GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | nutlin 3 results in increased expression of BAX mRNA | PMID:16949053 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | nutlin 3 results in increased expression of BAX; nutlin 3 results in increased expression of BAX mRNA; nutlin 3 results in increased expression of BAX protein | PMID:16014563 PMID:16439685 PMID:20422343 PMID:21109480 PMID:35213076 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [nutlin 3 co-treated with Bortezomib] results in increased activity of BAX protein; Cisplatin promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of BAX protein modified form]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of BAX mRNA] | PMID:20850924 PMID:21109480 PMID:35213076 | |
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