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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid
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Accession:CHEBI:174627 term browser browse the term
Synonyms:exact_synonym: 2-hydroxy-6-[(8E,11E)-pentadeca-8,11,14-trienyl]benzoic acid
 related_synonym: Formula=C22H30O3;   InChI=1S/C22H30O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19-17-15-18-20(23)21(19)22(24)25/h2,4-5,7-8,15,17-18,23H,1,3,6,9-14,16H2,(H,24,25)/b5-4+,8-7+;   InChIKey=QUVGEKPNSCFQIR-AOSYACOCSA-N;   SMILES=OC=1C(=C(CCCCCCC/C=C/C/C=C/CC=C)C=CC1)C(O)=O
 xref: CAS:18654-18-7;   Chemspider:4534900;   HMDB:HMDB0031059
 xref_mesh: MESH:C088115



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2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2 protein] CTD PMID:18349320 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] CTD PMID:18349320 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO anacardic acid inhibits the reaction [Dronabinol results in increased expression of BDNF mRNA] CTD PMID:28481360 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:18349320 NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] CTD PMID:18349320 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636
JBrowse link
G CASP3 caspase 3 multiple interactions EXP
ISO
[anacardic acid co-treated with TNF protein] results in increased cleavage of CASP3 protein
[anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein]] which results in decreased cleavage of CASP3 protein
CTD PMID:18349320 PMID:31927229 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CASP8 caspase 8 multiple interactions EXP [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein CTD PMID:18349320 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836
JBrowse link
G CASP9 caspase 9 multiple interactions EXP [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP9 protein CTD PMID:18349320 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:18349320 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:18349320 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687
JBrowse link
G CREBBP CREB binding protein decreases activity ISO anacardic acid results in decreased activity of CREBBP protein CTD PMID:31927229 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713
JBrowse link
G EGF epidermal growth factor decreases response to substance EXP anacardic acid results in decreased susceptibility to EGF protein CTD PMID:18349320 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EP300 E1A binding protein p300 multiple interactions
decreases activity
decreases expression
affects activity
ISO
EXP
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]
anacardic acid results in decreased activity of EP300 protein
anacardic acid results in decreased expression of EP300 protein
anacardic acid affects the activity of EP300 protein
CTD PMID:18349320 PMID:23297412 PMID:31927229 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions ISO anacardic acid promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA] CTD PMID:29054681 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:18349320 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IFNL1 interferon lambda 1 multiple interactions EXP anacardic acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA] CTD PMID:37611859 NCBI chr19:39,296,407...39,298,673
Ensembl chr19:39,296,407...39,298,673
JBrowse link
G IFNL2 interferon lambda 2 multiple interactions EXP anacardic acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL2 mRNA] CTD PMID:37611859 NCBI chr19:39,268,396...39,270,188
Ensembl chr19:39,268,396...39,270,188
JBrowse link
G IL1B interleukin 1 beta decreases response to substance EXP anacardic acid results in decreased susceptibility to IL1B protein CTD PMID:18349320 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL33 interleukin 33 multiple interactions EXP anacardic acid inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL33 mRNA]; anacardic acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] CTD PMID:37545493 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP anacardic acid inhibits the reaction [Tretinoin results in increased expression of ITGAM] CTD PMID:24819975 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G KAT2B lysine acetyltransferase 2B decreases activity ISO anacardic acid results in decreased activity of KAT2B protein CTD PMID:31927229 NCBI chr 3:20,040,446...20,154,404
Ensembl chr 3:20,040,446...20,154,404
JBrowse link
G KL klotho multiple interactions ISO anacardic acid inhibits the reaction [Dronabinol results in increased expression of KL mRNA] CTD PMID:28481360 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143
JBrowse link
G MAP3K14 mitogen-activated protein kinase kinase kinase 14 decreases activity EXP anacardic acid results in decreased activity of MAP3K14 protein CTD PMID:18349320 NCBI chr17:45,263,119...45,317,020
Ensembl chr17:45,263,119...45,317,029
JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 decreases activity EXP anacardic acid results in decreased activity of MAP3K7 protein CTD PMID:18349320 NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086
JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions ISO anacardic acid binds to and results in decreased activity of MMP2 protein CTD PMID:22745359 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP
ISO
anacardic acid inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
anacardic acid binds to and results in decreased activity of MMP9 protein
CTD PMID:18349320 PMID:22745359 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:18349320 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G MYH7 myosin heavy chain 7 multiple interactions ISO anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:15593114 NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
