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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionEXP 6480464CTDCisplatin results in decreased expression of CCND1 mRNAPMID:18172885 PMID:22023808
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDCisplatin results in decreased expression of CCND1 proteinPMID:20195699 PMID:31303961 PMID:34687144
Ccnd1increases expressionISOCcnd1 (Mus musculus)6480464CTDCisplatin results in increased expression of CCND1 mRNA; Cisplatin results in increased expression of CCND1 proteinPMID:21151649 PMID:25043994
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTD[Cisplatin co-treated with cordycepin] results in decreased expression of CCND1 protein; [Cisplatin co-treated with Pemetrexed co-treated with Valproic Acid] results in decreased expression of CCND1 protein; [Cisplatin co-treated with Pemetrexed co-treated with Vorinostat] results in decreased expression of CCND1 protein; [Cisplatin co-treated with Quercetin] results in increased expression of CCND1 mRNA; [Estradiol results in increased expression of CCND1 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CCND1 mRNA]; Cisplatin promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased expression of CCND1 protein]; Cisplatin promotes the reaction [SC-66 compound results in decreased expression of CCND1 protein]; Cisplatin results in decreased activity of [CCND1 protein binds to CDK4 protein]; SC-66 compound promotes the reaction [Cisplatin results in decreased expression of CCND1 protein]PMID:19351772 PMID:20195699 PMID:21592546 PMID:27514524 PMID:28323900 PMID:33520990 PMID:34687144
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTDChlorogenic Acid inhibits the reaction [Cisplatin results in increased expression of CCND1 protein]PMID:25043994
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