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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of insulin receptor signaling pathway
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Accession:GO:0046626 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of insulin receptor signaling.
Synonyms:exact_synonym: regulation of insulin receptor signalling pathway
 only_in_taxon: NCBITaxon:6072 ! Eumetazoa



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regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ffar3 free fatty acid receptor 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:24748202)
UniProt
RGD
PMID:24748202 GO_REF:0000024 NCBI chr 1:95,232,804...95,234,144 JBrowse link
G Fut7 fucosyltransferase 7 involved_in ISO (PMID:17229154) RGD PMID:17229154 NCBI chr 3:28,635,913...28,640,407 JBrowse link
G Mir494 microRNA 494 acts_upstream_of_or_within ISO (PMID:24349514) RGD PMID:24349514 NCBI chr 6:128,728,710...128,728,792 JBrowse link
G Mzb1 marginal zone B and B1 cell-specific protein involved_in ISS
ISO
GO_REF:0000024
(PMID:21688198)
UniProt
RGD
PMID:21688198 GO_REF:0000024 NCBI chr18:27,513,087...27,515,148 JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 involved_in ISO (PMID:26205492) RGD PMID:26205492 NCBI chr13:45,897,275...45,926,491 JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase involved_in IEA
ISO
GO_REF:0000107
(PMID:18288188)
Ensembl
RGD
PMID:18288188 GO_REF:0000107 NCBI chr  X:70,811,317...70,856,123 JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 IMP RGD PMID:12941932 RGD:1625241 NCBI chr 3:156,638,811...156,687,503 JBrowse link
G Rarres2 retinoic acid receptor responder 2 involved_in ISO (PMID:18242188) RGD PMID:18242188 NCBI chr 4:77,522,549...77,525,733 JBrowse link
G Rbm4 RNA binding motif protein 4 acts_upstream_of_or_within ISO (PMID:23129807) RGD PMID:23129807 NCBI chr 1:211,507,845...211,516,907 JBrowse link
G Sesn3 sestrin 3 involved_in ISO (PMID:25377878) RGD PMID:25377878 NCBI chr 8:19,415,307...19,470,943 JBrowse link
G Sik2 salt-inducible kinase 2 involved_in ISO (PMID:12624099) RGD PMID:12624099 NCBI chr 8:60,121,913...60,221,707 JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO MGI:1857938 (PMID:12403809) RGD PMID:12403809 NCBI chr10:14,125,679...14,160,317 JBrowse link
G Vwa2 von Willebrand factor A domain containing 2 involved_in ISO (PMID:15699509) RGD PMID:15699509 NCBI chr 1:255,922,263...255,963,920 JBrowse link
insulin receptor recycling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsd cathepsin D involved_in ISO
IEA
(PMID:27703010)
GO_REF:0000107
RGD
Ensembl
PMID:27703010 GO_REF:0000107 NCBI chr 1:206,956,945...206,968,821 JBrowse link
G Ide insulin degrading enzyme involved_in ISO (PMID:27703010) RGD PMID:27703010 NCBI chr 1:244,415,495...244,516,925 JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 involved_in ISO MGI:2384135 (PMID:17068137) RGD PMID:17068137 NCBI chr 3:156,638,811...156,687,503 JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:15632081)
Ensembl
RGD
PMID:15632081 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:27322061) RGD PMID:27322061 NCBI chr 8:51,238,713...51,401,458 JBrowse link
negative regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07028769.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Ahsg alpha-2-HS-glycoprotein IDA RGD PMID:2766355 RGD:632173 NCBI chr11:78,121,388...78,127,998 JBrowse link
G Ankrd26 ankyrin repeat domain containing 26 acts_upstream_of_or_within ISO MGI:3774418 (PMID:21842266) RGD PMID:21842266 NCBI chr 4:151,670,604...151,740,032 JBrowse link
G Blvrb biliverdin reductase B involved_in ISO (PMID:38056462) RGD PMID:38056462 NCBI chr 1:91,866,258...91,883,921 JBrowse link
G Cul7 cullin 7 involved_in IEA
ISO
GO_REF:0000107
(PMID:18498745)
Ensembl
RGD
PMID:18498745 GO_REF:0000107 NCBI chr 9:14,319,102...14,333,035 JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO (PMID:17849011), (PMID:7830796) RGD PMID:7830796 PMID:17849011 NCBI chr 1:22,518,051...22,583,044 JBrowse link
G Fbxw8 F-box and WD repeat domain containing 8 involved_in IEA
ISO
GO_REF:0000107
(PMID:18498745)
Ensembl
RGD
PMID:18498745 GO_REF:0000107 NCBI chr12:38,426,466...38,517,076 JBrowse link
