1 Y box binding protein 1 IMP RGD PMID:12554649 RGD:727501 NCBI chr 5:138,319,754...138,336,721
Ensembl chr 5:138,319,762...138,336,475
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20015
    negative regulation of biological process 5698
      negative regulation of signaling 1403
        negative regulation of signal transduction 1243
          negative regulation of insulin receptor signaling pathway 43
            negative regulation of insulin receptor signaling pathway by insulin receptor internalization 0
            negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan 0
Path 2
Term Annotations click to browse term
  biological_process 20015
    response to stimulus 10570
      response to chemical 6331
        response to organic substance 3853
          response to organonitrogen compound 1453
            response to peptide 689
              response to peptide hormone 594
                response to insulin 352
                  cellular response to insulin stimulus 267
                    insulin receptor signaling pathway 134
                      regulation of insulin receptor signaling pathway 82
                        negative regulation of insulin receptor signaling pathway 43
                          negative regulation of insulin receptor signaling pathway by insulin receptor internalization 0
                          negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.