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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:quinolone
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Accession:CHEBI:23765 term browser browse the term
Synonyms:related_synonym: quinolones
 alt_id: MESH:D015363
 xref_mesh: MESH:D015363



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quinolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO [copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; [copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein; resveratrol inhibits the reaction [[copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein]; resveratrol inhibits the reaction [[copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased activity of AHR protein] CTD PMID:27180721 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Alad aminolevulinate dehydratase multiple interactions ISO Quinolones inhibits the reaction [Nitroprusside results in decreased activity of ALAD protein] CTD PMID:29317251 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Alb albumin affects binding ISO Quinolones analog binds to ALB protein CTD PMID:21820989 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions
increases expression
ISO [Quinolones co-treated with Oxygen deficiency] results in increased expression of BNIP3 mRNA; Quinolones inhibits the reaction [Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of BNIP3 protein]]
Quinolones results in increased expression of BNIP3 mRNA
CTD PMID:26082309 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Cat catalase multiple interactions ISO Quinolones inhibits the reaction [Nitroprusside results in decreased activity of CAT protein] CTD PMID:29317251 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Quinolones results in decreased expression of CCND1 protein CTD PMID:27592390 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO [copper(II) nitrate binds to 1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA; [copper(II) nitrate binds to 5-methyl-1,10-phenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA; [copper(II) nitrate binds to bathophenanthroline binds to Quinolones] which results in increased expression of CYP1A1 mRNA CTD PMID:27180721 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO Quinolones inhibits the reaction [7-methylguanosine 5'-diphosphate analog binds to EIF4E protein]; Quinolones inhibits the reaction [RNA Caps binds to EIF4E protein] CTD PMID:27592390 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO Quinolones inhibits the reaction [Mustard Gas inhibits the reaction [Oxygen deficiency results in increased stability of HIF1A protein]]; Quinolones promotes the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Quinolones results in increased expression of and affects the localization of HIF1A protein CTD PMID:26082309 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Quinolones results in decreased expression of MYC protein CTD PMID:27592390 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Tbxas1 thromboxane A synthase 1 decreases activity ISO Quinolones analog results in decreased activity of TBXAS1 protein CTD PMID:1311763 NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions
ISO Quinolones results in increased expression of VEGFA mRNA
[Quinolones co-treated with Oxygen deficiency] results in increased expression of VEGFA mRNA; Quinolones inhibits the reaction [Mustard Gas inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]]
CTD PMID:26082309 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 6-anilino-5,8-quinolinedione inhibits the reaction [sodium bichromate results in increased ubiquitination of BCL2 protein]
6-anilino-5,8-quinolinedione results in decreased expression of BCL2 protein
CTD PMID:18544562 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor decreases response to substance ISO BDNF protein results in decreased susceptibility to 6-anilino-5,8-quinolinedione CTD PMID:22261313 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP 6-anilino-5,8-quinolinedione results in increased expression of and results in increased secretion of HSP90AA1 protein CTD PMID:10617604 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP 6-anilino-5,8-quinolinedione results in increased expression of HSP90AB1 protein CTD PMID:10617604 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Il4 interleukin 4 decreases secretion ISO 6-anilino-5,8-quinolinedione results in decreased secretion of IL4 protein CTD PMID:16533816 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases secretion ISO 6-anilino-5,8-quinolinedione results in decreased secretion of IL5 protein CTD PMID:16533816 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 6-anilino-5,8-quinolinedione inhibits the reaction [heat stable toxin (E coli) results in decreased expression of VEGFA protein] CTD PMID:17828804 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
aripiprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadl acyl-CoA dehydrogenase, long chain decreases expression EXP Aripiprazole results in decreased expression of ACADL mRNA CTD PMID:17868501 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of ADORA2A mRNA CTD PMID:31476115 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B decreases expression EXP Aripiprazole results in decreased expression of ARPC1B mRNA CTD PMID:17868501 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747
JBrowse link
G Bcl10 BCL10, immune signaling adaptor multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of BCL10 mRNA CTD PMID:31476115 NCBI chr 2:234,840,880...234,850,520
Ensembl chr 2:234,840,858...234,850,523
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of BCL2L1 mRNA CTD PMID:31476115 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl6 BCL6, transcription repressor multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of BCL6 mRNA CTD PMID:31476115 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of BID mRNA CTD PMID:31476115 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G C1r complement C1r multiple interactions ISO Aripiprazole promotes the reaction [Ozone results in decreased expression of C1R mRNA] CTD PMID:31476115 NCBI chr 4:157,412,718...157,423,483
Ensembl chr 4:157,412,692...157,423,484
JBrowse link
G C2 complement C2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of C2 mRNA CTD PMID:31476115 NCBI chr20:3,951,474...3,970,376
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Cbx7 chromobox 7 decreases expression
increases expression
EXP Aripiprazole results in decreased expression of CBX7 mRNA
Aripiprazole results in increased expression of CBX7 mRNA
CTD PMID:17868501 NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CCL19 mRNA CTD PMID:31476115 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CCL2 mRNA CTD PMID:31476115 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CCL20 mRNA CTD PMID:31476115 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 multiple interactions ISO Aripiprazole inhibits the reaction [Ozone results in increased expression of CCL22 mRNA] CTD PMID:31476115 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CCL3 mRNA CTD PMID:31476115 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CCL4 mRNA CTD PMID:31476115 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CCL5 mRNA CTD PMID:31476115 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CCR3 mRNA CTD PMID:31476115 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
JBrowse link
G Cd274 CD274 molecule multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CD274 mRNA CTD PMID:31476115 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd33 CD33 molecule multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CD33 mRNA CTD PMID:31476115 NCBI chr 1:93,935,418...93,940,452
Ensembl chr 1:93,930,971...93,950,149
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CD44 mRNA CTD PMID:31476115 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cd70 Cd70 molecule multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CD70 mRNA CTD PMID:31476115 NCBI chr 9:2,006,563...2,009,715
Ensembl chr 9:2,006,563...2,009,715
JBrowse link
G Cd83 CD83 molecule multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CD83 mRNA CTD PMID:31476115 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083
JBrowse link
G Cdh5 cadherin 5 multiple interactions ISO Aripiprazole inhibits the reaction [Ozone results in increased expression of CDH5 mRNA] CTD PMID:31476115 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CDKN1A mRNA CTD PMID:31476115 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CEBPB mRNA CTD PMID:31476115 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cfb complement factor B multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CFB mRNA CTD PMID:31476115 NCBI chr20:3,970,643...3,976,510 JBrowse link
G Cldn5 claudin 5 decreases expression EXP Aripiprazole results in decreased expression of CLDN5 mRNA CTD PMID:17868501 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression EXP Aripiprazole results in increased expression of CNR1 mRNA CTD PMID:17868501 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Comt catechol-O-methyltransferase increases expression EXP Aripiprazole results in increased expression of COMT mRNA CTD PMID:17868501 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Creb5 cAMP responsive element binding protein 5 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CREB5 mRNA CTD PMID:31476115 NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325