G Gpr21 G protein-coupled receptor 21 acts_upstream_of_or_within ISO MGI:5314799 (PMID:22653059) RGD PMID:22653059 NCBI chr 3:21,275,289...21,279,008 JBrowse link
G Grb10 growth factor receptor bound protein 10 involved_in IEA
ISO
IBA
GO_REF:0000107
(PMID:15664450)
GO_REF:0000033
Ensembl
RGD
GO_Central
PMID:15664450 GO_REF:0000033 GO_REF:0000107 NCBI chr14:90,708,653...90,816,399 JBrowse link
G Grb14 growth factor receptor bound protein 14 involved_in IDA
IBA
ISO
IEA
IMP
GO_REF:0000033
(PMID:16246733)
GO_REF:0000107
GO_Central
RGD
Ensembl
PMID:16246733 PMID:9748281 PMID:18657188 GO_REF:0000033 GO_REF:0000107, RGD:61620, RGD:2307023 NCBI chr 3:49,568,210...49,683,805 JBrowse link
G Grb7 growth factor receptor bound protein 7 NOT|involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:83,443,387...83,453,057 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO
IEA
IDA
(PMID:17569761)
GO_REF:0000107
PMID:8524413
RGD
Ensembl
PMID:17569761 PMID:8524413 GO_REF:0000107, RGD:8554844 NCBI chr 1:89,943,669...89,953,514 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in IDA PMID:8524413 BHF-UCL PMID:8524413 RGD:8554844 NCBI chr11:76,004,502...76,154,665 JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO
GO_REF:0000107
(PMID:16865359)
Ensembl
RGD
PMID:16865359 GO_REF:0000107 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F involved_in NAS PMID:26908121 ParkinsonsUK-UCL PMID:26908121 RGD:11059577 NCBI chr 1:183,190,480...183,270,276 JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K involved_in ISO
IBA
(PMID:12556481)
(PMID:19250614)
GO_REF:0000033
RGD
GO_Central
PMID:12556481 PMID:19250614 GO_REF:0000033 NCBI chr10:60,474,262...60,495,813 JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IMP RGD PMID:11692174 RGD:2312443 NCBI chr 1:156,183,043...156,197,500 JBrowse link
G Irs1 insulin receptor substrate 1 involved_in IMP PMID:15069075 BHF-UCL PMID:15069075 RGD:8554248 NCBI chr 9:91,001,137...91,053,959 JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 involved_in ISO (PMID:18458160) RGD PMID:18458160 NCBI chr 1:232,381,720...232,500,834 JBrowse link
G Lep leptin involved_in ISO (PMID:14677856) RGD PMID:14677856 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Lonp1 lon peptidase 1, mitochondrial acts_upstream_of_or_within ISO (PMID:9813005) RGD PMID:9813005 NCBI chr 9:1,447,444...1,459,771 JBrowse link
G Mir143 microRNA 143 acts_upstream_of_or_within ISO (PMID:21441927) RGD PMID:21441927 NCBI chr18:55,101,006...55,101,110 JBrowse link
G Mir15b microRNA 15b involved_in ISO (PMID:26179126) RGD PMID:26179126 NCBI chr 2:153,245,200...153,245,297 JBrowse link
G Mir195 microRNA 195 involved_in ISO (PMID:25240198) RGD PMID:25240198 NCBI chr10:54,951,838...54,951,924 JBrowse link
G Mstn myostatin involved_in ISO (PMID:16182246) RGD PMID:16182246 NCBI chr 9:48,452,533...48,458,933 JBrowse link
G Nck1 NCK adaptor protein 1 involved_in ISO (PMID:21707536) RGD PMID:21707536 NCBI chr 8:109,897,723...109,958,247 JBrowse link
G Ncl nucleolin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:9813005)
Ensembl
RGD
PMID:9813005 GO_REF:0000107 NCBI chr 9:94,447,559...94,456,083 JBrowse link
G Ncoa5 nuclear receptor coactivator 5 acts_upstream_of_or_within ISO MGI:5581698 (PMID:24332041) RGD PMID:24332041 NCBI chr 3:153,736,420...153,769,838 JBrowse link
G Nucb2 nucleobindin 2 IDA RGD PMID:22486620 RGD:9831186 NCBI chr 1:170,750,830...170,787,356 JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 involved_in ISO (PMID:19079291) RGD PMID:19079291 NCBI chr 9:85,284,335...85,503,035 JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:31091439)
UniProt
Ensembl
RGD
PMID:31091439 GO_REF:0000024 GO_REF:0000107 NCBI chr17:86,405,080...86,576,597 JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta involved_in ISO
IEA
ISS
(PMID:31091439)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:31091439 GO_REF:0000024 GO_REF:0000107 NCBI chr10:83,202,379...83,231,292 JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:31091439)
UniProt
Ensembl
RGD
PMID:31091439 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:64,905,322...64,920,380 JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IMP RGD PMID:20501641 RGD:6484547 NCBI chr 2:55,967,766...56,003,450 JBrowse link
