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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:6925
Term: microcystin-LR
Definition: A microcystin consisting of D-alanyl, L-leucyl, (3S)-3-methyl-D-beta-aspartyl,L-arginyl, 2S,3S,4E,6E,8S,9S)-3-amino-4,5,6,7-tetradehydro-9-methoxy-2,6,8-trimethyl-10-phenyldecanoyl, D-gamma-glutamyl, and 2,3-didehydro-N-methylalanyl residues joined into a 25-membered macrocycle. Produced by the cyanobacterium Microcystis aeruginosa, it is the most studied of the microcystins.
Chemical ID: MESH:C057862
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCcnd1 (Mus musculus)6480464CTDcyanoginosin LR results in decreased expression of CCND1 mRNA; cyanoginosin LR results in decreased expression of CCND1 proteinPMID:28414124
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDcyanoginosin LR results in increased expression of CCND1 proteinPMID:36115647
Ccnd1increases expressionISOCcnd1 (Mus musculus)6480464CTDcyanoginosin LR results in increased expression of CCND1 mRNA; cyanoginosin LR results in increased expression of CCND1 proteinPMID:17654400 PMID:36115647 PMID:36288207
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDMK 2206 inhibits the reaction [cyanoginosin LR results in increased expression of CCND1 protein]PMID:36115647
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTDWortmannin inhibits the reaction [cyanoginosin LR results in increased expression of CCND1 protein]PMID:36288207
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