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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carteolol
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Accession:CHEBI:3437 term browser browse the term
Definition:A quinolone that has formula C16H24N2O3.
Synonyms:exact_synonym: 5-[3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydroquinolin-2(1H)-one
 related_synonym: Formula=C16H24N2O3;   InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20);   InChIKey=LWAFSWPYPHEXKX-UHFFFAOYSA-N;   SMILES=CC(C)(C)NCC(O)COc1cccc2NC(=O)CCc12;   carteololum
 xref: Beilstein:1221735;   CAS:51781-06-7;   DrugBank:DB00521;   Drug_Central:520;   KEGG:C06874;   KEGG:D07624;   LINCS:LSM-1541
 xref_mesh: MESH:D002354
 xref: Patent:DE2302027;   Patent:US3910924;   Wikipedia:Carteolol
 cyclic_relationship: is_conjugate_base_of CHEBI:61202


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carteolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Carteolol binds to and results in decreased activity of ADRB1 protein CTD PMID:11436944 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Carteolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Arrb1 arrestin, beta 1 increases expression ISO Carteolol results in increased expression of ARRB1 protein CTD PMID:37120125 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Arrb2 arrestin, beta 2 increases expression ISO Carteolol results in increased expression of ARRB2 protein CTD PMID:37120125 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Atm ATM serine/threonine kinase multiple interactions
increases expression		 ISO Carteolol results in increased expression of and results in increased phosphorylation of ATM protein
Carteolol results in increased expression of ATM mRNA		 CTD PMID:37120125 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Cat catalase affects activity ISO Carteolol affects the activity of CAT protein CTD PMID:37120125 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl27 C-C motif chemokine ligand 27 increases expression ISO Carteolol results in increased expression of CCL27 mRNA CTD PMID:37120125 NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO Carteolol affects the expression of CDKN1A mRNA CTD PMID:37120125 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Carteolol results in increased expression of CDKN2A mRNA CTD PMID:37120125 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Fahd1 fumarylacetoacetate hydrolase domain containing 1 affects expression ISO Carteolol affects the expression of FAHD1 mRNA CTD PMID:37120125 NCBI chr10:13,873,539...13,874,978
Ensembl chr10:13,873,527...13,875,012 		JBrowse link
G Gpx1 glutathione peroxidase 1 affects activity ISO Carteolol affects the activity of GPX1 protein CTD PMID:37120125 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Carteolol results in increased phosphorylation of H2AX protein CTD PMID:37120125 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hk2 hexokinase 2 affects expression ISO Carteolol affects the expression of HK2 mRNA CTD PMID:37120125 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Il10 interleukin 10 increases expression ISO Carteolol results in increased expression of IL10 mRNA CTD PMID:37120125 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Carteolol results in increased expression of IL1A mRNA CTD PMID:37120125 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il6 interleukin 6 increases expression ISO Carteolol results in increased expression of IL6 mRNA CTD PMID:37120125 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lmnb1 lamin B1 decreases expression ISO Carteolol results in decreased expression of LMNB1 protein CTD PMID:37120125 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta affects localization ISO Carteolol affects the localization of MAP1LC3B protein CTD PMID:37120125 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Carteolol results in increased expression of and results in increased phosphorylation of MAPK1 protein CTD PMID:37120125 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Carteolol results in increased expression of and results in increased phosphorylation of MAPK3 protein CTD PMID:37120125 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Carteolol results in decreased expression of MKI67 protein CTD PMID:37120125 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mtor mechanistic target of rapamycin kinase affects expression ISO Carteolol affects the expression of MTOR protein CTD PMID:37120125 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase affects expression ISO Carteolol affects the expression of NAMPT mRNA CTD PMID:37120125 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects expression ISO Carteolol affects the expression of NFE2L2 mRNA CTD PMID:37120125 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression ISO Carteolol results in increased expression of NFKB1 mRNA CTD PMID:37120125 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nox4 NADPH oxidase 4 increases expression ISO Carteolol results in increased expression of NOX4 protein CTD PMID:37120125 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 affects expression ISO Carteolol affects the expression of PARP1 mRNA CTD PMID:37120125 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Sirt1 sirtuin 1 affects expression ISO Carteolol affects the expression of SIRT1 mRNA CTD PMID:37120125 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 affects activity ISO Carteolol affects the activity of SOD1 protein CTD PMID:37120125 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 affects activity ISO Carteolol affects the activity of SOD2 protein CTD PMID:37120125 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Carteolol results in increased expression of TGFB1 mRNA CTD PMID:37120125 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Carteolol results in increased expression of TNF mRNA CTD PMID:37120125 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects expression ISO Carteolol affects the expression of TP53 mRNA CTD PMID:37120125 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
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  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            cardiovascular drug 8613
              antihypertensive agent 1943
                carteolol 33
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  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
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            nucleon 19806
              atomic nucleus 19806
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                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organonitrogen heterocyclic compound 18126
                                    quinolines 2653
                                      quinolone 336
                                        carteolol 33
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