JBrowse link
G Crebbp CREB binding protein decreases expression EXP Aripiprazole results in decreased expression of CREBBP mRNA CTD PMID:17868501 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Crmp1 collapsin response mediator protein 1 increases expression EXP Aripiprazole results in increased expression of CRMP1 mRNA CTD PMID:17868501 NCBI chr14:73,509,933...73,556,192
Ensembl chr14:73,509,933...73,556,177
JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CSF1 mRNA CTD PMID:31476115 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CSF2 mRNA CTD PMID:31476115 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CSF3 mRNA CTD PMID:31476115 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CX3CL1 mRNA CTD PMID:31476115 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CXCL1 mRNA CTD PMID:31476115 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CXCL2 mRNA CTD PMID:31476115 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CXCL1 mRNA CTD PMID:31476115 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr5 C-X-C motif chemokine receptor 5 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CXCR5 mRNA CTD PMID:31476115 NCBI chr 8:44,842,098...44,858,425
Ensembl chr 8:44,843,413...44,857,893
JBrowse link
G Cxcr6 C-X-C motif chemokine receptor 6 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CXCR6 mRNA CTD PMID:31476115 NCBI chr 8:123,434,417...123,439,568
Ensembl chr 8:123,416,325...123,439,526
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CYBB mRNA CTD PMID:31476115 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of CYLD mRNA CTD PMID:31476115 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Ddr2 discoidin domain receptor tyrosine kinase 2 decreases expression EXP Aripiprazole results in decreased expression of DDR2 mRNA CTD PMID:17868501 NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363
JBrowse link
G Ddx50 DExD-box helicase 50 increases expression EXP Aripiprazole results in increased expression of DDX50 mRNA CTD PMID:17868501 NCBI chr20:30,561,623...30,591,324
Ensembl chr20:30,560,544...30,591,152
JBrowse link
G Ddx58 DEXD/H-box helicase 58 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of DDX58 mRNA CTD PMID:31476115 NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Dnal4 dynein, axonemal, light chain 4 decreases expression EXP Aripiprazole results in decreased expression of DNAL4 mRNA CTD PMID:17868501 NCBI chr 7:111,312,424...111,325,258
Ensembl chr 7:111,312,427...111,325,283
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression EXP Aripiprazole results in increased expression of DNMT3A mRNA CTD PMID:17868501 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP
ISO
[Aripiprazole binds to and results in increased activity of DRD2 protein] which results in increased susceptibility to Methamphetamine CTD PMID:17069544 PMID:17327886 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dusp4 dual specificity phosphatase 4 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of DUSP4 mRNA CTD PMID:31476115 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dusp6 dual specificity phosphatase 6 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of DUSP6 mRNA CTD PMID:31476115 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Ebi3 Epstein-Barr virus induced 3 multiple interactions ISO Aripiprazole promotes the reaction [Ozone results in increased expression of EBI3 mRNA] CTD PMID:31476115 NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544
JBrowse link
G Egr1 early growth response 1 increases expression EXP Aripiprazole results in increased expression of EGR1 mRNA; Aripiprazole results in increased expression of EGR1 protein CTD PMID:17868501 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 increases expression EXP Aripiprazole results in increased expression of EGR2 mRNA CTD PMID:17868501 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Egr4 early growth response 4 increases expression EXP Aripiprazole results in increased expression of EGR4 mRNA CTD PMID:17868501 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of ELANE mRNA CTD PMID:31476115 NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
JBrowse link
G Elavl2 ELAV like RNA binding protein 2 increases expression EXP Aripiprazole results in increased expression of ELAVL2 mRNA CTD PMID:17868501 NCBI chr 5:105,960,872...106,086,539
Ensembl chr 5:105,960,875...106,109,097
JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of ETS1 mRNA CTD PMID:31476115 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Exoc2 exocyst complex component 2 increases expression EXP Aripiprazole results in increased expression of EXOC2 mRNA CTD PMID:17868501 NCBI chr17:33,506,289...33,698,246
Ensembl chr17:33,506,338...33,693,289
JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO Aripiprazole inhibits the reaction [Ozone results in increased expression of F2RL1 mRNA] CTD PMID:31476115 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 multiple interactions
increases expression
ISO [Aripiprazole co-treated with Ozone] results in increased expression of FEZ1 mRNA
Aripiprazole results in increased expression of FEZ1 mRNA
CTD PMID:31476115 NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Aripiprazole results in decreased expression of FN1 mRNA CTD PMID:31476115 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Hbegf heparin-binding EGF-like growth factor decreases expression EXP Aripiprazole results in decreased expression of HBEGF mRNA CTD PMID:17868501 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Aripiprazole binds to and affects the activity of HTR1A protein; Aripiprazole binds to and results in increased activity of HTR1A protein CTD PMID:17069544 PMID:21823597 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
decreases response to substance
affects response to substance
ISO Aripiprazole binds to and results in decreased activity of HTR2A protein; Aripiprazole binds to and results in increased activity of HTR2A protein; Aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]
HTR2A gene SNP results in decreased susceptibility to Aripiprazole
HTR2A protein affects the susceptibility to Aripiprazole
CTD PMID:16314884 PMID:21823597 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C multiple interactions ISO Aripiprazole binds to and affects the activity of HTR2C protein CTD PMID:21823597 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of ICAM1 mRNA CTD PMID:31476115 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Icam4 intercellular adhesion molecule 4, Landsteiner-Wiener blood group multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of ICAM4 mRNA CTD PMID:31476115 NCBI chr 8:19,566,075...19,567,171
Ensembl chr 8:19,566,075...19,567,171
JBrowse link
G Icoslg inducible T-cell co-stimulator ligand multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of ICOSLG mRNA CTD PMID:31476115 NCBI chr20:10,600,420...10,610,718
Ensembl chr20:10,600,420...10,610,703
JBrowse link
G Ifnb1 interferon beta 1 increases expression
multiple interactions
ISO Aripiprazole results in increased expression of IFNB1 mRNA
Aripiprazole promotes the reaction [Ozone results in increased expression of IFNB1 mRNA]
CTD PMID:31476115 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of IFNG mRNA CTD PMID:31476115 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifngr1 interferon gamma receptor 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IFNGR1 mRNA CTD PMID:31476115 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IKBKE mRNA CTD PMID:31476115 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Il11 interleukin 11 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL11 mRNA CTD PMID:31476115 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL1A mRNA CTD PMID:31476115 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL1B mRNA CTD PMID:31476115 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r2 interleukin 1 receptor type 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL1R2 mRNA CTD PMID:31476115 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
JBrowse link
G Il1rap interleukin 1 receptor accessory protein multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL1RAP mRNA CTD PMID:31476115 NCBI chr11:74,062,999...74,199,530
Ensembl chr11:74,070,304...74,199,530
JBrowse link
G Il1rapl2 interleukin 1 receptor accessory protein-like 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL1RAPL2 mRNA CTD PMID:31476115 NCBI chr  X:100,961,509...102,271,753
Ensembl chr  X:100,961,812...102,271,753
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL1RL1 mRNA CTD PMID:31476115 NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL23A mRNA CTD PMID:31476115 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il24 interleukin 24 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL24 mRNA CTD PMID:31476115 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il2rg interleukin 2 receptor subunit gamma multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of IL2RG mRNA CTD PMID:31476115 NCBI chr  X:66,395,330...66,399,026
Ensembl chr  X:66,392,542...66,399,823
