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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:46742
Term: Nutlin-3
Definition: A Nutlin that has formula C30H30Cl2N4O4.
Chemical ID: MESH:C482205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionISOBax (Mus musculus)6480464CTDnutlin 3 results in increased expression of BAX mRNAPMID:16949053
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDnutlin 3 results in increased expression of BAX; nutlin 3 results in increased expression of BAX mRNA; nutlin 3 results in increased expression of BAX proteinPMID:16014563 PMID:16439685 PMID:20422343 PMID:21109480 PMID:35213076
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[nutlin 3 co-treated with Bortezomib] results in increased activity of BAX protein; Cisplatin promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of BAX protein modified form]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]PMID:20850924 PMID:21109480 PMID:35213076
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