|
G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
EXP |
Salicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA] |
CTD |
PMID:25108154 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
decreases activity multiple interactions |
ISO |
Salicylic Acid results in decreased activity of AKR1C1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin]]; Salicylic Acid inhibits the reaction [AKR1C1 protein results in decreased susceptibility to Cisplatin] |
CTD |
PMID:19010312 PMID:23165153 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
decreases activity increases expression |
ISO |
Salicylic Acid results in decreased activity of AKR1C2 protein Salicylic Acid results in increased expression of AKR1C2 mRNA |
CTD |
PMID:19010312 PMID:20491607 |
|
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases activity |
ISO |
Salicylic Acid results in decreased activity of AKR1C3 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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G |
Arg1 |
arginase 1 |
multiple interactions |
EXP |
Salicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] |
CTD |
PMID:25108154 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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|
G |
Asic3 |
acid sensing ion channel subunit 3 |
decreases activity |
EXP |
Salicylic Acid results in decreased activity of ASIC3 protein |
CTD |
PMID:11588175 |
|
NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643
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|
G |
Casp1 |
caspase 1 |
increases phosphorylation |
ISO |
Salicylic Acid results in increased phosphorylation of CASP1 protein |
CTD |
PMID:30842373 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP ISO |
Salicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA] Salicylic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] |
CTD |
PMID:25108154 PMID:36416909 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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|
G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
Salicylic Acid results in increased expression of CXCL2 protein |
CTD |
PMID:23178550 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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|
G |
Gpx2 |
glutathione peroxidase 2 |
decreases expression |
EXP |
Salicylic acid decreases expression of Gpx2 mRNA in proximal and distal colon |
RGD |
PMID:16038882 |
RGD:152998891 |
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions affects expression |
ISO |
Potassium Chloride affects the reaction [Salicylic Acid affects the expression of ICAM1 protein] |
CTD |
PMID:30842373 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
|
|
G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Salicylic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] |
CTD |
PMID:36416909 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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|
G |
Il1a |
interleukin 1 alpha |
increases expression |
ISO |
Salicylic Acid results in increased expression of IL1A protein |
CTD |
PMID:23178550 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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|
G |
Il1b |
interleukin 1 beta |
increases expression |
ISO |
Salicylic Acid results in increased expression of IL1B protein |
CTD |
PMID:30842373 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il4 |
interleukin 4 |
decreases expression decreases secretion |
ISO |
Salicylic Acid results in decreased expression of IL4 mRNA Salicylic Acid results in decreased secretion of IL4 protein |
CTD |
PMID:11238116 |
|
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
Salicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA] Salicylic Acid inhibits the reaction [Mercury results in increased expression of IL6] |
CTD |
PMID:23742082 PMID:25108154 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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|
G |
Maff |
MAF bZIP transcription factor F |
increases expression |
ISO |
Salicylic Acid results in increased expression of MAFF mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
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|
G |
Mpo |
myeloperoxidase |
increases activity |
ISO |
Salicylic Acid results in increased activity of MPO protein |
CTD |
PMID:24060682 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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|
G |
Mt1 |
metallothionein 1 |
increases expression |
ISO |
Salicylic Acid results in increased expression of MT1A mRNA |
CTD |
PMID:20491607 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Salicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] |
CTD |
PMID:25108154 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
Salicylic Acid inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]] |
CTD |
PMID:25108154 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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|
G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
Salicylic Acid inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA] |
CTD |
PMID:25108154 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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|
G |
Psmb10 |
proteasome 20S subunit beta 10 |
increases expression |
ISO |
Salicylic Acid results in increased expression of PSMB10 mRNA |
CTD |
PMID:23165153 |
|
NCBI chr19:33,830,958...33,833,442
Ensembl chr19:33,827,229...33,833,626
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G |
Psmb9 |
proteasome 20S subunit beta 9 |
increases expression |
ISO |
Salicylic Acid results in increased expression of PSMB9 mRNA |
CTD |
PMID:23165153 |
|
NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512
|
|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
dorsomorphin inhibits the reaction [Salicylic Acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Niacinamide inhibits the reaction [Salicylic Acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Salicylic Acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein] |
CTD |
PMID:25108154 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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|
G |
Sirt1 |
sirtuin 1 |
multiple interactions |
EXP |
[Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Salicylic Acid |
CTD |
PMID:25108154 |
|
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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|
G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
EXP ISO |
Salicylic Acid inhibits the reaction [SLC16A1 protein results in increased transport of Benzoic Acid] Salicylic Acid inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] |
CTD |
PMID:10714609 PMID:15804185 |
|
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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|
G |
Slc22a25 |
solute carrier family 22, member 25 |
decreases activity increases uptake |
ISO |
Salicylic Acid results in decreased activity of SLC22A9 protein SLC22A9 protein results in increased uptake of Salicylic Acid |
CTD |
PMID:12388633 |
|
NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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|
G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases activity increases uptake |
ISO |
Salicylic Acid results in decreased activity of SLC22A6 protein SLC22A6 protein results in increased uptake of Salicylic Acid |
CTD |
PMID:12388633 |
|
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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|
G |
Slc22a7 |
solute carrier family 22 member 7 |
decreases activity multiple interactions increases uptake |
ISO EXP |
Salicylic Acid results in decreased activity of SLC22A7 protein Salicylic Acid promotes the reaction [SLC22A7 protein results in increased export of Orotic Acid] SLC22A7 protein results in increased uptake of Salicylic Acid |
CTD |
PMID:12388633 PMID:22981274 |
|
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
Salicylic Acid inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA] Salicylic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein] |
CTD |
PMID:25108154 PMID:36416909 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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|
G |
Txn1 |
thioredoxin 1 |
increases expression |
ISO |
Salicylic Acid results in increased expression of TXN mRNA |
CTD |
PMID:20491607 |
|
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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|
G |
Ugt1a2 |
UDP glucuronosyltransferase 1 family, polypeptide A2 |
increases glucuronidation |
ISO |
UGT1A3 protein results in increased glucuronidation of Salicylic Acid |
CTD |
PMID:15117964 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions increases expression |
EXP |
4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in decreased expression of NFKBIA protein]; 4-trifluoromethylsalicylic acid results in increased expression of and results in increased phosphorylation of NFKBIA protein 4-trifluoromethylsalicylic acid results in increased expression of NFKBIA mRNA |
CTD |
PMID:16421291 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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|
G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
4-trifluoromethylsalicylic acid inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] |
CTD |
PMID:16421291 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
4-trifluoromethylsalicylic acid inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] |
CTD |
PMID:10101034 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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|
|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2 protein] |
CTD |
PMID:18349320 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] |
CTD |
PMID:18349320 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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|
G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [Dronabinol results in increased expression of BDNF mRNA] |
CTD |
PMID:28481360 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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|
G |
Birc3 |
baculoviral IAP repeat-containing 3 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] |
CTD |
PMID:18349320 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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|
G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] |
CTD |
PMID:18349320 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein]] which results in decreased cleavage of CASP3 protein [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP3 protein |
CTD |
PMID:18349320 PMID:31927229 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein |
CTD |
PMID:18349320 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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|
G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[anacardic acid co-treated with TNF protein] results in increased cleavage of CASP9 protein |
CTD |
PMID:18349320 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of CCND1 protein] |
CTD |
PMID:18349320 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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|
G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of CFLAR protein] |
CTD |
PMID:18349320 |
|
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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|
G |
Crebbp |
CREB binding protein |
decreases activity |
ISO |
anacardic acid results in decreased activity of CREBBP protein |
CTD |
PMID:31927229 |
|
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Egf |
epidermal growth factor |
decreases response to substance |
ISO |
anacardic acid results in decreased susceptibility to EGF protein |
CTD |
PMID:18349320 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G |
Ep300 |
E1A binding protein p300 |
multiple interactions affects activity decreases activity decreases expression |
EXP ISO |
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of EP300 protein] anacardic acid affects the activity of EP300 protein anacardic acid results in decreased activity of EP300 protein anacardic acid results in decreased expression of EP300 protein |
CTD |
PMID:18349320 PMID:23297412 PMID:31927229 |
|
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
anacardic acid promotes the reaction [manganese chloride results in increased expression of HMOX1 mRNA] |
CTD |
PMID:29054681 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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|
G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] |
CTD |
PMID:18349320 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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|
G |
Ifnl1 |
interferon, lambda 1 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IFNL1 mRNA] |
CTD |
PMID:37611859 |
|
NCBI chr 1:83,798,651...83,800,297
Ensembl chr 1:83,798,703...83,800,235
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|
G |
Il1b |
interleukin 1 beta |
decreases response to substance |
ISO |
anacardic acid results in decreased susceptibility to IL1B protein |
CTD |
PMID:18349320 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Il33 |
interleukin 33 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL33 mRNA]; anacardic acid inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] |
CTD |
PMID:37545493 |
|
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Itgam |
integrin subunit alpha M |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [Tretinoin results in increased expression of ITGAM] |
CTD |
PMID:24819975 |
|
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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G |
Kat2b |
lysine acetyltransferase 2B |
decreases activity |
ISO |
anacardic acid results in decreased activity of KAT2B protein |
CTD |
PMID:31927229 |
|
NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
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G |
Kl |
Klotho |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [Dronabinol results in increased expression of KL mRNA] |
CTD |
PMID:28481360 |
|
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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G |
Map3k14 |
mitogen-activated protein kinase kinase kinase 14 |
decreases activity |
ISO |
anacardic acid results in decreased activity of MAP3K14 protein |
CTD |
PMID:18349320 |
|
NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523
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G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
decreases activity |
ISO |
anacardic acid results in decreased activity of MAP3K7 protein |
CTD |
PMID:18349320 |
|
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
anacardic acid binds to and results in decreased activity of MMP2 protein |
CTD |
PMID:22745359 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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|
G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of MMP9 protein] anacardic acid binds to and results in decreased activity of MMP9 protein |
CTD |
PMID:18349320 PMID:22745359 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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|
G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of MYC protein] |
CTD |
PMID:18349320 |
|
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
|
|
G |
Myh7 |
myosin heavy chain 7 |
multiple interactions |
EXP |
anacardic acid inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] |
CTD |
PMID:15593114 |
|
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
increases expression multiple interactions |
EXP |
anacardic acid results in increased expression of NFE2L2 mRNA [anacardic acid results in increased susceptibility to manganese chloride] which results in increased expression of NFE2L2 mRNA; anacardic acid inhibits the reaction [manganese chloride results in increased activity of NFE2L2 protein]; manganese chloride promotes the reaction [anacardic acid results in increased expression of NFE2L2 mRNA] |
CTD |
PMID:29054681 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]] |
CTD |
PMID:18349320 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anacardic acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:18349320 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Prkcd |
protein kinase C, delta |
multiple interactions |
EXP |
anacardic acid inhibits the reaction [Paraquat results in increased cleavage of and results in increased activity of PRKCD protein] |
CTD |
PMID:21777615 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] |
CTD |
PMID:18349320 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein affects the localization of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]] |
CTD |
PMID:18349320 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Runx2 |
RUNX family transcription factor 2 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [Tretinoin results in increased expression of RUNX2 mRNA] |
CTD |
PMID:24819975 |
|
NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Sp7 |
Sp7 transcription factor |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [Tretinoin results in increased expression of SP7 mRNA] |
CTD |
PMID:24819975 |
|
NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
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G |
Spp1 |
secreted phosphoprotein 1 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [Tretinoin results in increased expression of SPP1 mRNA] |
CTD |
PMID:24819975 |
|
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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G |
Syn1 |
synapsin I |
multiple interactions |
ISO |
anacardic acid affects the reaction [Dronabinol affects the expression of SYN1 protein] |
CTD |
PMID:28481360 |
|
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases response to substance |
ISO |
[anacardic acid co-treated with TNF protein] results in increased cleavage of CASP3 protein; [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP8 protein; [anacardic acid co-treated with TNF protein] results in increased cleavage of CASP9 protein; anacardic acid inhibits the reaction [4-octylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of and results in increased secretion of TNF protein]; anacardic acid inhibits the reaction [nonylphenol results in increased expression of TNF]; anacardic acid inhibits the reaction [TNF protein affects the localization of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; anacardic acid inhibits the reaction [TNF protein results in increased activity of [RELA protein binds to NFKB1 protein]]; anacardic acid inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of MYC protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 mRNA]; anacardic acid inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; anacardic acid inhibits the reaction [TNF protein results in increased expression of XIAP protein]; anacardic acid inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] anacardic acid results in decreased susceptibility to TNF protein |
CTD |
PMID:18349320 PMID:20056579 PMID:24039973 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [[Fluorouracil results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein]; anacardic acid inhibits the reaction [Genistein promotes the reaction [trichostatin A results in increased acetylation of TP53 protein]] [anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein]] which results in decreased cleavage of CASP3 protein; anacardic acid inhibits the reaction [Sodium Fluoride results in increased acetylation of TRP53 protein] |
CTD |
PMID:26768552 PMID:27129209 PMID:31927229 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tradd |
TNFRSF1A-associated via death domain |
decreases activity |
ISO |
anacardic acid results in decreased activity of TRADD protein |
CTD |
PMID:18349320 |
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NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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G |
Traf2 |
Tnf receptor-associated factor 2 |
decreases activity |
ISO |
anacardic acid results in decreased activity of TRAF2 protein |
CTD |
PMID:18349320 |
|
NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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G |
Ube2c |
ubiquitin-conjugating enzyme E2C |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [[Fluorouracil results in increased acetylation of TP53 protein mutant form] which results in increased expression of UBE2C protein] |
CTD |
PMID:27129209 |
|
NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of VEGFA protein] |
CTD |
PMID:18349320 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Xiap |
X-linked inhibitor of apoptosis |
multiple interactions |
ISO |
anacardic acid inhibits the reaction [TNF protein results in increased expression of XIAP protein] |
CTD |
PMID:18349320 |
|
NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700
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G |
Ar |
androgen receptor |
multiple interactions |
ISO |
homosalate binds to and results in decreased activity of AR protein; homosalate inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]; homosalate inhibits the reaction [Metribolone results in increased activity of AR protein] |
CTD |
PMID:12730620 PMID:15537743 PMID:18324785 PMID:24004914 |
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NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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G |
Areg |
amphiregulin |
increases expression multiple interactions |
ISO |
homosalate results in increased expression of AREG mRNA Polystyrenes promotes the reaction [homosalate results in increased expression of AREG mRNA] |
CTD |
PMID:38381479 |
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NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
increases expression multiple interactions |
ISO |
homosalate results in increased expression of BHLHE40 mRNA Polystyrenes promotes the reaction [homosalate results in increased expression of BHLHE40 mRNA] |
CTD |
PMID:38381479 |
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NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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G |
Birc2 |
baculoviral IAP repeat-containing 2 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in increased expression of BIRC2 mRNA |
CTD |
PMID:38381479 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G |
Capns1 |
calpain, small subunit 1 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in decreased expression of CAPNS1 mRNA |
CTD |
PMID:38381479 |
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NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795
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G |
Cep295 |
centrosomal protein 295 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in increased expression of CEP295 mRNA |
CTD |
PMID:38381479 |
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NCBI chr 8:12,156,568...12,194,542
Ensembl chr 8:12,156,554...12,194,552
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G |
Dpysl2 |
dihydropyrimidinase-like 2 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in increased expression of DPYSL2 mRNA |
CTD |
PMID:38381479 |
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NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions increases expression |
ISO |
homosalate binds to and results in increased activity of ESR1 protein; Polystyrenes promotes the reaction [homosalate results in increased expression of ESR1 mRNA] |
CTD |
PMID:24004914 PMID:38381479 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
homosalate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Hist2h2be |
histone cluster 2 H2B family member E |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in increased expression of H2BC11 mRNA |
CTD |
PMID:38381479 |
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NCBI chr 2:183,780,583...183,783,030
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases activity |
ISO |
homosalate results in decreased activity of KCNH2 protein |
CTD |
PMID:28551711 |
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NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Krt86 |
keratin 86 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in decreased expression of KRT86 mRNA |
CTD |
PMID:38381479 |
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NCBI chr 7:132,591,489...132,598,142
Ensembl chr 7:132,591,545...132,598,021
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G |
Mex3b |
mex-3 RNA binding family member B |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in decreased expression of MEX3B mRNA |
CTD |
PMID:38381479 |
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NCBI chr 1:136,855,130...136,859,365
Ensembl chr 1:136,855,130...136,859,354
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G |
N4bp3 |
Nedd4 binding protein 3 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in decreased expression of N4BP3 mRNA |
CTD |
PMID:38381479 |
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NCBI chr10:35,898,031...35,906,704
Ensembl chr10:35,899,096...35,907,001
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G |
Nrip1 |
nuclear receptor interacting protein 1 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in increased expression of NRIP1 mRNA |
CTD |
PMID:38381479 |
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NCBI chr11:14,895,843...14,979,490
Ensembl chr11:14,895,553...14,981,761
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G |
Pgr |
progesterone receptor |
multiple interactions |
ISO |
homosalate binds to and results in decreased activity of PGR protein |
CTD |
PMID:15537743 |
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NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G |
Psen2 |
presenilin 2 |
multiple interactions increases expression |
ISO |
Polystyrenes promotes the reaction [homosalate results in increased expression of PSEN2 mRNA] |
CTD |
PMID:38381479 |
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NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
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G |
Rasgrp1 |
RAS guanyl releasing protein 1 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in increased expression of RASGRP1 mRNA |
CTD |
PMID:38381479 |
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NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
multiple interactions increases expression |
ISO |
[Polystyrenes co-treated with homosalate] results in increased expression of SGK1 protein; Fulvestrant inhibits the reaction [[Polystyrenes co-treated with homosalate] results in increased expression of SGK1 protein] homosalate results in increased expression of SGK1 mRNA; Polystyrenes results in increased expression of [homosalate results in increased expression of SGK1 mRNA] |
CTD |
PMID:38381479 |
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NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Stc1 |
stanniocalcin 1 |
increases expression |
ISO |
homosalate results in increased expression of STC1 mRNA; Polystyrenes results in increased expression of [homosalate results in increased expression of STC1 mRNA] |
CTD |
PMID:38381479 |
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NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
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G |
Tmtc1 |
transmembrane O-mannosyltransferase targeting cadherins 1 |
multiple interactions increases expression |
ISO |
Polystyrenes promotes the reaction [homosalate results in increased expression of TMTC1 mRNA] |
CTD |
PMID:38381479 |
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NCBI chr 4:181,142,937...181,357,979
Ensembl chr 4:181,146,251...181,359,289
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G |
Tpr |
translocated promoter region, nuclear basket protein |
increases expression multiple interactions |
ISO |
homosalate results in increased expression of TPR mRNA Polystyrenes promotes the reaction [homosalate results in increased expression of TPR mRNA] |
CTD |
PMID:38381479 |
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NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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G |
Vasn |
vasorin |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in decreased expression of VASN mRNA |
CTD |
PMID:38381479 |
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NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357
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G |
Yy2 |
YY2 transcription factor |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in increased expression of YY2 mRNA |
CTD |
PMID:38381479 |
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NCBI chr X:37,438,425...37,442,047
Ensembl chr X:37,410,811...37,464,430
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G |
Zdhhc20 |
zinc finger DHHC-type palmitoyltransferase 20 |
multiple interactions |
ISO |
[homosalate co-treated with Polystyrenes] results in increased expression of ZDHHC20 mRNA |
CTD |
PMID:38381479 |
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NCBI chr15:31,980,057...32,039,006
Ensembl chr15:31,983,155...32,038,989
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
ISO |
3,3',4',5-tetrachlorosalicylanilide results in increased expression of ATF3 mRNA |
CTD |
PMID:27965148 |
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NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Dnajb4 |
DnaJ heat shock protein family (Hsp40) member B4 |
increases expression |
ISO |
3,3',4',5-tetrachlorosalicylanilide results in increased expression of DNAJB4 mRNA |
CTD |
PMID:27965148 |
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NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089
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G |
Iyd |
iodotyrosine deiodinase |
multiple interactions |
ISO |
3,3',4',5-tetrachlorosalicylanilide inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] |
CTD |
PMID:33352258 |
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NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
3,3',4',5-tetrachlorosalicylanilide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
Clozapine promotes the reaction [Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]]; Raclopride inhibits the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]]; Raclopride promotes the reaction [Dopamine promotes the reaction [AGT protein results in increased secretion of Aldosterone]] |
CTD |
PMID:11549694 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Calca |
calcitonin-related polypeptide alpha |
multiple interactions |
EXP |
Raclopride inhibits the reaction [Dextroamphetamine results in increased expression of CALCA protein] |
CTD |
PMID:11398184 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
decreases expression |
EXP |
Raclopride results in decreased expression of CAMK4 protein |
CTD |
PMID:19289156 |
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NCBI chr18:24,582,988...24,811,918
Ensembl chr18:24,585,269...24,802,487
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G |
Camkk1 |
calcium/calmodulin-dependent protein kinase kinase 1 |
decreases expression |
EXP |
Raclopride results in decreased expression of CAMKK1 protein |
CTD |
PMID:19289156 |
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NCBI chr10:57,637,335...57,660,498
Ensembl chr10:57,637,391...57,660,498
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G |
Camkk2 |
calcium/calmodulin-dependent protein kinase kinase 2 |
decreases expression |
EXP |
Raclopride results in decreased expression of CAMKK2 protein |
CTD |
PMID:19289156 |
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NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279
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G |
Crh |
corticotropin releasing hormone |
decreases expression |
ISO |
Raclopride results in decreased expression of CRH mRNA |
CTD |
PMID:16205782 |
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NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions increases expression |
EXP |
DRD2 protein affects the reaction [Raclopride results in increased expression of CTNNB1 protein] |
CTD |
PMID:16144542 |
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NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions |
ISO |
Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole] |
CTD |
PMID:8103921 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Drd2 |
dopamine receptor D2 |
multiple interactions affects binding increases response to substance |
ISO EXP |
[Dopamine co-treated with Raclopride] promotes the reaction [Dopamine binds to DRD2 protein]; Cocaine affects the reaction [Raclopride binds to DRD2] Raclopride binds to DRD2 protein [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate; [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Nicotine; [Raclopride binds to and results in decreased activity of DRD2 protein] which results in increased abundance of Dopamine; DRD2 protein affects the reaction [Raclopride results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Raclopride results in increased expression of GSK3A protein]; Raclopride binds to and results in decreased activity of DRD2 protein; Saponins inhibits the reaction [Raclopride binds to DRD2 protein] Amlodipine inhibits the reaction [Raclopride binds to DRD2 protein]; bisphenol A promotes the reaction [Raclopride binds to DRD2 protein]; Diltiazem inhibits the reaction [Raclopride binds to DRD2 protein]; Flunarizine inhibits the reaction [Raclopride binds to DRD2 protein]; manidipine inhibits the reaction [Raclopride binds to DRD2 protein]; Raclopride inhibits the reaction [[[Apomorphine binds to and results in increased activity of DRD1 protein] co-treated with [Apomorphine binds to and results in increased activity of DRD2 protein]] results in decreased susceptibility to Pentylenetetrazole]; Verapamil inhibits the reaction [Raclopride binds to DRD2 protein] Raclopride binds to DRD2 protein; Raclopride binds to DRD2 protein alternative form DRD2 protein alternative form results in increased susceptibility to Raclopride Raclopride binds to DRD2; Raclopride binds to DRD2 protein |
CTD |
PMID:1833784 PMID:7901417 PMID:8103921 PMID:8804920 PMID:9533112 PMID:11454915 PMID:12476322 PMID:12673668 PMID:14756803 PMID:15010698 PMID:15341276 PMID:15542624 PMID:16144542 PMID:16251992 PMID:17948891 PMID:18058087 PMID:19289156 PMID:19439595 PMID:20169576 More...
