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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionEXP 6480464CTDQuercetin results in decreased expression of CCND1 proteinPMID:9581680
Ccnd1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in increased expression of CCND1 protein]; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased expression of CCND1 mRNA]; Quercetin inhibits the reaction [Ethanol results in increased expression of CCND1 protein]; Quercetin inhibits the reaction [Oxygen deficiency results in decreased expression of CCND1 protein]; Quercetin inhibits the reaction [Warfarin results in increased expression of CCND1 mRNA]PMID:18506933 PMID:23117658 PMID:25164625 PMID:26476374
Ccnd1affects expressionISOCCND1 (Homo sapiens)6480464CTDQuercetin affects the expression of CCND1 mRNAPMID:32530119
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of CCND1 mRNA; Quercetin results in decreased expression of CCND1 proteinPMID:12469199 PMID:12888923 PMID:15309432 PMID:18323654 PMID:18787224 PMID:19440933 PMID:20596804 PMID:20658310 PMID:25293876 PMID:30152185
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDQuercetin results in increased expression of CCND1 mRNAPMID:14715546
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of CCND1 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein; [Quercetin co-treated with IL6 protein] results in decreased expression of CCND1 mRNA; [Quercetin co-treated with IL6 protein] results in decreased expression of CCND1 protein; Quercetin inhibits the reaction [IL6 protein promotes the reaction [STAT3 protein binds to CCND1 promoter]]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA]; Quercetin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Tamoxifen affects the reaction [Quercetin affects the expression of CCND1 mRNA]PMID:12589822 PMID:20438634 PMID:22394507 PMID:27470402 PMID:27514524 PMID:32530119
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