GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ccnd1 | affects response to substance | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | CCND1 mRNA affects the susceptibility to Arsenic Trioxide | PMID:23911876 | Ccnd1 | decreases activity | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased activity of CCND1 promoter | PMID:17617380 | Ccnd1 | decreases expression | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of CCND1 mRNA; Arsenic Trioxide results in decreased expression of CCND1 protein | PMID:12480548 PMID:12883267 PMID:17530438 PMID:17617380 PMID:19128835 PMID:20435036 PMID:20458559 PMID:20723298 PMID:22362285 PMID:23440206 PMID:25416439 PMID:25945059 PMID:28565807 PMID:28901456 PMID:29059232 PMID:30093655 PMID:34413873 PMID:36442592 | Ccnd1 | decreases methylation | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased methylation of CCND1 promoter | PMID:29159499 | Ccnd1 | decreases response to substance | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | CCND1 mRNA results in decreased susceptibility to Arsenic Trioxide | PMID:23911876 | Ccnd1 | increases expression | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of CCND1 mRNA; Arsenic Trioxide results in increased expression of CCND1 protein | PMID:20862710 PMID:23255470 PMID:29159499 PMID:29442453 | Ccnd1 | increases expression | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of CCND1 mRNA; Arsenic Trioxide results in increased expression of CCND1 protein | PMID:15073043 | Ccnd1 | multiple interactions | ISO | CCND1 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased expression of CCND1 protein]; 9-methoxy-2-methylellipticinium acetate inhibits the reaction [Arsenic Trioxide results in increased expression of CCND1 protein]; [Arsenic Trioxide co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CCND1 mRNA; [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of CHUK protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein; [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of GSK3B protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein; [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of IKBKB protein] which results in increased phosphorylation of and results in increased ubiquitination of and results in increased degradation of CCND1 protein; [BIBR 1532 co-treated with Arsenic Trioxide] affects the expression of CCND1 mRNA; [Genistein co-treated with Arsenic Trioxide] results in decreased expression of CCND1 protein; [ruxolitinib co-treated with Arsenic Trioxide] results in decreased expression of CCND1 mRNA; AKT1 protein affects the reaction [Arsenic Trioxide results in increased expression of CCND1 protein]; Arsenic Trioxide affects the reaction [KEAP1 protein results in increased expression of CCND1 protein]; Arsenic Trioxide promotes the reaction [Sorafenib results in decreased expression of CCND1 protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of CCND1 protein]; CAB39L protein alternative form inhibits the reaction [Arsenic Trioxide results in decreased expression of CCND1 protein]; KEAP1 protein inhibits the reaction [Arsenic Trioxide results in decreased expression of CCND1 mRNA]; MAPK1 protein affects the reaction [Arsenic Trioxide results in increased expression of CCND1 protein]; MAPK3 protein affects the reaction [Arsenic Trioxide results in increased expression of CCND1 protein]; Sorafenib promotes the reaction [Arsenic Trioxide results in decreased expression of CCND1 protein]; Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of CCND1 protein] | PMID:18922899 PMID:20862710 PMID:21078540 PMID:22684020 PMID:23949314 PMID:25416439 PMID:29059232 PMID:30012499 PMID:30093655 PMID:32645343 | Ccnd1 | multiple interactions | ISO | Ccnd1 (Mus musculus) | 6480464 | CTD | [Genistein co-treated with Arsenic Trioxide] results in decreased expression of CCND1 protein | PMID:21078540 | | ||||||||||||||||||||||
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