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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:34202
Term: 2,2',4,4',5,5'-hexachlorobiphenyl
Definition: A hexachlorobiphenyl that has formula C12H4Cl6.
Chemical ID: MESH:C014024
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCND1 mRNA; 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCND1 proteinPMID:20394812
Ccnd1decreases expressionISOCcnd1 (Mus musculus)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCND1 proteinPMID:20394812
Ccnd1increases degradationISOCCND1 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased degradation of CCND1 proteinPMID:20394812
Ccnd1increases phosphorylationISOCCND1 (Homo sapiens)6480464CTD2,4,5,2',4',5'-hexachlorobiphenyl results in increased phosphorylation of CCND1 proteinPMID:20394812
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of CCND1 protein]PMID:20394812
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