RGD Reference Report - Synergistic effect of cyclin D1 and c-Myc leads to more aggressive and invasive mammary tumors in severe combined immunodeficient mice. - Rat Genome Database

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Synergistic effect of cyclin D1 and c-Myc leads to more aggressive and invasive mammary tumors in severe combined immunodeficient mice.

Authors: Wang, Y  Thakur, A  Sun, Y  Wu, J  Biliran, H  Bollig, A  Liao, DJ 
Citation: Wang Y, etal., Cancer Res. 2007 Apr 15;67(8):3698-707.
RGD ID: 2296037
Pubmed: PMID:17440082   (View Abstract at PubMed)
DOI: DOI:10.1158/0008-5472.CAN-06-4000   (Journal Full-text)

Cyclin D1 is one of the most commonly overexpressed oncogenes in breast cancer; yet, it is not clear whether cyclin D1 alone is capable of causing malignant transformation of mammary epithelial cells. Here, we show that ectopic expression of cyclin D1 in benign mouse mammary epithelial cells promotes cell proliferation, anchorage-independent growth in soft agar, and tumorigenesis in severe combined immunodeficient mice. To address the possible interaction of cyclin D1 and c-myc in malignant transformation, we used cyclin D1/c-myc dual-expressing clones, which displayed more aggressive and invasive phenotype than cyclin D1-expressing clones. These data provide evidence that overexpression of cyclin D1 or coexpression with c-myc could cause invasive malignant transformation of benign mouse mammary epithelial cells. Furthermore, microarray analysis of cyclin D1 and cyclin D1/c-myc clones showed that these two tumor-producing clones might use distinct invasive pathways. In summary, overexpression of cyclin D1 may commit mammary epithelia to a tumor-prone phenotype in which cooperation with other genes, such as synergy with c-myc, may lead to a more aggressive phenotype.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Mammary Neoplasms  ISOCcnd1 (Mus musculus)2296037; 2296037 RGD 
Experimental Mammary Neoplasms  IMP 2296037 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnd1  (cyclin D1)

Genes (Mus musculus)
Ccnd1  (cyclin D1)

Genes (Homo sapiens)
CCND1  (cyclin D1)


Additional Information