Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of insulin receptor signaling pathway
go back to main search page
Accession:GO:0046627 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.
Synonyms:exact_synonym: down regulation of insulin receptor signaling pathway;   downregulation of insulin receptor signaling pathway;   negative regulation of insulin receptor signalling pathway
 narrow_synonym: inhibition of insulin receptor signaling pathway


show annotations for term's descendants           Sort by:
 
negative regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahsg alpha-2-HS-glycoprotein IDA RGD PMID:2766355 RGD:632173 NCBI chr11:78,117,903...78,145,956 JBrowse link
G Ankrd26 ankyrin repeat domain 26 acts_upstream_of_or_within ISO MGI:3774418 (MGI:5297321|PMID:21842266) RGD PMID:21842266 MGI:5297321 NCBI chr 4:151,670,604...151,740,032
Ensembl chr 4:151,672,037...151,739,968
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO
IEA
(PMID:17849011), (PMID:7830796)
GO_REF:0000107
RGD
Ensembl
PMID:7830796 PMID:17849011 GO_REF:0000107 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Gpr21 G protein-coupled receptor 21 acts_upstream_of_or_within ISO MGI:5314799 (MGI:5448902|PMID:22653059) RGD PMID:22653059 MGI:5448902 NCBI chr 3:21,275,007...21,279,008
Ensembl chr 3:21,275,007...21,277,930
JBrowse link
G Grb10 growth factor receptor bound protein 10 involved_in IBA
ISO
IEA
PMID:21873635
(MGI:3847873|PMID:15664450)
GO_REF:0000107
GO_REF:0000002
RGD
Ensembl
InterPro
PMID:15664450 PMID:21873635 GO_REF:0000002 GO_REF:0000107 MGI:3847873, RGD:13792537 NCBI chr14:86,495,054...86,602,815
Ensembl chr14:86,495,054...86,602,806
JBrowse link
G Grb14 growth factor receptor bound protein 14 involved_in IDA
IBA
ISO
IEA
IMP
PMID:21873635
(PMID:16246733)
GO_REF:0000107
RGD
Ensembl
PMID:16246733 PMID:9748281 PMID:21873635 PMID:18657188 GO_REF:0000107, RGD:61620, RGD:13792537, RGD:2307023 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889
JBrowse link
G Grb7 growth factor receptor bound protein 7 NOT|involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (PMID:17569761) RGD PMID:17569761 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO
GO_REF:0000107
(MGI:3828398|PMID:16865359)
Ensembl
RGD
PMID:16865359 GO_REF:0000107 MGI:3828398 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F involved_in NAS PMID:26908121 ParkinsonsUK-UCL PMID:26908121 RGD:11059577 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K involved_in IBA
ISO
PMID:21873635
(MGI:5294535|PMID:19250614)
(PMID:12556481)
RGD PMID:12556481 PMID:19250614 PMID:21873635 MGI:5294535, RGD:13792537 NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:11692174 RGD:2312443 NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
JBrowse link
G Irs1 insulin receptor substrate 1 involved_in IMP PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 involved_in ISO (PMID:18458160) RGD PMID:18458160 NCBI chr 1:222,877,962...223,074,514
Ensembl chr 1:222,877,622...223,074,514
JBrowse link
G Lmbrd1 LMBR1 domain containing 1 acts_upstream_of_or_within ISO MGI:5559223 (MGI:5543853|PMID:24078630) RGD PMID:24078630 MGI:5543853 NCBI chr 9:27,096,387...27,178,095
Ensembl chr 9:27,096,297...27,178,090
JBrowse link
G Mir143 microRNA 143 acts_upstream_of_or_within ISO (MGI:5289772|PMID:21441927) RGD PMID:21441927 MGI:5289772 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110
JBrowse link
G Mstn myostatin involved_in ISO (MGI:3604221|PMID:16182246) RGD PMID:16182246 MGI:3604221 NCBI chr 9:48,453,982...48,458,809
Ensembl chr 9:48,452,533...48,458,933
JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:21707536) RGD PMID:21707536 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300
JBrowse link
G Ncoa5 nuclear receptor coactivator 5 acts_upstream_of_or_within ISO MGI:5581698 (MGI:5559256|PMID:24332041) RGD PMID:24332041 MGI:5559256 NCBI chr 3:153,736,420...153,769,838
Ensembl chr 3:153,736,420...153,769,553
JBrowse link
G Nucb2 nucleobindin 2 IDA RGD PMID:22486620 RGD:9831186 NCBI chr 1:170,750,830...170,787,356
Ensembl chr 1:170,750,877...170,787,353
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 involved_in ISO (PMID:19079291) RGD PMID:19079291 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in ISS
ISO
GO_REF:0000024
(PMID:31091439)
UniProt
RGD
PMID:31091439 GO_REF:0000024 NCBI chr17:81,496,669...81,668,180 JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta involved_in ISO
ISS
(PMID:31091439)
GO_REF:0000024
RGD
UniProt
PMID:31091439 GO_REF:0000024 NCBI chr10:82,706,016...82,734,938
Ensembl chr10:82,701,098...82,734,938
JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:31091439)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:31091439 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:63,020,004...63,035,086
Ensembl chr 7:63,020,000...63,035,078
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IMP RGD PMID:20501641 RGD:6484547 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkca protein kinase C, alpha acts_upstream_of_or_within ISO MGI:2679305 (MGI:2677557|PMID:11923480) RGD PMID:11923480 MGI:2677557 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta involved_in IDA PMID:11714718 UniProt PMID:11714718 RGD:8553365 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcd protein kinase C, delta involved_in IEA
ISO
GO_REF:0000107
(MGI:3836105|PMID:18285345)
Ensembl
RGD
PMID:18285345 GO_REF:0000107 MGI:3836105 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prkcq protein kinase C, theta involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15364919)
UniProt
Ensembl
RGD
PMID:15364919 GO_REF:0000024 GO_REF:0000107 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704
JBrowse link
G Prkcz protein kinase C, zeta involved_in ISO (PMID:15069075) RGD PMID:15069075 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:4941441|PMID:20484139), (MGI:5488890|PMID:12612081)
UniProt
RGD
PMID:12612081 PMID:20484139 GO_REF:0000024 MGI:4941441 MGI:5488890 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E involved_in IDA
ISO
PMID:15738637
(MGI:3772995|PMID:18006633)
RGD PMID:18006633 PMID:15738637 MGI:3772995, RGD:8553759 NCBI chr 1:190,344,331...190,494,815
Ensembl chr 1:190,344,401...190,489,534
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (MGI:6379079|PMID:26063811) RGD PMID:26063811 MGI:6379079 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IMP RGD PMID:18073321 RGD:2298860 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 involved_in ISO
IMP
(PMID:18952604) RGD PMID:18952604 PMID:18952604 RGD:8554230 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Slc27a4 solute carrier family 27 member 4 involved_in ISO (PMID:25603556) RGD PMID:25603556 NCBI chr 3:13,075,022...13,087,943
Ensembl chr 3:13,075,022...13,087,943
JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3045683|PMID:15169905)
Ensembl
RGD
PMID:15169905 GO_REF:0000107 MGI:3045683 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs3 suppressor of cytokine signaling 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:3045683|PMID:15169905)
Ensembl
RGD
PMID:15169905 GO_REF:0000107 MGI:3045683 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Tns2 tensin 2 involved_in ISO (PMID:23401856) RGD PMID:23401856 NCBI chr 7:133,229,746...133,247,889
Ensembl chr 7:133,206,364...133,247,888
JBrowse link
G Trim72 tripartite motif containing 72 acts_upstream_of_or_within ISO (MGI:5602876|PMID:23965929) RGD PMID:23965929 MGI:5602876 NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606
JBrowse link
G Tsc2 TSC complex subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Tsc2_v2 TSC complex subunit 2, variant 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537
G Ybx1 Y box binding protein 1 IMP RGD PMID:12554649 RGD:727501 NCBI chr 5:132,882,137...132,899,108
Ensembl chr 5:132,882,145...132,898,862
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    cellular process 18340
      signal transduction 6882
        negative regulation of signal transduction 1264
          negative regulation of insulin receptor signaling pathway 45
            negative regulation of insulin receptor signaling pathway by insulin receptor internalization 0
            negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan 0
Path 2
Term Annotations click to browse term
  biological_process 19492
    response to stimulus 10358
      response to chemical 6187
        response to organic substance 3893
          response to organonitrogen compound 1476
            response to peptide 703
              response to peptide hormone 607
                response to insulin 360
                  cellular response to insulin stimulus 271
                    insulin receptor signaling pathway 135
                      regulation of insulin receptor signaling pathway 84
                        negative regulation of insulin receptor signaling pathway 45
                          negative regulation of insulin receptor signaling pathway by insulin receptor internalization 0
                          negative regulation of insulin receptor signaling pathway involved in determination of adult lifespan 0
paths to the root