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Gene: LOC102012303 (NADH-cytochrome b5 reductase 3) Chinchilla lanigera

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Symbol:

LOC102012303 (Ensembl: CYB5R3)

Name:

NADH-cytochrome b5 reductase 3 (Ensembl:cytochrome b5 reductase 3)

RGD ID:

8916076

Description:

ENCODES a protein that exhibits ADP binding (ortholog); AMP binding (ortholog); cytochrome-b5 reductase activity, acting on NAD(P)H (ortholog); INVOLVED IN nitric oxide biosynthetic process (ortholog); ASSOCIATED WITH breast cancer (ortholog); common variable immunodeficiency 4 (ortholog); Cyanosis (ortholog); FOUND IN cytosol (ortholog); endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	27,969,949 - 27,979,909 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	27,971,140 - 27,979,905 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

common variable immunodeficiency 4 (ISO)

Cyanosis (ISO)

Developmental Delay with Variable Intellectual Impairment and Behavioral Abnormalities (ISO)

estrogen-receptor negative breast cancer (ISO)

genetic disease (ISO)

intellectual disability (ISO)

methemoglobinemia (ISO)

NADH Cytochrome B5 Reductase Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

nitric oxide biosynthetic process (ISO)

Cellular Component

cytosol (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum membrane (ISO)

lipid droplet (ISO)

mitochondrial membrane (ISO)

mitochondrial outer membrane (ISO)

mitochondrion (ISO)

nitric-oxide synthase complex (ISO)

Molecular Function

ADP binding (ISO)

AMP binding (ISO)

cytochrome-b5 reductase activity, acting on NAD(P)H (ISO)

FAD binding (ISO)

flavin adenine dinucleotide binding (ISO)

NAD binding (ISO)

nitrite reductase (NO-forming) activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LOC102012303
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	27,969,949 - 27,979,909 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	27,971,140 - 27,979,905 (-)	NCBI	ChiLan1.0	ChiLan1.0

CYB5R3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	42,617,840 - 42,649,392 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	42,615,730 - 42,720,870 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	43,013,846 - 43,045,398 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	41,344,763 - 41,375,349 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	41,339,318 - 41,367,516	NCBI
Celera	22	26,924,326 - 26,955,882 (-)	NCBI		Celera
Cytogenetic Map	22	q13.2	NCBI
HuRef	22	25,974,473 - 26,005,949 (-)	NCBI		HuRef
CHM1_1	22	42,972,995 - 43,004,519 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	43,098,710 - 43,130,267 (-)	NCBI		T2T-CHM13v2.0

Cyb5r3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	83,037,696 - 83,060,641 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	83,037,695 - 83,056,793 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	83,153,495 - 83,176,440 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	83,153,494 - 83,172,592 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	82,983,931 - 83,002,638 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	82,981,267 - 82,999,974 (-)	NCBI		MGSCv36	mm8
Celera	15	85,286,802 - 85,305,568 (-)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	39.4	NCBI

Cyb5r3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	116,186,729 - 116,204,290 (-)	NCBI		GRCr8
mRatBN7.2	7	114,306,686 - 114,324,247 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	114,306,685 - 114,324,298 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	116,061,829 - 116,079,400 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	118,286,246 - 118,303,784 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	118,255,692 - 118,273,230 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,024,003 - 124,041,564 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,023,995 - 124,041,594 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	124,006,942 - 124,024,503 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	121,187,821 - 121,205,382 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	121,222,050 - 121,239,612 (-)	NCBI
Celera	7	110,620,903 - 110,638,468 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

LOC100982559
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	52,453,476 - 52,484,518 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	55,145,984 - 55,177,005 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	23,513,724 - 23,544,746 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	41,666,548 - 41,694,104 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	41,666,548 - 41,694,104 (-)	Ensembl	panpan1.1		panPan2

CYB5R3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	22,829,898 - 22,848,284 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	22,819,221 - 22,848,284 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	22,756,034 - 22,783,841 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	23,565,239 - 23,592,996 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	23,565,191 - 23,595,635 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	23,282,809 - 23,310,756 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	23,602,619 - 23,630,348 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	23,777,463 - 23,805,206 (+)	NCBI		UU_Cfam_GSD_1.0

LOC101962805
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	6,411,149 - 6,427,796 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	549,938 - 564,195 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	552,369 - 564,195 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CYB5R3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	6,146,276 - 6,170,212 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	6,146,230 - 6,170,209 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	3,604,124 - 3,628,138 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYB5R3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	25,172,513 - 25,191,139 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666045	100,266,413 - 100,298,273 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101718541
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	6,182,129 - 6,198,400 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	6,182,156 - 6,198,395 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013511507	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01014539	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01020264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01016413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000022305 ⟹ ENSCLAP00000022100

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955413	27,969,949 - 27,979,909 (-)	Ensembl

RefSeq Acc Id:

XM_013511507 ⟹ XP_013366961

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955413	27,971,140 - 27,979,905 (-)	NCBI

