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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:78761
Term: ML-7
Definition: An N-sulfonyldiazepane resullting from the formal condensation of 5-iodo-1-naphthylsulfonic acid with one of the nitrogens of 1,4-diazepane. It is a selective inhibitor of myosin light chain kinase (EC 2.7.11.18).
Chemical ID: MESH:C070571
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1multiple interactionsEXP 6480464CTDML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 mRNA]; ML 7 inhibits the reaction [EGF protein results in increased expression of CCND1 protein]PMID:16799973
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDML 7 results in decreased expression of CCND1 proteinPMID:18710790
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