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NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
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G |
Drd3 |
dopamine receptor D3 |
multiple interactions |
EXP |
[Raclopride binds to and results in decreased activity of DRD3 protein] which results in increased abundance of Dopamine; Raclopride binds to and results in decreased activity of DRD3 protein |
CTD |
PMID:15341276 PMID:19289156 |
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NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
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G |
Fadd |
Fas associated via death domain |
multiple interactions |
EXP |
Raclopride affects the reaction [Cocaine affects the expression of FADD protein] |
CTD |
PMID:18580876 |
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NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Raclopride results in increased expression of FOS protein |
CTD |
PMID:17913375 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
ISO |
Raclopride inhibits the reaction [Methamphetamine results in increased expression of GFAP protein] |
CTD |
PMID:16088948 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
multiple interactions increases expression |
EXP |
DRD2 protein affects the reaction [Raclopride results in increased expression of GSK3A protein] |
CTD |
PMID:16144542 |
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NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
Raclopride inhibits the reaction [Dronabinol results in increased activity of MAPK1 protein] |
CTD |
PMID:11553284 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
Raclopride inhibits the reaction [Dronabinol results in increased activity of MAPK3 protein] |
CTD |
PMID:11553284 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
affects response to substance |
ISO |
NR4A1 affects the susceptibility to Raclopride |
CTD |
PMID:14603264 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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|
G |
Plat |
plasminogen activator, tissue type |
multiple interactions |
ISO |
Raclopride inhibits the reaction [Methamphetamine results in increased expression of PLAT mRNA] |
CTD |
PMID:15659235 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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|
G |
Ppp1r1b |
protein phosphatase 1, regulatory (inhibitor) subunit 1B |
increases phosphorylation |
ISO |
Raclopride results in increased phosphorylation of PPP1R1B protein |
CTD |
PMID:12064480 |
|
NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775
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|
G |
Rgs2 |
regulator of G-protein signaling 2 |
multiple interactions increases expression |
EXP |
Raclopride promotes the reaction [Amphetamine results in increased expression of RGS2 mRNA] Raclopride results in increased expression of RGS2 mRNA |
CTD |
PMID:10098858 |
|
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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|
G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
Raclopride inhibits the reaction [Methamphetamine results in decreased expression of TH protein] |
CTD |
PMID:16088948 |
|
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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|
G |
Bmp6 |
bone morphogenetic protein 6 |
increases expression |
ISO |
Aminosalicylic Acid results in increased expression of BMP6 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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G |
Ereg |
epiregulin |
increases expression |
ISO |
Aminosalicylic Acid results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
|
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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|
G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Aminosalicylic Acid results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
increases expression |
ISO |
Aminosalicylic Acid results in increased expression of MET mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
|
|
G |
Nat1 |
N-acetyltransferase 1 |
increases acetylation |
ISO |
NAT1 protein results in increased acetylation of Aminosalicylic Acid |
CTD |
PMID:15627487 PMID:16003948 |
|
NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
|
|
G |
Nat2 |
N-acetyltransferase 2 |
multiple interactions |
ISO |
[Peroxynitrous Acid results in decreased activity of NAT2 protein] which results in decreased acetylation of Aminosalicylic Acid |
CTD |
PMID:19248797 |
|
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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|
G |
Pid1 |
phosphotyrosine interaction domain containing 1 |
increases expression |
ISO |
Aminosalicylic Acid results in increased expression of PID1 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
|
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G |
Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
ISO |
Aminosalicylic Acid results in increased expression of SLC7A11 mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G |
Slpi |
secretory leukocyte peptidase inhibitor |
increases expression |
ISO |
Aminosalicylic Acid results in increased expression of SLPI mRNA |
CTD |
PMID:32816093 |
|
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
|
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
affects response to substance |
ISO |
ABCC1 gene SNP affects the susceptibility to nitazoxanide |
CTD |
PMID:25622337 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Ar |
androgen receptor |
multiple interactions |
ISO |
nitazoxanide binds to and results in decreased activity of AR protein |
CTD |
PMID:25752796 |
|
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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|
G |
Arg1 |
arginase 1 |
increases expression multiple interactions |
ISO |
nitazoxanide results in increased expression of ARG1 mRNA; nitazoxanide results in increased expression of ARG1 protein nitazoxanide inhibits the reaction [Lipopolysaccharides results in decreased expression of ARG1 mRNA] |
CTD |
PMID:38663798 |
|
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
|
|
G |
Atf4 |
activating transcription factor 4 |
multiple interactions increases expression |
ISO |
nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein] nitazoxanide results in increased expression of ATF4 protein |
CTD |
PMID:19664635 |
|
NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] |
CTD |
PMID:38663798 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G |
Cdx2 |
caudal type homeo box 2 |
multiple interactions increases expression |
ISO |
nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of CDX2 protein] nitazoxanide results in increased expression of CDX2 protein |
CTD |
PMID:38663798 |
|
NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
|
|
G |
Dock8 |
dedicator of cytokinesis 8 |
affects response to substance |
ISO |
DOCK8 gene SNP affects the susceptibility to nitazoxanide |
CTD |
PMID:25622337 |
|
NCBI chr 1:222,649,309...222,842,474
Ensembl chr 1:222,649,309...222,842,474
|
|
G |
Eif2a |
eukaryotic translation initiation factor 2A |
multiple interactions increases phosphorylation |
ISO |
IFNA2 protein promotes the reaction [nitazoxanide results in increased phosphorylation of EIF2A protein]; nitazoxanide promotes the reaction [EIF2A protein results in increased expression of ATF4 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:19664635 |
|
NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
|
|
G |
Eif2ak2 |
eukaryotic translation initiation factor 2-alpha kinase 2 |
multiple interactions |
ISO |
IFNA2 protein promotes the reaction [nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of and results in increased activity of EIF2AK2 protein]; nitazoxanide promotes the reaction [EIF2AK2 protein results in increased phosphorylation of EIF2A protein] |
CTD |
PMID:19664635 |
|
NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971
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|
G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of IL17A mRNA] |
CTD |
PMID:38663798 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of IL6 protein]; nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] nitazoxanide inhibits the reaction [IL6 protein results in decreased expression of TJP1 protein] |
CTD |
PMID:38663798 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation multiple interactions |
ISO |
nitazoxanide results in decreased phosphorylation of JAK2 protein nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of JAK2 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein] |
CTD |
PMID:38663798 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
|
|
G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased secretion of MPO protein] |
CTD |
PMID:38663798 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:38663798 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
increases activity |
ISO |
nitazoxanide results in increased activity of NR1I3 protein |
CTD |
PMID:30247703 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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|
G |
Ocln |
occludin |
multiple interactions |
ISO |
nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein] |
CTD |
PMID:38663798 |
|
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
|
|
G |
Slit3 |
slit guidance ligand 3 |
affects response to substance |
ISO |
SLIT3 gene SNP affects the susceptibility to nitazoxanide |
CTD |
PMID:25622337 |
|
NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
|
|
G |
Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions decreases phosphorylation |
ISO |
nitazoxanide inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of STAT3 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] nitazoxanide results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:38663798 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
|
|
G |
Susd6 |
sushi domain containing 6 |
affects response to substance |
ISO |
SUSD6 gene SNP affects the susceptibility to nitazoxanide |
CTD |
PMID:25622337 |
|
NCBI chr 6:100,437,834...100,531,621
Ensembl chr 6:100,437,642...100,531,606
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|
G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
ISO |
nitazoxanide inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein] nitazoxanide inhibits the reaction [IL6 protein results in decreased expression of TJP1 protein]; nitazoxanide inhibits the reaction [Lipopolysaccharides results in decreased expression of TJP1 protein] |
CTD |
PMID:38663798 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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|
G |
Abca1 |
ATP binding cassette subfamily A member 1 |
decreases expression multiple interactions affects expression increases expression |
ISO |
Aspirin results in decreased expression of ABCA1 mRNA Aspirin affects the expression of and affects the activity of ABCA1 protein; PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]; PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein] Aspirin results in increased expression of ABCA1 mRNA; Aspirin results in increased expression of ABCA1 protein |
CTD |
PMID:15037193 PMID:20137092 PMID:21088444 |
|
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression multiple interactions increases activity |
ISO EXP |
Aspirin results in increased expression of ABCB1 mRNA; Aspirin results in increased expression of ABCB1 protein [Aspirin results in increased expression of ABCB1 protein] which results in decreased uptake of clopidogrel Aspirin results in increased activity of ABCB1 protein |
CTD |
PMID:19840843 PMID:21900887 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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|
G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases activity |
EXP |
Aspirin results in increased activity of ABCB1B protein |
CTD |
PMID:19840843 |
|
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
increases expression |
ISO |
Aspirin results in increased expression of ABCC1 mRNA; Aspirin results in increased expression of ABCC1 protein |
CTD |
PMID:21900887 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
increases expression |
ISO |
Aspirin results in increased expression of ABCC4 mRNA; Aspirin results in increased expression of ABCC4 protein |
CTD |
PMID:21900887 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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|
G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
increases expression |
ISO |
Aspirin results in increased expression of ABCC5 mRNA; Aspirin results in increased expression of ABCC5 protein |
CTD |
PMID:21900887 |
|
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Acaca |
acetyl-CoA carboxylase alpha |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of ACACA protein modified form CES1 protein promotes the reaction [Aspirin results in increased expression of ACACA protein modified form] |
CTD |
PMID:25743752 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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|
G |
Acadm |
acyl-CoA dehydrogenase medium chain |
increases expression |
ISO |
Aspirin results in increased expression of ACADM mRNA; Aspirin results in increased expression of ACADM protein |
CTD |
PMID:25743752 |
|
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
|
|
G |
Acap3 |
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 |
increases expression |
ISO |
Aspirin results in increased expression of ACAP3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 5:166,501,150...166,515,477
Ensembl chr 5:166,500,781...166,515,481
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|
G |
Ace |
angiotensin I converting enzyme |
affects response to substance |
ISO |
ACE polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:18727619 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Acin1 |
apoptotic chromatin condensation inducer 1 |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of ACIN1 mRNA Aspirin results in increased expression of ACIN1 mRNA |
CTD |
PMID:11906190 PMID:15928584 |
|
NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001
|
|
G |
Actb |
actin, beta |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ACTB protein] |
CTD |
PMID:17303692 |
|
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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|
G |
Actr3 |
actin related protein 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of ACTR3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
|
|
G |
Adam33 |
ADAM metallopeptidase domain 33 |
affects response to substance |
ISO |
ADAM33 SNP affects the susceptibility to Aspirin |
CTD |
PMID:17061022 |
|
NCBI chr 3:118,262,395...118,283,456
Ensembl chr 3:118,271,029...118,283,461
|
|
G |
Adamts1 |
ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of ADAMTS1 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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|
G |
Adk |
adenosine kinase |
affects binding |
EXP |
Aspirin binds to ADK protein |
CTD |
PMID:15236443 |
|
NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
|
|
G |
Adora1 |
adenosine A1 receptor |
affects response to substance |
ISO |
ADORA1 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:19019667 |
|
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
|
|
G |
Adora2a |
adenosine A2a receptor |
affects response to substance |
ISO |
ADORA2A polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:19019667 |
|
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
|
|
G |
Adora3 |
adenosine A3 receptor |
affects response to substance |
ISO |
ADORA3 protein affects the susceptibility to Aspirin |
CTD |
PMID:20716228 |
|
NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
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|
G |
Adrb2 |
adrenoceptor beta 2 |
affects response to substance |
ISO |
ADRB2 polymorphism affects the susceptibility to Aspirin; ADRB2 SNP affects the susceptibility to Aspirin |
CTD |
PMID:18159608 PMID:18379861 |
|
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
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|
G |
Agt |
angiotensinogen |
affects activity |
ISO |
Aspirin affects the activity of AGT protein |
CTD |
PMID:3189434 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA] |
CTD |
PMID:22306536 |
|
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
|
|
G |
Ahr |
aryl hydrocarbon receptor |
increases expression multiple interactions |
ISO EXP |
Aspirin results in increased expression of AHR mRNA AHR mutant form inhibits the reaction [Aspirin results in increased activity of PON1 protein]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of APOA1 mRNA]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of PON1 mRNA] |
CTD |
PMID:18519978 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Aif1l |
allograft inflammatory factor 1-like |
increases expression |
ISO |
Aspirin results in increased expression of AIF1L mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 3:15,229,476...15,254,033
Ensembl chr 3:15,229,524...15,254,023
|
|
G |
Aimp2 |
aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 |
decreases expression |
EXP |
Aspirin results in decreased expression of AIMP2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769
|
|
G |
Akr1c1 |
aldo-keto reductase family 1, member C1 |
decreases activity |
ISO |
Aspirin results in decreased activity of AKR1C1 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
|
|
G |
Akr1c2 |
aldo-keto reductase family 1, member C2 |
decreases activity |
ISO |
Aspirin results in decreased activity of AKR1C2 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
|
|
G |
Akr1c3 |
aldo-keto reductase family 1, member C3 |
decreases activity |
ISO |
Aspirin results in decreased activity of AKR1C3 protein |
CTD |
PMID:19010312 |
|
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
|
|
G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases expression increases activity |
ISO |
[troglitazone co-treated with Aspirin] results in decreased expression of AKT1 protein; [troglitazone co-treated with Aspirin] results in decreased expression of AKT1 protein modified form; Aspirin results in decreased phosphorylation of and results in decreased activity of AKT1 protein Aspirin results in increased expression of AKT1 mRNA Aspirin results in increased activity of AKT1 protein |
CTD |
PMID:19908241 PMID:20116423 PMID:20457246 PMID:21617849 |
|
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
|
|
G |
Akt2 |
AKT serine/threonine kinase 2 |
increases expression |
ISO |
Aspirin results in increased expression of AKT2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
|
|
G |
Alas1 |
5'-aminolevulinate synthase 1 |
increases expression |
EXP |
Aspirin results in increased expression of ALAS1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917
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Alb |
albumin |
multiple interactions decreases secretion |
ISO |
ALB protein binds to and affects the transport of Aspirin; Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein]; Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of ALB protein]; Aspirin inhibits the reaction [Warfarin binds to ALB protein]; Aspirin inhibits the reaction [zomepirac glucuronide binds to ALB protein]; Aspirin promotes the reaction [menadione epoxide analog binds to ALB protein] Aspirin results in decreased secretion of ALB protein |
CTD |
PMID:1981713 PMID:8831264 PMID:17303692 PMID:25499135 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
affects binding |
EXP |
Aspirin binds to ALDH1A1 protein |
CTD |
PMID:15236443 |
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NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
decreases expression |
ISO |
Aspirin results in decreased expression of ALDOA mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Angptl3 |
angiopoietin-like 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of ANGPTL3 mRNA |
CTD |
PMID:27089845 |
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NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
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G |
Ano9 |
anoctamin 9 |
increases expression |
ISO |
Aspirin results in increased expression of ANO9 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900
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G |
Anpep |
alanyl aminopeptidase, membrane |
increases activity increases expression |
ISO |
Aspirin results in increased activity of ANPEP protein Aspirin results in increased expression of ANPEP mRNA; Aspirin results in increased expression of ANPEP protein |
CTD |
PMID:16216591 |
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NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
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G |
Ap2b1 |
adaptor related protein complex 2 subunit beta 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of AP2B1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases response to substance increases expression |
ISO |
APAF1 results in increased susceptibility to Aspirin Aspirin results in increased expression of APAF1 mRNA |
CTD |
PMID:11228543 PMID:20457246 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apoa1 |
apolipoprotein A1 |
multiple interactions increases expression increases activity |
ISO EXP |
AHR mutant form inhibits the reaction [Aspirin results in increased expression of APOA1 mRNA]; Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]; PPARA affects the reaction [Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]] Aspirin results in increased activity of APOA1 mRNA |