Sequence:

show sequence

GCGCGCAAAGCCACGCCCCCTCCCCGAGCTGACGCGGGCGCGGGCGGCGGCGGCCACTGTCTCG
GTGTCTCGGCGAGCGGCGGGGCGGCGGCACAGCCACCATGGGGGCCCAGCTGAGCACGTTGGGG
CGCGTGGCGCTCTCCCCTGTCTGGTTCCTCTACAGCCTGTTCATGAAGCTGTTCCAGCGCCCGC
GGCCGGCCCTCACCCTCGAGAGCCCTGACATCAAGTACCCACTTCGGCTCATCGACAGGGAGGT
CATCAGCCATGACACGCGGCGCTTCCGCTTCGCCCTGCCGTCCCCCGAGCACATCTTGGGCCTG
CCTGTCGGCCAGCACATCTACCTCTCCGCTCGAATCGATGGGAACCTGGTCATCCGGCCCTACA
CGCCCGTCTCCAGCGACGATGACAAGGGCTTTGTGGACCTGGTCATCAAGGTCTACTTCAAGGA
CACACACCCCAAGTTCCCTGCGGGGGGGAAGATGTCGCAGTACCTGGAAAGCATGCAGATTGGA
GACACCATCGAGTTCCGGGGCCCCAACGGGCTGCTGGTGTACCAGGGCCGAGGGAAGTTTGCCA
TTCGGCCCGACAAGAAGTCCAGCCCTGTGATCAAGACGGCCAAGTCGGTGGGCATGATCGCCGG
AGGGACAGGCATCACCCCCATGCTGCAGGTGATCCGGGCCATCATGAAGGACCCAGAAGACCGC
ACCGTGTGCCACCTGCTCTTTGCCAACCAGACCGAGAAGGACATCCTGCTGCGGCCCGAGCTGG
AGGAACTGAGGAACGCGAACTCCGATCGCTTCAAGCTGTGGTACACGCTGGACAAGGCCCCCGA
GGCCTGGGACTACAGCGAGGGCTTCGTGAACGAGGAGATGATCCGGGACCACCTCCCGCCGCCG
GGTGAGGAGACGCTGGTGCTGATGTGCGGGCCACCGCCCATGATCCAGTTCGCCTGCCTGCCCA
ACCTGGAGCGCCTGGGCCACGCCAAGGAGCGCTGCTTCTCCTTCTGAGCTGGGACCGCGCCTCC
GCTCTGCCCGCCTGCTGCTCTCGTCCTCCCCTGCCGCCCCACGGGGCTGCTGCGCCCACCGGGG
CCCGGGTTCAGCCCGGCCTGCCTGTGCCTTGGTGGCGCCGCTGGGGACACGCCTGTCGCTGCTC
TGCGAACCCCGCCTGGGGCCCAGGCTGAGGTCGCCAGACCCTCGTACTGCCCGGCCCTGGAAGG
GGGGGAGCGCAGGGCTTCGGGGCCCAGCCTGCCCCCCGCCACGGCCACCCTCACCGACACTACA
CGAGACAACTGACTCCTGAAGCCCCTCCCAGAGCCCACAGGCCCCGCTGGCTGGAGCCCCTCTC
TCAGGGGACCCCAGCATTTCTCCAGCACCCCCAGACACTCAGGCAGCCCTGGGCGCCCCAGGTT
GCCAGCCTGGCGGAGTGCAGAGGTCCCAGCCCCGAGGGACATCAGCCCCTCGGCCCCCACCCGC
CTCCCTGCGCCCCGCGGGGGCCTGCCCAGTGCCTCTCCTCTGACAGACGCCCTTGGGGGCTTCT
AGACAACAGCTGTGTCGCCTTCCACGTAGCGGCTTTCTTGGAGTCATGTATGAGCAGAGAAAGA
ATTCAAGTAAAACTTTGCTACTCAGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_013366961	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000022100
	ENSCLAP00000022100.1

RefSeq Acc Id:

XP_013366961 ⟸ XM_013511507

- UniProtKB:

A0A8C2W562 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGAQLSTLGRVALSPVWFLYSLFMKLFQRPRPALTLESPDIKYPLRLIDREVISHDTRRFRFAL
PSPEHILGLPVGQHIYLSARIDGNLVIRPYTPVSSDDDKGFVDLVIKVYFKDTHPKFPAGGKMS
QYLESMQIGDTIEFRGPNGLLVYQGRGKFAIRPDKKSSPVIKTAKSVGMIAGGTGITPMLQVIR
AIMKDPEDRTVCHLLFANQTEKDILLRPELEELRNANSDRFKLWYTLDKAPEAWDYSEGFVNEE
MIRDHLPPPGEETLVLMCGPPPMIQFACLPNLERLGHAKERCFSF

hide sequence

Ensembl Acc Id:

ENSCLAP00000022100 ⟸ ENSCLAT00000022305

Protein Domains

FAD-binding FR-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015151	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022305	ENTREZGENE
	ENSCLAT00000022305.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.80	UniProtKB/TrEMBL
	Translation factors	UniProtKB/TrEMBL
InterPro	CBR-like	UniProtKB/TrEMBL
	Cbr1-like_FAD-bd_dom	UniProtKB/TrEMBL
	FAD-bd_FR_type	UniProtKB/TrEMBL
	Flavoprot_Pyr_Nucl_cyt_Rdtase	UniProtKB/TrEMBL
	FNR_nucleotide-bd	UniProtKB/TrEMBL
	OxRdtase_FAD/NAD-bd	UniProtKB/TrEMBL
	Riboflavin_synthase-like_b-brl	UniProtKB/TrEMBL
NCBI Gene	LOC102012303	ENTREZGENE
PANTHER	NADH-CYTOCHROME B5 REDUCTASE 3	UniProtKB/TrEMBL
	PTHR19370	UniProtKB/TrEMBL
Pfam	FAD_binding_6	UniProtKB/TrEMBL
	NAD_binding_1	UniProtKB/TrEMBL
PRINTS	CYTB5RDTASE	UniProtKB/TrEMBL
	FPNCR	UniProtKB/TrEMBL
PROSITE	FAD_FR	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52343	UniProtKB/TrEMBL
	SSF63380	UniProtKB/TrEMBL
UniProt	A0A8C2W562	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-08-25	LOC102012303	NADH-cytochrome b5 reductase 3		NADH-cytochrome b5 reductase 3-like	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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