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL4R mRNA CTD PMID:31476115 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL5 mRNA CTD PMID:31476115 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL6 mRNA; Aripiprazole promotes the reaction [Ozone results in increased expression of IL6 mRNA] CTD PMID:31476115 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il7r interleukin 7 receptor multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of IL7R mRNA CTD PMID:31476115 NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of INPP5D mRNA CTD PMID:31476115 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 multiple interactions ISO Aripiprazole promotes the reaction [Ozone results in increased expression of IRAK2 mRNA] CTD PMID:31476115 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
JBrowse link
G Irf8 interferon regulatory factor 8 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of IRF8 mRNA CTD PMID:31476115 NCBI chr19:48,790,483...48,812,363
Ensembl chr19:48,790,588...48,811,829
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 increases expression
multiple interactions
ISO Aripiprazole results in increased expression of ISG20 mRNA
[Aripiprazole co-treated with Ozone] results in increased expression of ISG20 mRNA
CTD PMID:31476115 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of ITGA2 mRNA CTD PMID:31476115 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itga5 integrin subunit alpha 5 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of ITGA5 mRNA CTD PMID:31476115 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Aripiprazole inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Aripiprazole results in decreased activity of KCNH2 protein
CTD PMID:21158687 PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 increases expression EXP Aripiprazole results in increased expression of KCNJ3 mRNA CTD PMID:17868501 NCBI chr 3:39,944,896...40,106,646
Ensembl chr 3:39,945,351...40,109,124
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of LIF mRNA CTD PMID:31476115 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lrrn3 leucine rich repeat neuronal 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of LRRN3 mRNA CTD PMID:31476115 NCBI chr 6:58,489,060...58,520,322
Ensembl chr 6:58,489,010...58,520,330
JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of LTA mRNA CTD PMID:31476115 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Ltb lymphotoxin beta multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of LTB mRNA CTD PMID:31476115 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of LYN mRNA CTD PMID:31476115 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Maob monoamine oxidase B increases expression EXP Aripiprazole results in increased expression of MAOB mRNA CTD PMID:17868501 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression EXP Aripiprazole results in increased expression of MAPK6 mRNA CTD PMID:17868501 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of MAPKAPK2 mRNA CTD PMID:31476115 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of NFKB1 mRNA CTD PMID:31476115 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO Aripiprazole promotes the reaction [Ozone results in increased expression of NFKB2 mRNA] CTD PMID:31476115 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of NFKBIA mRNA CTD PMID:31476115 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of NLRP3 mRNA CTD PMID:31476115 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions
increases expression
ISO [Aripiprazole co-treated with Ozone] results in increased expression of NOD2 mRNA
Aripiprazole results in increased expression of NOD2 mRNA
CTD PMID:31476115 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Npdc1 neural proliferation, differentiation and control, 1 decreases expression EXP Aripiprazole results in decreased expression of NPDC1 mRNA CTD PMID:17868501 NCBI chr 3:8,220,446...8,226,446 JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of NT5E mRNA CTD PMID:31476115 NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
JBrowse link
G Ntm neurotrimin decreases expression EXP Aripiprazole results in decreased expression of NTM mRNA CTD PMID:17868501 NCBI chr 8:27,376,582...28,366,604
Ensembl chr 8:27,377,773...28,366,595
JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of PDCD1LG2 mRNA CTD PMID:31476115 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938
JBrowse link
G Pdgfc platelet derived growth factor C multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of PDGFC mRNA CTD PMID:31476115 NCBI chr 2:166,316,870...166,493,449
Ensembl chr 2:166,316,803...166,493,433
JBrowse link
G Pdp1 pyruvate dehydrogenase phosphatase catalytic subunit 1 increases expression EXP Aripiprazole results in increased expression of PDP1 mRNA CTD PMID:17868501 NCBI chr 5:25,446,843...25,455,107
Ensembl chr 5:25,446,272...25,455,217
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of PLAU mRNA CTD PMID:31476115 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of PLAUR mRNA CTD PMID:31476115 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Pou2f2 POU class 2 homeobox 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of POU2F2 mRNA CTD PMID:31476115 NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261
JBrowse link
G Prg2 proteoglycan 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of PRG2 mRNA CTD PMID:31476115 NCBI chr 3:70,062,535...70,066,102
Ensembl chr 3:70,062,535...70,066,101
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of PRKCD mRNA CTD PMID:31476115 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352
JBrowse link
G Prl prolactin multiple interactions
increases secretion
decreases secretion
decreases expression
ISO
EXP
Aripiprazole inhibits the reaction [haloperidol decanoate results in increased expression of PRL protein]; Aripiprazole inhibits the reaction [Risperidone results in increased secretion of PRL protein]
Aripiprazole results in increased secretion of PRL protein
Aripiprazole results in decreased secretion of PRL protein
Aripiprazole inhibits the reaction [talipexole results in decreased secretion of PRL protein]; Haloperidol inhibits the reaction [Aripiprazole results in decreased secretion of PRL protein]
Aripiprazole results in decreased expression of PRL protein
CTD PMID:8613910 PMID:17873694 PMID:19230981 PMID:19519261 PMID:19653986 More... NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prodh1 proline dehydrogenase 1 decreases expression EXP Aripiprazole results in decreased expression of PRODH mRNA CTD PMID:17868501 NCBI chr11:82,910,043...82,927,305
Ensembl chr11:82,910,137...82,927,305
JBrowse link
G Psmc6 proteasome 26S subunit, ATPase 6 increases expression EXP Aripiprazole results in increased expression of PSMC6 mRNA CTD PMID:17868501 NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of PTGS2 mRNA CTD PMID:31476115 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of PYCARD mRNA CTD PMID:31476115 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rab3a RAB3A, member RAS oncogene family increases expression EXP Aripiprazole results in increased expression of RAB3A mRNA CTD PMID:17868501 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression EXP Aripiprazole results in increased expression of RASD1 mRNA CTD PMID:17868501 NCBI chr10:44,766,451...44,775,773
Ensembl chr10:44,766,455...44,768,186
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of RELB mRNA CTD PMID:31476115 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507
JBrowse link
G Sae1 SUMO1 activating enzyme subunit 1 increases expression EXP Aripiprazole results in increased expression of SAE1 mRNA CTD PMID:17868501 NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
JBrowse link
G Sbno2 strawberry notch homolog 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of SBNO2 mRNA CTD PMID:31476115 NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527
JBrowse link
G Serpinb2 serpin family B member 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of SERPINB2 mRNA CTD PMID:31476115 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Sh2b2 SH2B adaptor protein 2 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of SH2B2 mRNA CTD PMID:31476115 NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844
JBrowse link
G Slamf6 SLAM family member 6 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of SLAMF6 mRNA CTD PMID:31476115 NCBI chr13:84,384,561...84,405,300
Ensembl chr13:84,383,742...84,405,300
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects binding ISO Aripiprazole binds to SLC6A4 protein CTD PMID:21823597 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression EXP Aripiprazole results in decreased expression of SLCO2B1 mRNA CTD PMID:17868501 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link
G Slit3 slit guidance ligand 3 increases expression EXP Aripiprazole results in increased expression of SLIT3 mRNA CTD PMID:17868501 NCBI chr10:19,571,798...20,156,634
Ensembl chr10:19,571,684...20,156,634
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of SMAD3 mRNA CTD PMID:31476115 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Socs1 suppressor of cytokine signaling 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of SOCS1 mRNA CTD PMID:31476115 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Syt17 synaptotagmin 17 decreases expression
multiple interactions
ISO Aripiprazole results in decreased expression of SYT17 mRNA
[Aripiprazole co-treated with Ozone] results in decreased expression of SYT17 mRNA
CTD PMID:31476115 NCBI chr 1:172,695,275...172,761,906
