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meloxicam - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:meloxicam
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Accession:CHEBI:6741 term browser browse the term
Definition:A benzothiazine that is piroxicam in which the pyridin-2-yl group is replaced by a 5-methyl-1,3-thiazol-2-yl group. A non-steroidal anti-inflammatory drug and selective inhibitor of COX-2, it is used particularly for the management of rheumatoid arthritis.
Synonyms:exact_synonym: 4-hydroxy-2-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide
 related_synonym: Formula=C14H13N3O4S2;   InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,18H,1-2H3,(H,15,16,19);   InChIKey=ZRVUJXDFFKFLMG-UHFFFAOYSA-N;   Mobic;   SMILES=CN1C(C(=O)Nc2ncc(C)s2)=C(O)c2ccccc2S1(=O)=O;   UNII-VG2QF83CGL;   meloxicamum
 xref: CAS:71125-38-7;   DrugBank:DB00814;   Drug_Central:1676;   HMDB:HMDB0014952;   KEGG:C08169;   KEGG:D00969
 xref_mesh: MESH:C065757
 xref: PMID:10092958;   PMID:12387696;   PMID:16197363;   PMID:16623613;   PMID:16863437;   PMID:18405470;   PMID:19821429;   PMID:23306395;   PMID:23388116;   PMID:23406022;   PMID:24041211;   PMID:24084190;   PMID:28166217;   PMID:8882380;   PMID:9219316;   Patent:DE2756113;   Patent:US4233299;   Reaxys:5886369;   VSDB:1751


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meloxicam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Meloxicam inhibits the reaction [Doxorubicin results in increased activity of ABCB1 protein]; Meloxicam inhibits the reaction [Doxorubicin results in increased expression of ABCB1 protein] CTD PMID:15501994 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 affects binding ISO ABCC4 protein binds to meloxicam CTD PMID:17939016 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in decreased expression of ABL1 protein CTD PMID:35920412 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in decreased phosphorylation of AKT1 protein CTD PMID:35920412 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein] CTD PMID:16928369 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO meloxicam results in increased expression of BAX protein
[Cilostazol co-treated with Meloxicam] results in increased expression of BAX mRNA
CTD PMID:19709125 PMID:35920412 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP meloxicam inhibits the reaction [KNG1 protein binds to and results in increased activity of BDKRB1 protein] CTD PMID:11159707 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO
EXP
Meloxicam results in increased activity of CASP3 protein
[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Meloxicam affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Meloxicam inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]
Meloxicam inhibits the reaction [Diquat results in increased expression of CASP3 protein modified form]
[Meloxicam co-treated with Cilostazol] results in increased activity of CASP3 protein
CTD PMID:19709125 PMID:24799355 PMID:29315975 PMID:29484840 PMID:35920412 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
EXP
ISO
Meloxicam inhibits the reaction [Diquat results in increased expression of CASP9 protein modified form]
Meloxicam results in increased activity of CASP9 protein
[Meloxicam co-treated with Cilostazol] results in increased activity of CASP9 protein
CTD PMID:29484840 PMID:35920412 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases expression
ISO
EXP
meloxicam inhibits the reaction [Doxorubicin results in decreased activity of CAT protein]
Meloxicam results in decreased expression of CAT protein
Meloxicam affects the expression of and affects the activity of CAT protein
CTD PMID:24799355 PMID:25034942 PMID:38036073 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chat choline O-acetyltransferase multiple interactions ISO meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein] CTD PMID:16928369 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein results in increased metabolism of and results in increased susceptibility to Meloxicam] which results in increased chemical synthesis of Pyruvaldehyde; CYP1A2 protein results in increased metabolism of and results in increased susceptibility to Meloxicam CTD PMID:33253783 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Ereg epiregulin multiple interactions ISO [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of EREG mRNA] CTD PMID:22583689 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO meloxicam inhibits the reaction [Paraquat results in decreased expression of GCLC protein] CTD PMID:20851755 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Meloxicam affects the expression of and affects the activity of GPX1 protein CTD PMID:38036073 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Meloxicam inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Meloxicam inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Meloxicam inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Meloxicam inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:34755645 NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; Meloxicam affects the reaction [Formaldehyde affects the expression of IL1B protein] CTD PMID:29315975 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO meloxicam inhibits the reaction [Doxorubicin results in increased expression of IL6 protein] CTD PMID:24799355 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kng1 kininogen 1 multiple interactions EXP Meloxicam inhibits the reaction [KNG1 protein binds to and results in increased activity of BDKRB1 protein] CTD PMID:11159707 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Meloxicam inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:34755645 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Meloxicam inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:34755645 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in decreased expression of MYC protein CTD PMID:35920412 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO meloxicam inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein] CTD PMID:20851755 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Meloxicam inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein] CTD PMID:34755645 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions ISO meloxicam inhibits the reaction [Paraquat promotes the reaction [Quinones binds to PARK7 protein]] CTD PMID:20851755 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO meloxicam results in decreased expression of PCNA protein CTD PMID:19709125 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO [Meloxicam co-treated with Cilostazol] results in increased expression of and results in increased phosphorylation of PRKAA1 protein CTD PMID:35920412 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Meloxicam results in decreased activity of PTGS1 protein CTD PMID:25034942 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
decreases activity
ISO
EXP
meloxicam results in increased expression of PTGS2 protein
[Meloxicam results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprostone; [Meloxicam results in decreased activity of PTGS2 protein] which results in decreased susceptibility to Chlorpyrifos; Meloxicam inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]
meloxicam results in decreased activity of PTGS2 protein
[meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased expression of EREG mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein]
Meloxicam inhibits the reaction [Diquat results in increased expression of PTGS2 protein]; Meloxicam inhibits the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]
CTD PMID:10791687 PMID:11159707 PMID:12417326 PMID:16928369 PMID:17164136 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 decreases activity ISO Meloxicam results in decreased activity of SCN5A protein CTD PMID:33617802 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Sell selectin L affects expression ISO meloxicam affects the expression of SELL protein CTD PMID:12147693 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Meloxicam affects the expression of and affects the activity of SOD1 protein CTD PMID:38036073 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Meloxicam affects the expression of and affects the activity of SOD2 protein CTD PMID:38036073 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO [Rutin co-treated with Meloxicam] inhibits the reaction [Formaldehyde affects the activity of SORD protein]; Meloxicam inhibits the reaction [Formaldehyde affects the activity of SORD protein] CTD PMID:29315975 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO meloxicam inhibits the reaction [Doxorubicin results in increased expression of TNF protein] CTD PMID:24799355 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link

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  CHEBI ontology 20845
    role 20805
      biological role 20803
        pharmacological role 19889
          analgesic 14882
            meloxicam 35
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  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    p-block element atom 20766
                      carbon group element atom 20699
                        carbon atom 20693
                          organic molecular entity 20693
                            heteroorganic entity 20202
                              organochalcogen compound 19890
                                organooxygen compound 19792
                                  carbon oxoacid 19137
                                    carboxylic acid 19134
                                      carboacyl group 18064
                                        univalent carboacyl group 18064
                                          carbamoyl group 17899
                                            carboxamide 17899
                                              monocarboxylic acid amide 15935
                                                meloxicam 35
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