ONTOLOGY REPORT - ANNOTATIONS
Term: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Accession: GO:0000288
browse the term
Definition: A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability.
Synonyms: exact_synonym: deadenylation-dependent mRNA decay; mRNA breakdown, deadenylation-dependent decay; mRNA catabolic process, deadenylation-dependent; mRNA catabolic process, deadenylylation-dependent; mRNA catabolism, deadenylation-dependent; mRNA catabolism, deadenylylation-dependent; mRNA degradation, deadenylation-dependent decay; nuclear mRNA catabolic process, deadenylation-dependent decay
xref: Reactome:R-HSA-429914 "Deadenylation-dependent mRNA decay"
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Cnot1
CCR4-NOT transcription complex, subunit 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr19:9,255,190...9,346,574
Ensembl chr19:9,255,194...9,346,574
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Cnot6l
CCR4-NOT transcription complex, subunit 6-like
acts_upstream_of_or_within
ISO
(PMID:17452450)
RGD
PMID:17452450
NCBI chr14:13,410,499...13,502,511
Ensembl chr14:13,411,281...13,498,203
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Pabpn1l
PABPN1 like
involved_in acts_upstream_of_or_within
IBA ISO
GO_REF:0000033 MGI:6509577 (PMID:32558204)
GO_Central RGD
PMID:32558204
GO_REF:0000033
NCBI chr19:50,669,965...50,673,409
Ensembl chr19:50,669,967...50,673,366
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Pde12
phosphodiesterase 12
involved_in
ISO IBA IEA
(PMID:21245038) GO_REF:0000033 GO_REF:0000107
RGD GO_Central Ensembl
PMID:21245038
GO_REF:0000033 GO_REF:0000107
NCBI chr16:1,920,062...1,925,638
Ensembl chr16:1,915,386...1,925,887
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Rc3h1
ring finger and CCCH-type domains 1
involved_in
ISO IBA
(PMID:26000482) GO_REF:0000033
RGD GO_Central
PMID:26000482
GO_REF:0000033
NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
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Rc3h2
ring finger and CCCH-type domains 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:21,121,531...21,186,711
Ensembl chr 3:21,110,679...21,179,933
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Zfp36
zinc finger protein 36
involved_in acts_upstream_of_or_within
ISO
(PMID:23644599) (PMID:15814898)
RGD
PMID:15814898 PMID:23644599
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Zfp36l1
zinc finger protein 36, C3H type-like 1
acts_upstream_of_or_within
ISO
(PMID:15814898)
RGD
PMID:15814898
NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
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Zfp36l2
zinc finger protein 36, C3H type-like 2
acts_upstream_of_or_within
ISO
(PMID:15814898)
RGD
PMID:15814898
NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064
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Cnot7
CCR4-NOT transcription complex, subunit 7
involved_in acts_upstream_of_or_within
ISO
(PMID:31439799) MGI:109382 (PMID:18625844)
RGD
PMID:18625844 PMID:31439799
NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576
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Dcp1a
decapping mRNA 1A
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:5,656,960...5,702,151
Ensembl chr16:5,656,773...5,702,140
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Dcp1b
decapping mRNA 1B
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:152,358,267...152,395,747
Ensembl chr 4:152,358,241...152,397,145
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Dcp2
decapping mRNA 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557
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Dcps
decapping enzyme, scavenger
involved_in
IEA IBA
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104
InterPro GO_Central UniProt
GO_REF:0000002 GO_REF:0000033 GO_REF:0000104
NCBI chr 8:33,468,669...33,524,407
Ensembl chr 8:33,415,671...33,524,389
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Lsm1
LSM1 homolog, mRNA degradation associated
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:66,277,345...66,288,852
Ensembl chr16:66,277,345...66,288,852
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Noct
nocturnin
acts_upstream_of_or_within
ISO
MGI:1298230 (PMID:18625844)
RGD
PMID:18625844
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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Pan3
