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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1multiple interactionsEXP 6480464CTD[Celecoxib co-treated with sulindac sulfone] results in decreased expression of CCND1 proteinPMID:17908994
Ccnd1affects expressionISOCCND1 (Homo sapiens)6480464CTDCelecoxib affects the expression of CCND1PMID:19846907
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDCelecoxib results in decreased expression of CCND1 mRNA; Celecoxib results in decreased expression of CCND1 proteinPMID:17270149
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDCelecoxib inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Celecoxib promotes the reaction [Gemcitabine results in decreased expression of CCND1 protein]PMID:15489888 PMID:16060994
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTDCelecoxib inhibits the reaction [deoxynivalenol results in increased expression of CCND1 protein]PMID:32416088
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