G Prkca protein kinase C, alpha acts_upstream_of_or_within ISO MGI:2679305 (PMID:11923480) RGD PMID:11923480 NCBI chr10:93,388,991...93,787,617 JBrowse link
G Prkcb protein kinase C, beta involved_in IDA PMID:11714718 UniProt PMID:11714718 RGD:8553365 NCBI chr 1:186,263,397...186,594,743 JBrowse link
G Prkcd protein kinase C, delta involved_in IEA
ISO
GO_REF:0000107
(PMID:14583092), (PMID:18285345)
Ensembl
RGD
PMID:14583092 PMID:18285345 GO_REF:0000107 NCBI chr16:5,775,681...5,806,122 JBrowse link
G Prkcq protein kinase C, theta involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:15364919)
UniProt
Ensembl
RGD
PMID:15364919 GO_REF:0000024 GO_REF:0000107 NCBI chr17:72,156,215...72,288,508 JBrowse link
G Prkcz protein kinase C, zeta involved_in ISO (PMID:15069075) RGD PMID:15069075 NCBI chr 5:171,101,774...171,212,694 JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:12612081), (PMID:20484139)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:12612081 PMID:20484139 GO_REF:0000024 GO_REF:0000107 NCBI chr18:61,229,012...61,294,662 JBrowse link
G Ptpre protein tyrosine phosphatase, receptor type, E involved_in IDA
ISO
PMID:15738637
(PMID:18006633)
RGD PMID:18006633 PMID:15738637 RGD:8553759 NCBI chr 1:190,344,331...190,494,815 JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F IMP RGD PMID:8557682 RGD:1642757 NCBI chr 5:131,741,959...131,824,000 JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:26063811) RGD PMID:26063811 NCBI chr 3:96,861,785...97,017,702 JBrowse link
G Rbx1 ring-box 1 involved_in ISO (PMID:18498745) RGD PMID:18498745 NCBI chr 7:114,870,893...114,881,194 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IMP RGD PMID:18073321 RGD:2298860 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 involved_in
acts_upstream_of_or_within
IMP
ISO
PMID:18952604
(PMID:18498745), (PMID:18952604)
MGI:102548|MGI:1927343|MGI:87986|MGI:99454 (PMID:15249583)
RGD PMID:15249583 PMID:18498745 PMID:18952604 PMID:18952604 RGD:8554230 NCBI chr10:71,817,794...71,865,211 JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 acts_upstream_of_or_within ISO MGI:102548|MGI:1270849|MGI:87986|MGI:99454 (PMID:15249583) RGD PMID:15249583 NCBI chr 1:210,880,824...210,887,556 JBrowse link
G Slc27a4 solute carrier family 27 member 4 involved_in ISO (PMID:25603556) RGD PMID:25603556 NCBI chr 3:13,075,022...13,087,943 JBrowse link
G Socs1 suppressor of cytokine signaling 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:15169905)
Ensembl
RGD
PMID:15169905 GO_REF:0000107 NCBI chr10:5,389,574...5,391,265 JBrowse link
G Socs3 suppressor of cytokine signaling 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:15169905)
Ensembl
RGD
PMID:15169905 GO_REF:0000107 NCBI chr10:103,692,579...103,695,975 JBrowse link
G Tns2 tensin 2 involved_in ISO
IBA
(PMID:23401856)
GO_REF:0000033
RGD
GO_Central
PMID:23401856 GO_REF:0000033 NCBI chr 7:133,229,746...133,247,889 JBrowse link
G Trim72 tripartite motif containing 72 acts_upstream_of_or_within ISO (PMID:23965929) RGD PMID:23965929 NCBI chr 1:182,613,753...182,621,613 JBrowse link
G Tsc2 TSC complex subunit 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:14,125,679...14,160,317 JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Tsc2_v2 TSC complex subunit 2, variant 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Ybx1 Y box binding protein 1 IMP RGD PMID:12554649 RGD:727501 NCBI chr 5:138,167,444...138,188,155 JBrowse link
G Zfp592 zinc finger protein 592 acts_upstream_of_or_within ISO (PMID:9813005) RGD PMID:9813005 NCBI chr 1:144,355,227...144,411,686 JBrowse link
positive regulation of insulin receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 IMP RGD PMID:18394428 RGD:2317907 NCBI chr13:48,411,438...48,431,251 JBrowse link
G Agt angiotensinogen IDA RGD PMID:24184594 RGD:11039409 NCBI chr19:69,426,540...69,447,017 JBrowse link
G C1qtnf12 C1q and TNF related 12 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:22275362)
GO_Central
RGD
PMID:22275362 GO_REF:0000033 NCBI chr 5:171,833,854...171,838,229 JBrowse link
G Erfe erythroferrone involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:99,404,512...99,412,383 JBrowse link
G Gkap1 G kinase anchoring protein 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:25586176)
UniProt
Ensembl
RGD