poly(A) specific ribonuclease subunit PAN3
acts_upstream_of_or_within
ISO
(PMID:18625844)
RGD
PMID:18625844
NCBI chr12:7,476,707...7,595,384
Ensembl chr12:7,476,697...7,599,204
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Patl1
PAT1 homolog 1, processing body mRNA decay factor
involved_in
ISO IBA IEA ISS
(PMID:20584987), (PMID:20852261) GO_REF:0000033 GO_REF:0000002 GO_REF:0000024
RGD GO_Central InterPro UniProt
PMID:20584987 PMID:20852261
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033
NCBI chr 1:208,831,115...208,862,904
Ensembl chr 1:208,831,115...208,862,857
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Patl2
PAT1 homolog 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:109,072,958...109,087,425
Ensembl chr 3:109,075,290...109,083,253
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St3gal4
ST3 beta-galactoside alpha-2,3-sialyltransferase 4
involved_in
IEA
GO_REF:0000002 GO_REF:0000104
InterPro UniProt
GO_REF:0000002 GO_REF:0000104
NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389
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Eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
involved_in
ISO
(PMID:32354837)
RGD
PMID:32354837
NCBI chr14:78,056,115...78,099,846
Ensembl chr14:78,056,297...78,098,793
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Csde1
cold shock domain containing E1
involved_in
ISO IEA
(PMID:11051545) GO_REF:0000107
RGD Ensembl
PMID:11051545
GO_REF:0000107
NCBI chr 2:190,546,015...190,582,787
Ensembl chr 2:190,554,980...190,582,784
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Dhx9
DExH-box helicase 9
involved_in
ISO
(PMID:19029303)
RGD
PMID:19029303
NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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Hnrnpd
heterogeneous nuclear ribonucleoprotein D
involved_in
ISO
(PMID:11051545)
RGD
PMID:11051545
NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
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Hnrnpu
heterogeneous nuclear ribonucleoprotein U
involved_in
ISO IEA
(PMID:19029303) GO_REF:0000107
RGD Ensembl
PMID:19029303
GO_REF:0000107
NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588
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Igf2bp1
insulin-like growth factor 2 mRNA binding protein 1
involved_in
ISO
(PMID:19029303)
RGD
PMID:19029303
NCBI chr10:80,908,300...80,951,097
Ensembl chr10:80,908,076...80,951,129
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Pabpc1
poly(A) binding protein, cytoplasmic 1
involved_in
ISO
(PMID:11051545)
RGD
PMID:11051545
NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744
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Paip1
poly(A) binding protein interacting protein 1
involved_in
ISO
(PMID:11051545)
RGD
PMID:11051545
NCBI chr 2:51,523,190...51,550,241
Ensembl chr 2:51,522,921...51,550,241
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Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
involved_in
ISO IEA
(PMID:11051545), (PMID:19029303) GO_REF:0000107
RGD Ensembl
PMID:11051545 PMID:19029303
GO_REF:0000107
NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
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Ybx1
Y box binding protein 1
involved_in
ISO
(PMID:19029303)
RGD
PMID:19029303
NCBI chr 5:132,882,137...132,898,885
Ensembl chr 5:132,882,145...132,898,862
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Tent4a
terminal nucleotidyltransferase 4A
involved_in
ISO
(PMID:30026317)
RGD
PMID:30026317
NCBI chr 1:33,765,949...33,799,405
Ensembl chr 1:33,765,672...33,799,433
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Tent4b
terminal nucleotidyltransferase 4B
involved_in
ISO
(PMID:30026317)
RGD
PMID:30026317
NCBI chr19:18,807,616...18,868,969
Ensembl chr19:18,807,525...18,869,537
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Tob1
transducer of ErbB-2.1
involved_in
ISO IEA ISS
(PMID:18377426) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:18377426
GO_REF:0000024 GO_REF:0000107
NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215
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Cnot2
CCR4-NOT transcription complex, subunit 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:52,130,445...52,222,338
Ensembl chr 7:52,130,441...52,223,575
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Cnot3
CCR4-NOT transcription complex, subunit 3
