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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:7939
Term: parthenolide
Definition: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).
Chemical ID: MESH:C002669
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDparthenolide results in decreased expression of CCND1 mRNA; parthenolide results in decreased expression of CCND1 proteinPMID:21928377
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDparthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 mRNA]; parthenolide promotes the reaction [SC-203048 results in decreased expression of CCND1 protein]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 mRNA]; SC-203048 promotes the reaction [parthenolide results in decreased expression of CCND1 protein]PMID:21928377
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