CTD |
PMID:9399670 PMID:18519978 PMID:21088444 |
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NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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G |
Apoc1 |
apolipoprotein C1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [APOC1 results in increased abundance of Triglycerides] |
CTD |
PMID:21862721 |
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NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
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G |
Apoe |
apolipoprotein E |
affects response to substance multiple interactions |
ISO |
APOE polymorphism affects the susceptibility to Aspirin Aspirin inhibits the reaction [APOE gene mutant form results in decreased susceptibility to Arachidonic Acid] Aspirin inhibits the reaction [APOE gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]] |
CTD |
PMID:15084783 PMID:20530721 |
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NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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G |
App |
amyloid beta precursor protein |
multiple interactions |
ISO |
Aspirin inhibits the reaction [[Benzo(a)pyrene affects the expression of APP protein] which results in increased abundance of amyloid beta-protein (1-42)] |
CTD |
PMID:37364758 |
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NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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G |
Aprt |
adenine phosphoribosyl transferase |
decreases expression |
ISO |
Aspirin results in decreased expression of APRT mRNA |
CTD |
PMID:15928584 |
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NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431
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G |
Arl6ip5 |
ADP-ribosylation factor like GTPase 6 interacting protein 5 |
increases expression |
ISO |
Aspirin results in increased expression of ARL6IP5 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608
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G |
Arpp19 |
cAMP-regulated phosphoprotein 19 |
increases expression |
ISO |
Aspirin results in increased expression of ARPP19 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:75,779,640...75,802,474
Ensembl chr 8:75,779,523...75,802,452 Ensembl chr 8:75,779,523...75,802,452
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G |
Asic1 |
acid sensing ion channel subunit 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of ASIC1 mRNA |
CTD |
PMID:11588175 |
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NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
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G |
Asic2 |
acid sensing ion channel subunit 2 |
decreases expression |
EXP |
Aspirin results in decreased expression of ASIC2 mRNA |
CTD |
PMID:11588175 |
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NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424
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G |
Asic3 |
acid sensing ion channel subunit 3 |
decreases expression decreases activity |
EXP |
Aspirin results in decreased expression of ASIC3 mRNA Aspirin results in decreased activity of ASIC3 protein |
CTD |
PMID:11588175 |
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NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643
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G |
Asl |
argininosuccinate lyase |
decreases expression |
ISO |
Aspirin results in decreased expression of ASL mRNA |
CTD |
PMID:15928584 |
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NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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G |
Astn2 |
astrotactin 2 |
increases expression |
ISO |
Aspirin results in increased expression of ASTN2 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 5:78,758,142...79,744,021
Ensembl chr 5:78,758,142...79,748,273
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G |
Atf4 |
activating transcription factor 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of ATF4 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atm |
ATM serine/threonine kinase |
increases expression |
ISO |
Aspirin results in increased expression of ATM mRNA |
CTD |
PMID:20457246 |
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NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atp2a1 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 |
increases expression |
ISO |
Aspirin results in increased expression of ATP2A1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
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G |
Atp5f1e |
ATP synthase F1 subunit epsilon |
increases expression |
ISO |
Aspirin results in increased expression of ATP5F1E mRNA |
CTD |
PMID:15928584 |
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NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
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G |
Atp6v0b |
ATPase H+ transporting V0 subunit B |
decreases expression |
ISO |
Aspirin results in decreased expression of ATP6V0B mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401
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G |
Atp6v0d1 |
ATPase H+ transporting V0 subunit D1 |
decreases expression |
ISO |
Aspirin results in decreased expression of ATP6V0D1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450
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G |
Atr |
ATR serine/threonine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of ATR mRNA |
CTD |
PMID:20514442 |
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NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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G |
Atraid |
all-trans retinoic acid-induced differentiation factor |
decreases expression |
ISO |
Aspirin results in decreased expression of ATRAID mRNA |
CTD |
PMID:15928584 |
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NCBI chr 6:25,315,236...25,319,821
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G |
Aurka |
aurora kinase A |
increases expression |
ISO |
Aspirin results in increased expression of AURKA mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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G |
B2m |
beta-2 microglobulin |
increases expression |
ISO |
Aspirin results in increased expression of B2M mRNA |
CTD |
PMID:15456535 |
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NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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G |
B4galt1 |
beta-1,4-galactosyltransferase 1 |
increases expression |
ISO |
Aspirin results in increased expression of B4GALT1 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
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G |
Bad |
BCL2-associated agonist of cell death |
decreases expression |
ISO |
Aspirin results in decreased expression of BAD mRNA |
CTD |
PMID:20457246 |
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NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
Aspirin results in increased expression of BAK1 protein |
CTD |
PMID:11532860 |
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NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
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G |
Bap1 |
BRCA1 associated deubiquitinase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of BAP1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr16:6,446,709...6,455,535
Ensembl chr16:6,446,709...6,455,535
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression increases localization decreases expression |
ISO EXP |
Aspirin promotes the reaction [Fluorouracil results in increased expression of BAX protein]; CASP8 affects the reaction [Aspirin results in increased localization of BAX protein]; Fluorouracil promotes the reaction [Aspirin results in increased expression of BAX protein] Aspirin inhibits the reaction [Cisplatin results in increased expression of BAX protein] Bee Venoms inhibits the reaction [Aspirin results in increased expression of BAX protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of BAX protein] Aspirin results in decreased expression of BAX mRNA; Aspirin results in decreased expression of BAX protein |
CTD |
PMID:11228543 PMID:11532860 PMID:15976387 PMID:15986848 PMID:16880202 PMID:18636671 PMID:19212664 PMID:20457246 PMID:30885738 PMID:37179038 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Baz1b |
bromodomain adjacent to zinc finger domain, 1B |
decreases expression |
ISO |
Aspirin results in decreased expression of BAZ1B mRNA |
CTD |
PMID:15928584 |
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NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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G |
Bbc3 |
Bcl-2 binding component 3 |
increases expression increases response to substance |
ISO |
Aspirin results in increased expression of BBC3 mRNA BBC3 results in increased susceptibility to Aspirin |
CTD |
PMID:19936928 |
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NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
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G |
Bbln |
bublin coiled coil protein |
increases expression |
ISO |
Aspirin results in increased expression of BBLN mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 3:15,674,577...15,677,322
Ensembl chr 3:15,674,580...15,677,374
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G |
Bbof1 |
basal body orientation factor 1 |
increases expression |
ISO |
Aspirin results in increased expression of BBOF1 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 6:104,055,246...104,081,036
Ensembl chr 6:104,055,241...104,082,071
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G |
Bcar3 |
BCAR3 adaptor protein, NSP family member |
increases expression |
ISO |
Aspirin results in increased expression of BCAR3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression increases expression |
ISO EXP |
Aspirin inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BCL2 protein]; Aspirin inhibits the reaction [Cisplatin results in decreased expression of BCL2 mRNA]; Aspirin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] Aspirin results in decreased expression of BCL2 mRNA; Aspirin results in decreased expression of BCL2 protein Aspirin inhibits the reaction [Azoxymethane results in increased expression of BCL2 mRNA] Aspirin results in increased expression of BCL2 mRNA; Aspirin results in increased expression of BCL2 protein |
CTD |
PMID:12490308 PMID:14636445 PMID:15976387 PMID:16199534 PMID:17342322 PMID:18564172 PMID:18636671 PMID:19424877 PMID:19595669 PMID:19966835 PMID:20043115 PMID:20457246 PMID:20886344 PMID:23799623 PMID:25449198 PMID:37179038 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of BCL2L1 protein Aspirin results in increased expression of BCL2L1 mRNA |
CTD |
PMID:17342322 PMID:20457246 PMID:20886344 |
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NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl2l11 |
Bcl2-like 11 |
increases expression |
ISO |
Aspirin results in increased expression of BCL2L11 mRNA |
CTD |
PMID:19936928 |
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NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF mRNA alternative form]; Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BDNF protein]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased methylation of BDNF promoter alternative form] |
CTD |
PMID:34979192 PMID:37364758 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Bid |
BH3 interacting domain death agonist |
multiple interactions increases cleavage |
ISO |
[Aspirin co-treated with TNFSF10 protein] results in increased cleavage of BID protein; CASP8 affects the reaction [Aspirin results in increased cleavage of BID protein] |
CTD |
PMID:15976387 PMID:18483385 |
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NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
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G |
Bin1 |
bridging integrator 1 |
increases expression |
EXP |
Aspirin results in increased expression of BIN1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
multiple interactions increases expression decreases expression |
ISO |
[Aspirin co-treated with TNFSF10 protein] results in decreased expression of BIRC5 protein; Aspirin inhibits the reaction [E2F1 protein binds to BIRC5 promoter]; epoxomicin inhibits the reaction [Aspirin results in decreased expression of BIRC5 protein] Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of BIRC5 protein] Aspirin results in increased expression of BIRC5 mRNA Aspirin results in decreased expression of BIRC5 mRNA; Aspirin results in decreased expression of BIRC5 protein |
CTD |
PMID:11906190 PMID:17342322 PMID:17848598 PMID:18483385 PMID:25449198 |
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NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Blmh |
bleomycin hydrolase |
decreases expression |
ISO |
Aspirin results in decreased expression of BLMH mRNA |
CTD |
PMID:14976132 |
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NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212
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G |
Bmf |
Bcl2 modifying factor |
increases expression |
ISO |
Aspirin results in increased expression of BMF mRNA |
CTD |
PMID:19936928 |
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NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bmp6 |
bone morphogenetic protein 6 |
increases expression |
ISO |
Aspirin results in increased expression of BMP6 mRNA |
CTD |
PMID:32816093 |
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NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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G |
Bnip3l |
BCL2 interacting protein 3 like |
increases expression |
ISO |
Aspirin results in increased expression of BNIP3L mRNA |
CTD |
PMID:15928584 |
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NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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G |
Brca1 |
BRCA1, DNA repair associated |
decreases expression |
ISO |
Aspirin results in decreased expression of BRCA1 mRNA |
CTD |
PMID:20457246 PMID:20514442 |
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NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Brd4 |
bromodomain containing 4 |
increases expression |
ISO |
Aspirin results in increased expression of BRD4 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:11,216,446...11,296,029
Ensembl chr 7:11,216,446...11,295,539
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G |
Btg1 |
BTG anti-proliferation factor 1 |
increases expression |
ISO EXP |
Aspirin results in increased expression of BTG1 mRNA |
CTD |
PMID:12800193 PMID:15928584 |
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NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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G |
Bzw1 |
basic leucine zipper and W2 domains 1 |
increases expression |
ISO |
Aspirin results in increased expression of BZW1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 9:59,930,672...59,944,468
Ensembl chr 9:59,930,744...59,944,430
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G |
Cacng1 |
calcium voltage-gated channel auxiliary subunit gamma 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of CACNG1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:92,652,924...92,665,612
Ensembl chr10:92,652,614...92,665,783
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G |
Cacng6 |
calcium voltage-gated channel auxiliary subunit gamma 6 |
affects response to substance |
ISO |
CACNG6 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20860846 |
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NCBI chr 1:65,732,910...65,747,377
Ensembl chr 1:65,732,632...65,747,341
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G |
Calca |
calcitonin-related polypeptide alpha |
decreases expression |
EXP |
Aspirin results in decreased expression of CALCA mRNA |
CTD |
PMID:11588175 |
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NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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G |
Calm1 |
calmodulin 1 |
multiple interactions |
ISO |
Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]] |
CTD |
PMID:20705923 |
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NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
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G |
Calm3 |
calmodulin 3 |
increases expression |
ISO |
Aspirin results in increased expression of CALM3 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
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G |
Canx |
calnexin |
decreases expression |
ISO |
Aspirin results in decreased expression of CANX mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Capn1 |
calpain 1 |
increases expression |
ISO |
Aspirin results in increased expression of CAPN1 mRNA |
CTD |
PMID:19266085 |
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NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177
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G |
Capn2 |
calpain 2 |
increases expression |
ISO |
Aspirin results in increased expression of CAPN2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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G |
Capns1 |
calpain, small subunit 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of CAPNS1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:85,444,613...85,454,861
Ensembl chr 1:85,444,608...85,454,795
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G |
Capsl |
calcyphosine-like |
increases expression |
ISO |
Aspirin results in increased expression of CAPSL mRNA |
CTD |
PMID:11906190 |
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NCBI chr 2:58,394,995...58,425,527
Ensembl chr 2:58,411,424...58,424,980
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Capza1 |
capping actin protein of muscle Z-line subunit alpha 1 |
increases expression |
ISO |
Aspirin results in increased expression of CAPZA1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:192,319,696...192,364,755
Ensembl chr 2:192,319,702...192,364,480
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G |
Capza2 |
capping actin protein of muscle Z-line subunit alpha 2 |
increases expression |
ISO |
Aspirin results in increased expression of CAPZA2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions increases expression decreases expression |
ISO EXP |
Aspirin results in increased activity of CASP3 protein Aspirin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein] Bee Venoms inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of CASP3 protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 protein] Aspirin results in increased expression of CASP3 mRNA; Aspirin results in increased expression of CASP3 protein [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein; [troglitazone co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Aspirin inhibits the reaction [Methotrexate results in decreased expression of CASP3 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP3 protein; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP3 protein]; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]] Aspirin results in decreased expression of CASP3 mRNA |
CTD |
PMID:11034327 PMID:11228543 PMID:11532860 PMID:12490308 PMID:14753751 PMID:15481331 PMID:16199534 PMID:16880202 PMID:17644113 PMID:18483385 PMID:19908241 PMID:21353610 PMID:21617849 PMID:23799623 PMID:30885738 PMID:37179038 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp6 |
caspase 6 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP6 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP6 protein |
CTD |
PMID:15481331 PMID:17644113 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Aspirin results in increased cleavage of and results in increased activity of CASP7 protein |
CTD |
PMID:15481331 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
multiple interactions increases expression increases activity |
ISO |
[Aspirin co-treated with TNFSF10 protein] results in increased activity of CASP8 protein; [Aspirin co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein; [TNFSF10 protein co-treated with Aspirin] results in increased cleavage of CASP8 protein; Aspirin results in increased cleavage of and results in increased activity of CASP8 protein; CASP8 affects the reaction [Aspirin results in increased cleavage of BID protein]; CASP8 affects the reaction [Aspirin results in increased localization of BAX protein] Aspirin results in increased expression of CASP8 mRNA Aspirin results in increased activity of CASP8 protein |
CTD |
PMID:11034327 PMID:15481331 PMID:15976387 PMID:16199534 PMID:18483385 PMID:20457246 PMID:21171083 More...
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
ISO |
[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased activity of CASP9 protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]; Aspirin results in increased cleavage of and results in increased activity of CASP9 protein; BCL2 protein inhibits the reaction [[TNFSF10 protein co-treated with Aspirin] results in increased cleavage of and results in increased activity of CASP9 protein] Aspirin results in increased activity of CASP9 protein |
CTD |
PMID:11034327 PMID:14753751 PMID:15481331 PMID:16199534 PMID:16880202 PMID:17644113 More...
