RGD Reference Report - Cyclin D1 is a strong prognostic factor for survival in pancreatic cancer: analysis of CD G870A polymorphism, FISH and immunohistochemistry. - Rat Genome Database

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Cyclin D1 is a strong prognostic factor for survival in pancreatic cancer: analysis of CD G870A polymorphism, FISH and immunohistochemistry.

Authors: Bachmann, Kai  Neumann, Anna  Hinsch, Andrea  Nentwich, Michael F  El Gammal, Alexander T  Vashist, Yogesh  Perez, Daniel  Bockhorn, Maximilian  Izbicki, Jakob R  Mann, Oliver 
Citation: Bachmann K, etal., J Surg Oncol. 2015 Mar;111(3):316-23. doi: 10.1002/jso.23826. Epub 2014 Dec 2.
RGD ID: 13462050
Pubmed: PMID:25470788   (View Abstract at PubMed)
DOI: DOI:10.1002/jso.23826   (Journal Full-text)


BACKGROUND AND OBJECTIVE: Cyclin D1 is an important regulator protein for the G1-S cell cycle phase transition. The aim of this trial was to evaluate the impact of the CCND1 polymorphism G870A and corresponding protein expression and CCND1 amplification on the survival of the patients.
METHODS: 425 patients with ductal pancreatic adenocarcinoma who underwent resection were included after histopathological confirmation. DNA was analyzed for Cyclin D1 polymorphisms, immunhistochemical examination and fluorescence in situ hybridization analysis of the tumor were performed.
RESULTS: Overall, the mean survival was 22.9 months (20.5-25.3). The survival in patients with Cyclin D1 G870A polymorphism Adenine/Adenine was 15.1 months (95% CI 11.3-18.9), 21.5 months (17.4-25.6) for Adenine/Guanine, and 29.4 months (95% CI 23.8-35.0) for Guanine/Guanine (P¿=¿0.003). A shorter survival was associated with strong/moderate protein expression in immunohistochemistry (IHC) compared to weak/no expression (P¿=¿0.028). Additionally, a significant coherency between unfavourable polymorphism (AA/AG) and increased protein expression was detected (P¿=¿0.005).
CONCLUSIONS: A strong impact on survival of Cyclin D1 G870A polymorphism and the detected corresponding protein expression was found. The biological mechanism of CCND1 in carcinogenesis has not been fully examined; but at present Cyclin D1 seems to be an interesting biomarker for the prognosis of ductal adenocarcinoma.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
pancreatic ductal adenocarcinoma severityIAGP 13462050DNA:snp:exon:c.870G>A (human)RGD 
pancreatic ductal adenocarcinoma severityISOCCND1 (Homo sapiens)13462050; 13462050DNA:snp:exon:c.870G>A (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Abnormal pancreas morphology severityIAGP 13462050DNA:snp:exon:c.870G>ARGD 
Objects Annotated

Genes (Rattus norvegicus)
Ccnd1  (cyclin D1)

Genes (Mus musculus)
Ccnd1  (cyclin D1)

Genes (Homo sapiens)
CCND1  (cyclin D1)


Additional Information