ISO anacardic acid results in increased expression of NFE2L2 mRNA
[anacardic acid results in increased susceptibility to manganese chloride] which results in increased expression of NFE2L2 mRNA; anacardic acid inhibits the reaction [manganese chloride results in increased activity of NFE2L2 protein]; manganese chloride promotes the reaction [anacardic acid results in increased expression of NFE2L2 mRNA]
CTD PMID:29054681 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:18349320 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anacardic acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:18349320 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
JBrowse link
G PRKCD protein kinase C delta multiple interactions ISO anacardic acid inhibits the reaction [Paraquat results in increased cleavage of and results in increased activity of PRKCD protein] CTD PMID:21777615 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:18349320 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP anacardic acid inhibits the reaction [TNF protein affects the localization of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]] CTD PMID:18349320 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions EXP anacardic acid inhibits the reaction [Tretinoin results in increased expression of RUNX2 mRNA] CTD PMID:24819975 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349
JBrowse link
G SP7 Sp7 transcription factor multiple interactions EXP anacardic acid inhibits the reaction [Tretinoin results in increased expression of SP7 mRNA] CTD PMID:24819975 NCBI chr12:53,326,575...53,344,793
Ensembl chr12:53,326,575...53,345,315
JBrowse link
G SPP1 secreted phosphoprotein 1 multiple interactions EXP anacardic acid inhibits the reaction [Tretinoin results in increased expression of SPP1 mRNA] CTD PMID:24819975 NCBI chr 4:87,975,714...87,983,411
Ensembl chr 4:87,975,667...87,983,532
JBrowse link
G SYN1 synapsin I multiple interactions ISO anacardic acid affects the reaction [Dronabinol affects the expression of SYN1 protein] CTD PMID:28481360 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases response to substance
EXP [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP3 protein; [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein; [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP9 protein; anacardic acid inhibits the reaction [4-octylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of TNF]; anacardic acid inhibits the reaction [TNF protein affects the localization of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]; anacardic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of MYC protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of XIAP protein]; anacardic acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]
anacardic acid results in decreased susceptibility to TNF protein
CTD PMID:18349320 PMID:20056579 PMID:24039973 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP
ISO
anacardic acid inhibits the reaction [[Fluorouracil results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein]; anacardic acid inhibits the reaction [Genistein promotes the reaction [trichostatin A results in increased acetylation of TP53 protein]]
[anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein]] which results in decreased cleavage of CASP3 protein; anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein]
CTD PMID:26768552 PMID:27129209 PMID:31927229 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G TRADD TNFRSF1A associated via death domain decreases activity EXP anacardic acid results in decreased activity of TRADD protein CTD PMID:18349320 NCBI chr16:67,154,185...67,159,909
Ensembl chr16:67,154,185...67,159,909
JBrowse link
G TRAF2 TNF receptor associated factor 2 decreases activity EXP anacardic acid results in decreased activity of TRAF2 protein CTD PMID:18349320 NCBI chr 9:136,881,958...136,926,607
Ensembl chr 9:136,881,912...136,926,607
JBrowse link
G UBE2C ubiquitin conjugating enzyme E2 C multiple interactions EXP anacardic acid inhibits the reaction [[Fluorouracil results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein] CTD PMID:27129209 NCBI chr20:45,812,644...45,816,952
Ensembl chr20:45,812,576...45,816,957
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of VEGFA protein] CTD PMID:18349320 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP anacardic acid inhibits the reaction [TNF protein results in increased expression of XIAP protein] CTD PMID:18349320 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 26050
    role 25966
      biological role 25945
        antimicrobial agent 21932
          antifungal agent 19719
            salicylic acid 1624
              2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      carbon group element atom 25447
                        carbon atom 25405
                          organic molecular entity 25405
                            heteroorganic entity 24781
                              organochalcogen compound 24394
                                organooxygen compound 24071
                                  carbon oxoacid 22773
                                    carboxylic acid 22753
                                      aromatic carboxylic acid 13402
                                        benzoic acids 13376
                                          benzoic acid 5811
                                            hydroxybenzoic acid 5215
                                              monohydroxybenzoic acid 2913
                                                salicylic acid 1624
                                                  2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid 45
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