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat |
catalase |
decreases activity increases expression |
EXP |
Aspirin results in decreased activity of CAT; Aspirin results in decreased activity of CAT protein Aspirin results in increased expression of CAT protein |
CTD |
PMID:6845354 PMID:9212780 PMID:10528994 PMID:17147060 PMID:17274466 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of CAV1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccl19 |
C-C motif chemokine ligand 19 |
increases expression |
ISO |
Aspirin results in increased expression of CCL19 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO EXP |
Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [Glucose results in increased expression of CCL2 protein]; Aspirin inhibits the reaction [Glucose results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]; Aspirin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]; Aspirin inhibits the reaction [TNF results in increased secretion of CCL2 protein] Aspirin inhibits the reaction [Oxaliplatin results in increased expression of CCL2 mRNA] |
CTD |
PMID:15136050 PMID:16600694 PMID:24211328 PMID:35574720 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of CCL3 mRNA |
CTD |
PMID:21353610 |
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NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccn2 |
cellular communication network factor 2 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Glucose results in increased expression of CCN2 mRNA]; Aspirin inhibits the reaction [Streptozocin results in increased expression of CCN2 mRNA] |
CTD |
PMID:14586741 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccna2 |
cyclin A2 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Methotrexate results in increased expression of CCNA2 protein] |
CTD |
PMID:23799623 |
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NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnb1 |
cyclin B1 |
multiple interactions increases expression |
ISO |
Aspirin inhibits the reaction [troglitazone results in decreased expression of CCNB1 protein] Aspirin results in increased expression of CCNB1 mRNA |
CTD |
PMID:11906190 PMID:19908241 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression increases expression |
ISO EXP |
Aspirin inhibits the reaction [Smoke analog results in increased expression of CCND1 protein]; Aspirin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CCND1 protein] Aspirin results in decreased expression of CCND1 mRNA; Aspirin results in decreased expression of CCND1 protein Aspirin results in increased expression of CCND1 mRNA |
CTD |
PMID:11313997 PMID:11593435 PMID:12800193 PMID:15489888 PMID:16878161 PMID:17357503 PMID:19207549 PMID:19595669 PMID:19966835 PMID:21721879 More...
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd3 |
cyclin D3 |
multiple interactions decreases expression |
ISO |
Aspirin promotes the reaction [troglitazone results in decreased expression of CCND3 protein]; troglitazone promotes the reaction [Aspirin results in decreased expression of CCND3 protein] Aspirin results in decreased expression of CCND3 mRNA; Aspirin results in decreased expression of CCND3 protein |
CTD |
PMID:14976132 PMID:19908241 |
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NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
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G |
Ccne1 |
cyclin E1 |
affects expression decreases expression |
EXP ISO |
Aspirin affects the expression of CCNE1 mRNA Aspirin results in decreased expression of CCNE1 mRNA |
CTD |
PMID:12800193 PMID:20457246 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccnj |
cyclin J |
increases expression |
ISO |
Aspirin results in increased expression of CCNJ mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:239,659,588...239,677,367
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G |
Ccr3 |
C-C motif chemokine receptor 3 |
affects response to substance increases expression |
ISO |
CCR3 gene SNP affects the susceptibility to Aspirin; CCR3 SNP affects the susceptibility to Aspirin Aspirin results in increased expression of CCR3 mRNA |
CTD |
PMID:18379861 PMID:20022477 PMID:20485159 |
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NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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G |
Cd151 |
CD151 molecule (Raph blood group) |
decreases expression |
ISO |
Aspirin results in decreased expression of CD151 protein |
CTD |
PMID:15381054 |
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NCBI chr 1:196,564,744...196,568,753
Ensembl chr 1:196,565,181...196,568,753
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G |
Cd274 |
CD274 molecule |
increases expression |
ISO |
Aspirin results in increased expression of CD274 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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G |
Cd36 |
CD36 molecule |
decreases expression increases expression |
ISO EXP |
Aspirin results in decreased expression of CD36 protein Aspirin results in increased expression of CD36 mRNA |
CTD |
PMID:15140583 PMID:15381054 PMID:18222077 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G |
Cd40lg |
CD40 ligand |
decreases expression |
ISO |
Aspirin results in decreased expression of CD40LG protein |
CTD |
PMID:15140583 PMID:15381054 |
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NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cd44 |
CD44 molecule |
decreases expression multiple interactions |
ISO EXP |
Aspirin results in decreased expression of CD44 protein alternative form Aspirin results in decreased expression of CD44 mRNA CTNNB1 affects the reaction [Aspirin results in decreased expression of CD44 protein alternative form] |
CTD |
PMID:12800193 PMID:16878161 |
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NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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G |
Cd55 |
CD55 molecule (Cromer blood group) |
affects expression |
EXP |
Aspirin affects the expression of CD55 mRNA |
CTD |
PMID:12800193 |
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NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
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G |
Cd6 |
Cd6 molecule |
decreases expression |
ISO |
Aspirin results in decreased expression of CD6 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:207,442,873...207,481,703
Ensembl chr 1:207,442,877...207,481,634
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G |
Cd74 |
CD74 molecule |
decreases expression |
ISO |
Aspirin results in decreased expression of CD74 mRNA |
CTD |
PMID:15928584 |
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NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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G |
Cd8a |
CD8 subunit alpha |
decreases expression |
ISO |
Aspirin results in decreased expression of CD8A mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
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G |
Cdc25a |
cell division cycle 25A |
decreases expression |
ISO |
Aspirin results in decreased expression of CDC25A mRNA |
CTD |
PMID:20457246 |
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NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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G |
Cdc37 |
cell division cycle 37, HSP90 cochaperone |
decreases expression |
ISO |
Aspirin results in decreased expression of CDC37 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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G |
Cdc42 |
cell division cycle 42 |
decreases expression |
ISO |
Aspirin results in decreased expression of CDC42 mRNA |
CTD |
PMID:14976132 |
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NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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G |
Cdh1 |
cadherin 1 |
affects methylation |
ISO |
Aspirin affects the methylation of CDH1 promoter |
CTD |
PMID:19184424 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdk19 |
cyclin-dependent kinase 19 |
increases expression |
ISO |
Aspirin results in increased expression of CDK19 mRNA |
CTD |
PMID:11906190 |
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NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression multiple interactions |
ISO |
Aspirin results in decreased expression of CDK2 mRNA; Aspirin results in decreased expression of CDK2 protein troglitazone promotes the reaction [Aspirin results in decreased expression of CDK2 protein] |
CTD |
PMID:19908241 PMID:20457246 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of CDK4 mRNA |
CTD |
PMID:20457246 |
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NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions decreases expression increases expression affects expression decreases activity |
ISO |
Aspirin inhibits the reaction [Camptothecin results in increased expression of CDKN1A protein]; Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]; Aspirin results in increased expression of and results in increased phosphorylation of CDKN1A protein; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; PTGS1 mutant form inhibits the reaction [Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]]; wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein] Aspirin results in decreased expression of CDKN1A mRNA Aspirin results in increased expression of CDKN1A mRNA; Aspirin results in increased expression of CDKN1A protein Aspirin affects the expression of CDKN1A protein Aspirin results in decreased activity of CDKN1A protein |
CTD |
PMID:14976132 PMID:15190207 PMID:19212664 PMID:19908241 PMID:20404564 PMID:20457246 PMID:21617849 More...
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions increases expression |
ISO |
[troglitazone co-treated with Aspirin] results in increased expression of CDKN1B protein Aspirin results in increased expression of CDKN1B protein |
CTD |
PMID:16880202 PMID:19908241 |
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NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cds1 |
CDP-diacylglycerol synthase 1 |
increases expression |
EXP |
Aspirin results in increased expression of CDS1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr14:7,820,328...7,882,943
Ensembl chr14:7,820,351...7,882,681
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G |
Cebpb |
CCAAT/enhancer binding protein beta |
multiple interactions |
ISO |
Aspirin promotes the reaction [CEBPB protein binds to IL4 promoter polymorphism] |
CTD |
PMID:20921925 |
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NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
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G |
Cenps |
centromere protein S |
increases expression |
ISO |
Aspirin results in increased expression of CENPS mRNA |
CTD |
PMID:15456535 |
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NCBI chr 5:159,563,917...159,573,534
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G |
Cep68 |
centrosomal protein 68 |
affects response to substance |
ISO |
CEP68 SNP affects the susceptibility to Aspirin |
CTD |
PMID:21072201 |
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NCBI chr14:94,447,973...94,470,533
Ensembl chr14:94,449,055...94,470,517
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G |
Ces1d |
carboxylesterase 1D |
multiple interactions |
ISO |
CES1 protein promotes the reaction [Aspirin results in increased expression of ACACA protein modified form]; CES1 protein promotes the reaction [Aspirin results in increased expression of PRKAA1 protein modified form] |
CTD |
PMID:25743752 |
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NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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G |
Ces2c |
carboxylesterase 2C |
increases hydrolysis |
ISO |
CES2C protein results in increased hydrolysis of Aspirin |
CTD |
PMID:22513142 |
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NCBI chr 1:260,391,190...260,398,757
Ensembl chr 1:260,388,902...260,398,790
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G |
Ces2e |
carboxylesterase 2E |
increases hydrolysis |
ISO |
CES2E protein results in increased hydrolysis of Aspirin |
CTD |
PMID:22513142 |
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NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856
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G |
Ces2h |
carboxylesterase 2H |
affects hydrolysis increases hydrolysis |
ISO |
CES2 protein affects the hydrolysis of Aspirin CES2 protein results in increased hydrolysis of Aspirin |
CTD |
PMID:9300133 PMID:18983829 |
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NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of CFLAR mRNA Aspirin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CFLAR protein] |
CTD |
PMID:20457246 PMID:25449198 |
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NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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G |
Chd2 |
chromodomain helicase DNA binding protein 2 |
increases expression |
ISO |
Aspirin results in increased expression of CHD2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:127,188,146...127,317,041
Ensembl chr 1:127,190,059...127,300,502
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G |
Chek2 |
checkpoint kinase 2 |
increases expression |
ISO |
Aspirin results in increased expression of CHEK2 mRNA |
CTD |
PMID:20457246 |
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NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Chmp1a |
charged multivesicular body protein 1A |
decreases expression |
ISO |
Aspirin results in decreased expression of CHMP1A mRNA |
CTD |
PMID:14976132 |
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NCBI chr19:51,238,153...51,246,433
Ensembl chr19:51,238,160...51,246,436
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
multiple interactions decreases phosphorylation |
ISO EXP |
Aspirin inhibits the reaction [TNF protein results in increased activity of CHUK protein] Aspirin results in decreased phosphorylation of CHUK protein |
CTD |
PMID:15489888 PMID:16310244 |
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NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cks1b |
CDC28 protein kinase regulatory subunit 1B |
increases expression |
ISO |
Aspirin results in increased expression of CKS1B mRNA |
CTD |
PMID:14976132 |
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NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
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G |
Cldn7 |
claudin 7 |
increases expression |
EXP |
Aspirin results in increased expression of CLDN7 mRNA |
CTD |
PMID:12800193 |
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NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171
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G |
Clip3 |
CAP-GLY domain containing linker protein 3 |
increases expression |
ISO |
Aspirin results in increased expression of CLIP3 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:85,547,170...85,563,187
Ensembl chr 1:85,547,206...85,563,184
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G |
Clk2 |
CDC-like kinase 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of CLK2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:174,570,614...174,582,645
Ensembl chr 2:174,570,653...174,588,985
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G |
Clk3 |
CDC-like kinase 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of CLK3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:58,152,155...58,167,196
Ensembl chr 8:58,152,155...58,168,181
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G |
Col26a1 |
collagen type XXVI alpha 1 chain |
affects response to substance |
ISO |
COL26A1 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:21086123 |
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NCBI chr12:19,792,693...19,938,556
Ensembl chr12:19,792,728...19,938,556
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G |
Col3a1 |
collagen type III alpha 1 chain |
decreases expression |
ISO |
Aspirin results in decreased expression of COL3A1 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
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G |
Col7a1 |
collagen type VII alpha 1 chain |
decreases expression |
ISO |
Aspirin results in decreased expression of COL7A1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:109,604,877...109,637,249
Ensembl chr 8:109,604,861...109,637,252
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G |
Cpne1 |
copine 1 |
increases expression |
ISO |
Aspirin results in increased expression of CPNE1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:144,587,531...144,629,911
Ensembl chr 3:144,588,995...144,598,636
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G |
Cpt1a |
carnitine palmitoyltransferase 1A |
increases expression |
ISO |
Aspirin results in increased expression of CPT1A mRNA; Aspirin results in increased expression of CPT1A protein |
CTD |
PMID:25743752 |
|
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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G |
Cracr2b |
calcium release activated channel regulator 2B |
increases expression |
ISO |
Aspirin results in increased expression of CRACR2B mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:196,558,407...196,563,961
Ensembl chr 1:196,558,588...196,563,771
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G |
Crebbp |
CREB binding protein |
increases expression |
ISO |
Aspirin results in increased expression of CREBBP mRNA |
CTD |
PMID:11906190 |
|
NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
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G |
Csf3r |
colony stimulating factor 3 receptor |
decreases expression |
ISO |
Aspirin results in decreased expression of CSF3R mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881
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G |
Csnk2a1 |
casein kinase 2 alpha 1 |
increases expression decreases expression |
ISO |
Aspirin results in increased expression of CSNK2A1 mRNA Aspirin results in decreased expression of CSNK2A1 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 3:140,709,984...140,756,757
Ensembl chr 3:140,709,991...140,756,696
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G |
Csta |
cystatin A |
increases expression |
ISO |
Aspirin results in increased expression of CSTA mRNA |
CTD |
PMID:15456535 PMID:15928584 |
|
NCBI chr11:64,620,483...64,631,488
Ensembl chr11:64,620,483...64,631,488
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G |
Ctnnb1 |
catenin beta 1 |
increases phosphorylation decreases localization multiple interactions increases ubiquitination |
ISO |
Aspirin results in increased phosphorylation of CTNNB1 protein Aspirin results in decreased localization of CTNNB1 protein benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Aspirin results in increased ubiquitination of CTNNB1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CCND1 protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CD44 protein alternative form]; CTNNB1 affects the reaction [Aspirin results in decreased expression of CMET protein]; CTNNB1 affects the reaction [Aspirin results in decreased expression of MYC protein]; Lithium Chloride inhibits the reaction [Aspirin results in increased phosphorylation of CTNNB1 protein] |
CTD |
PMID:12813129 PMID:16878161 PMID:17357503 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsb |
cathepsin B |
decreases expression |
ISO |
Aspirin results in decreased expression of CTSB mRNA |
CTD |
PMID:21353610 |
|
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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G |
Cx3cl1 |
C-X3-C motif chemokine ligand 1 |
multiple interactions decreases expression |
ISO |
Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of CX3CL1 protein] Aspirin results in decreased expression of CX3CL1 mRNA; Aspirin results in decreased expression of CX3CL1 protein |
CTD |
PMID:19493461 PMID:19997773 |
|
NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
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|
G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of CXCL1 protein]; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA] |
CTD |
PMID:14742690 PMID:17303692 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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|
G |
Cxcl3 |
C-X-C motif chemokine ligand 3 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of CXCL1 protein]; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA] |
CTD |
PMID:14742690 PMID:17303692 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G |
Cxcl6 |
C-X-C motif chemokine ligand 6 |
increases expression |
EXP |
Aspirin results in increased expression of CXCL5 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
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G |
Cyc1 |
cytochrome c-1 |
increases expression |
EXP |
Aspirin results in increased expression of CYC1 mRNA |
CTD |
PMID:8554334 |
|
NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
EXP |
Aspirin results in increased expression of CYP2E1 mRNA |
CTD |
PMID:11752103 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cysltr1 |
cysteinyl leukotriene receptor 1 |
increases expression multiple interactions affects response to substance |
ISO |
Aspirin results in increased expression of CYSLTR1 mRNA Aspirin inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA] CYSLTR1 gene SNP affects the susceptibility to Aspirin; CYSLTR1 SNP affects the susceptibility to Aspirin |
CTD |
PMID:16630147 PMID:17641958 PMID:18379861 PMID:19767084 PMID:20485159 |
|
NCBI chr X:71,661,421...71,690,012
Ensembl chr X:71,663,821...71,690,121
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G |
Cysltr2 |
cysteinyl leukotriene receptor 2 |
affects response to substance |
ISO |
CYSLTR2 gene SNP affects the susceptibility to Aspirin; CYSLTR2 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:15970796 PMID:20485159 |
|
NCBI chr15:48,189,476...48,228,750
Ensembl chr15:48,189,073...48,304,136
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G |
Dap |
death-associated protein |
decreases expression |
ISO |
Aspirin results in decreased expression of DAP mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 2:82,199,206...82,251,771
Ensembl chr 2:82,199,280...82,251,752
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO EXP |
Aspirin results in increased expression of DDIT3 mRNA |
CTD |
PMID:12800193 PMID:14976132 |
|
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddx18 |
DEAD-box helicase 18 |
decreases expression |
ISO |
Aspirin results in decreased expression of DDX18 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr13:32,729,697...32,743,161
Ensembl chr13:32,729,700...32,743,161
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G |
Ddx5 |
DEAD-box helicase 5 |
increases expression |
ISO |
Aspirin results in increased expression of DDX5 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283
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G |
Defa5 |
defensin alpha 5 |
increases expression |
EXP |
Aspirin results in increased expression of DEFA5 mRNA |
CTD |
PMID:20043115 |
|
NCBI chr16:70,342,530...70,344,854
Ensembl chr16:70,342,530...70,344,836
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G |
Dek |
DEK proto-oncogene |
increases expression |
ISO |
Aspirin results in increased expression of DEK mRNA |
CTD |
PMID:15928584 |
|
NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
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G |
Dennd5a |
DENN domain containing 5A |
increases expression |
ISO |
Aspirin results in increased expression of DENND5A mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 1:163,928,183...163,994,207
Ensembl chr 1:163,928,183...163,994,316
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
decreases expression |
ISO |
Aspirin results in decreased expression of DIABLO protein |
CTD |
PMID:15976387 |
|
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Dlst |
dihydrolipoamide S-succinyltransferase |
decreases expression |
ISO |
Aspirin results in decreased expression of DLST mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
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G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT1 mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT1 protein] |
CTD |
PMID:34979192 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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G |
Dnmt3a |
DNA methyltransferase 3 alpha |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3A mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3A protein] |
CTD |
PMID:34979192 |
|
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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G |
Dnmt3b |
DNA methyltransferase 3 beta |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3B mRNA]; Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of DNMT3B protein] |
CTD |
PMID:34979192 |
|
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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G |
Dusp1 |
dual specificity phosphatase 1 |
affects expression |
EXP |
Aspirin affects the expression of DUSP1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr10:16,680,478...16,683,275
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G |
Dusp5 |
dual specificity phosphatase 5 |
affects expression |
EXP |
Aspirin affects the expression of DUSP5 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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G |
Dusp6 |
dual specificity phosphatase 6 |
increases expression |
EXP |
Aspirin results in increased expression of DUSP6 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
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G |
E2f1 |
E2F transcription factor 1 |
multiple interactions decreases expression |
ISO |
[troglitazone co-treated with Aspirin] results in decreased expression of E2F1 protein; Aspirin inhibits the reaction [E2F1 protein binds to BIRC5 promoter] Aspirin results in decreased expression of E2F1 mRNA |
CTD |
PMID:17848598 PMID:19908241 PMID:20457246 |
|
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
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G |
Ednrb |
endothelin receptor type B |
multiple interactions |
ISO |
Aspirin inhibits the reaction [IL1B results in increased activity of EDNRB] |
CTD |
PMID:12126971 |
|
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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G |
