Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Nutlin-3
go back to main search page
Accession:CHEBI:46742 term browser browse the term
Definition:A Nutlin that has formula C30H30Cl2N4O4.
Synonyms:exact_synonym: rel-4-{[(4R,5S)-4,5-bis(4-chlorophenyl)-2-{2-[(propan-2-yl)oxy]-4-methoxyphenyl}-4,5-dihydro-1H-imidazol-1-yl]carbonyl}piperazin-2-one
 related_synonym: Formula=C30H30Cl2N4O4;   InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1;   InChIKey=BDUHCSBCVGXTJM-IZLXSDGUSA-N;   SMILES=COc1ccc(c(OC(C)C)c1)C1=N[C@@H]([C@@H](N1C(=O)N1CCNC(=O)C1)c1ccc(Cl)cc1)c1ccc(Cl)cc1;   cis-4-{[4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl}piperazin-2-one
 xref: Beilstein:10243211;   CAS:548472-68-0
 xref_mesh: MESH:C482205


show annotations for term's descendants           Sort by:
 
Nutlin-3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Nutlin-3 increases expression of ABCA1 mRNA and protein in human cell lines SK-HEP-1 and HCT116 RGD PMID:30580964 RGD:24922199 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [nutlin 3 co-treated with Bortezomib] results in increased activity of BAK1 protein CTD PMID:20850924 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [nutlin 3 co-treated with Bortezomib] results in increased activity of BAX protein; Cisplatin promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]
nutlin 3 results in increased expression of BAX; nutlin 3 results in increased expression of BAX mRNA; nutlin 3 results in increased expression of BAX protein
CTD PMID:16014563, PMID:16439685, PMID:16949053, PMID:20422343, PMID:20850924, PMID:21109480 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression
multiple interactions
ISO nutlin 3 results in increased expression of BBC3; nutlin 3 results in increased expression of BBC3 mRNA; nutlin 3 results in increased expression of BBC3 protein
nutlin 3 promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [nutlin 3 results in increased expression of BBC3 protein]
CTD PMID:16014563, PMID:16439685, PMID:20422343, PMID:21109480 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO nutlin 3 results in decreased expression of BCL2 CTD PMID:20422343 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO nutlin 3 promotes the reaction [TP53 protein binds to BCL2L1 protein]
nutlin 3 results in decreased expression of BCL2L1 protein
CTD PMID:16014563, PMID:21109480 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [nutlin 3 co-treated with Bortezomib] results in increased activity of CASP3 protein; nutlin 3 results in increased cleavage of and results in increased activity of CASP3 protein; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP3 protein] CTD PMID:16014563, PMID:20850924, PMID:21109480, PMID:22260869 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO nutlin 3 results in increased activity of CASP7 protein
TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP7 protein]
CTD PMID:22260869 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO nutlin 3 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16014563 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [nutlin 3 co-treated with Bortezomib] results in increased activity of CASP9 protein; nutlin 3 results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16014563, PMID:20850924 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO nutlin 3 results in increased expression of CDKN1A mRNA; nutlin 3 results in increased expression of CDKN1A protein
Cisplatin promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; Cisplatin promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]; nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]
CTD PMID:16014563, PMID:16439677, PMID:16439685, PMID:16949053, PMID:19098008, PMID:20530418, PMID:21109480, PMID:21205074, PMID:21624110 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 increases expression ISO nutlin 3 results in increased expression of DDB1 mRNA CTD PMID:16439677 NCBI chr 1:226,657,561...226,683,356
Ensembl chr 1:226,657,561...226,683,347
JBrowse link
G Edn1 endothelin 1 increases expression ISO nutlin 3 results in increased expression of EDN1 mRNA; nutlin 3 results in increased expression of EDN1 protein CTD PMID:19098008 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO [nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]] which results in increased susceptibility to Cisplatin; nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]; nutlin 3 promotes the reaction [TP53 protein results in increased expression of FAS protein] CTD PMID:21509038 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand multiple interactions ISO [nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]] which results in increased susceptibility to Cisplatin; nutlin 3 promotes the reaction [FAS protein binds to FASLG protein] CTD PMID:21509038 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO nutlin 3 results in increased expression of GADD45A protein CTD PMID:19098008 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO nutlin 3 results in increased expression of GDF15 mRNA CTD PMID:16439677 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA] CTD PMID:20530418 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Kitlg KIT ligand increases expression ISO nutlin 3 results in increased expression of KITLG mRNA; nutlin 3 results in increased expression of KITLG protein CTD PMID:19098008 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions
increases expression
