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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CCND1 mRNAPMID:22298810 PMID:34747641
Ccnd1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CCND1 mRNAPMID:16054898 PMID:21215274
Ccnd1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CCND1 mRNA; Tetrachlorodibenzodioxin results in increased expression of CCND1 proteinPMID:21496263 PMID:24136580 PMID:24231000 PMID:33387578
Ccnd1multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; [Tetrachlorodibenzodioxin binds to and results in increased activity of AHR protein] which results in decreased expression of CCND1 mRNA; AHR mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CCND1 mRNA]; resveratrol inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CCND1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of CCND1 protein]; XAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 mRNA]; XAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]PMID:21215274 PMID:21602191 PMID:24136580 PMID:24231000
Ccnd1affects expressionISOCCND1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin affects the expression of CCND1 mRNAPMID:20106945
Ccnd1affects expressionISOCcnd1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CCND1 mRNAPMID:21570461 PMID:28922406
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CCND1 mRNA; Tetrachlorodibenzodioxin results in decreased expression of CCND1 proteinPMID:15322241 PMID:16039398 PMID:9705214
Ccnd1decreases expressionISOCcnd1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CCND1 mRNA; Tetrachlorodibenzodioxin results in decreased expression of CCND1 proteinPMID:15652763 PMID:16611356 PMID:24013123 PMID:33956508
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of CCND1 mRNA; Tetrachlorodibenzodioxin results in increased expression of CCND1 proteinPMID:21496263 PMID:21632981 PMID:27312872
Ccnd1increases expressionISOCcnd1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CCND1 mRNAPMID:14728982 PMID:21496263
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; Estradiol promotes the reaction [Tetrachlorodibenzodioxin promotes the reaction [CDKN1A protein binds to CCND1 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[AHR protein binds to CDK4 protein binds to CCND1 protein] which results in increased phosphorylation of RB1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CCND1 protein]; Tetrachlorodibenzodioxin promotes the reaction [CDKN1A protein binds to CCND1 protein]PMID:19917880 PMID:27312872 PMID:9705214
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CCND1 protein]; 3'-methoxy-4'-nitroflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CCND1 protein]; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CCND1 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of CCND1 mRNA; AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of CCND1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [SHH protein results in increased expression of CCND1 protein]; Tetrachlorodibenzodioxin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [CDK4 protein binds to CCND1 protein]]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CCND1 promoter]PMID:14728982 PMID:17942748 PMID:19654925 PMID:20486776 PMID:20637255 PMID:24013123 PMID:25975270
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