Eef1a1 |
eukaryotic translation elongation factor 1 alpha 1 |
increases expression |
ISO |
Aspirin results in increased expression of EEF1A1 mRNA |
CTD |
PMID:14976132 |
|
NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839
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G |
Egfr |
epidermal growth factor receptor |
increases expression |
ISO |
Aspirin results in increased expression of EGFR mRNA |
CTD |
PMID:15456535 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Egr1 |
early growth response 1 |
increases expression |
EXP |
Aspirin results in increased expression of EGR1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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G |
Egr4 |
early growth response 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of EGR4 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
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G |
Ehhadh |
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase |
decreases expression |
ISO |
Aspirin results in decreased expression of EHHADH mRNA |
CTD |
PMID:27089845 |
|
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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G |
Ehmt2 |
euchromatic histone lysine methyltransferase 2 |
increases expression |
ISO |
Aspirin results in increased expression of EHMT2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547
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G |
Eif2s2 |
eukaryotic translation initiation factor 2 subunit beta |
increases expression |
ISO |
Aspirin results in increased expression of EIF2S2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions |
ISO |
Aspirin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein |
CTD |
PMID:23363784 |
|
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Elf4 |
E74 like ETS transcription factor 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of ELF4 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr X:127,587,401...127,639,063
Ensembl chr X:127,590,650...127,630,200
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G |
Elovl5 |
ELOVL fatty acid elongase 5 |
increases expression decreases expression |
ISO |
Aspirin results in increased expression of ELOVL5 mRNA Aspirin results in decreased expression of ELOVL5 mRNA |
CTD |
PMID:11906190 PMID:15928584 |
|
NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284
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G |
Enpp2 |
ectonucleotide pyrophosphatase/phosphodiesterase 2 |
decreases expression |
EXP |
Aspirin results in decreased expression of ENPP2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
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G |
Entpd2 |
ectonucleoside triphosphate diphosphohydrolase 2 |
increases expression |
EXP |
Aspirin results in increased expression of ENTPD2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866
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G |
Entpd4 |
ectonucleoside triphosphate diphosphohydrolase 4 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENTPD4 mRNA] |
CTD |
PMID:37364758 |
|
NCBI chr15:44,630,878...44,658,654
Ensembl chr15:44,630,873...44,658,706
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G |
Epdr1 |
ependymin related 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of EPDR1 mRNA |
CTD |
PMID:20457246 |
|
NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594
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G |
Ephx2 |
epoxide hydrolase 2 |
multiple interactions |
ISO |
Aspirin promotes the reaction [EPHX2 gene mutant form results in decreased susceptibility to Lipopolysaccharides]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 11,12-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [[Lipopolysaccharides co-treated with Aspirin] results in decreased abundance of 14,15-dihydroxyeicosatrienoic acid]; EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Prostaglandin D2]] |
CTD |
PMID:19896470 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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G |
Erbb2 |
erb-b2 receptor tyrosine kinase 2 |
decreases expression increases expression |
ISO |
Aspirin results in decreased expression of ERBB2 mRNA; Aspirin results in decreased expression of ERBB2 protein Aspirin results in increased expression of ERBB2 mRNA |
CTD |
PMID:19424877 PMID:20457246 |
|
NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
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G |
Erbin |
erbb2 interacting protein |
increases expression |
ISO |
Aspirin results in increased expression of ERBIN mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 2:34,926,962...35,028,440
Ensembl chr 2:34,928,863...35,027,852
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G |
Ercc5 |
ERCC excision repair 5, endonuclease |
increases expression |
ISO |
Aspirin results in increased expression of ERCC5 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472
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G |
Ereg |
epiregulin |
increases expression |
ISO |
Aspirin results in increased expression of EREG mRNA |
CTD |
PMID:32816093 |
|
NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
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G |
Ets2 |
ETS proto-oncogene 2, transcription factor |
decreases expression |
ISO |
Aspirin results in decreased expression of ETS2 mRNA |
CTD |
PMID:20457246 |
|
NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
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G |
Evi2b |
ecotropic viral integration site 2B |
increases expression |
ISO |
Aspirin results in increased expression of EVI2B mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:64,472,693...64,474,311
Ensembl chr10:64,471,505...64,481,560
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G |
Ezr |
ezrin |
decreases expression |
ISO |
Aspirin results in decreased expression of EZR mRNA |
CTD |
PMID:14976132 |
|
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
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G |
F2 |
coagulation factor II, thrombin |
affects cleavage multiple interactions |
ISO |
Aspirin affects the cleavage of F2 protein ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein] |
CTD |
PMID:16675000 |
|
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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G |
F2r |
coagulation factor II (thrombin) receptor |
decreases expression |
ISO |
Aspirin results in decreased expression of F2R protein |
CTD |
PMID:15140583 PMID:15381054 |
|
NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
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G |
Fas |
Fas cell surface death receptor |
affects expression multiple interactions increases expression |
ISO EXP |
Aspirin affects the expression of FAS protein Aspirin inhibits the reaction [Methotrexate results in increased expression of FAS protein] Aspirin results in increased expression of FAS mRNA Aspirin inhibits the reaction [Azoxymethane results in increased expression of FAS mRNA] |
CTD |
PMID:15200494 PMID:20043115 PMID:20457246 PMID:23799623 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
|
|
G |
Faslg |
Fas ligand |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Azoxymethane results in increased expression of FASLG mRNA] |
CTD |
PMID:20043115 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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|
G |
Fat3 |
FAT atypical cadherin 3 |
increases expression |
ISO |
Aspirin results in increased expression of FAT3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 8:12,691,470...13,274,336
Ensembl chr 8:12,694,019...13,273,135
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G |
Fbxl3 |
F-box and leucine-rich repeat protein 3 |
increases expression |
ISO |
Aspirin results in increased expression of FBXL3 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr15:79,906,795...79,926,678
Ensembl chr15:79,906,795...79,927,867
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G |
Fbxo11 |
F-box protein 11 |
increases expression |
ISO |
Aspirin results in increased expression of FBXO11 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662
|
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G |
Fcer1a |
Fc epsilon receptor Ia |
affects response to substance multiple interactions |
ISO |
FCER1A gene SNP affects the susceptibility to Aspirin; FCER1A polymorphism affects the susceptibility to Aspirin Aspirin inhibits the reaction [IL4 results in increased expression of FCER1A mRNA] |
CTD |
PMID:17125826 PMID:19767084 PMID:20485159 |
|
NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
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G |
Fcer1g |
Fc epsilon receptor Ig |
decreases expression affects response to substance |
ISO |
Aspirin results in decreased expression of FCER1G mRNA FCER1G SNP affects the susceptibility to Aspirin |
CTD |
PMID:15928584 PMID:18534082 PMID:18595682 |
|
NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443
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G |
Fdft1 |
farnesyl diphosphate farnesyl transferase 1 |
increases expression |
EXP |
Aspirin results in increased expression of FDFT1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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|
G |
Fer |
FER tyrosine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of FER mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451
|
|
G |
Fga |
fibrinogen alpha chain |
decreases secretion multiple interactions |
ISO |
Aspirin results in decreased secretion of FGA protein Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGA protein]; Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein] |
CTD |
PMID:17303692 |
|
NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528
|
|
G |
Fgb |
fibrinogen beta chain |
multiple interactions decreases secretion |
ISO |
Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein]; Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGB protein] Aspirin results in decreased secretion of FGB protein |
CTD |
PMID:17303692 |
|
NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979
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|
G |
Fgg |
fibrinogen gamma chain |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of FGG protein]; Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein] |
CTD |
PMID:17303692 |
|
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
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|
G |
Fgr |
FGR proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of FGR mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
|
|
G |
Flii |
FLII, actin remodeling protein |
decreases expression |
ISO |
Aspirin results in decreased expression of FLII mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:45,394,032...45,408,051
Ensembl chr10:45,394,032...45,407,970
|
|
G |
Flot2 |
flotillin 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of FLOT2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
|
|
G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Streptozocin results in increased expression of FN1] |
CTD |
PMID:14586741 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
|
|
G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression decreases expression |
EXP ISO |
Aspirin results in increased expression of FOS mRNA Aspirin results in decreased expression of FOS mRNA |
CTD |
PMID:12800193 PMID:20457246 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
|
|
G |
Fosb |
FosB proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
Aspirin results in decreased expression of FOSB mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
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|
G |
Fosl1 |
FOS like 1, AP-1 transcription factor subunit |
multiple interactions decreases expression increases expression |
ISO EXP |
Aspirin promotes the reaction [FOSL1 protein binds to PLAUR promoter] Aspirin results in decreased expression of FOSL1 mRNA; Aspirin results in decreased expression of FOSL1 protein Aspirin results in increased expression of FOSL1 mRNA |
CTD |
PMID:12800193 PMID:16893520 PMID:21721879 |
|
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
|
|
G |
Fosl2 |
FOS like 2, AP-1 transcription factor subunit |
increases expression |
EXP |
Aspirin results in increased expression of FOSL2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
|
|
G |
Fpr1 |
formyl peptide receptor 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of FPR1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
|
|
G |
Fpr2 |
formyl peptide receptor 2 |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of FPR2 [Aspirin results in increased abundance of lipoxin A4] which results in increased expression of FPR2 |
CTD |
PMID:19597002 |
|
NCBI chr 1:58,776,592...58,785,227
Ensembl chr 1:58,776,752...58,786,019
|
|
G |
Fsip1 |
fibrous sheath interacting protein 1 |
affects response to substance |
ISO |
FSIP1 SNP affects the susceptibility to Aspirin |
CTD |
PMID:20513247 |
|
NCBI chr 3:105,074,584...105,217,180
Ensembl chr 3:105,068,543...105,217,167
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|
G |
Fst |
follistatin |
affects expression |
EXP |
Aspirin affects the expression of FST mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
|
|
G |
Furin |
furin (paired basic amino acid cleaving enzyme) |
decreases expression |
ISO |
Aspirin results in decreased expression of FURIN mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:134,348,142...134,361,182
Ensembl chr 1:134,348,144...134,364,314
|
|
G |
Fxr2 |
FMR1 autosomal homolog 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of FXR2 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr10:54,350,577...54,370,964
Ensembl chr10:54,350,131...54,370,964
|
|
G |
G0s2 |
G0/G1switch 2 |
increases expression |
EXP |
Aspirin results in increased expression of G0S2 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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|
G |
G6pc3 |
glucose 6 phosphatase catalytic subunit 3 |
increases expression |
ISO |
Aspirin results in increased expression of G6PC3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases response to substance decreases activity |
ISO |
G6PD results in decreased susceptibility to Aspirin Aspirin results in decreased activity of G6PD protein mutant form |
CTD |
PMID:5432368 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
|
|
G |
Gabarap |
GABA type A receptor-associated protein |
decreases expression |
ISO |
Aspirin results in decreased expression of GABARAP mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:54,714,777...54,718,099
Ensembl chr10:54,714,198...54,717,765
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|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
decreases expression increases expression |
EXP ISO |
Aspirin results in decreased expression of GADD45A mRNA Aspirin results in increased expression of GADD45A mRNA |
CTD |
PMID:12800193 PMID:20514442 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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|
G |
Gas6 |
growth arrest specific 6 |
affects response to substance |
ISO |
GAS6 protein affects the susceptibility to Aspirin |
CTD |
PMID:16999853 |
|
NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904
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|
G |
Gast |
gastrin |
multiple interactions |
EXP |
[lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of GAST protein |
CTD |
PMID:15024038 |
|
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
|
|
G |
Gatd3a |
glutamine amidotransferase class 1 domain containing 3A |
increases expression |
ISO |
Aspirin results in increased expression of GATD3 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr20:10,514,793...10,522,894
Ensembl chr20:10,514,744...10,522,885
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|
G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
ISO |
Aspirin results in increased expression of GDF15 mRNA; Aspirin results in increased expression of GDF15 protein |
CTD |
PMID:14976132 PMID:15180942 |
|
NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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|
G |
Gdnf |
glial cell derived neurotrophic factor |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GDNF protein] |
CTD |
PMID:37364758 |
|
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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|
G |
Gfap |
glial fibrillary acidic protein |
decreases expression increases expression |
ISO EXP |
Aspirin results in decreased expression of GFAP mRNA; Aspirin results in decreased expression of GFAP protein Aspirin results in increased expression of GFAP mRNA |
CTD |
PMID:16516312 PMID:21353610 PMID:22954530 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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|
G |
Gfra3 |
GDNF family receptor alpha 3 |
increases expression |
ISO |
Aspirin results in increased expression of GFRA3 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr18:26,297,828...26,326,105
Ensembl chr18:26,297,829...26,326,105
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|
G |
Ggt1 |
gamma-glutamyltransferase 1 |
decreases activity |
EXP |
Aspirin analog results in decreased activity of GGT1 protein |
CTD |
PMID:20171274 |
|
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
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|
G |
Ghitm |
growth hormone inducible transmembrane protein |
increases expression |
ISO |
Aspirin results in increased expression of GHITM mRNA |
CTD |
PMID:15928584 |
|
NCBI chr16:12,885,551...12,897,887
Ensembl chr16:12,885,553...12,897,879
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|
G |
Gja1 |
gap junction protein, alpha 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of GJA1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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|
G |
Gkn1 |
gastrokine 1 |
affects expression |
ISO |
Aspirin affects the expression of GKN1 mRNA; Aspirin affects the expression of GKN1 protein |
CTD |
PMID:19145733 |
|
NCBI chr 4:119,790,101...119,795,389
Ensembl chr 4:119,790,101...119,795,389
|
|
G |
Gnb2 |
G protein subunit beta 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of GNB2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr12:19,159,002...19,164,021
Ensembl chr12:19,158,973...19,164,019
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|
G |
Gp1ba |
glycoprotein Ib platelet subunit alpha |
decreases response to substance increases response to substance affects response to substance |
ISO |
GP1BA SNP results in decreased susceptibility to Aspirin GP1BA polymorphism results in increased susceptibility to Aspirin GP1BA polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:17245331 PMID:17630485 PMID:19250145 |
|
NCBI chr10:55,352,938...55,355,804
Ensembl chr10:55,352,899...55,356,774
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|
G |
Gp6 |
glycoprotein VI |
decreases response to substance |
ISO |
GP6 gene polymorphism results in decreased susceptibility to Aspirin |
CTD |
PMID:16493486 |
|
NCBI chr 1:69,429,232...69,492,709
Ensembl chr 1:69,465,789...69,491,326
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions increases expression |
EXP |
fucoidan inhibits the reaction [Aspirin results in increased expression of GPT protein] |
CTD |
PMID:19788892 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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|
G |
Gpx1 |
glutathione peroxidase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of GPX1 mRNA |
CTD |
PMID:21353610 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases phosphorylation increases phosphorylation decreases activity |
ISO EXP |
Aspirin results in decreased phosphorylation of GSK3B protein Aspirin results in increased phosphorylation of GSK3B protein Aspirin results in decreased activity of GSK3B protein |
CTD |
PMID:11593435 PMID:12813129 PMID:19966835 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsn |
gelsolin |
affects expression |
EXP |
Aspirin affects the expression of GSN protein |
CTD |
PMID:23533533 |
|
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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|
G |
Gsta2 |
glutathione S-transferase alpha 2 |
affects binding |
EXP |
Aspirin binds to GSTA2 protein |
CTD |
PMID:15236443 |
|
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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|
G |
Gstm1 |
glutathione S-transferase mu 1 |
affects response to substance |
ISO |
GSTM1 mutant form affects the susceptibility to Aspirin |
CTD |
PMID:16433794 |
|
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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|
G |
Gsto1 |
glutathione S-transferase omega 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of GSTO1 mRNA |
CTD |
PMID:14976132 |
|
NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468
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G |
Gstt1 |
glutathione S-transferase theta 1 |
increases expression |
EXP |
Aspirin results in increased expression of GSTT1 protein |
CTD |
PMID:9729437 |
|
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
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G |
Gstt2 |
glutathione S-transferase theta 2 |
increases expression |
EXP |
Aspirin results in increased expression of GSTT2 protein |
CTD |
PMID:9729437 |
|
NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
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|
G |
Gtf2i |
general transcription factor II I |
decreases expression |
ISO |
Aspirin results in decreased expression of GTF2I mRNA |
CTD |
PMID:11906190 |
|
NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243
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|
G |
Gtpbp2 |
GTP binding protein 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of GTPBP2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 9:14,813,964...14,823,419
Ensembl chr 9:14,813,964...14,823,241
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|
G |
Guk1 |
guanylate kinase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of GUK1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107
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G |
Gzma |
granzyme A |
decreases expression |
ISO |
Aspirin results in decreased expression of GZMA mRNA |
CTD |
PMID:20457246 |
|
NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
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|
G |
H2ax |
H2A.X variant histone |
decreases expression |
ISO |
Aspirin results in decreased expression of H2AX protein |
CTD |
PMID:23363784 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hbegf |
heparin-binding EGF-like growth factor |
multiple interactions increases expression |
EXP |
apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of HBEGF mRNA]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of HBEGF protein] Aspirin results in increased expression of HBEGF mRNA; Aspirin results in increased expression of HBEGF protein |
CTD |
PMID:18482463 |
|
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
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|
G |
Hck |
HCK proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of HCK mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
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|
G |
Hcls1 |
hematopoietic cell specific Lyn substrate 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of HCLS1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr11:63,817,482...63,840,943
Ensembl chr11:63,817,476...63,841,014
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|
G |
Hdac1 |
histone deacetylase 1 |
increases expression |
ISO |
Aspirin results in increased expression of HDAC1 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
|
|
G |
Hdac3 |
histone deacetylase 3 |
multiple interactions |
ISO |
HDAC3 inhibits the reaction [Aspirin results in increased acetylation of and results in increased activity of NOS3 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]] |
CTD |
PMID:20705923 |
|
NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
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|
G |
Hdac4 |
histone deacetylase 4 |
increases expression |
ISO |
Aspirin results in increased expression of HDAC4 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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G |
Hdgf |
heparin binding growth factor |
decreases expression |
ISO |
Aspirin results in decreased expression of HDGF mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747
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|
G |
Hgf |
hepatocyte growth factor |
multiple interactions |
ISO |
Aspirin inhibits the reaction [HGF results in increased activity of MAPK1 protein]; Aspirin inhibits the reaction [HGF results in increased activity of MAPK3 protein]; Aspirin inhibits the reaction [HGF results in increased expression of MMP9] |
CTD |
PMID:11981761 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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|
G |
Hlcs |
holocarboxylase synthetase |
increases expression |
ISO |
Aspirin results in increased expression of HLCS mRNA |
CTD |
PMID:11906190 |
|
NCBI chr11:33,455,806...33,635,197
Ensembl chr11:33,455,809...33,624,222
|
|
G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:34755645 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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|
G |
Hmmr |
hyaluronan-mediated motility receptor |
increases expression |
ISO |
Aspirin results in increased expression of HMMR mRNA |
CTD |
PMID:11906190 |
|
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
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|
G |
Hmox1 |
heme oxygenase 1 |
increases expression |
ISO EXP |
Aspirin results in increased expression of HMOX1 Aspirin analog results in increased expression of HMOX1 mRNA |
CTD |
PMID:15901601 PMID:19100325 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Hnf1a |
HNF1 homeobox A |
decreases expression |
EXP |
Aspirin results in decreased expression of HNF1A mRNA |
CTD |
PMID:12800193 |
|
NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
|
|
G |
Hnmt |
histamine N-methyltransferase |
affects response to substance |
ISO |
HNMT gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:20485159 |
|
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
|
|
G |
Hnrnpa1 |
heterogeneous nuclear ribonucleoprotein A1 |
decreases expression |
EXP |
Aspirin results in decreased expression of HNRNPA1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
