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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.5.1.15 (dihydropteroate synthase) inhibitor
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Accession:CHEBI:50502 term browser browse the term
Definition:An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dihydropteroate synthase (EC 2.5.1.15), an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate.
Synonyms:related_synonym: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor;   (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors;   2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor;   2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitors;   7,8-dihydropteroate synthase inhibitor;   7,8-dihydropteroate synthase inhibitors;   7,8-dihydropteroate synthetase inhibitor;   7,8-dihydropteroate synthetase inhibitors;   7,8-dihydropteroic acid synthetase inhibitor;   7,8-dihydropteroic acid synthetase inhibitors;   DHPS inhibitor;   DHPS inhibitors;   EC 2.5.1.15 (dihydropteroate synthase) inhibitors;   EC 2.5.1.15 inhibitor;   EC 2.5.1.15 inhibitors;   dihydropteroate diphosphorylase inhibitor;   dihydropteroate diphosphorylase inhibitors;   dihydropteroate pyrophosphorylase inhibitor;   dihydropteroate pyrophosphorylase inhibitors;   dihydropteroate synthase inhibitor;   dihydropteroate synthase inhibitors;   dihydropteroate synthetase inhibitor;   dihydropteroate synthetase inhibitors;   dihydropteroic synthetase inhibitor;   dihydropteroic synthetase inhibitors
 xref: Wikipedia:Dihydropteroate_synthase_inhibitor


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co-trimoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases secretion EXP Trimethoprim, Sulfamethoxazole Drug Combination results in increased secretion of INS protein modified form CTD PMID:14714756 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
N-succinylsulfathiazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDIT4 DNA damage inducible transcript 4 multiple interactions
increases expression		 ISO [Folic Acid deficiency co-treated with succinylsulfathiazole] results in decreased expression of DDIT4 protein
succinylsulfathiazole results in increased expression of DDIT4 protein		 CTD PMID:33957263 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO succinylsulfathiazole results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:33957263 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation ISO succinylsulfathiazole results in decreased phosphorylation of MTOR protein CTD PMID:33957263 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G PDPK1 3-phosphoinositide dependent protein kinase 1 decreases expression
multiple interactions		 ISO succinylsulfathiazole results in decreased expression of PDPK1 protein
Folic Acid deficiency inhibits the reaction [succinylsulfathiazole results in decreased expression of PDPK1 protein]		 CTD PMID:33957263 NCBI chr16:2,538,021...2,603,188
Ensembl chr16:2,537,979...2,603,188 		JBrowse link
nitrososulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1B10 aldo-keto reductase family 1 member B10 increases expression EXP 4-nitrososulfamethoxazole results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412 		JBrowse link
G HMGB1 high mobility group box 1 increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein CTD PMID:28444390 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G IFNG interferon gamma increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IFNG protein CTD PMID:22331489 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL13 interleukin 13 increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL13 protein CTD PMID:22331489 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL1A interleukin 1 alpha increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL1A protein CTD PMID:28444390 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL1B protein CTD PMID:28444390 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL5 interleukin 5 increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL5 protein CTD PMID:22331489 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of IL6 protein CTD PMID:28444390 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G MPO myeloperoxidase affects binding
multiple interactions		 EXP 4-nitrososulfamethoxazole binds to MPO protein
[[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole		 CTD PMID:25531135 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP 4-nitrososulfamethoxazole results in increased expression of NQO1 mRNA CTD PMID:28444390 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G SRXN1 sulfiredoxin 1 increases expression EXP 4-nitrososulfamethoxazole results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200 		JBrowse link
