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Gene: CYB5R3 (cytochrome b5 reductase 3) Homo sapiens
Symbol: CYB5R3
Name: cytochrome b5 reductase 3
Description: Exhibits FAD binding activity. Predicted to be involved in several processes, including L-ascorbic acid metabolic process; neutrophil degranulation; and xenobiotic metabolic process. Localizes to the endoplasmic reticulum and lipid droplet. Implicated in breast cancer and methemoglobinemia. Biomarker of estrogen-receptor negative breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B5R; DIA1; diaphorase 1; diaphorase-1; mutant NADH-cytochrome b5 reductase; NADH-cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form
Mus musculus (house mouse) : Cyb5r3 (cytochrome b5 reductase 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyb5r3 (cytochrome b5 reductase 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102012303 (NADH-cytochrome b5 reductase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100982559 (NADH-cytochrome b5 reductase 3)
Canis lupus familiaris (dog) : CYB5R3 (cytochrome b5 reductase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101962805 (NADH-cytochrome b5 reductase 3)
Sus scrofa (pig) : LOC100524254 (NADH-cytochrome b5 reductase 3-like)
Chlorocebus sabaeus (green monkey) : CYB5R3 (cytochrome b5 reductase 3)
Heterocephalus glaber (naked mole-rat) : LOC101718541 (NADH-cytochrome b5 reductase 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2242,617,840 - 42,649,392 (-)Ensembl
GRCh382242,617,840 - 42,649,392 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372243,013,846 - 43,045,405 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,344,763 - 41,375,349 (-)NCBINCBI36hg18NCBI36
Build 342241,339,318 - 41,367,516NCBI
Celera2226,924,326 - 26,955,882 (-)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2225,974,473 - 26,005,949 (-)NCBIHuRef
CHM1_12242,972,995 - 43,004,519 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CYB5R3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731731
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.