GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccnd1 | decreases expression | EXP | | 6480464 | CTD | Cisplatin results in decreased expression of CCND1 mRNA | PMID:18172885 PMID:22023808 | Ccnd1 | decreases expression | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | Cisplatin results in decreased expression of CCND1 protein | PMID:20195699 PMID:31303961 PMID:34687144 | Ccnd1 | increases expression | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | Cisplatin results in increased expression of CCND1 mRNA; Cisplatin results in increased expression of CCND1 protein | PMID:21151649 PMID:25043994 | Ccnd1 | multiple interactions | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | [Cisplatin co-treated with cordycepin] results in decreased expression of CCND1 protein; [Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in decreased expression of CCND1 protein; [Cisplatin co-treated with Pemetrexed co-treated with Vorinostat] results in decreased expression of CCND1 protein; [Cisplatin co-treated with Quercetin] results in increased expression of CCND1 mRNA; [Estradiol results in increased expression of CCND1 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CCND1 mRNA]; Cisplatin promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CCND1 protein]; Cisplatin promotes the reaction [SC-66 compound results in decreased expression of CCND1 protein]; Cisplatin results in decreased activity of [CCND1 protein binds to CDK4 protein]; SC-66 compound promotes the reaction [Cisplatin results in decreased expression of CCND1 protein] | PMID:19351772 PMID:20195699 PMID:21592546 PMID:27514524 PMID:28323900 PMID:33520990 PMID:34687144 | Ccnd1 | multiple interactions | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | Chlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CCND1 protein] | PMID:25043994 | |
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