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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Nutlin
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Accession:CHEBI:46741 term browser browse the term
Definition:Nutlins (for Nutley inhibitors) are a family of cis-imidazoline analogues. They are MDM2 antagonists and are named after the location (Nutley) in which they were developed.
Synonyms:related_synonym: Nutlins


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Nutlin-3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Nutlin-3 increases expression of ABCA1 mRNA and protein in human cell lines SK-HEP-1 and HCT116 RGD PMID:30580964 RGD:24922199 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
decreases expression
multiple interactions		 ISO ABCB1 protein affects the susceptibility to nutlin 3
nutlin 3 results in decreased expression of ABCB1 protein
PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCB1 protein]		 CTD PMID:33974899 PMID:35213076 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
decreases expression		 ISO PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCC1 protein] CTD PMID:35213076 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression
multiple interactions		 ISO nutlin 3 results in decreased expression of ABCC2 protein
PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCC2 protein]		 CTD PMID:35213076 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [nutlin 3 co-treated with Bortezomib] results in increased activity of BAK1 protein CTD PMID:20850924 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [nutlin 3 co-treated with Bortezomib] results in increased activity of BAX protein; Cisplatin promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of BAX protein modified form]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]
nutlin 3 results in increased expression of BAX; nutlin 3 results in increased expression of BAX mRNA; nutlin 3 results in increased expression of BAX protein		 CTD PMID:16014563 PMID:16439685 PMID:16949053 PMID:20422343 PMID:20850924 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions		 ISO nutlin 3 results in increased expression of BBC3; nutlin 3 results in increased expression of BBC3 mRNA; nutlin 3 results in increased expression of BBC3 protein
nutlin 3 promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [nutlin 3 results in increased expression of BBC3 protein]		 CTD PMID:16014563 PMID:16439685 PMID:20422343 PMID:21109480 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO nutlin 3 results in decreased expression of BCL2; nutlin 3 results in decreased expression of BCL2 protein
PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of BCL2 protein]		 CTD PMID:20422343 PMID:35213076 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression		 ISO nutlin 3 promotes the reaction [TP53 protein binds to BCL2L1 protein]
nutlin 3 results in decreased expression of BCL2L1 protein		 CTD PMID:16014563 PMID:21109480 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO [nutlin 3 co-treated with Bortezomib] results in increased activity of CASP3 protein; nutlin 3 results in increased cleavage of and results in increased activity of CASP3 protein; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP3 protein] CTD PMID:16014563 PMID:20850924 PMID:21109480 PMID:22260869 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO nutlin 3 results in increased activity of CASP7 protein
TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP7 protein]		 CTD PMID:22260869 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO nutlin 3 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16014563 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [nutlin 3 co-treated with Bortezomib] results in increased activity of CASP9 protein; nutlin 3 results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16014563 PMID:20850924 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO nutlin 3 results in increased expression of CDKN1A mRNA; nutlin 3 results in increased expression of CDKN1A protein
Cisplatin promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; Cisplatin promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]; nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of CDKN1A protein modified form]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]		 CTD PMID:16014563 PMID:16439677 PMID:16439685 PMID:16949053 PMID:19098008 More... NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression ISO nutlin 3 results in increased expression of DDB1 mRNA CTD PMID:16439677 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676 		JBrowse link
G Edn1 endothelin 1 increases expression ISO nutlin 3 results in increased expression of EDN1 mRNA; nutlin 3 results in increased expression of EDN1 protein CTD PMID:19098008 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]] which results in increased susceptibility to Cisplatin; nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]; nutlin 3 promotes the reaction [TP53 protein results in increased expression of FAS protein] CTD PMID:21509038 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]] which results in increased susceptibility to Cisplatin; nutlin 3 promotes the reaction [FAS protein binds to FASLG protein] CTD PMID:21509038 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO nutlin 3 results in increased expression of GADD45A protein CTD PMID:19098008 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO nutlin 3 results in increased expression of GDF15 mRNA CTD PMID:16439677 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA] CTD PMID:20530418 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G H19 H19 imprinted maternally expressed transcript decreases expression ISO nutlin 3 results in decreased expression of H19 mRNA CTD PMID:25860607 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134 		JBrowse link
G Kitlg KIT ligand increases expression ISO nutlin 3 results in increased expression of KITLG mRNA; nutlin 3 results in increased expression of KITLG protein CTD PMID:19098008 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression
decreases expression		 ISO [nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein; nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]; nutlin 3 inhibits the reaction [TP73 binds to MDM2]; nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 results in increased activity of and results in increased expression of MDM2 protein; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of MDM2 protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of MDM2 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 protein]
nutlin 3 results in increased expression of MDM2 mRNA; nutlin 3 results in increased expression of MDM2 protein; nutlin 3 results in increased expression of MDM2 protein modified form		 CTD PMID:16014563 PMID:16439685 PMID:16949053 PMID:19098008 PMID:20422343 More... NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO TP53 mutant form inhibits the reaction [nutlin 3 results in increased cleavage of PARP1 protein] CTD PMID:22260869 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO nutlin 3 results in increased expression of PCNA mRNA CTD PMID:16439677 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO nutlin 3 results in increased expression of PERP mRNA CTD PMID:16949053 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions		 ISO nutlin 3 results in increased expression of PMAIP1 protein
[nutlin 3 co-treated with Bortezomib] results in increased expression of PMAIP1 protein; [nutlin 3 co-treated with Cisplatin] results in increased expression of PMAIP1 mRNA		 CTD PMID:16014563 PMID:20850924 PMID:21109480 PMID:21205074 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pvt1 Pvt1 oncogene multiple interactions ISO PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCB1 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCC1 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCC2 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of BCL2 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of MDM2 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of BAX protein modified form]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of CDKN1A protein modified form]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of TP53 protein modified form]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of TP53 protein] CTD PMID:35213076 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA] CTD PMID:20530418 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Tp53 tumor protein p53 increases activity
multiple interactions
increases expression
increases stability
increases response to substance		 ISO nutlin 3 results in increased activity of TP53 protein
[nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein; [nutlin 3 results in increased stability of TP53 protein] which results in increased susceptibility to Cisplatin; [nutlin 3 results in increased stability of TP53 protein] which results in increased susceptibility to Fluorouracil; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [Camptothecin results in increased expression of TP53 protein]; nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]; nutlin 3 promotes the reaction [Cisplatin results in increased expression of TP53 mRNA]; nutlin 3 promotes the reaction [Cisplatin results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [Cisplatin results in increased localization of TP53 protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [Methotrexate results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [TP53 protein binds to BCL2L1 protein]; nutlin 3 promotes the reaction [TP53 protein results in increased expression of FAS protein]; nutlin 3 results in increased expression of and affects the localization of TP53 protein; nutlin 3 results in increased expression of and results in increased localization of and results in increased activity of TP53 protein; nutlin 3 results in increased expression of and results in increased phosphorylation of TP53 protein; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of TP53 protein modified form]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of MDM2 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP3 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP7 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of BBC3 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 protein]
nutlin 3 results in increased expression of TP53 mRNA; nutlin 3 results in increased expression of TP53 protein; nutlin 3 results in increased expression of TP53 protein modified form
TP53 results in increased susceptibility to nutlin 3
nutlin 3 results in increased activity of TRP53 protein
nutlin 3 results in increased expression of TRP53 protein		 CTD PMID:16014563 PMID:16439677 PMID:16439685 PMID:16949053 PMID:18092340 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO nutlin 3 results in increased expression of TP53I3 mRNA; nutlin 3 results in increased expression of TP53I3 protein CTD PMID:16439677 PMID:16439685 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO nutlin 3 inhibits the reaction [TP73 binds to MDM2] CTD PMID:20422343 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO nutlin 3 results in increased expression of ZMAT3 mRNA; nutlin 3 results in increased expression of ZMAT3 protein CTD PMID:16439685 NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      application 19653
        pharmaceutical 19494
          drug 19494
            antineoplastic agent 17763
              Nutlin 34
                Nutlin-3 34
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19731
                        carbon atom 19727
                          organic molecular entity 19727
                            heteroorganic entity 19484
                              organochalcogen compound 19248
                                organooxygen compound 19165
                                  carbon oxoacid 18633
                                    carboxylic acid 18630
                                      carboacyl group 17703
                                        univalent carboacyl group 17703
                                          carbamoyl group 17553
                                            carboxamide 17553
                                              monocarboxylic acid amide 15683
                                                urea 5580
                                                  ureas 5578
                                                    N-carbamoylpiperazine 35
                                                      Nutlin 34
                                                        Nutlin-3 34
paths to the root