|
|
G |
Hnrnpc |
heterogeneous nuclear ribonucleoprotein C |
decreases expression |
EXP |
Aspirin results in decreased expression of HNRNPC mRNA |
CTD |
PMID:12800193 |
|
NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
|
|
G |
Hnrnpdl |
heterogeneous nuclear ribonucleoprotein D-like |
decreases expression |
ISO |
Aspirin results in decreased expression of HNRNPDL mRNA |
CTD |
PMID:15456535 |
|
NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506
|
|
G |
Hnrnpu |
heterogeneous nuclear ribonucleoprotein U |
increases expression |
ISO |
Aspirin results in increased expression of HNRNPU mRNA |
CTD |
PMID:15928584 |
|
NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588
|
|
G |
Hnrnpul1 |
heterogeneous nuclear ribonucleoprotein U-like 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of HNRNPUL1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:81,228,404...81,264,121
Ensembl chr 1:81,228,404...81,262,592
|
|
G |
Hsf1 |
heat shock transcription factor 1 |
increases activity |
ISO |
Aspirin results in increased activity of HSF1 protein |
CTD |
PMID:10328874 |
|
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
|
|
G |
Hspa1a |
heat shock protein family A (Hsp70) member 1A |
increases expression |
ISO |
Aspirin results in increased expression of HSPA1A mRNA |
CTD |
PMID:15456535 |
|
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
decreases expression |
ISO |
Aspirin results in decreased expression of HSPA5 mRNA |
CTD |
PMID:14976132 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
|
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G |
Hspb1 |
heat shock protein family B (small) member 1 |
increases expression |
EXP |
Aspirin results in increased expression of HSPB1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G |
Iars1 |
isoleucyl-tRNA synthetase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of IARS1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression multiple interactions |
ISO EXP |
Aspirin results in decreased expression of ICAM1 mRNA; Aspirin results in decreased expression of ICAM1 protein Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]; Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]] |
CTD |
PMID:14762100 PMID:16310244 PMID:18059344 |
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NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Id2 |
inhibitor of DNA binding 2 |
affects expression |
EXP |
Aspirin affects the expression of ID2 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Ido1 |
indoleamine 2,3-dioxygenase 1 |
affects response to substance |
ISO |
IDO1 affects the susceptibility to Aspirin |
CTD |
PMID:19489917 |
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NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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G |
Ifi30 |
IFI30, lysosomal thiol reductase |
decreases expression |
ISO |
Aspirin results in decreased expression of IFI30 mRNA |
CTD |
PMID:15928584 |
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NCBI chr16:18,675,590...18,679,655
Ensembl chr16:18,675,613...18,681,175
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G |
Ifng |
interferon gamma |
multiple interactions increases expression |
ISO EXP |
Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]]; Aspirin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IFNG protein] Aspirin results in increased expression of IFNG protein fucoidan promotes the reaction [Aspirin results in increased expression of IFNG protein] Aspirin inhibits the reaction [Acetaminophen results in increased expression of IFNG mRNA] |
CTD |
PMID:15379866 PMID:19164858 PMID:19788892 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ift27 |
intraflagellar transport 27 |
increases expression |
ISO |
Aspirin results in increased expression of IFT27 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr 7:109,738,622...109,754,416
Ensembl chr 7:109,738,622...109,754,416
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G |
Igf2 |
insulin-like growth factor 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of IGF2 mRNA |
CTD |
PMID:9399670 |
|
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Igf2r |
insulin-like growth factor 2 receptor |
increases expression |
ISO |
Aspirin results in increased expression of IGF2R mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
decreases activity decreases phosphorylation decreases expression |
ISO EXP |
Aspirin results in decreased activity of IKBKB protein Aspirin results in decreased phosphorylation of IKBKB protein Aspirin results in decreased expression of IKBKB protein |
CTD |
PMID:16199534 PMID:16310244 PMID:16880202 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
increases response to substance multiple interactions increases expression affects response to substance |
ISO EXP |
IL10 polymorphism results in increased susceptibility to Aspirin fucoidan promotes the reaction [Aspirin results in increased expression of IL10 protein] IL10 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:16030091 PMID:19222424 PMID:19788892 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:15379866 |
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NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:15379866 |
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NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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G |
Il13 |
interleukin 13 |
affects response to substance |
ISO |
IL13 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:22123380 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il17a |
interleukin 17A |
affects response to substance |
ISO |
IL17A polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:22123380 |
|
NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il18 |
interleukin 18 |
multiple interactions affects response to substance |
ISO |
Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL18 mRNA] IL18 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:19164858 PMID:21692767 |
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NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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G |
Il1a |
interleukin 1 alpha |
multiple interactions increases expression |
ISO |
[Aspirin co-treated with IL1A] results in increased expression of TNF mRNA; Aspirin promotes the reaction [IL1A results in increased expression of CXCL1 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of IL1B mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of IL6 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [IL1A results in increased phosphorylation of MAPK14 protein]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 mRNA]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 protein]; IL1A promotes the reaction [Aspirin results in increased phosphorylation of MAPK14 protein] Aspirin results in increased expression of IL1A mRNA |
CTD |
PMID:14742690 PMID:32816093 |
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NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression decreases expression affects response to substance |
ISO EXP |
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]]; Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]; Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]; Aspirin inhibits the reaction [IL1B results in increased activity of EDNRB]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of Dinoprostone]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Aspirin promotes the reaction [IL1A results in increased expression of IL1B mRNA]; Celecoxib inhibits the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased expression of ICAM1 protein]]; Celecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; Naproxen promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]]; rofecoxib promotes the reaction [Aspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased abundance of Dinoprostone]] Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein]; Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of RELA protein]; Aspirin inhibits the reaction [Azoxymethane results in increased expression of IL1B mRNA]; Aspirin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL1B protein]; Aspirin promotes the reaction [Acetic Acid results in increased expression of IL1B protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; lipopolysaccharide, Helicobacter pylori inhibits the reaction [Aspirin results in increased expression of IL1B protein] Aspirin results in decreased expression of IL1B mRNA IL1B polymorphism affects the susceptibility to Aspirin Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; Aspirin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; Aspirin inhibits the reaction [Cisplatin results in increased expression of IL1B mRNA] Aspirin results in increased expression of IL1B mRNA |
CTD |
PMID:11376495 PMID:11826407 PMID:12126971 PMID:14742690 PMID:14762100 PMID:14976132 PMID:15024038 PMID:16529823 PMID:19164858 PMID:20043115 PMID:21353610 PMID:21893697 PMID:22039321 PMID:22132000 PMID:32816093 PMID:36988346 PMID:37179038 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1r2 |
interleukin 1 receptor type 2 |
affects response to substance |
ISO |
IL1R2 affects the susceptibility to Aspirin |
CTD |
PMID:19489917 |
|
NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
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G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Salmonella Vaccines results in increased expression of IL1RN protein] |
CTD |
PMID:12045164 |
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NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il2 |
interleukin 2 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] |
CTD |
PMID:15379866 |
|
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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G |
Il24 |
interleukin 24 |
increases expression |
ISO |
Aspirin results in increased expression of IL24 mRNA |
CTD |
PMID:32816093 |
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NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
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G |
Il2rb |
interleukin 2 receptor subunit beta |
increases expression |
ISO |
Aspirin results in increased expression of IL2RB mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
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G |
Il2rg |
interleukin 2 receptor subunit gamma |
decreases expression |
ISO |
Aspirin results in decreased expression of IL2RG mRNA |
CTD |
PMID:15928584 |
|
NCBI chr X:66,395,330...66,399,026
Ensembl chr X:66,392,542...66,399,823
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G |
Il4 |
interleukin 4 |
multiple interactions decreases secretion decreases expression increases expression |
ISO |
Aspirin inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Aspirin inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]; Aspirin inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]; Aspirin inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein]; Aspirin promotes the reaction [CEBPB protein binds to IL4 promoter polymorphism] Aspirin results in decreased secretion of IL4 protein Aspirin results in decreased expression of IL4 mRNA Aspirin results in increased expression of IL4 mRNA |
CTD |
PMID:11238116 PMID:19767084 PMID:20921925 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
multiple interactions increases expression decreases expression |
ISO EXP |
Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Aspirin promotes the reaction [IL1A results in increased expression of IL6 mRNA]; Aspirin results in decreased expression of and results in decreased secretion of IL6 protein; IL6 protein inhibits the reaction [Aspirin results in decreased expression of STAT3 protein modified form] Aspirin results in increased expression of IL6 protein Aspirin inhibits the reaction [Oxaliplatin results in increased expression of IL6 mRNA]; Aspirin inhibits the reaction [Oxaliplatin results in increased expression of IL6 protein]; fucoidan inhibits the reaction [Aspirin results in increased expression of IL6 protein] Aspirin inhibits the reaction [Cisplatin results in increased expression of IL6 mRNA]; Aspirin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Aspirin results in decreased expression of IL6 protein Aspirin results in decreased expression of IL6 mRNA |
CTD |
PMID:14742690 PMID:15379866 PMID:16413386 PMID:19595669 PMID:19788892 PMID:19896470 PMID:20886344 PMID:35574720 PMID:37179038 More...
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il6st |
interleukin 6 cytokine family signal transducer |
decreases expression |
ISO |
Aspirin results in decreased expression of IL6ST mRNA |
CTD |
PMID:19595669 |
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NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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G |
Il7r |
interleukin 7 receptor |
increases expression |
ISO |
Aspirin results in increased expression of IL7R mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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G |
Ilk |
integrin-linked kinase |
decreases activity decreases expression |
ISO |
Aspirin results in decreased activity of ILK protein Aspirin results in decreased expression of ILK mRNA |
CTD |
PMID:11593435 PMID:15928584 |
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NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
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G |
Insig1 |
insulin induced gene 1 |
increases expression |
ISO EXP |
Aspirin results in increased expression of INSIG1 mRNA |
CTD |
PMID:12800193 PMID:15928584 |
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NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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G |
Iqgap2 |
IQ motif containing GTPase activating protein 2 |
increases expression |
ISO |
Aspirin results in increased expression of IQGAP2 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279
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G |
Irf1 |
interferon regulatory factor 1 |
increases expression |
ISO |
Aspirin results in increased expression of IRF1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
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G |
Irf9 |
interferon regulatory factor 9 |
decreases expression |
ISO |
Aspirin results in decreased expression of IRF9 mRNA |
CTD |
PMID:15928584 |
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NCBI chr15:29,095,474...29,101,924
Ensembl chr15:29,095,789...29,101,236
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G |
Irs1 |
insulin receptor substrate 1 |
affects response to substance |
ISO |
IRS1 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:15066917 |
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Itga2 |
integrin subunit alpha 2 |
decreases response to substance multiple interactions |
ISO |
ITGA2 polymorphism results in decreased susceptibility to Aspirin ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Epinephrine]; ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel] |
CTD |
PMID:15205592 PMID:16214444 PMID:18231737 |
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NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
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G |
Itga2b |
integrin subunit alpha 2b |
decreases expression multiple interactions |
ISO |
Aspirin results in decreased expression of ITGA2B protein Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGA2B protein]] |
CTD |
PMID:15140583 PMID:15381054 PMID:18413191 |
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NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168
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G |
Itga5 |
integrin subunit alpha 5 |
decreases expression |
ISO |
Aspirin results in decreased expression of ITGA5 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
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G |
Itgb2 |
integrin subunit beta 2 |
multiple interactions |
ISO |
Aspirin results in decreased expression of [ITGA2B protein binds to ITGB2 protein] |
CTD |
PMID:15140583 |
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NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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G |
Itgb3 |
integrin subunit beta 3 |
multiple interactions increases expression decreases response to substance affects response to substance |
ISO |
Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]; Aspirin results in decreased expression of [ITGA2B protein binds to ITGB3 protein]; Glucose inhibits the reaction [Aspirin inhibits the reaction [Arachidonic Acid results in increased expression of ITGB3 protein]]; ITGB3 polymorphism affects the reaction [Aspirin affects the cleavage of F2 protein] Aspirin results in increased expression of ITGB3 mRNA; Aspirin results in increased expression of ITGB3 protein ITGB3 gene polymorphism results in decreased susceptibility to Aspirin; ITGB3 polymorphism results in decreased susceptibility to Aspirin; ITGB3 results in decreased susceptibility to Aspirin ITGB3 gene polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:13678940 PMID:15381054 PMID:15840736 PMID:16153930 PMID:16675000 PMID:17184645 PMID:18413191 PMID:21035850 More...
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NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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G |
Itgb4 |
integrin subunit beta 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of ITGB4 mRNA |
CTD |
PMID:14976132 |
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NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression |
ISO |
Aspirin inhibits the reaction [Glucose results in increased expression of JUN protein]; Aspirin promotes the reaction [JUN protein binds to PLAUR promoter] Aspirin results in increased expression of JUN mRNA |
CTD |
PMID:14976132 PMID:16600694 PMID:16893520 PMID:20457246 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
Aspirin results in increased expression of JUNB mRNA |
CTD |
PMID:12800193 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
Aspirin results in decreased expression of JUND mRNA |
CTD |
PMID:14976132 |
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NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Kat7 |
lysine acetyltransferase 7 |
decreases expression |
ISO |
Aspirin results in decreased expression of KAT7 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:80,221,519...80,255,590
Ensembl chr10:80,221,524...80,255,567
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G |
Kcnmb4 |
potassium calcium-activated channel subfamily M regulatory beta subunit 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of KCNMB4 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
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G |
Kctd13 |
potassium channel tetramerization domain containing 13 |
increases expression |
EXP |
Aspirin results in increased expression of KCTD13 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 1:181,534,534...181,552,843
Ensembl chr 1:181,534,515...181,552,881
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G |
Kdm5b |
lysine demethylase 5B |
decreases expression |
ISO |
Aspirin results in decreased expression of KDM5B mRNA |
CTD |
PMID:15928584 |
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NCBI chr13:46,001,589...46,073,868
Ensembl chr13:46,002,542...46,073,872
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G |
Kif20b |
kinesin family member 20B |
decreases expression |
ISO |
Aspirin results in decreased expression of KIF20B mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:232,428,293...232,483,798
Ensembl chr 1:232,428,371...232,483,787
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G |
Kif21a |
kinesin family member 21A |
increases expression |
ISO |
Aspirin results in increased expression of KIF21A mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:122,062,523...122,179,051
Ensembl chr 7:122,062,537...122,178,999
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G |
Kif3a |
kinesin family member 3a |
increases expression affects response to substance |
ISO |
Aspirin results in increased expression of KIF3A mRNA KIF3A polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20922562 |
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NCBI chr10:37,725,930...37,761,183
Ensembl chr10:37,725,970...37,759,191
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G |
Klrb1a |
killer cell lectin like receptor B1A |
increases expression |
ISO |
Aspirin results in increased expression of KLRB1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:161,890,577...161,904,050
Ensembl chr 4:161,890,577...161,961,675
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G |
Kng1 |
kininogen 1 |
decreases activity |
EXP |
Aspirin results in decreased activity of KNG1 |
CTD |
PMID:1334751 |
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NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
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G |
Kpna3 |
karyopherin subunit alpha 3 |
increases expression |
ISO |
Aspirin results in increased expression of KPNA3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr15:35,536,310...35,610,066
Ensembl chr15:35,536,316...35,610,419
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G |
Lck |
LCK proto-oncogene, Src family tyrosine kinase |
decreases expression |
ISO |
Aspirin results in decreased expression of LCK mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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G |
Lcn2 |
lipocalin 2 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Azoxymethane results in decreased expression of LCN2 mRNA] |
CTD |
PMID:20043115 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G |
Lct |
lactase |
multiple interactions increases activity decreases activity |
EXP |
[Aspirin results in decreased activity of LCT protein] which results in decreased transport of Glucose Aspirin results in increased activity of LCT; Aspirin results in increased activity of LCT protein |
CTD |
PMID:16382204 PMID:16855794 PMID:17147060 PMID:18604318 |
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NCBI chr13:39,781,929...39,824,456
Ensembl chr13:39,781,929...39,824,456
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G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
ISO |
Aspirin inhibits the reaction [LDLR gene mutant form results in decreased susceptibility to Arachidonic Acid] Aspirin inhibits the reaction [LDLR gene mutant form promotes the reaction [Arachidonic Acid results in increased abundance of 11-dehydro-thromboxane B2]]; Aspirin promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Aspirin promotes the reaction [Cholesterol, LDL binds to LDLR protein] |
CTD |
PMID:10395027 PMID:20530721 |
|
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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G |
Lep |
leptin |
multiple interactions |
EXP |
[lipopolysaccharide, Helicobacter pylori co-treated with Aspirin] results in increased expression of LEP protein |
CTD |
PMID:15024038 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Lif |
LIF, interleukin 6 family cytokine |
increases expression |
ISO |
Aspirin results in increased expression of LIF mRNA; Aspirin results in increased expression of LIF protein |
CTD |
PMID:21035850 |
|
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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G |
Lmna |
lamin A/C |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of LMNA protein] |
CTD |
PMID:17644113 |
|
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
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G |
Lmo7 |
LIM domain 7 |
increases expression |
ISO |
Aspirin results in increased expression of LMO7 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783
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G |
Lta |
lymphotoxin alpha |
affects response to substance |
ISO |
LTA gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:16931544 |
|
NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
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G |
Ltc4s |
leukotriene C4 synthase |
affects response to substance |
ISO |
LTC4S affects the susceptibility to Aspirin; LTC4S gene SNP affects the susceptibility to Aspirin; LTC4S polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:15100686 PMID:16433794 PMID:19767084 PMID:19862937 PMID:20485159 |
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NCBI chr10:34,560,476...34,562,790
Ensembl chr10:34,560,360...34,562,651
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G |
Ly9 |
lymphocyte antigen 9 |
increases expression |
ISO |
Aspirin results in increased expression of LY9 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823
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G |
Lyn |
LYN proto-oncogene, Src family tyrosine kinase |
increases expression |
ISO |
Aspirin results in increased expression of LYN mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
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G |
Madd |
MAP-kinase activating death domain |
decreases expression |
ISO |
Aspirin results in decreased expression of MADD mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 3:77,114,330...77,157,865
Ensembl chr 3:77,114,314...77,157,701
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
increases expression |
ISO |
Aspirin results in increased expression of MAP2K1 mRNA |
CTD |
PMID:20457246 |
|
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAP2K2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Map2k5 |
mitogen activated protein kinase kinase 5 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAP2K5 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
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G |
Map4k4 |
mitogen-activated protein kinase kinase kinase kinase 4 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAP4K4 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases activity decreases expression |
ISO |
Aspirin inhibits the reaction [HGF results in increased activity of MAPK1 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Aspirin results in decreased phosphorylation of and results in decreased activity of MAPK1 protein Aspirin results in increased activity of MAPK1 protein Aspirin results in decreased expression of MAPK1 protein modified form |
CTD |
PMID:10993886 PMID:11981761 PMID:15447849 PMID:20116423 PMID:21617849 PMID:34755645 More...