G TNF tumor necrosis factor increases secretion EXP 4-nitrososulfamethoxazole results in increased secretion of TNF protein CTD PMID:28444390 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP 4-nitrososulfamethoxazole results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
sulfacetamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMBS hydroxymethylbilane synthase decreases activity ISO Sulfacetamide decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
sulfadiazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases hydroxylation EXP CYP2C8 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases hydroxylation EXP CYP2C9 protein results in increased hydroxylation of Sulfadiazine CTD PMID:15843491 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression EXP Sulfadiazine results in decreased expression of GRIN1 mRNA CTD PMID:34748853 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756 		JBrowse link
G HMBS hydroxymethylbilane synthase decreases activity ISO Sulfadiazine decreases activity of purified Hmbs protein RGD PMID:6893114 RGD:26923963 NCBI chr11:119,084,881...119,093,549
Ensembl chr11:119,084,866...119,093,834 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP [Sulfadiazine co-treated with Pyrimethamine] results in decreased expression of IL6 protein; [Trimethoprim co-treated with Sulfadiazine] results in increased expression of IL6 protein CTD PMID:10888991 PMID:37722575 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G LPO lactoperoxidase decreases expression EXP Sulfadiazine results in decreased expression of LPO mRNA CTD PMID:34748853 NCBI chr17:58,238,584...58,268,518
Ensembl chr17:58,218,548...58,268,518 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases expression EXP Sulfadiazine results in decreased expression of MTOR mRNA CTD PMID:34748853 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NAT2 N-acetyltransferase 2 increases acetylation EXP NAT2 protein results in increased acetylation of Sulfadiazine CTD PMID:15843491 NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G OLIG2 oligodendrocyte transcription factor 2 decreases expression EXP Sulfadiazine results in decreased expression of OLIG2 mRNA CTD PMID:34748853 NCBI chr21:33,025,935...33,029,185
Ensembl chr21:33,025,935...33,029,196 		JBrowse link
G SHANK2 SH3 and multiple ankyrin repeat domains 2 decreases expression EXP Sulfadiazine results in decreased expression of SHANK2 mRNA CTD PMID:34748853 NCBI chr11:70,467,854...71,253,228
Ensembl chr11:70,467,854...71,252,577 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 decreases expression EXP Sulfadiazine results in decreased expression of SLC6A4 mRNA CTD PMID:34748853 NCBI chr17:30,194,319...30,235,697
Ensembl chr17:30,194,319...30,236,002 		JBrowse link
sulfamethazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases activity EXP Sulfamethazine results in increased activity of CYP3A4 protein CTD PMID:12065438 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G NAT2 N-acetyltransferase 2 increases acetylation
increases metabolic processing
affects acetylation		 EXP NAT2 protein results in increased acetylation of Sulfamethazine
NAT2 protein results in increased metabolism of Sulfamethazine
NAT2 polymorphism affects the acetylation of Sulfamethazine		 CTD PMID:12222688 PMID:15627487 PMID:15880531 PMID:21317369 PMID:28516247 More... NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Sulfamethazine results in increased activity of NR1I2 protein CTD PMID:12065438 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
sulfamethizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1B interleukin 1 beta multiple interactions ISO Sulfamethizole inhibits the reaction [Poloxalene results in increased expression of IL1B protein] CTD PMID:36799065 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions ISO Sulfamethizole inhibits the reaction [Poloxalene results in increased expression of MTOR protein] CTD PMID:36799065 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Sulfamethizole inhibits the reaction [Poloxalene results in increased expression of TNF protein] CTD PMID:36799065 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
sulfamethoxazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 EXP Sulfamethoxazole results in decreased activity of ABCB11 protein
Sulfamethoxazole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:24014644 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ACAN aggrecan decreases expression ISO Sulfamethoxazole results in decreased expression of ACAN mRNA CTD PMID:26107568 NCBI chr15:88,803,436...88,875,353
Ensembl chr15:88,803,436...88,875,353 		JBrowse link