PMID:25586176 GO_REF:0000024 GO_REF:0000107 NCBI chr17:6,383,963...6,423,684 JBrowse link
G Igf2 insulin-like growth factor 2 involved_in ISO
IBA
(PMID:11500939)
GO_REF:0000033
RGD
GO_Central
PMID:11500939 GO_REF:0000033 NCBI chr 1:197,814,409...197,831,802 JBrowse link
G Ins2 insulin 2 involved_in ISO (PMID:7513704)
(PMID:7688386)
RGD PMID:7513704 PMID:7688386 NCBI chr 1:207,272,738...207,421,998 JBrowse link
G Irs1 insulin receptor substrate 1 involved_in ISO
IMP
IEA
(PMID:7493946)
PMID:18285345
GO_REF:0000107
RGD
Ensembl
PMID:7493946 PMID:18285345 GO_REF:0000107, RGD:8553881 NCBI chr 9:91,001,137...91,053,959 JBrowse link
G Lep leptin IDA RGD PMID:20977462 RGD:5128575 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate IMP RGD PMID:19252893 RGD:9685323 NCBI chr20:42,240,185...42,245,882 JBrowse link
G Mfn2 mitofusin 2 IMP RGD PMID:25034891 RGD:13204821 NCBI chr 5:158,304,285...158,335,502 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16446356)
Ensembl
RGD
PMID:16446356 GO_REF:0000107 NCBI chr 7:25,733,471...25,829,440 JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 acts_upstream_of_or_within ISO (PMID:24931609) RGD PMID:24931609 NCBI chr13:45,897,275...45,926,491 JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase IMP RGD PMID:24085037 RGD:13208948 NCBI chr11:84,612,943...84,690,025 JBrowse link
G Osbpl8 oxysterol binding protein-like 8 acts_upstream_of_or_within
involved_in
ISO (PMID:21441927)
(PMID:23812417)
RGD PMID:21441927 PMID:23812417 NCBI chr 7:46,596,944...46,749,888 JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 IMP RGD PMID:25199455 RGD:11533947 NCBI chr 1:161,522,399...161,637,623 JBrowse link
G Prkcz protein kinase C, zeta involved_in IMP PMID:9374484 UniProt PMID:9374484 RGD:8553908 NCBI chr 5:171,101,774...171,212,694 JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 involved_in ISO
IEA
(PMID:7493946)
GO_REF:0000107
RGD
Ensembl
PMID:7493946 GO_REF:0000107 NCBI chr12:41,026,079...41,085,577 JBrowse link
G Serpina12 serpin family A member 12 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5568548 (PMID:22837305)
Ensembl
RGD
PMID:22837305 GO_REF:0000107 NCBI chr 6:122,952,552...122,967,271 JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA
(PMID:21241768)
GO_REF:0000107
RGD
Ensembl
PMID:21241768 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Snx5 sorting nexin 5 involved_in ISO (PMID:25825816) RGD PMID:25825816 NCBI chr 3:152,075,258...152,094,508 JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:11001060)
UniProt
RGD
PMID:11001060 GO_REF:0000024 NCBI chr 1:249,057,324...249,279,703 JBrowse link
G Sorl1 sortilin related receptor 1 involved_in ISO (PMID:27322061) RGD PMID:27322061 NCBI chr 8:51,238,713...51,401,458 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase IDA RGD PMID:14985360 RGD:1581139 NCBI chr 3:166,511,616...166,559,463 JBrowse link
G Tsc2 TSC complex subunit 2 acts_upstream_of_or_within ISO MGI:1270849|MGI:1927343 (PMID:15249583) RGD PMID:15249583 NCBI chr10:14,125,679...14,160,317 JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (PMID:29420538) RGD PMID:29420538 NCBI chr 2:174,795,831...174,811,980 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    response to stimulus 11012
      regulation of response to stimulus 4324
        regulation of signal transduction 3279
          regulation of insulin receptor signaling pathway 92
            negative regulation of insulin receptor signaling pathway + 57
            positive regulation of insulin receptor signaling pathway + 30
Path 2
Term Annotations click to browse term
  biological_process 20534
    biological regulation 13821
      regulation of biological process 13375
        regulation of cellular process 13013
          signal transduction 7250
            cell surface receptor signaling pathway 2882
              enzyme-linked receptor protein signaling pathway 1062
                cell surface receptor protein tyrosine kinase signaling pathway 671
                  insulin receptor signaling pathway 198
                    regulation of insulin receptor signaling pathway 92
                      negative regulation of insulin receptor signaling pathway + 57
                      positive regulation of insulin receptor signaling pathway + 30
paths to the root