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk12 |
mitogen-activated protein kinase 12 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAPK12 mRNA |
CTD |
PMID:20514442 |
|
NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions increases phosphorylation |
ISO |
Aspirin promotes the reaction [IL1A results in increased phosphorylation of MAPK14 protein]; IL1A promotes the reaction [Aspirin results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:14742690 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases expression increases activity |
ISO |
Aspirin inhibits the reaction [HGF results in increased activity of MAPK3 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Aspirin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein Aspirin results in decreased expression of MAPK3 protein modified form Aspirin results in increased activity of MAPK3 protein |
CTD |
PMID:10993886 PMID:11981761 PMID:15447849 PMID:20116423 PMID:21617849 PMID:34755645 More...
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapkapk3 |
MAPK activated protein kinase 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of MAPKAPK3 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568
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G |
Mcam |
melanoma cell adhesion molecule |
increases expression |
ISO |
Aspirin results in increased expression of MCAM mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 8:44,479,391...44,487,575
Ensembl chr 8:44,479,376...44,487,571
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression multiple interactions |
ISO |
Aspirin results in decreased expression of MCL1 protein Aspirin results in increased degradation of and results in decreased expression of MCL1 protein |
CTD |
PMID:19936928 PMID:20116423 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mcm5 |
minichromosome maintenance complex component 5 |
decreases expression |
EXP |
Aspirin results in decreased expression of MCM5 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
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G |
Mcm6 |
minichromosome maintenance complex component 6 |
decreases expression |
EXP |
Aspirin results in decreased expression of MCM6 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr13:39,826,745...39,851,937
Ensembl chr13:39,826,763...39,851,960
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G |
Mdm2 |
MDM2 proto-oncogene |
decreases expression |
ISO |
Aspirin results in decreased expression of MDM2 mRNA |
CTD |
PMID:20457246 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Med4 |
mediator complex subunit 4 |
increases expression |
ISO |
Aspirin results in increased expression of MED4 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr15:48,696,542...48,706,818
Ensembl chr15:48,696,511...48,706,820
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G |
Met |
MET proto-oncogene, receptor tyrosine kinase |
decreases expression increases expression multiple interactions |
ISO |
Aspirin results in decreased expression of CMET protein Aspirin results in increased expression of MET mRNA CTNNB1 affects the reaction [Aspirin results in decreased expression of CMET protein] |
CTD |
PMID:16878161 PMID:32816093 |
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NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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G |
Mir1306 |
microRNA 1306 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of MIR1306 mRNA] |
CTD |
PMID:37364758 |
|
NCBI chr11:82,709,651...82,709,723
Ensembl chr11:82,709,637...82,709,719
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G |
Mir26b |
microRNA 26b |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Benzo(a)pyrene results in decreased expression of MIR26B mRNA] |
CTD |
PMID:37364758 |
|
NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] |
CTD |
PMID:29031619 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mlf2 |
myeloid leukemia factor 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of MLF2 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 4:157,739,651...157,744,325
Ensembl chr 4:157,728,756...157,744,317
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G |
Mmp13 |
matrix metallopeptidase 13 |
increases expression multiple interactions |
EXP |
Aspirin results in increased expression of MMP13 mRNA [Aspirin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased cleavage of MMP13 protein |
CTD |
PMID:12800193 PMID:21360558 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression multiple interactions decreases secretion |
ISO EXP |
Aspirin results in decreased expression of MMP2 [Aspirin co-treated with Carbon Tetrachloride] results in increased expression of MMP2 protein Aspirin results in decreased secretion of MMP2 protein Aspirin results in decreased expression of MMP2 mRNA |
CTD |
PMID:18971601 PMID:19462226 PMID:21360558 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp3 |
matrix metallopeptidase 3 |
multiple interactions |
EXP |
Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP3 mRNA] |
CTD |
PMID:20043115 |
|
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression multiple interactions |
EXP |
Aspirin results in decreased expression of MMP7 mRNA Aspirin inhibits the reaction [Azoxymethane results in increased expression of MMP7 mRNA] |
CTD |
PMID:12800193 PMID:20043115 |
|
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases secretion decreases expression decreases activity |
ISO EXP |
Aspirin inhibits the reaction [HGF results in increased expression of MMP9] Aspirin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein] Aspirin results in decreased secretion of MMP9 protein Aspirin results in decreased expression of MMP9 mRNA Aspirin results in decreased expression of MMP9; Aspirin results in decreased expression of MMP9 mRNA Aspirin results in decreased activity of MMP9 protein |
CTD |
PMID:11981761 PMID:15928584 PMID:18971601 PMID:19462226 PMID:19880272 PMID:20137092 PMID:29031619 More...
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mob2 |
MOB kinase activator 2 |
increases expression |
ISO |
Aspirin results in increased expression of MOB2 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 1:197,092,991...197,149,978
Ensembl chr 1:197,092,994...197,149,933
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G |
Mpo |
myeloperoxidase |
multiple interactions increases expression |
EXP |
Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Bee Venoms inhibits the reaction [Aspirin results in increased expression of MPO protein]; Ranitidine inhibits the reaction [Aspirin results in increased expression of MPO protein] |
CTD |
PMID:21893697 PMID:22039321 PMID:30885738 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mpzl1 |
myelin protein zero-like 1 |
increases expression |
EXP |
Aspirin results in increased expression of MPZL1 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr13:77,852,467...77,889,305
Ensembl chr13:77,852,467...77,896,616
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G |
Mrpl46 |
mitochondrial ribosomal protein L46 |
increases expression |
ISO |
Aspirin results in increased expression of MRPL46 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr 1:132,698,872...132,707,639
Ensembl chr 1:132,698,601...132,707,628
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G |
Ms4a2 |
membrane spanning 4-domains A2 |
affects response to substance |
ISO |
MS4A2 polymorphism affects the susceptibility to Aspirin; MS4A2 SNP affects the susceptibility to Aspirin |
CTD |
PMID:16839402 PMID:18379861 PMID:18534082 |
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NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310
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G |
Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
increases expression |
EXP |
Aspirin results in increased expression of COX1 mRNA |
CTD |
PMID:8554334 |
|
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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G |
Mt-nd1 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 |
increases expression multiple interactions |
EXP ISO |
Aspirin results in increased expression of ND1 mRNA Aspirin inhibits the reaction [Cisplatin results in decreased expression of ND1 mRNA] |
CTD |
PMID:8554334 PMID:37179038 |
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NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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G |
Mt-nd3 |
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of ND3 mRNA] |
CTD |
PMID:37179038 |
|
NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
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G |
Mt1 |
metallothionein 1 |
increases expression multiple interactions |
EXP ISO |
Aspirin results in increased expression of MT1A mRNA Aspirin inhibits the reaction [Copper results in increased activity of MT1 promoter] |
CTD |
PMID:12800193 PMID:14576086 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Mta1 |
metastasis associated 1 |
increases expression |
ISO |
Aspirin results in increased expression of MTA1 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr 6:132,178,608...132,217,641
Ensembl chr 6:132,178,853...132,217,641
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
Aspirin results in decreased phosphorylation of and results in increased expression of MTOR protein |
CTD |
PMID:23363784 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mttp |
microsomal triglyceride transfer protein |
decreases expression |
ISO |
Aspirin results in decreased expression of MTTP mRNA |
CTD |
PMID:27089845 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G |
Mx1 |
MX dynamin like GTPase 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of MX1 mRNA |
CTD |
PMID:15928584 |
|
NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression increases expression multiple interactions |
EXP ISO |
Aspirin results in decreased expression of MYC mRNA Aspirin results in decreased expression of MYC mRNA; Aspirin results in decreased expression of MYC protein Aspirin results in increased expression of MYC mRNA CTNNB1 affects the reaction [Aspirin results in decreased expression of MYC protein] |
CTD |
PMID:11906190 PMID:12800193 PMID:16878161 PMID:20457246 PMID:21721879 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Naa15 |
N(alpha)-acetyltransferase 15, NatA auxiliary subunit |
decreases expression |
EXP |
Aspirin results in decreased expression of NAA15 mRNA |
CTD |
PMID:12800193 |
|
NCBI chr 2:135,458,018...135,520,756
Ensembl chr 2:135,457,948...135,520,756
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G |
Naa38 |
N(alpha)-acetyltransferase 38, NatC auxiliary subunit |
increases expression |
ISO |
Aspirin results in increased expression of NAA38 mRNA |
CTD |
PMID:15456535 |
|
NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494
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G |
Nat1 |
N-acetyltransferase 1 |
decreases activity |
EXP |
Aspirin results in decreased activity of NAT1 protein |
CTD |
PMID:15796213 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Nat2 |
N-acetyltransferase 2 |
affects response to substance |
ISO |
NAT2 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20602614 |
|
NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions decreases expression |
ISO |
Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA] Aspirin results in decreased expression of NCF1 mRNA |
CTD |
PMID:21353610 PMID:22306536 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Ndst2 |
N-deacetylase and N-sulfotransferase 2 |
increases expression |
ISO |
Aspirin results in increased expression of NDST2 mRNA |
CTD |
PMID:11906190 |
|
NCBI chr15:3,563,515...3,573,801
Ensembl chr15:3,563,358...3,573,801
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G |
Ndufs4 |
NADH:ubiquinone oxidoreductase subunit S4 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of NDUFS4 mRNA] |
CTD |
PMID:37179038 |
|
NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions decreases expression decreases localization increases activity |
ISO EXP |
Aspirin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Aspirin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Aspirin promotes the reaction [NFKB1 protein binds to SAT1 promoter] Aspirin results in decreased expression of NFKB1 mRNA Aspirin results in decreased localization of NFKB1 protein Aspirin inhibits the reaction [[Lipopolysaccharides co-treated with TNF protein co-treated with IL1B protein] results in increased activity of NFKB1 protein] [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]] Aspirin results in increased activity of NFKB1 protein |
CTD |
PMID:9281604 PMID:11826407 PMID:14976132 PMID:15489888 PMID:16262603 PMID:17259377 PMID:20457246 More...
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NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases expression decreases degradation increases expression increases degradation |
ISO EXP |
Aspirin inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIA protein]; Aspirin results in decreased phosphorylation of and results in increased expression of NFKBIA protein Aspirin results in decreased expression of NFKBIA mRNA Aspirin results in decreased degradation of NFKBIA protein Aspirin results in increased expression of NFKBIA protein Aspirin results in increased degradation of NFKBIA protein |
CTD |
PMID:14753751 PMID:15036249 PMID:15188000 PMID:15489888 PMID:15770215 PMID:16199534 PMID:16310244 PMID:16880202 PMID:16936242 PMID:20457246 PMID:34755645 More...
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nfkbib |
NFKB inhibitor beta |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased degradation of NFKBIB protein]; Aspirin inhibits the reaction [TNF results in increased phosphorylation of NFKBIB protein] |
CTD |
PMID:14753751 PMID:15036249 |
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NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
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Nfkbiz |
NFKB inhibitor zeta |
increases expression |
ISO |
Aspirin results in increased expression of NFKBIZ mRNA |
CTD |
PMID:15928584 |
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NCBI chr11:44,782,676...44,810,722
Ensembl chr11:44,782,676...44,810,723
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Ngfr |
nerve growth factor receptor |
increases expression |
ISO |
Aspirin analog results in increased expression of NGFR protein |
CTD |
PMID:17447067 |
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NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Ninj1 |
ninjurin 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of NINJ1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nkg7 |
natural killer cell granule protein 7 |
decreases expression |
ISO |
Aspirin results in decreased expression of NKG7 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:93,844,748...93,845,975
Ensembl chr 1:93,844,902...93,845,983
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Nkx2-1 |
NK2 homeobox 1 |
affects expression |
EXP |
Aspirin affects the expression of NKX2-1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
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Nlrp3 |
NLR family, pyrin domain containing 3 |
affects response to substance |
ISO |
NLRP3 SNP affects the susceptibility to Aspirin |
CTD |
PMID:19767079 |
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NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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Nme6 |
NME/NM23 nucleoside diphosphate kinase 6 |
increases expression |
ISO |
Aspirin results in increased expression of NME6 mRNA |
CTD |
PMID:15456535 |
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NCBI chr 8:109,832,085...109,839,301
Ensembl chr 8:109,832,589...109,839,301
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Nolc1 |
nucleolar and coiled-body phosphoprotein 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of NOLC1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 1:244,921,275...244,932,089
Ensembl chr 1:244,921,377...244,932,088
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Nos2 |
nitric oxide synthase 2 |
multiple interactions decreases expression increases expression |
ISO EXP |
Ascorbic Acid inhibits the reaction [Aspirin results in increased expression of NOS2 protein] [Aspirin results in decreased expression of NOS2 protein] which results in decreased chemical synthesis of Nitric Oxide Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA] |
CTD |
PMID:10860828 PMID:16310244 PMID:17218764 PMID:21893697 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Everolimus results in decreased expression of NOS3 protein]; Aspirin inhibits the reaction [Paclitaxel results in decreased expression of NOS3 protein]; Aspirin inhibits the reaction [Sirolimus results in decreased expression of NOS3 protein]; Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]; Aspirin results in increased acetylation of and results in increased activity of NOS3 protein; HDAC3 inhibits the reaction [Aspirin results in increased acetylation of and results in increased activity of NOS3 protein]; HDAC3 protein inhibits the reaction [Aspirin promotes the reaction [NOS3 protein binds to CALM1 protein]] |
CTD |
PMID:19520256 PMID:20705923 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Npepps |
aminopeptidase puromycin sensitive |
decreases expression |
ISO |
Aspirin results in decreased expression of NPEPPS mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:82,191,454...82,273,967
Ensembl chr10:82,191,456...82,273,967
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G |
Nppb |
natriuretic peptide B |
affects expression multiple interactions increases expression |
EXP ISO |
Aspirin affects the expression of NPPB mRNA [carvedilol co-treated with temocapril hydrochloride co-treated with Spironolactone co-treated with Aspirin] affects the expression of NPPB protein Aspirin results in increased expression of NPPB mRNA |
CTD |
PMID:12800193 PMID:21378469 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G |
Npr1 |
natriuretic peptide receptor 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of NPR1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions increases activity |
ISO |
Acetylcysteine inhibits the reaction [Aspirin analog results in increased activity of NQO1 protein] |
CTD |
PMID:23035985 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr4a3 |
nuclear receptor subfamily 4, group A, member 3 |
increases expression |
ISO |
Aspirin results in increased expression of NR4A3 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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G |
Nrcam |
neuronal cell adhesion molecule |
decreases expression |
ISO |
Aspirin results in decreased expression of NRCAM mRNA |
CTD |
PMID:15456535 |
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NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
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G |
Nrf1 |
nuclear respiratory factor 1 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of NRF1 protein] |
CTD |
PMID:37179038 |
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NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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G |
Nubp2 |
NUBP iron-sulfur cluster assembly factor 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of NUBP2 mRNA |
CTD |
PMID:15456535 PMID:15928584 |
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NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969
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G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
increases expression |
ISO |
Aspirin results in increased expression of OAS1 mRNA |
CTD |
PMID:14976132 |
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NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
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G |
Odc1 |
ornithine decarboxylase 1 |
increases expression increases response to substance |
ISO |
Aspirin results in increased expression of ODC1 mRNA ODC1 polymorphism results in increased susceptibility to Aspirin |
CTD |
PMID:14976132 PMID:18413818 |
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NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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G |
Orc4 |
origin recognition complex, subunit 4 |
increases expression |
ISO |
Aspirin results in increased expression of ORC4 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824
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G |
Osm |
oncostatin M |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of OSM protein] |
CTD |
PMID:17303692 |
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NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313
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G |
Osr1 |
odd-skipped related transcription factor 1 |
increases expression |
ISO |
Aspirin results in increased expression of OSR1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 6:32,369,561...32,380,822
Ensembl chr 6:32,373,816...32,380,817
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G |
Otc |
ornithine transcarbamylase |
decreases expression |
ISO |
Aspirin results in decreased expression of OTC protein |
CTD |
PMID:8295421 |
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NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918
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G |
P2ry1 |
purinergic receptor P2Y1 |
decreases response to substance affects response to substance |
ISO |
P2RY1 polymorphism results in decreased susceptibility to Aspirin; P2RY1 SNP results in decreased susceptibility to Aspirin P2RY1 affects the susceptibility to Aspirin |
CTD |
PMID:15757620 PMID:17559347 PMID:21429568 |
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NCBI chr 2:145,241,975...145,248,186
Ensembl chr 2:145,241,849...145,248,457
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G |
P2ry12 |
purinergic receptor P2Y12 |
affects response to substance |
ISO |
P2RY12 affects the susceptibility to Aspirin |
CTD |
PMID:14597584 |
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NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361
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G |
Pag1 |
phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
increases expression |
ISO |
Aspirin results in increased expression of PAG1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
[Aspirin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PARP1 protein]; Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]; Aspirin promotes the reaction [troglitazone results in increased cleavage of PARP1 protein]; Aspirin results in increased cleavage of and results in increased activity of PARP1 protein; BCL2 protein inhibits the reaction [Aspirin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; troglitazone promotes the reaction [Aspirin results in increased cleavage of PARP1 protein] |
CTD |
PMID:9694730 PMID:11228543 PMID:11532860 PMID:15481331 PMID:16199534 PMID:17644113 PMID:18483385 PMID:19595669 PMID:19908241 More...