G ALB albumin multiple interactions EXP Sulfamethoxazole metabolite binds to and results in increased metabolism of ALB protein CTD PMID:19358516 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G COL2A1 collagen type II alpha 1 chain decreases expression ISO Sulfamethoxazole results in decreased expression of COL2A1 mRNA CTD PMID:26107568 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP Sulfamethoxazole results in increased secretion of CXCL8 protein CTD PMID:22609641 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions ISO [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions EXP Sulfamethoxazole metabolite binds to and results in increased metabolism of GSTP1 protein CTD PMID:19358516 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656 		JBrowse link
G HLA-G major histocompatibility complex, class I, G affects expression EXP Sulfamethoxazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125 		JBrowse link
G IFNG interferon gamma increases secretion ISO Sulfamethoxazole analog results in increased secretion of IFNG protein CTD PMID:15588915 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL5 interleukin 5 increases secretion ISO Sulfamethoxazole analog results in increased secretion of IL5 protein CTD PMID:15588915 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G MIR155 microRNA 155 increases expression EXP Sulfamethoxazole results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR18A microRNA 18a increases expression EXP Sulfamethoxazole results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr13:91,350,751...91,350,821
Ensembl chr13:91,350,751...91,350,821 		JBrowse link
G MIR21 microRNA 21 increases expression EXP Sulfamethoxazole results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr17:59,841,266...59,841,337
Ensembl chr17:59,841,266...59,841,337 		JBrowse link
G MPO myeloperoxidase multiple interactions EXP [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole] which results in increased chemical synthesis of 4-nitrososulfamethoxazole; [MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Sulfamethoxazole CTD PMID:25531135 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NAT2 N-acetyltransferase 2 increases metabolic processing EXP NAT2 protein results in increased metabolism of Sulfamethoxazole CTD PMID:16847467 NCBI chr 8:18,386,301...18,401,218
Ensembl chr 8:18,391,282...18,401,218 		JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase decreases expression EXP Sulfamethoxazole results in decreased expression of PHYH mRNA CTD PMID:15342952 NCBI chr10:13,277,799...13,300,064
Ensembl chr10:13,277,796...13,302,412 		JBrowse link
G PIR pirin increases expression EXP Sulfamethoxazole results in increased expression of PIR mRNA CTD PMID:22609641 NCBI chr  X:15,384,799...15,493,333
Ensembl chr  X:15,384,799...15,493,564 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO [SOD2 co-treated with CYP3A4] affects the susceptibility to Sulfamethoxazole CTD PMID:19501153 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOX9 SRY-box transcription factor 9 decreases expression ISO Sulfamethoxazole results in decreased expression of SOX9 mRNA CTD PMID:26107568 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416 		JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYB5B cytochrome b5 type B multiple interactions EXP [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr16:69,424,619...69,466,264
Ensembl chr16:69,398,402...69,466,264 		JBrowse link
G CYB5R3 cytochrome b5 reductase 3 multiple interactions EXP [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine; [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr22:42,617,840...42,649,392
Ensembl chr22:42,615,730...42,720,870 		JBrowse link
G MTARC1 mitochondrial amidoxime reducing component 1 multiple interactions EXP [MTARC1 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 1:220,786,913...220,819,659
Ensembl chr 1:220,786,352...220,819,659 		JBrowse link
G MTARC2 mitochondrial amidoxime reducing component 2 multiple interactions EXP [MTARC2 protein co-treated with CYB5B protein co-treated with CYB5R3 protein co-treated with NAD] results in increased reduction of sulfamethoxazole hydroxylamine CTD PMID:25170804 NCBI chr 1:220,748,322...220,784,815
Ensembl chr 1:220,748,225...220,784,815 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        biochemical role 25168
          enzyme inhibitor 22346
            EC 2.* (transferase) inhibitor 16023
              EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor 3363
                EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 3363
                  EC 2.5.1.15 (dihydropteroate synthase) inhibitor 47
                    asulam 0
                    asulam-potassium 0
                    asulam-sodium 0
                    sulfacetamide 1
                    sulfacetamide sodium 0
                    sulfacetamide sodium anhydrous + 0
                    sulfachloropyridazine 0
                    sulfadiazine 11
                    sulfamethazine + 3
                    sulfamethizole 3
                    sulfamethoxazole + 34
                    sulfamethoxypyridazine 0
                    sulfathiazole + 4
                    sulfathiourea 0
paths to the root