Ensembl chr 1:172,696,120...172,761,960
JBrowse link
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of TAB1 mRNA CTD PMID:31476115 NCBI chr 7:111,675,829...111,707,058
Ensembl chr 7:111,686,371...111,707,058
JBrowse link
G Tacr3 tachykinin receptor 3 decreases expression
increases expression
EXP Aripiprazole results in decreased expression of TACR3 mRNA
Aripiprazole results in increased expression of TACR3 mRNA
CTD PMID:17868501 NCBI chr 2:223,266,536...223,363,791
Ensembl chr 2:223,266,536...223,363,791
JBrowse link
G Thbd thrombomodulin multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of THBD mRNA CTD PMID:31476115 NCBI chr 3:135,863,366...135,867,018
Ensembl chr 3:135,862,835...135,867,193
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions ISO Aripiprazole inhibits the reaction [Ozone results in increased expression of THBS1 mRNA] CTD PMID:31476115 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of TICAM1 mRNA CTD PMID:31476115 NCBI chr 9:1,102,559...1,115,573 JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of TLR3 mRNA CTD PMID:31476115 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr5 toll-like receptor 5 increases expression
multiple interactions
ISO Aripiprazole results in increased expression of TLR5 mRNA
[Aripiprazole co-treated with Ozone] results in decreased expression of TLR5 mRNA
CTD PMID:31476115 NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Aripiprazole promotes the reaction [Ozone results in increased expression of TNF mRNA] CTD PMID:31476115 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip3 TNF alpha induced protein 3 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of TNFAIP3 mRNA CTD PMID:31476115 NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO Aripiprazole inhibits the reaction [Ozone results in increased expression of TNFRSF11B mRNA] CTD PMID:31476115 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF12A mRNA CTD PMID:31476115 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of TNFRSF14 mRNA CTD PMID:31476115 NCBI chr 5:165,486,069...165,494,421
Ensembl chr 5:165,484,262...165,493,703
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF1B mRNA CTD PMID:31476115 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tnfrsf8 TNF receptor superfamily member 8 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF8 mRNA CTD PMID:31476115 NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of TNFRSF9 mRNA CTD PMID:31476115 NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of TNFSF10 mRNA CTD PMID:31476115 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tnfsf12 TNF superfamily member 12 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in decreased expression of TNFSF12 mRNA CTD PMID:31476115 NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
JBrowse link
G Tnfsf15 TNF superfamily member 15 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of TNFSF15 mRNA CTD PMID:31476115 NCBI chr 5:77,140,099...77,156,142
Ensembl chr 5:77,139,878...77,156,228
JBrowse link
G Tnfsf18 TNF superfamily member 18 multiple interactions ISO [Aripiprazole co-treated with Ozone] results in increased expression of TNFSF18 mRNA CTD PMID:31476115 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169
JBrowse link
G Tubb2a tubulin, beta 2A class IIa decreases expression EXP Aripiprazole results in decreased expression of TUBB2A mRNA CTD PMID:17868501 NCBI chr17:30,796,842...30,800,713
Ensembl chr17:30,747,503...30,800,714
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Aripiprazole promotes the reaction [Ozone results in increased expression of VEGFA mRNA] CTD PMID:31476115 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase increases expression EXP Aripiprazole results in increased expression of WEE1 mRNA CTD PMID:17868501 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
JBrowse link
G Zfp354c zinc finger protein 354C increases expression EXP Aripiprazole results in increased expression of ZNF354C mRNA CTD PMID:17868501 NCBI chr10:35,129,720...35,145,717
Ensembl chr10:35,132,959...35,145,661
JBrowse link
carteolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Carteolol binds to and results in decreased activity of ADRB1 protein CTD PMID:11436944 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Carteolol binds to and results in decreased activity of ADRB2 protein CTD PMID:11436944 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
ciprofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Ciprofloxacin results in decreased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Ciprofloxacin results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases export
multiple interactions
increases expression
ISO ABCC4 protein results in increased export of Ciprofloxacin
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin
Ciprofloxacin results in increased expression of ABCC4 mRNA; Ciprofloxacin results in increased expression of ABCC4 protein
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin; Gemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin]
CTD PMID:19307362 PMID:22162766 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Ciprofloxacin results in increased expression of ABCG2 protein CTD PMID:26947806 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of AKT1 protein CTD PMID:26947806 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Ciprofloxacin results in increased expression of ALDH1A1 protein CTD PMID:26947806 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases localization
increases expression
ISO BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein]
Ciprofloxacin results in increased expression of BAX protein
CTD PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Etoposide co-treated with Ciprofloxacin] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein] CTD PMID:11832715 PMID:12063570 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Ciprofloxacin results in increased cleavage of and results in increased activity of CASP3 protein
Ciprofloxacin results in increased activity of CASP3 protein
CTD PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Ciprofloxacin results in increased activity of CASP8 protein CTD PMID:11875713 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Ciprofloxacin results in increased activity of CASP9 protein CTD PMID:11875713 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cav1 caveolin 1 increases expression ISO Ciprofloxacin results in increased expression of CAV1 protein CTD PMID:26947806 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO
EXP
Ciprofloxacin results in decreased expression of CCNB1 protein
Ciprofloxacin results in increased expression of CCNB1 mRNA; Ciprofloxacin results in increased expression of CCNB1 protein
CTD PMID:10741713 PMID:18512786 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Ciprofloxacin results in decreased expression of CCNE1 protein CTD PMID:10741713 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Ciprofloxacin results in increased expression of CD44 protein CTD PMID:26947806 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Ciprofloxacin results in increased expression of CDK1 mRNA; Ciprofloxacin results in increased expression of CDK1 protein CTD PMID:18512786 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases phosphorylation ISO Ciprofloxacin results in decreased phosphorylation of CDK2 protein CTD PMID:10741713 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Ciprofloxacin results in decreased expression of CDKN1A; Ciprofloxacin results in decreased expression of CDKN1A protein CTD PMID:10741713 PMID:12063570 PMID:12632069 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA] CTD PMID:11052920 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP Ciprofloxacin results in increased expression of CHEK1 protein CTD PMID:18512786 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Ciprofloxacin results in increased expression of CSF2 protein CTD PMID:11125792 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Ciprofloxacin results in decreased expression of CXCL2 protein CTD PMID:18197910 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine] CTD PMID:11145498 PMID:11151749 PMID:15592331 PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Ciprofloxacin results in decreased expression of CYP2C11 mRNA CTD PMID:12621481 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Ciprofloxacin results in decreased activity of CYP3A4 protein CTD PMID:11145498 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Ciprofloxacin results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:12621481 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases activity
EXP Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
Ciprofloxacin results in decreased activity of DHODH protein
CTD PMID:9776318 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression ISO Ciprofloxacin results in decreased expression of FGF15 mRNA CTD PMID:24657338 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases response to substance ISO G6PD protein mutant form results in increased susceptibility to Ciprofloxacin CTD PMID:20127091 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein] CTD PMID:29679711 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in increased expression of IFNG mRNA; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]]
Ciprofloxacin results in decreased expression of IFNG protein
