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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDdiallyl trisulfide results in decreased expression of CCND1 mRNA; diallyl trisulfide results in decreased expression of CCND1 proteinPMID:14693049 PMID:23430952 PMID:24415872
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased expression of CCND1 mRNA; diallyl trisulfide results in increased expression of CCND1 proteinPMID:19823037 PMID:24415872
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