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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDzoledronic acid results in decreased expression of CCND1 mRNAPMID:16621245 PMID:24714768
Ccnd1decreases expressionISOCcnd1 (Mus musculus)6480464CTDzoledronic acid results in decreased expression of CCND1 proteinPMID:19789217
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTD[zoledronic acid co-treated with Doxorubicin] results in decreased expression of CCND1 proteinPMID:19789217
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