ISO [nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein; nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]; nutlin 3 inhibits the reaction [TP73 binds to MDM2]; nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 results in increased activity of and results in increased expression of MDM2 protein; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of MDM2 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 protein]
nutlin 3 results in increased expression of MDM2 mRNA; nutlin 3 results in increased expression of MDM2 protein; nutlin 3 results in increased expression of MDM2 protein modified form
CTD PMID:16014563, PMID:16439685, PMID:16949053, PMID:19098008, PMID:20422343, PMID:21109480, PMID:21509038, PMID:21624110, PMID:22044530, PMID:22260869 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO TP53 mutant form inhibits the reaction [nutlin 3 results in increased cleavage of PARP1 protein] CTD PMID:22260869 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pcna proliferating cell nuclear antigen increases expression ISO nutlin 3 results in increased expression of PCNA mRNA CTD PMID:16439677 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Perp p53 apoptosis effector related to PMP22 increases expression ISO nutlin 3 results in increased expression of PERP mRNA CTD PMID:16949053 NCBI chr 1:14,224,392...14,236,838
Ensembl chr 1:14,224,393...14,236,846
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions
ISO nutlin 3 results in increased expression of PMAIP1 protein
[nutlin 3 co-treated with Bortezomib] results in increased expression of PMAIP1 protein; [nutlin 3 co-treated with Cisplatin] results in increased expression of PMAIP1 mRNA
CTD PMID:16014563, PMID:20850924, PMID:21109480, PMID:21205074 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA] CTD PMID:20530418 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Tp53 tumor protein p53 increases activity
increases expression
increases response to substance
increases stability
multiple interactions
ISO nutlin 3 results in increased activity of TP53 protein
nutlin 3 results in increased expression of TRP53 protein
nutlin 3 results in increased activity of TRP53 protein
TP53 results in increased susceptibility to nutlin 3
nutlin 3 results in increased stability of TP53 protein
nutlin 3 results in increased expression of TP53 mRNA; nutlin 3 results in increased expression of TP53 protein; nutlin 3 results in increased expression of TP53 protein modified form
[nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein; [nutlin 3 results in increased stability of TP53 protein] which results in increased susceptibility to Cisplatin; [nutlin 3 results in increased stability of TP53 protein] which results in increased susceptibility to Fluorouracil; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [Camptothecin results in increased expression of TP53 protein]; nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]; nutlin 3 promotes the reaction [Cisplatin results in increased expression of TP53 mRNA]; nutlin 3 promotes the reaction [Cisplatin results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [Cisplatin results in increased localization of TP53 protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [Methotrexate results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [TP53 protein binds to BCL2L1 protein]; nutlin 3 promotes the reaction [TP53 protein results in increased expression of FAS protein]; nutlin 3 results in increased expression of and affects the localization of TP53 protein; nutlin 3 results in increased expression of and results in increased localization of and results in increased activity of TP53 protein; nutlin 3 results in increased expression of and results in increased phosphorylation of TP53 protein; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of MDM2 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP3 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP7 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of BBC3 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 protein]
CTD PMID:16014563, PMID:16439677, PMID:16439685, PMID:16949053, PMID:18092340, PMID:19098008, PMID:20530418, PMID:21109480, PMID:21205074, PMID:21212465, PMID:21509038, PMID:21532991, PMID:21624110, PMID:22044530, PMID:22260869, PMID:24726431 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO nutlin 3 results in increased expression of TP53I3 mRNA; nutlin 3 results in increased expression of TP53I3 protein CTD PMID:16439677, PMID:16439685 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO nutlin 3 inhibits the reaction [TP73 binds to MDM2] CTD PMID:20422343 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO nutlin 3 results in increased expression of ZMAT3 mRNA; nutlin 3 results in increased expression of ZMAT3 protein CTD PMID:16439685 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        antimicrobial agent 17334
          antiviral agent 10253
            anticoronaviral agent 8944
              Nutlin-3 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        carboacyl group 17372
                                          univalent carboacyl group 17372
                                            carbamoyl group 17158
                                              carboxamide 17158
                                                monocarboxylic acid amide 14569
                                                  urea 4989
                                                    ureas 4987
                                                      N-carbamoylpiperazine 30
                                                        Nutlin 29
                                                          Nutlin-3 29
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.