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:65,555,924...65,572,167
Ensembl chr 1:65,555,924...65,572,167
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Cnot6
CCR4-NOT transcription complex, subunit 6
involved_in
ISO IEA ISS
(PMID:20595389) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:20595389
GO_REF:0000024 GO_REF:0000107
NCBI chr10:33,978,785...34,031,025
Ensembl chr10:33,980,831...34,031,025
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Cnot7
CCR4-NOT transcription complex, subunit 7
acts_upstream_of_or_within involved_in
ISO
(PMID:18625844) (PMID:21336257)
RGD
PMID:18625844 PMID:21336257
NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576
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Mlh1
mutL homolog 1
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:1857946 (PMID:11337385)
Ensembl RGD
PMID:11337385
GO_REF:0000107
NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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Pan2
poly(A) specific ribonuclease subunit PAN2
involved_in
IEA IBA
GO_REF:0000104 GO_REF:0000033
UniProt GO_Central
GO_REF:0000033 GO_REF:0000104
NCBI chr 7:729,146...747,744
Ensembl chr 7:729,562...747,744
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Pan3
poly(A) specific ribonuclease subunit PAN3
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr12:7,476,707...7,595,384
Ensembl chr12:7,476,697...7,599,204
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Parn
poly(A)-specific ribonuclease
acts_upstream_of_or_within involved_in
ISO IBA
(PMID:18337750) GO_REF:0000033
RGD GO_Central
PMID:18337750
GO_REF:0000033
NCBI chr10:1,410,636...1,548,573
Ensembl chr10:1,410,642...1,548,560
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Pnldc1
PARN like ribonuclease domain containing exonuclease 1
involved_in
ISO IBA
(PMID:27515512) GO_REF:0000033
RGD GO_Central
PMID:27515512
GO_REF:0000033
NCBI chr 1:47,843,224...47,861,675
Ensembl chr 1:47,843,224...47,861,674
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Samd4a
sterile alpha motif domain containing 4A
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr15:20,135,994...20,352,131
Ensembl chr15:20,134,377...20,348,380
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Samd4b
sterile alpha motif domain containing 4B
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:83,689,413...83,728,652
Ensembl chr 1:83,689,413...83,713,853
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Zfp36
zinc finger protein 36
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 (PMID:15814898) (PMID:23644599)
Ensembl RGD
PMID:15814898 PMID:23644599
GO_REF:0000107
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Ago2
argonaute RISC catalytic component 2
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:19716330)
UniProt Ensembl RGD
PMID:19716330
GO_REF:0000024 GO_REF:0000107
NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974
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Cnot1
CCR4-NOT transcription complex, subunit 1
involved_in
ISO
(PMID:21278420)
RGD
PMID:21278420
NCBI chr19:9,255,190...9,346,574
Ensembl chr19:9,255,194...9,346,574
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Cnot7
CCR4-NOT transcription complex, subunit 7
involved_in
ISO
(PMID:21278420) (PMID:19716330)
RGD
PMID:19716330 PMID:21278420
NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576
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Cpeb3
cytoplasmic polyadenylation element binding protein 3
involved_in
ISO
(PMID:21336257)
RGD
PMID:21336257
NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560
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Dhx36
DEAH-box helicase 36
involved_in
ISO
(PMID:14731398)
RGD
PMID:14731398
NCBI chr 2:146,856,469...146,894,577
Ensembl chr 2:146,856,469...146,894,572
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Pabpc1
poly(A) binding protein, cytoplasmic 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:19716330)
UniProt RGD
PMID:19716330
GO_REF:0000024
NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744
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Tnrc6b
trinucleotide repeat containing adaptor 6B
involved_in
ISO
(PMID:19716330)
RGD
PMID:19716330
NCBI chr 7:112,252,351...112,469,829
Ensembl chr 7:112,252,359...112,461,790
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Tnrc6c
trinucleotide repeat containing adaptor 6C
