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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:10136
Term: gingerol
Definition: A beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger.
Chemical ID: MESH:C007845
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDgingerol results in decreased expression of CCND1 mRNA; gingerol results in decreased expression of CCND1 proteinPMID:18058799 PMID:28249781
Ccnd1increases expressionISOCcnd1 (Mus musculus)6480464CTDgingerol results in increased expression of CCND1 mRNA; gingerol results in increased expression of CCND1 proteinPMID:26498061
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTD[gingerol co-treated with Cycloheximide] results in increased degradation of CCND1 proteinPMID:18058799
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