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcbp1 |
poly(rC) binding protein 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PCBP1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500
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G |
Pcdh17 |
protocadherin 17 |
increases expression |
ISO |
Aspirin results in increased expression of PCDH17 mRNA |
CTD |
PMID:11906190 |
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NCBI chr15:60,222,088...60,316,172
Ensembl chr15:60,222,004...60,313,999
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G |
Pcna |
proliferating cell nuclear antigen |
increases expression |
EXP |
Aspirin results in increased expression of PCNA protein |
CTD |
PMID:14563943 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pcnp |
PEST proteolytic signal containing nuclear protein |
increases expression |
ISO |
Aspirin results in increased expression of PCNP mRNA |
CTD |
PMID:15928584 |
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NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348
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G |
Pcsk1 |
proprotein convertase subtilisin/kexin type 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PCSK1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
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G |
Pcsk7 |
proprotein convertase subtilisin/kexin type 7 |
decreases expression |
ISO |
Aspirin results in decreased expression of PCSK7 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:46,202,079...46,224,699
Ensembl chr 8:46,202,131...46,224,705
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G |
Pdcd10 |
programmed cell death 10 |
increases expression |
ISO |
Aspirin results in increased expression of PDCD10 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions |
ISO |
Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein] |
CTD |
PMID:17303692 |
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NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Pdlim7 |
PDZ and LIM domain 7 |
decreases expression |
ISO |
Aspirin results in decreased expression of PDLIM7 mRNA |
CTD |
PMID:15928584 |
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NCBI chr17:9,124,565...9,139,814
Ensembl chr17:9,124,649...9,139,811
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PECAM1 mRNA; Aspirin results in decreased expression of PECAM1 protein |
CTD |
PMID:15381054 PMID:15456535 |
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NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Pef1 |
penta-EF hand domain containing 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PEF1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 5:142,451,791...142,475,061
Ensembl chr 5:142,451,778...142,475,067
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G |
Pepd |
peptidase D |
increases activity |
ISO |
Aspirin results in increased activity of PEPD protein |
CTD |
PMID:16991207 |
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NCBI chr 1:87,536,650...87,681,233
Ensembl chr 1:87,536,609...87,681,231
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G |
Pf4 |
platelet factor 4 |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PF4 protein] |
CTD |
PMID:17303692 |
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NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
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G |
Pfkfb3 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
decreases expression |
ISO |
Aspirin results in decreased expression of PFKFB3 mRNA |
CTD |
PMID:11906190 |
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NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125
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G |
Pfn1 |
profilin 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PFN1 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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G |
Phb1 |
prohibitin 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PHB1 mRNA |
CTD |
PMID:14976132 |
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NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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G |
Phb2 |
prohibitin 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of PHB2 mRNA |
CTD |
PMID:15928584 |
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NCBI chr 4:157,517,662...157,522,268
Ensembl chr 4:157,517,577...157,522,272
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G |
Pi4kb |
phosphatidylinositol 4-kinase beta |
decreases expression |
ISO |
Aspirin results in decreased expression of PI4KB mRNA |
CTD |
PMID:15928584 |
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NCBI chr 2:182,540,377...182,572,684
Ensembl chr 2:182,540,567...182,588,488
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G |
Picalm |
phosphatidylinositol binding clathrin assembly protein |
decreases expression |
ISO |
Aspirin results in decreased expression of PICALM mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:144,056,415...144,138,045
Ensembl chr 1:144,056,721...144,137,557
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G |
Pik3c2a |
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
decreases expression |
ISO |
Aspirin results in decreased expression of PIK3C2A mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
decreases expression |
ISO |
Aspirin results in decreased expression of PIK3R1 mRNA |
CTD |
PMID:20457246 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pilrb2l8 |
paired immunoglobin like type 2 receptor beta 2 like 8 |
increases expression |
ISO |
Aspirin results in increased expression of ZNF37A mRNA |
CTD |
PMID:11906190 |
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NCBI chr12:17,744,315...17,756,074
Ensembl chr12:17,752,830...17,755,922
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G |
Pitx1 |
paired-like homeodomain 1 |
increases expression |
ISO |
Aspirin results in increased expression of PITX1 mRNA |
CTD |
PMID:11906190 |
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NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,794,134...8,800,291
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G |
Pla2g4a |
phospholipase A2 group 4A |
decreases expression |
ISO |
Aspirin results in decreased expression of PLA2G4A mRNA |
CTD |
PMID:10706128 |
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NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
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G |
Pla2g6 |
phospholipase A2 group VI |
increases expression |
ISO |
Aspirin results in increased expression of PLA2G6 mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:110,851,378...110,891,557
Ensembl chr 7:110,851,378...110,891,114
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G |
Plaur |
plasminogen activator, urokinase receptor |
multiple interactions affects expression increases expression |
ISO EXP |
Aspirin promotes the reaction [FOSL1 protein binds to PLAUR promoter]; Aspirin promotes the reaction [H4C16 protein modified form binds to PLAUR promoter]; Aspirin promotes the reaction [JUN protein binds to PLAUR promoter] Aspirin affects the expression of PLAUR mRNA Aspirin results in increased expression of PLAUR mRNA; Aspirin results in increased expression of PLAUR protein |
CTD |
PMID:12800193 PMID:16893520 |
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NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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G |
Plcd4 |
phospholipase C, delta 4 |
increases expression |
EXP |
Aspirin results in increased expression of PLCD4 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
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G |
Plin2 |
perilipin 2 |
increases expression |
EXP |
Aspirin results in increased expression of PLIN2 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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G |
Pmaip1 |
phorbol-12-myristate-13-acetate-induced protein 1 |
increases expression increases response to substance |
ISO |
Aspirin results in increased expression of PMAIP1 mRNA; Aspirin results in increased expression of PMAIP1 protein PMAIP1 results in increased susceptibility to Aspirin |
CTD |
PMID:15928584 PMID:19936928 |
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NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429
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G |
Polr2a |
RNA polymerase II subunit A |
increases expression |
ISO |
Aspirin results in increased expression of POLR2A mRNA |
CTD |
PMID:11906190 |
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NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455
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G |
Pon1 |
paraoxonase 1 |
increases expression increases activity multiple interactions |
ISO EXP |
Aspirin results in increased expression of PON1 mRNA Aspirin results in increased activity of PON1 mRNA; Aspirin results in increased activity of PON1 protein AHR mutant form inhibits the reaction [Aspirin results in increased activity of PON1 protein]; AHR mutant form inhibits the reaction [Aspirin results in increased expression of PON1 mRNA] |
CTD |
PMID:18519978 |
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NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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G |
Por |
cytochrome p450 oxidoreductase |
decreases expression |
ISO |
Aspirin results in decreased expression of POR mRNA |
CTD |
PMID:15928584 |
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NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
affects activity multiple interactions increases expression decreases expression decreases activity |
ISO |
Aspirin affects the activity of PPARA protein PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]; PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein]; PPARA affects the reaction [Aspirin promotes the reaction [APOA1 affects the transport of Cholesterol]] Aspirin results in increased expression of PPARA mRNA Aspirin results in increased expression of PPARA; Aspirin results in increased expression of PPARA mRNA; Aspirin results in increased expression of PPARA protein Aspirin results in decreased expression of PPARA protein Aspirin results in decreased activity of PPARA protein |
CTD |
PMID:15646027 PMID:16816107 PMID:18971601 PMID:19462226 PMID:19880272 PMID:21088444 More...
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
decreases activity increases expression decreases expression |
ISO EXP |
Aspirin results in decreased activity of PPARD protein Aspirin results in increased expression of PPARD mRNA Aspirin results in decreased expression of PPARD protein |
CTD |
PMID:12800193 PMID:15646027 PMID:18678619 |
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NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases activity decreases expression increases expression multiple interactions |
ISO EXP |
Aspirin results in decreased activity of PPARG protein Aspirin results in decreased expression of PPARG mRNA Aspirin results in increased expression of PPARG mRNA Aspirin results in increased expression of PPARG; Aspirin results in increased expression of PPARG mRNA; Aspirin results in increased expression of PPARG protein Aspirin inhibits the reaction [Niacin results in increased activity of PPARG protein] |
CTD |
PMID:15646027 PMID:16386710 PMID:18222077 PMID:18971601 PMID:19462226 PMID:19880272 More...
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA] |
CTD |
PMID:37179038 |
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppbp |
pro-platelet basic protein |
multiple interactions |
ISO |
Aspirin inhibits the reaction [thrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PPBP protein] |
CTD |
PMID:17303692 |
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NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130
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G |
Ppib |
peptidylprolyl isomerase B |
decreases expression |
ISO |
Aspirin results in decreased expression of PPIB mRNA |
CTD |
PMID:15928584 |
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NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428
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G |
Ppig |
peptidylprolyl isomerase G |
increases expression |
ISO |
Aspirin results in increased expression of PPIG mRNA |
CTD |
PMID:15928584 |
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NCBI chr 3:54,484,023...54,512,929
Ensembl chr 3:54,484,023...54,512,926
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G |
Ppp1r12a |
protein phosphatase 1, regulatory subunit 12A |
decreases expression |
ISO |
Aspirin results in decreased expression of PPP1R12A mRNA |
CTD |
PMID:11906190 |
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NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
EXP |
Aspirin results in increased expression of PPP1R15A mRNA |
CTD |
PMID:12800193 |
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NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Ppp1r2 |
protein phosphatase 1, regulatory (inhibitor) subunit 2 |
decreases expression |
ISO |
Aspirin results in decreased expression of PPP1R2 mRNA |
CTD |
PMID:11906190 |
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NCBI chr11:69,472,676...69,494,468
Ensembl chr11:69,472,555...69,494,463
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G |
Ppp4c |
protein phosphatase 4, catalytic subunit |
decreases expression |
ISO |
Aspirin results in decreased expression of PPP4C mRNA |
CTD |
PMID:15928584 |
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NCBI chr 1:181,392,899...181,399,703
Ensembl chr 1:181,392,923...181,399,659
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G |
Prep |
prolyl endopeptidase |
decreases expression |
ISO |
Aspirin results in decreased expression of PREP mRNA |
CTD |
PMID:15928584 |
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NCBI chr20:48,556,211...48,653,165
Ensembl chr20:48,556,280...48,654,466
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
increases expression multiple interactions |
ISO |
Aspirin results in increased expression of PRKAA1 protein modified form Aspirin inhibits the reaction [Cisplatin results in decreased expression of PRKAA1 protein] CES1 protein promotes the reaction [Aspirin results in increased expression of PRKAA1 protein modified form] |
CTD |
PMID:25743752 PMID:37179038 |
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NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkcb |
protein kinase C, beta |
multiple interactions affects expression |
ISO |
Aspirin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] Aspirin affects the expression of PRKCB protein |
CTD |
PMID:17644113 |
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NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Prkcd |
protein kinase C, delta |
increases cleavage |
ISO |
Aspirin results in increased cleavage of PRKCD protein |
CTD |
PMID:11228543 |
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NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Prkce |
protein kinase C, epsilon |
multiple interactions |
ISO |
Aspirin inhibits the reaction [Deoxycholic Acid results in increased cleavage of PRKCE protein] |
CTD |
PMID:17644113 |
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NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719
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G |
Prnp |
prion protein |
increases expression |
EXP |
Aspirin results in increased expression of PRNP mRNA |
CTD |
PMID:12800193 |
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NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
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G |
Psat1 |
phosphoserine aminotransferase 1 |
decreases expression |
EXP |
Aspirin results in decreased expression of PSAT1 mRNA |
CTD |
PMID:12800193 |
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NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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G |
Psd |
pleckstrin and Sec7 domain containing |
increases expression |
ISO |
Aspirin results in increased expression of PSD mRNA |
CTD |
PMID:11906190 |
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NCBI chr 1:245,173,279...245,188,681
Ensembl chr 1:245,173,279...245,189,356
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G |
Psmc6 |
proteasome 26S subunit, ATPase 6 |
decreases expression |
ISO |
Aspirin results in decreased expression of PSMC6 mRNA |
CTD |
PMID:11906190 |
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NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
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G |
Psmd12 |
proteasome 26S subunit, non-ATPase 12 |
increases expression |
ISO |
Aspirin results in increased expression of PSMD12 mRNA |
CTD |
PMID:15928584 |
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NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
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G |
Ptgdr2 |
prostaglandin D2 receptor 2 |
affects response to substance |
ISO |
PTGDR2 gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:20485159 |
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NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213
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G |
Ptger2 |
prostaglandin E receptor 2 |
affects response to substance |
ISO |
PTGER2 SNP affects the susceptibility to Aspirin |
CTD |
PMID:15496426 |
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NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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G |
Ptger3 |
prostaglandin E receptor 3 |
affects response to substance |
ISO |
PTGER3 polymorphism affects the susceptibility to Aspirin |
CTD |
PMID:20587336 |
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NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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G |
Ptges |
prostaglandin E synthase |
decreases expression |
ISO |
Aspirin results in decreased expression of PTGES mRNA; Aspirin results in decreased expression of PTGES protein |
CTD |
PMID:19880272 |
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NCBI chr 3:14,177,892...14,189,236
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G |
Ptgir |
prostaglandin I2 receptor |
affects response to substance |
ISO |
PTGIR gene SNP affects the susceptibility to Aspirin |
CTD |
PMID:20485159 |
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NCBI chr 1:77,579,596...77,581,979
Ensembl chr 1:77,579,596...77,581,979
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions affects expression affects response to substance decreases activity decreases expression decreases response to substance increases acetylation |
ISO EXP |
[Aspirin results in increased acetylation of PTGS1 protein] which results in decreased chemical synthesis of Thromboxane A2; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS1 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS1 protein]; Aspirin inhibits the reaction [PTGS1 protein results in increased susceptibility to Methamphetamine]; PTGS1 mutant form inhibits the reaction [Aspirin promotes the reaction [romidepsin results in increased expression of CDKN1A protein]] Aspirin affects the expression of PTGS1 protein PTGS1 polymorphism affects the susceptibility to Aspirin Aspirin analog results in decreased activity of PTGS1 protein; Aspirin results in decreased activity of PTGS1 protein Aspirin results in decreased expression of PTGS1 mRNA Aspirin promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of PTGS1 protein]; PTGS1 results in decreased susceptibility to [Hydrochloric Acid co-treated with Aspirin] PTGS1 gene polymorphism results in decreased susceptibility to Aspirin; PTGS1 gene SNP results in decreased susceptibility to Aspirin |
CTD |
PMID:12242329 PMID:15236176 PMID:15843042 PMID:16141368 PMID:16150050 PMID:16484611 PMID:16493486 PMID:19036898 PMID:19390185 PMID:19493461 PMID:20404564 PMID:21163909 PMID:21513785 PMID:23533533 More...
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases activity increases expression decreases expression affects response to substance decreases degradation |
ISO EXP |
Ascorbic Acid inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [[Arachidonic Acid results in increased activity of PTGS2 protein] which results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [Arachidonic Acid results in increased activity of PTGS2 protein]; Aspirin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [PTGS2 protein results in increased susceptibility to Methamphetamine]; Aspirin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [TNF results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 mRNA]; Aspirin promotes the reaction [IL1A results in increased expression of PTGS2 protein]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 mRNA]; IL1A promotes the reaction [Aspirin results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Aspirin results in decreased degradation of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [Aspirin results in increased expression of PTGS2 protein] Aspirin results in decreased activity of PTGS2 protein; Aspirin results in decreased activity of PTGS2 protein mutant form Aspirin results in increased expression of PTGS2; Aspirin results in increased expression of PTGS2 mRNA; Aspirin results in increased expression of PTGS2 protein Aspirin results in decreased expression of PTGS2 protein [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of PTGS2 mRNA]; apple polyphenol extract inhibits the reaction [Aspirin results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA] [[Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 mRNA; [Aspirin co-treated with Hydrochloric Acid] results in increased expression of PTGS2 protein; Aspirin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Aspirin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] PTGS2 gene SNP affects the susceptibility to Aspirin; PTGS2 SNP affects the susceptibility to Aspirin Aspirin results in decreased expression of PTGS2 mRNA; Aspirin results in decreased expression of PTGS2 protein |
CTD |
PMID:9726391 PMID:10706128 PMID:12231391 PMID:12781040 PMID:14742690 PMID:15236176 PMID:15489888 PMID:15843042 PMID:15861417 PMID:16310244 PMID:16336399 PMID:16804302 PMID:17218764 PMID:17595529 PMID:18197933 PMID:18482463 PMID:19493461 PMID:19755647 PMID:19880272 PMID:20223228 PMID:20485159 PMID:21163909 PMID:21360558 PMID:21513785 PMID:21893697 PMID:22245433 PMID:32816093 PMID:34755645 More...
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptp4a1 |
protein tyrosine phosphatase 4A1 |
increases expression |
ISO |
Aspirin results in increased expression of PTP4A1 mRNA |
CTD |
PMID:14976132 |
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NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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