CTD PMID:16006447 PMID:16968468 PMID:18337667 PMID:19401694 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]]
CTD PMID:16939481 PMID:19401694 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:16968468 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
Ciprofloxacin results in decreased expression of IL1B protein
CTD PMID:9267955 PMID:11052920 PMID:12428247 PMID:16148020 PMID:18197910 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]] CTD PMID:19401694 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 increases expression ISO Ciprofloxacin results in increased expression of IL3 mRNA; Ciprofloxacin results in increased expression of IL3 protein CTD PMID:11125792 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 decreases expression ISO Ciprofloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:9267955 PMID:11052920 PMID:19401694 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Ciprofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA CTD PMID:29679711 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of MAPK1 protein CTD PMID:26947806 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of MAPK3 protein CTD PMID:26947806 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mb myoglobin multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein CTD PMID:29679711 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Ciprofloxacin results in increased expression of MCL1 protein CTD PMID:32437906 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA CTD PMID:29679711 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217
JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA CTD PMID:29679711 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Ciprofloxacin results in decreased expression of MITF protein CTD PMID:32437906 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
Ciprofloxacin results in increased expression of MMP1 mRNA
CTD PMID:12428247 PMID:16148020 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
Ciprofloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin results in increased expression of MMP3 mRNA
CTD PMID:12428247 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Ciprofloxacin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:24101390 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nanog Nanog homeobox increases expression ISO Ciprofloxacin results in increased expression of NANOG protein CTD PMID:26947806 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 decreases response to substance ISO NOD2 gene SNP results in decreased susceptibility to Ciprofloxacin CTD PMID:18371140 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Ciprofloxacin results in increased expression of NR0B2 mRNA CTD PMID:24657338 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ciprofloxacin results in increased cleavage of PARP1 protein CTD PMID:10741713 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Ciprofloxacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:159,582,746...159,598,945 JBrowse link
G Plk1 polo-like kinase 1 increases expression EXP Ciprofloxacin results in increased expression of PLK1 protein CTD PMID:18512786 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Ciprofloxacin results in decreased activity of PON1 protein CTD PMID:16880604 PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO Ciprofloxacin results in increased expression of POU5F1 protein CTD PMID:26947806 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prom1 prominin 1 increases expression ISO Ciprofloxacin results in increased expression of PROM1 protein CTD PMID:26947806 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Ciprofloxacin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Ciprofloxacin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects localization
decreases expression
ISO Ciprofloxacin affects the localization of SLC2A1 mRNA
Ciprofloxacin results in decreased expression of SLC2A1 mRNA
CTD PMID:19022360 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc51b solute carrier family 51 subunit beta decreases expression ISO Ciprofloxacin results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases expression ISO Ciprofloxacin results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO Ciprofloxacin results in decreased expression of SNAI1 protein CTD PMID:26947806 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO Ciprofloxacin results in decreased expression of SNAI2 protein CTD PMID:26947806 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Ciprofloxacin results in decreased expression of SOX2 protein CTD PMID:26947806 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO
EXP
Ciprofloxacin results in increased expression of TGFB1 mRNA
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TGFB1 mRNA
CTD PMID:18337667 PMID:19371339 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression ISO Ciprofloxacin results in decreased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TNF mRNA; [irinotecan co-treated with Ciprofloxacin] promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]]
Ciprofloxacin results in decreased expression of TNF protein
CTD PMID:9267955 PMID:11052920 PMID:16939481 PMID:16968468 PMID:18197910 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha affects binding
multiple interactions
ISO Ciprofloxacin binds to TOP2A protein
[Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein]; [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein]
CTD PMID:21413765 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349
JBrowse link
difloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO difloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
enrofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cat catalase multiple interactions
decreases activity
EXP Selenium inhibits the reaction [enrofloxacin results in decreased activity of CAT protein] CTD PMID:27083143 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Enrofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
gatifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gcg glucagon increases secretion
increases expression
multiple interactions
ISO
EXP
gatifloxacin results in increased secretion of GCG protein
gatifloxacin results in increased expression of GCG protein
[gatifloxacin co-treated with GCG protein] affects the secretion of INS1 protein; GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA]; GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA]
Diazoxide inhibits the reaction [gatifloxacin results in increased secretion of GCG protein]
gatifloxacin results in increased expression of GCG mRNA
CTD PMID:23200776 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gcgr glucagon receptor multiple interactions
affects expression
EXP GCG protein promotes the reaction [gatifloxacin affects the expression of GCGR mRNA] CTD PMID:23200776 NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640
JBrowse link
G Ins2 insulin 2 multiple interactions
decreases expression
EXP GCG protein affects the reaction [gatifloxacin results in decreased expression of INS2 mRNA] CTD PMID:23200776 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO [Gatifloxacin binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; Gatifloxacin binds to and results in decreased activity of KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 increases expression ISO gatifloxacin results in increased expression of PCSK1 mRNA CTD PMID:23200776 NCBI chr 2:4,395,543...4,442,434
Ensembl chr 2:4,395,543...4,442,434
JBrowse link
ivacaftor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity
ISO [ivacaftor co-treated with Colforsin co-treated with lumacaftor] results in increased activity of CFTR protein mutant form; [ivacaftor co-treated with Colforsin] results in increased activity of CFTR protein; [ivacaftor results in increased activity of CFTR protein mutant form] which affects the transport of Sodium; [ivacaftor results in increased activity of CFTR protein mutant form] which results in increased secretion of Chlorides
ivacaftor results in increased activity of CFTR protein; ivacaftor results in increased activity of CFTR protein mutant form
CTD PMID:19846789 PMID:21083385 PMID:21602569 PMID:32374624 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
lomefloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO lomefloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
moxifloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma decreases expression ISO moxifloxacin results in decreased expression of IFNG protein CTD PMID:16006447 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO moxifloxacin results in decreased secretion of IL1B protein CTD PMID:16352735 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 decreases expression ISO moxifloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO moxifloxacin results in decreased activity of KCNH2 protein CTD PMID:24052561 PMID:27553911 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK1 protein CTD PMID:16352735 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO moxifloxacin results in decreased phosphorylation of MAPK3 protein CTD PMID:16352735 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases secretion
decreases secretion
ISO Moxifloxacin results in increased secretion of MMP1 protein
Moxifloxacin results in decreased secretion of MMP1 protein
