Ccnd1 Rat Gene (cyclin D1) - Rat Genome Database

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Keyword

Gene:
Ccnd1 ( Rattus norvegicus )
cyclin D1
Description: a cell cycle protein involved in the regulation of cell proliferation; associated with many cancers and other diseases
ArrayIDs: 1371643_at; 6078295; X75207_s_at; 1371150_at; 1383075_at; 6258724; D14014_at; 6621309; rc_AI231257_at; 5619063; rc_AA957218_at; D14014_g_at; 5797996; rc_AI029058_s_at; 5637897; 6361635; 5926198;  (details...)
Gene Type: protein-coding

Additional Data

Homologs
Homo sapiens: CCND1     See the Human gene in context in:     UCSC     NCBI MapViewer

Mus musculus: Ccnd1     See the Mouse gene in context in:     UCSC     NCBI MapViewer

Comparative Map Data
Species Symbol Map Name Chr. Position
Rattus norvegicus Ccnd1 Rat Celera Assembly 1 197647116 - 197656584
RGSC genome assembly v3.4 1 205357283 - 205366751
Cytogenetic 1 q42
genome assembly 3.1 1 205510735 - 205520201
Mus musculus Ccnd1 Mouse genome assembly build 36.1 7 152115836 - 152125830
Cytogenetic 7 7 F5
Homo sapiens CCND1 human genome assembly 11 69165053 - 69178422
Human genome assembly build 36.2 11 69165054 - 69178423
Cytogenetic 11 q13

View comparative maps:      NCBI MapViewer

Genome
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Browsers:

Annotation
Molecular Function

Gene Ontology

protein kinase activity,  protein kinase binding,  protein complex binding ... (details...)
Biological Process

Note Reference

mediates hepatocyte proliferation 727766

required for G1 progression in the cell cycle 68222

Gene Ontology

re-entry into mitotic cell cycle,  regulation of cell cycle,  response to iron ion ... (details...)
Cellular Component

Gene Ontology

nucleus,  nucleoplasm,  intracellular ... (details...)
Disease

Note Reference

expression is lower in the thioacetamide-induced cirrhosis after partial hepatectomy 70813

Ontology

Carcinoma, Squamous Cell,  Penile Neoplasms,  Prostatic Intraepithelial Neoplasia ... (details...)
Phenotype

Ontology

tumorigenesis,  cardiac hypertrophy,  Increased Cell Size ... (details...)
Expression

Note Reference

significant in blood vessels of angiotensin 2 infused rats 68887

Pathway

Ontology

S phase pathway,  G1 phase pathway (details...)
Regulation

Note Reference

transcription inhibited by by nonessential amino acids (NEAA) deprivation 727766

induced by several different growth factors including colony stimulating factor-1, epidermal growth factor, and angiotensin 68887

External Links
Databases
DATABASE ID SOURCE
SMART: CYCLIN IPI
PROSITE: CYCLINS IPI
UNIPARC: UPI0000D57A19 IPI
UNIPARC: UPI00001275C1 IPI
KEGG Report: rno:58919 ENTREZGENE
HomoloGene Group ID: 1334 ENTREZGENE
Germonline: 68384
Pfam: Cyclin_C IPI
Pfam: Cyclin_N IPI
KEGG Pathway: 04310 ENTREZGENE
KEGG Pathway: 04115 ENTREZGENE
KEGG Pathway: 05216 ENTREZGENE
KEGG Pathway: 05222 ENTREZGENE
KEGG Pathway: 05221 ENTREZGENE
KEGG Pathway: 05219 ENTREZGENE
KEGG Pathway: 04110 ENTREZGENE
KEGG Pathway: 05220 ENTREZGENE
KEGG Pathway: 05210 ENTREZGENE
KEGG Pathway: 05213 ENTREZGENE
KEGG Pathway: 04510 ENTREZGENE
KEGG Pathway: 05214 ENTREZGENE
KEGG Pathway: 04630 ENTREZGENE
KEGG Pathway: 05218 ENTREZGENE
KEGG Pathway: 05223 ENTREZGENE
KEGG Pathway: 05212 ENTREZGENE
KEGG Pathway: 05200 ENTREZGENE
KEGG Pathway: 05215 ENTREZGENE
InterPro: Cyclin_related. IPI
InterPro: Cyclin_N. IPI
InterPro: Cyclin_C. IPI
InterPro: Cyclin_A_B_D_E. IPI
InterPro: Cyclin-like. IPI
InterPro: Cyclin. IPI
InterPro: CycD. IPI
IPI: IPI00952332 IPI
IPI: IPI00190352 IPI
Ensembl Protein: ENSRNOP00000063177 IPI
Ensembl Protein: ENSRNOP00000028411 IPI
Gene3D-CATH: Cyclin_related IPI
Entrez Gene: Ccnd1 ENTREZGENE
PIRSF: Cyclin_A_B_D_E IPI
UniProt: Q1JUA4_RAT IPI
UniProt: Q99NB4_RAT IPI
UniProt: Q1RP72_RAT IPI
UniProt: CCND1_RAT IPI
Ensembl Genes: ENSRNOG00000020918 IPI
Superfamily-SCOP: Cyclin_like IPI
PANTHER: CycD IPI
Sequences
Nucleotide: X75207 Get FASTA Search GEO Profiles
Nucleotide: EV775485 Get FASTA Search GEO Profiles
Nucleotide: D14014 Get FASTA Search GEO Profiles
Nucleotide: CB326145 Get FASTA Search GEO Profiles
Nucleotide: CA510842 Get FASTA Search GEO Profiles
Nucleotide: AM258963 Get FASTA Search GEO Profiles
Nucleotide: AB256048 Get FASTA Search GEO Profiles
Nucleotide: CH473953 Get FASTA Search GEO Profiles
Nucleotide: AF148946 Get FASTA Search GEO Profiles
Nucleotide: AF067056 Get FASTA Search GEO Profiles
Nucleotide: AB042564 Get FASTA Search GEO Profiles
Nucleotide: NM_171992 Get FASTA Search GEO Profiles
(View all 12 Nucleotide Accessions)
Protein: Q99NB4 Get FASTA
Protein: Q1RP72 Get FASTA
Protein: P39948 Get FASTA
Protein: CAA53020 Get FASTA
Protein: BAA03115 Get FASTA
Protein: CAJ88858 Get FASTA
Protein: BAE94258 Get FASTA
Protein: EDM12270 Get FASTA
Protein: EDM12269 Get FASTA
Protein: EDM12268 Get FASTA
Protein: EDM12267 Get FASTA
Protein: BAB40333 Get FASTA
Protein: NP_741989 Get FASTA
(View all 13 Protein Accessions)
Clusters
UniGene: 22279

References
Curated References
61 references in RGD related to Ccnd1

Other References
56 other references at PubMed related to Ccnd1

Database Information
RGD ID 68384
History

Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference

10-JUN-02: Ccnd1 cyclin D1 APPROVED Symbol and Name status set to approved 70586