RGD Reference Report - Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer. - Rat Genome Database

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Elevated Orai1 and STIM1 expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer.

Authors: Xia, Jianling  Wang, Hongqiang  Huang, Hongxiang  Sun, Li  Dong, Shaoting  Huang, Na  Shi, Min  Bin, Jianping  Liao, Yulin  Liao, Wangjun 
Citation: Xia J, etal., Cancer Lett. 2016 Oct 10;381(1):31-40. doi: 10.1016/j.canlet.2016.07.014. Epub 2016 Jul 16.
RGD ID: 152995400
Pubmed: PMID:27431311   (View Abstract at PubMed)
DOI: DOI:10.1016/j.canlet.2016.07.014   (Journal Full-text)

ORAI calcium release-activated calcium modulator 1 (Orai1)- and stromal interacting molecule 1 (STIM1)-mediated store-operated Ca(2+) entry (SOCE) have been increasingly implicated in tumor progression; however, its role in gastric cancer (GC) is not well elucidated. We aimed to determine whether SOCE influences GC prognosis and elucidate the underlying mechanisms. Orai1 and STIM1 expressions were higher in GC tissues compared to adjacent non-tumor tissues according to RT-PCR and western blotting. Higher Orai1 and/or STIM1 expression was associated with more advanced disease, more frequent recurrence, and higher mortality rates in our study of 327 GC patients. The disease-free survival rates of Stage I-III patients and the overall survival rates of Stage IV patients were significantly worse when the tumors had high Orai1 and/or STIM1 expressions. Orai1 and/or STIM1 knockdown caused significantly reduced tumor growth and metastasis in athymic mice. Orai1 and/or STIM1 knockdown lowered the proliferation, metabolism, migration, and invasion of two GC cell lines. Also, Orai1 and/or STIM1 knockdown changed the markers of the cell cycle and epithelial-mesenchymal transition (EMT). These effects were reversed by metastasis-associated in colon cancer-1 (MACC1) overexpression. In summary, the composite molecules of SOCE suggest a poor prognosis for GC by promoting tumor cell proliferation, metabolism, migration, and invasion by targeting MACC1.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Neoplasm Metastasis treatmentIEP 152995400; 152995400; 152995400; 152995400; 152995400; 152995400associated with stomach cancer and human cells in mouse model RGD 
Neoplasm Metastasis treatmentISOCCND1 (Homo sapiens)152995400; 152995400associated with stomach cancer and human cells in mouse model RGD 
Neoplasm Metastasis treatmentISOCDH1 (Homo sapiens)152995400; 152995400associated with stomach cancer and human cells in mouse model RGD 
Neoplasm Metastasis treatmentISOFN1 (Homo sapiens)152995400; 152995400associated with stomach cancer and human cells in mouse model RGD 
Neoplasm Metastasis treatmentISOKRAS (Homo sapiens)152995400; 152995400associated with stomach cancer and human cells in mouse model RGD 
Neoplasm Metastasis treatmentISOMACC1 (Homo sapiens)152995400; 152995400associated with stomach cancer and human cells in mouse model RGD 
Neoplasm Metastasis treatmentIMP 152995400; 152995400associated with stomach cancer and human cells in mouse modelRGD 
Neoplasm Metastasis treatmentISOORAI1 (Homo sapiens)152995400; 152995400associated with stomach cancer and human cells in mouse modelRGD 
Neoplasm Metastasis treatmentISOSTIM1 (Homo sapiens)152995400; 152995400associated with stomach cancer and human cells in mouse modelRGD 
Neoplasm Metastasis treatmentISOVIM (Homo sapiens)152995400; 152995400associated with stomach cancer and human cells in mouse model RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnd1  (cyclin D1)
Cdh1  (cadherin 1)
Fn1  (fibronectin 1)
Kras  (KRAS proto-oncogene, GTPase)
Macc1  (MET transcriptional regulator MACC1)
Orai1  (ORAI calcium release-activated calcium modulator 1)
Stim1  (stromal interaction molecule 1)
Vim  (vimentin)

Genes (Mus musculus)
Ccnd1  (cyclin D1)
Cdh1  (cadherin 1)
Fn1  (fibronectin 1)
Kras  (Kirsten rat sarcoma viral oncogene homolog)
Macc1  (metastasis associated in colon cancer 1)
Orai1  (ORAI calcium release-activated calcium modulator 1)
Stim1  (stromal interaction molecule 1)
Vim  (vimentin)

Genes (Homo sapiens)
CCND1  (cyclin D1)
CDH1  (cadherin 1)
FN1  (fibronectin 1)
KRAS  (KRAS proto-oncogene, GTPase)
MACC1  (MET transcriptional regulator MACC1)
ORAI1  (ORAI calcium release-activated calcium modulator 1)
STIM1  (stromal interaction molecule 1)
VIM  (vimentin)


Additional Information