CTD PMID:24890593 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp3 matrix metallopeptidase 3 decreases secretion
increases secretion
ISO Moxifloxacin results in decreased secretion of MMP3 protein
Moxifloxacin results in increased secretion of MMP3 protein
CTD PMID:24890593 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases secretion ISO Moxifloxacin results in decreased secretion of MMP9 protein CTD PMID:24890593 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Moxifloxacin results in decreased activity of PON1 protein CTD PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO moxifloxacin results in decreased expression of RELA protein CTD PMID:16352735 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO moxifloxacin results in decreased secretion of TNF protein CTD PMID:16352735 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [moxifloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of moxifloxacin CTD PMID:15769885 NCBI chr 9:88,696,981...88,808,465 JBrowse link
norfloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Norfloxacin results in increased expression of AIFM1 protein CTD PMID:32320760 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression ISO Norfloxacin results in increased expression of BAD protein CTD PMID:32320760 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Norfloxacin results in increased expression of BAX protein CTD PMID:32320760 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Norfloxacin results in decreased expression of BCL2 protein CTD PMID:32320760 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp2 caspase 2 affects activity ISO Norfloxacin affects the activity of CASP2 protein CTD PMID:32320760 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
JBrowse link
G Casp8 caspase 8 affects activity ISO Norfloxacin affects the activity of CASP8 protein CTD PMID:32320760 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects binding
multiple interactions
EXP Norfloxacin binds to CYP1A2 protein
Norfloxacin inhibits the reaction [CYP1A2 protein results in increased metabolism of Phenacetin]
CTD PMID:8905919 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Norfloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Norfloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
[biphenylylacetic acid co-treated with Norfloxacin] results in increased expression of IL1B mRNA; [biphenylylacetic acid co-treated with Norfloxacin] results in increased expression of IL1B protein
CTD PMID:16148020 PMID:16824509 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Norfloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Norfloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Norfloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein] CTD PMID:16148020 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Norfloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Norfloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
Norfloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mr1 major histocompatibility complex, class I-related affects expression ISO Norfloxacin affects the expression of MR1 mRNA CTD PMID:25811541 NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Norfloxacin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
pefloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Pefloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
quinolin-2(1H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 multiple interactions ISO 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Isoflurophate]; 2-hydroxyquinoline inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] CTD PMID:21382471 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
streptonigrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases response to substance
ISO [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin; [Dimethyl Fumarate results in increased activity of NQO1 protein] which results in increased susceptibility to Streptonigrin
NQO1 protein results in increased susceptibility to Streptonigrin
CTD PMID:8615901 PMID:10368308 PMID:15655414 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
tipifarnib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 gene SNP affects the susceptibility to tipifarnib CTD PMID:15122075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tipifarnib inhibits the reaction [CSF2 protein results in increased phosphorylation of AKT1 protein] CTD PMID:22315502 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ap1b1 adaptor related protein complex 1 subunit beta 1 increases expression EXP tipifarnib results in increased expression of AP1B1 mRNA CTD PMID:16403772 NCBI chr14:79,879,482...79,930,778
Ensembl chr14:79,879,533...79,930,778
JBrowse link
G Apc APC regulator of WNT signaling pathway increases expression EXP tipifarnib results in increased expression of APC mRNA CTD PMID:16403772 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression EXP tipifarnib results in increased expression of BMP6 mRNA CTD PMID:16403772 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [tipifarnib co-treated with Paclitaxel] results in increased activity of CASP3 protein CTD PMID:15728126 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Tamoxifen co-treated with tipifarnib] results in decreased expression of CCND1 protein CTD PMID:17876043 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Tamoxifen co-treated with tipifarnib] results in increased expression of CDKN1B protein CTD PMID:17876043 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases activity
ISO tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK1 protein]; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK3 protein]; tipifarnib inhibits the reaction [CSF2 protein results in increased phosphorylation of AKT1 protein]
tipifarnib results in decreased activity of CSF2 protein
CTD PMID:22315502 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [tipifarnib co-treated with Paclitaxel] affects the localization of CYCS protein CTD PMID:15728126 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Fgf14 fibroblast growth factor 14 increases expression EXP tipifarnib results in increased expression of FGF14 mRNA CTD PMID:16403772 NCBI chr15:101,045,038...101,679,888
Ensembl chr15:101,045,036...101,679,900
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 increases expression EXP tipifarnib results in increased expression of FGFR2 mRNA CTD PMID:16403772 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Gabbr2 gamma-aminobutyric acid type B receptor subunit 2 increases expression EXP tipifarnib results in increased expression of GABBR2 mRNA CTD PMID:16403772 NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP tipifarnib results in decreased expression of GNAI2 mRNA CTD PMID:16403772 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Hras HRas proto-oncogene, GTPase increases response to substance
decreases metabolic processing
EXP
ISO
HRAS gene mutant form results in increased susceptibility to tipifarnib
tipifarnib results in decreased metabolism of HRAS protein
CTD PMID:15728126 PMID:16403772 PMID:16648579 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Igf2 insulin-like growth factor 2 increases expression EXP tipifarnib results in increased expression of IGF2 mRNA CTD PMID:16403772 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Il18 interleukin 18 multiple interactions ISO geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein]]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL18 protein] CTD PMID:21430599 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO tipifarnib inhibits the reaction [[MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL1B protein]
geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]]; tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL1B protein]
CTD PMID:21430599 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Jak3 Janus kinase 3 increases expression EXP tipifarnib results in increased expression of JAK3 mRNA CTD PMID:16403772 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression EXP tipifarnib results in increased expression of KRAS mRNA CTD PMID:16403772 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 increases expression EXP tipifarnib results in increased expression of LPAR1 mRNA CTD PMID:16403772 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895
JBrowse link
G Maf MAF bZIP transcription factor increases expression EXP tipifarnib results in increased expression of MAF mRNA CTD PMID:16403772 NCBI chr19:43,353,867...43,713,162
Ensembl chr19:43,360,342...43,712,365
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP tipifarnib results in increased expression of MAP3K1 mRNA CTD PMID:16403772 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK1 protein; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK1 protein] CTD PMID:19383813 PMID:22315502 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases expression EXP tipifarnib results in increased expression of MAPK12 mRNA CTD PMID:16403772 NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK3 protein; tipifarnib inhibits the reaction [CSF2 protein results in decreased phosphorylation of MAPK3 protein] CTD PMID:19383813 PMID:22315502 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mos MOS proto-oncogene, serine/threonine kinase increases expression EXP tipifarnib results in increased expression of MOS mRNA CTD PMID:16403772 NCBI chr 5:16,859,957...16,861,264
