GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccnd1 | affects expression | EXP | | 6480464 | CTD | bisphenol A affects the expression of CCND1 mRNA | PMID:25181051 | Ccnd1 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of CCND1 mRNA; bisphenol A results in decreased expression of CCND1 protein | PMID:25381574 PMID:25963729 PMID:30816183 PMID:32145629 PMID:32528016 PMID:32714078 PMID:34947998 | Ccnd1 | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of CCND1 mRNA | PMID:35192832 | Ccnd1 | multiple interactions | EXP | | 6480464 | CTD | [DKK1 protein co-treated with bisphenol A] results in decreased expression of CCND1 mRNA; bisphenol A inhibits the reaction [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in increased expression of CCND1 mRNA]; bisphenol A inhibits the reaction [WNT3A protein results in increased expression of CCND1 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of CCND1 mRNA] | PMID:25381574 PMID:25963729 | Ccnd1 | affects expression | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | bisphenol A affects the expression of CCND1 mRNA | PMID:22307313 PMID:27998958 | Ccnd1 | decreases activity | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | bisphenol A results in decreased activity of CCND1 protein | PMID:33485121 | Ccnd1 | decreases expression | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of CCND1 mRNA; bisphenol A results in decreased expression of CCND1 protein | PMID:29275510 PMID:29383186 PMID:30036487 | Ccnd1 | decreases expression | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | bisphenol A results in decreased expression of CCND1 mRNA; bisphenol A results in decreased expression of CCND1 protein | PMID:23704952 PMID:24909818 PMID:33485121 PMID:35278557 PMID:37372067 | Ccnd1 | increases expression | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of CCND1; bisphenol A results in increased expression of CCND1 mRNA; bisphenol A results in increased expression of CCND1 protein | PMID:19361625 PMID:20678512 PMID:21277958 PMID:21826169 PMID:22552626 PMID:22735500 PMID:23229410 PMID:23524099 PMID:23810794 PMID:23933164 PMID:24156707 PMID:25130739 PMID:25933419 PMID:27366082 PMID:28808208 PMID:29307715 PMID:33516137 | Ccnd1 | increases expression | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of CCND1 mRNA; bisphenol A results in increased expression of CCND1 protein | PMID:31011801 PMID:32156529 PMID:32353937 PMID:35479511 | Ccnd1 | multiple interactions | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to CCND1 protein modified form]; [bisphenol A co-treated with Resveratrol] results in decreased expression of CCND1 mRNA; bisphenol A inhibits the reaction [Tamoxifen results in decreased expression of CCND1 mRNA]; Fulvestrant inhibits the reaction [bisphenol A results in increased expression of CCND1 protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of CCND1 protein]; Genistein inhibits the reaction [bisphenol A results in increased expression of CCND1]; MYC protein promotes the reaction [bisphenol A results in increased expression of CCND1 protein]; Resveratrol inhibits the reaction [bisphenol A results in increased expression of CCND1 protein] | PMID:19361625 PMID:22552626 PMID:22735500 PMID:23229410 PMID:23810794 PMID:23933164 PMID:25933419 PMID:28751236 PMID:28808208 PMID:30467747 | Ccnd1 | multiple interactions | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]; 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine inhibits the reaction [bisphenol A results in decreased activity of CCND1 protein]; [bisphenol A co-treated with oligomycin A] results in decreased expression of CCND1 protein; [Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA; Acetylcysteine inhibits the reaction [bisphenol A results in decreased activity of CCND1 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of CCND1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [bisphenol A results in decreased activity of CCND1 protein]; GPER1 protein affects the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of CCND1 mRNA]; HDAC2 protein affects the reaction [bisphenol A results in decreased expression of CCND1 protein]; RTKI cpd inhibits the reaction [[Fulvestrant co-treated with bisphenol A] results in decreased expression of CCND1 mRNA] | PMID:24909818 PMID:28446726 PMID:33485121 PMID:37372067 | | ||||||||||||||||||||||
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