involved_in
ISO
(PMID:21984185)
RGD
PMID:21984185
NCBI chr10:102,908,958...102,979,543
Ensembl chr10:102,868,828...102,978,194
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Tob1
transducer of ErbB-2.1
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:21336257) GO_REF:0000107
UniProt RGD Ensembl
PMID:21336257
GO_REF:0000024 GO_REF:0000107
NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215
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Zfp36
zinc finger protein 36
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:12748283) GO_REF:0000104 (PMID:21278420)
UniProt RGD
PMID:12748283 PMID:21278420
GO_REF:0000024 GO_REF:0000104
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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Zfp36l1
zinc finger protein 36, C3H type-like 1
involved_in
IDA
PMID:12748283
UniProt
PMID:12748283
RGD:11344945
NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
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Zfp36l2
zinc finger protein 36, C3H type-like 2
involved_in
ISO
(PMID:22367205)
RGD
PMID:22367205
NCBI chr 6:10,490,032...10,494,073
Ensembl chr 6:10,490,032...10,494,064
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Ago2
argonaute RISC catalytic component 2
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:19716330) GO_REF:0000107
UniProt RGD Ensembl
PMID:19716330
GO_REF:0000024 GO_REF:0000107
NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974
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Btg2
BTG anti-proliferation factor 2
acts_upstream_of_or_within
ISO
(PMID:18337750)
RGD
PMID:18337750
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Cnot1
CCR4-NOT transcription complex, subunit 1
involved_in
ISO
(PMID:21278420), (PMID:23644599)
RGD
PMID:21278420 PMID:23644599
NCBI chr19:9,255,190...9,346,574
Ensembl chr19:9,255,194...9,346,574
G
Cnot7
CCR4-NOT transcription complex, subunit 7
involved_in
ISO
(PMID:21278420) (PMID:19716330)
RGD
PMID:19716330 PMID:21278420
NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576
G
Cpeb3
cytoplasmic polyadenylation element binding protein 3
involved_in
ISO
(PMID:21336257)
RGD
PMID:21336257
NCBI chr 1:234,749,138...234,931,219
Ensembl chr 1:234,751,733...234,931,560
G
Eif4enif1
eukaryotic translation initiation factor 4E nuclear import factor 1
involved_in
ISO
(PMID:32354837)
RGD
PMID:32354837
NCBI chr14:78,056,115...78,099,846
Ensembl chr14:78,056,297...78,098,793
G
Pabpc1
poly(A) binding protein, cytoplasmic 1
involved_in
ISS ISO
GO_REF:0000024 (PMID:19716330)
UniProt RGD
PMID:19716330
GO_REF:0000024
NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744
G
Polr2g
RNA polymerase II subunit G
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:205,689,160...205,692,537
Ensembl chr 1:205,689,160...205,692,686
G
Tnrc6a
trinucleotide repeat containing adaptor 6A
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:177,561,898...177,715,669
Ensembl chr 1:177,646,030...177,715,660
G
Tnrc6b
trinucleotide repeat containing adaptor 6B
involved_in
ISO IBA
(PMID:19716330) GO_REF:0000033
RGD GO_Central
PMID:19716330
GO_REF:0000033
NCBI chr 7:112,252,351...112,469,829
Ensembl chr 7:112,252,359...112,461,790
G
Tnrc6c
trinucleotide repeat containing adaptor 6C
involved_in
ISO IBA
(PMID:21984185) GO_REF:0000033
RGD GO_Central
PMID:21984185
GO_REF:0000033
NCBI chr10:102,908,958...102,979,543
Ensembl chr10:102,868,828...102,978,194
G
Tob1
transducer of ErbB-2.1
involved_in
ISO IEA ISS
(PMID:21336257) GO_REF:0000107 GO_REF:0000024
RGD Ensembl UniProt
PMID:21336257
GO_REF:0000024 GO_REF:0000107
NCBI chr10:79,163,093...79,165,131
Ensembl chr10:79,160,154...79,165,215
G
Zfp36
zinc finger protein 36
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:20595389), (PMID:21278420) GO_REF:0000107 (PMID:10330172)
UniProt RGD Ensembl
PMID:10330172 PMID:20595389 PMID:21278420
GO_REF:0000024 GO_REF:0000107
NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
G
Caprin1
cell cycle associated protein 1
involved_in
ISS IEA ISO
GO_REF:0000024 GO_REF:0000107 (PMID:31439799)
UniProt Ensembl RGD
PMID:31439799
GO_REF:0000024 GO_REF:0000107
NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
G
Rc3h1
ring finger and CCCH-type domains 1
involved_in
ISO
(PMID:31636267)
RGD
PMID:31636267
NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
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