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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:64212
Term: sulindac sulfone
Definition: A sulfone metabolite of sulindac that inhibits cell growth by inducing apoptosis independently of cyclooxygenase inhibition. It inhibits the development and induces regression of premalignant adenomatous polyps. Lipoxygenase and Cox-2 inhibitor.
Chemical ID: MESH:C025463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1multiple interactionsEXP 6480464CTD[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 proteinPMID:17908994
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDsulindac sulfone results in decreased expression of CCND1 mRNA; sulindac sulfone results in decreased expression of CCND1 proteinPMID:12392815 PMID:15188006
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