Ensembl chr 5:16,859,957...16,861,264
JBrowse link
G Mras muscle RAS oncogene homolog increases expression EXP tipifarnib results in increased expression of MRAS mRNA CTD PMID:16403772 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
JBrowse link
G Mrgprf MAS related GPR family member F increases expression EXP tipifarnib results in increased expression of MRGPRF mRNA CTD PMID:16403772 NCBI chr 1:200,464,100...200,473,588
Ensembl chr 1:200,463,973...200,473,660
JBrowse link
G Mvk mevalonate kinase multiple interactions ISO tipifarnib inhibits the reaction [[MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] which results in increased secretion of IL1B protein]; tipifarnib inhibits the reaction [MVK protein mutant form results in increased susceptibility to lipopolysaccharide, E coli O55-B5] CTD PMID:21430599 NCBI chr12:42,141,391...42,158,858
Ensembl chr12:42,141,384...42,158,882
JBrowse link
G Mybbp1a MYB binding protein 1a increases expression EXP tipifarnib results in increased expression of MYBBP1A mRNA CTD PMID:16403772 NCBI chr10:57,056,913...57,067,263
Ensembl chr10:57,056,874...57,067,255
JBrowse link
G Ndrg2 NDRG family member 2 decreases expression EXP tipifarnib results in decreased expression of NDRG2 mRNA CTD PMID:16403772 NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626
JBrowse link
G Nf2 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor increases expression EXP tipifarnib results in increased expression of NF2 mRNA CTD PMID:16403772 NCBI chr14:79,627,399...79,710,709
Ensembl chr14:79,627,399...79,710,667
JBrowse link
G Pgap2 post-GPI attachment to proteins 2 increases expression EXP tipifarnib results in increased expression of PGAP2 mRNA CTD PMID:16403772 NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma increases expression EXP tipifarnib results in increased expression of PIK3C2G mRNA CTD PMID:16403772 NCBI chr 4:172,483,752...172,851,623
Ensembl chr 4:172,484,345...172,850,544
JBrowse link
G Plaat3 phospholipase A and acyltransferase 3 increases expression EXP tipifarnib results in increased expression of PLAAT3 mRNA CTD PMID:16403772 NCBI chr 1:204,782,608...204,816,397
Ensembl chr 1:204,782,729...204,817,667
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO tipifarnib promotes the reaction [PTPN11 protein mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] CTD PMID:22315502 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Rab14 RAB14, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB14 mRNA CTD PMID:16403772 NCBI chr 3:18,501,953...18,523,253
Ensembl chr 3:18,501,963...18,523,172
JBrowse link
G Rab29 RAB29, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB29 mRNA CTD PMID:16403772 NCBI chr13:43,307,757...43,313,420
Ensembl chr13:43,307,775...43,313,417
JBrowse link
G Rab2a RAB2A, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB2 mRNA CTD PMID:16403772 NCBI chr 5:21,676,219...21,738,833
Ensembl chr 5:21,676,129...21,739,899
JBrowse link
G Rab38 RAB38, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB38 mRNA CTD PMID:16403772 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Rab3c RAB3C, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB3C mRNA CTD PMID:16403772 NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:41,627,720...41,843,749
JBrowse link
G Rab8b RAB8B, member RAS oncogene family increases expression EXP tipifarnib results in increased expression of RAB8B mRNA CTD PMID:16403772 NCBI chr 8:67,458,921...67,536,466
Ensembl chr 8:67,458,923...67,536,384
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase increases expression EXP tipifarnib results in increased expression of RAF1 mRNA CTD PMID:16403772 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Ralgds ral guanine nucleotide dissociation stimulator decreases expression EXP tipifarnib results in decreased expression of RALGDS mRNA CTD PMID:16403772 NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059
JBrowse link
G Rgs8 regulator of G-protein signaling 8 increases expression EXP tipifarnib results in increased expression of RGS8 mRNA CTD PMID:16403772 NCBI chr13:65,804,703...65,848,953
Ensembl chr13:65,804,797...65,846,807
JBrowse link
G Rheb Ras homolog, mTORC1 binding multiple interactions
decreases activity
ISO [tipifarnib results in decreased activity of RHEB protein] which results in increased susceptibility to Cisplatin CTD PMID:20554106 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Rin1 Ras and Rab interactor 1 increases expression EXP tipifarnib results in increased expression of RIN1 mRNA CTD PMID:16403772 NCBI chr 1:202,355,729...202,362,731
Ensembl chr 1:202,355,890...202,362,729
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases expression EXP tipifarnib results in increased expression of ROCK1 mRNA CTD PMID:16403772 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 increases expression EXP tipifarnib results in increased expression of ROCK2 mRNA CTD PMID:16403772 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression EXP tipifarnib results in increased expression of RRAD mRNA CTD PMID:16403772 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP tipifarnib results in decreased expression of TGFB1 mRNA CTD PMID:16403772 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP tipifarnib results in increased expression of TGFBR2 mRNA CTD PMID:16403772 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO geraniol promotes the reaction [tipifarnib inhibits the reaction [[Alendronate co-treated with Lovastatin co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of TNF protein]] CTD PMID:21430599 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 decreases expression EXP tipifarnib results in decreased expression of TP53 mRNA CTD PMID:16403772 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 increases expression EXP tipifarnib results in increased expression of VAV1 mRNA CTD PMID:16403772 NCBI chr 9:2,161,985...2,209,951
Ensembl chr 9:2,157,900...2,208,937
JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression EXP tipifarnib results in increased expression of ZMAT3 mRNA CTD PMID:16403772 NCBI chr 2:115,106,050...115,136,863
Ensembl chr 2:115,106,966...115,136,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    chemical entity 19800
      molecular entity 19799
        polyatomic entity 19721
          molecule 19572
            organic molecule 19549
              organic cyclic compound 19343
                organic aromatic compound 19189
                  quinolines 2598
                    quinolone 306
                      (+)-Plicamine 0
                      (E)-1-hydroxy-2-(non-1-en-1-yl)quinolin-4-one 0
                      1,2,3,4-tetrahydroquinoline-2,4-dione 0
                      1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid + 0
                      1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-piperidin-4-yl-3,4-dihydroquinolin-2(1H)-one 0
                      1-Cyclopropyl-4-oxo-5-methyl-6-fluoro-7-[(2-aminoethyl)amino]-1,4-dihydroquinoline-3-carboxylic acid 0
                      1-Cyclopropyl-4-oxo-5-methyl-6-fluoro-7-[(2-aminopropyl)amino]-1,4-dihydroquinoline-3-carboxylic acid 0
                      1-allyl-4-hydroxy-2-oxo-N-(1,3-thiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide 0
                      1-allyl-4-hydroxy-2-oxo-N-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide 0
                      1-butyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-hydroxy-2-oxoquinoline-3-carboxamide 0
                      1-cyclohexyl-5-\{4-[(4-hydroxy-2-oxo-3,4-dihydro-1H-quinolin-6-yl)oxy]butyl\}-4H-1lambda5,2,3,4-tetrazol-1-ylium 0
                      1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-N-[4-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]-1,4-dihydroquinoline-3-carboxamide 0
                      1-cyclopropyl-6-fluoro-5-methyl-7-(3-methyl-4-sulfopiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 0
                      1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carbonyloxysulfonic acid 0
                      2-heptyl-3-hydroxy-4-quinolone 0
                      2-heptyl-4-quinolone 0
                      2-hydroxy-4-quinolone-3-carboxylic acid 0
                      3,4-Quinolinediol, 2-nonyl- 0
                      3-(5-\{[4-(aminomethyl)piperidin-1-yl]methyl\}-1H-indol-2-yl)quinolin-2(1H)-one 0
                      3-Methyl-quinolin-2,8-diol 0
                      3-Methyl-quinolin-2-ol 0
                      3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one 0
                      3-amino-7-hydroxy-3,4-dihydro-1H-quinolin-2-one 0
                      3-benzyl-4-hydroxyquinolin-2(1H)-one 0
                      3-farnesyl-3-hydroxy-2-methyl-1-oxo-1lambda(5)-quinolin-4-one 0
                      3-hydroxy-2-methylquinolin-4(1H)-one 0
                      3-hydroxyquinolin-4(1H)-one 0
                      3-methylquinolin-2(1H)-one 0
                      4-hydroxy-1-isobutyl-N-(4-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide 0
                      4-hydroxy-1-isobutyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide 0
                      4-hydroxy-1-isopentyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide 0
                      4-hydroxy-1-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydro-3-quinolinecarboxamide 0
                      4-hydroxy-2-quinolone 0
                      4-methylquinolin-2(1H)-one 0
                      4-quinolone + 0
                      4-quinolone-3-carboxaldehyde 0
                      5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one 0
                      5,6-dihydroxy-3-methylquinolin-2(1H)-one 0
                      5,8-Dihydroxy-3,4-dihydrocarbostyril 0
                      5-hydroxyquinolin-2(1H)-one 0
                      6-anilino-5,8-quinolinedione 7
                      6-chloro-4-hydroxy-3-(phenylmethyl)-1H-quinolin-2-one 0
                      6-chloro-7-[2-(4-morpholinyl)ethylamino]quinoline-5,8-dione 0
                      6-hydroxy-3-methylquinolin-2(1H)-one 0
                      6-hydroxyquinolin-2(1H)-one 0
                      7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one 0
                      7-hydroxy-4-methyl-1H-quinolin-2-one 0
                      7-hydroxyquinolin-2(1H)-one 0
                      8-chloroquinolin-2(1H)-one 0
                      8-hydroxyquinolin-2(1H)-one 0
                      8-methylquinolin-2(1H)-one 0
                      AS1842856 0
                      Diazaquinomycin A 0
                      ELQ-271 0
                      Indacaterol fumarate 0
                      LSM-1581 0
                      LSM-5335 0
                      LSM-5567 0
                      N-methylcorydaldine 0
                      Ofloxacin methyl ester 0
                      Quinolinediol 0
                      RSL5 0
                      Selagine 0
                      abediterol 0
                      aripiprazole 163
                      aripiprazole lauroxil 0
                      aurachin C + 0
                      carteolol 2
                      ciprofloxacin + 74
                      difloxacin 1
                      elvitegravir + 0
                      enrofloxacin 2
                      finafloxacin 0
                      gatifloxacin + 5
                      indacaterol 0
                      ivacaftor + 1
                      lomefloxacin + 1
                      moxifloxacin 16
                      norfloxacin 13
                      pefloxacin + 1
                      quinolin-2(1H)-one 1
                      sparfloxacin 0
                      streptonigrin 1
                      thalifolin 0
                      tipifarnib 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  organonitrogen heterocyclic compound 17661
                                    quinolines 2598
                                      quinolone 306
                                        (+)-Plicamine 0
                                        (E)-1-hydroxy-2-(non-1-en-1-yl)quinolin-4-one 0
                                        1,2,3,4-tetrahydroquinoline-2,4-dione 0
                                        1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid + 0
                                        1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-piperidin-4-yl-3,4-dihydroquinolin-2(1H)-one 0
                                        1-Cyclopropyl-4-oxo-5-methyl-6-fluoro-7-[(2-aminoethyl)amino]-1,4-dihydroquinoline-3-carboxylic acid 0
                                        1-Cyclopropyl-4-oxo-5-methyl-6-fluoro-7-[(2-aminopropyl)amino]-1,4-dihydroquinoline-3-carboxylic acid 0
                                        1-allyl-4-hydroxy-2-oxo-N-(1,3-thiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide 0
                                        1-allyl-4-hydroxy-2-oxo-N-(4-phenyl-1,3-thiazol-2-yl)-1,2-dihydroquinoline-3-carboxamide 0
                                        1-butyl-N-(5-ethyl-1,3,4-thiadiazol-2-yl)-4-hydroxy-2-oxoquinoline-3-carboxamide 0
                                        1-cyclohexyl-5-\{4-[(4-hydroxy-2-oxo-3,4-dihydro-1H-quinolin-6-yl)oxy]butyl\}-4H-1lambda5,2,3,4-tetrazol-1-ylium 0
                                        1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-N-[4-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)phenyl]-1,4-dihydroquinoline-3-carboxamide 0
                                        1-cyclopropyl-6-fluoro-5-methyl-7-(3-methyl-4-sulfopiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid 0
                                        1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carbonyloxysulfonic acid 0
                                        2-heptyl-3-hydroxy-4-quinolone 0
                                        2-heptyl-4-quinolone 0
                                        2-hydroxy-4-quinolone-3-carboxylic acid 0
                                        3,4-Quinolinediol, 2-nonyl- 0
                                        3-(5-\{[4-(aminomethyl)piperidin-1-yl]methyl\}-1H-indol-2-yl)quinolin-2(1H)-one 0
                                        3-Methyl-quinolin-2,8-diol 0
                                        3-Methyl-quinolin-2-ol 0
                                        3-[5-(piperidin-1-ylmethyl)-1H-indol-2-yl]-6-(1H-pyrazol-4-yl)quinolin-2(1H)-one 0
                                        3-amino-7-hydroxy-3,4-dihydro-1H-quinolin-2-one 0
                                        3-benzyl-4-hydroxyquinolin-2(1H)-one 0
                                        3-farnesyl-3-hydroxy-2-methyl-1-oxo-1lambda(5)-quinolin-4-one 0
                                        3-hydroxy-2-methylquinolin-4(1H)-one 0
                                        3-hydroxyquinolin-4(1H)-one 0
                                        3-methylquinolin-2(1H)-one 0
                                        4-hydroxy-1-isobutyl-N-(4-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide 0
                                        4-hydroxy-1-isobutyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide 0
                                        4-hydroxy-1-isopentyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide 0
                                        4-hydroxy-1-methyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxo-1,2-dihydro-3-quinolinecarboxamide 0
                                        4-hydroxy-2-quinolone 0
                                        4-methylquinolin-2(1H)-one 0
                                        4-quinolone + 0
                                        4-quinolone-3-carboxaldehyde 0
                                        5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one 0
                                        5,6-dihydroxy-3-methylquinolin-2(1H)-one 0
                                        5,8-Dihydroxy-3,4-dihydrocarbostyril 0
                                        5-hydroxyquinolin-2(1H)-one 0
                                        6-anilino-5,8-quinolinedione 7
                                        6-chloro-4-hydroxy-3-(phenylmethyl)-1H-quinolin-2-one 0
                                        6-chloro-7-[2-(4-morpholinyl)ethylamino]quinoline-5,8-dione 0
                                        6-hydroxy-3-methylquinolin-2(1H)-one 0
                                        6-hydroxyquinolin-2(1H)-one 0
                                        7-chloro-3-[cyclopropyl(oxo)methyl]-4-hydroxy-1H-quinolin-2-one 0
                                        7-hydroxy-4-methyl-1H-quinolin-2-one 0
                                        7-hydroxyquinolin-2(1H)-one 0
                                        8-chloroquinolin-2(1H)-one 0
                                        8-hydroxyquinolin-2(1H)-one 0
                                        8-methylquinolin-2(1H)-one 0
                                        AS1842856 0
                                        Diazaquinomycin A 0
                                        ELQ-271 0
                                        Indacaterol fumarate 0
                                        LSM-1581 0
                                        LSM-5335 0
                                        LSM-5567 0
                                        N-methylcorydaldine 0
                                        Ofloxacin methyl ester 0
                                        Quinolinediol 0
                                        RSL5 0
                                        Selagine 0
                                        abediterol 0
                                        aripiprazole 163
                                        aripiprazole lauroxil 0
                                        aurachin C + 0
                                        carteolol 2
                                        ciprofloxacin + 74
                                        difloxacin 1
                                        elvitegravir + 0
                                        enrofloxacin 2
                                        finafloxacin 0
                                        gatifloxacin + 5
                                        indacaterol 0
                                        ivacaftor + 1
                                        lomefloxacin + 1
                                        moxifloxacin 16
                                        norfloxacin 13
                                        pefloxacin + 1
                                        quinolin-2(1H)-one 1
                                        sparfloxacin 0
                                        streptonigrin 1
                                        thalifolin 0
                                        tipifarnib 57
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