RGD Reference Report - Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma. - Rat Genome Database

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Expression and significance of cyclin D1, p27kip1 protein in bronchioloalveolar carcinoma.

Authors: Yuan, Jian-qun  Xu, Jing-yao  Zhang, Jing  He, Qi-cai  Zhu, Jia  Sheng, Cai-xia 
Citation: Yuan JQ, etal., J Zhejiang Univ Sci. 2004 Feb;5(2):235-41.
RGD ID: 13434930
Pubmed: PMID:14674039   (View Abstract at PubMed)


PURPOSE: To investigate the relationship between expression of cell cycle-related protein cyclin D1, p27kip1 and the pathogenesis of bronchioloalveolar carcinoma (BAC) and the value of prediction of prognosis.
METHODS: Cyclin D1 and p27kip1 protein were detected by immunohistochemical En Vision method in 43 BACs.
RESULTS: The positivity of cyclin D1 in BAC was 65.1% (28/43), which was significantly higher than that in normal pulmonary tissue (0/13), P<0.01. No statistically significant association was found between cyclin D1 expression data and sex, age, tobacco-use history, histologic subtype (mucinous vs nonmucinous), stromal fibrosis, lymph node metastasis, clinical stage or postoperative survival period (P>0.05), while cyclin D1 expression was found to be negatively correlated with tumor size (P<0.05). The positivity of p27kip1 in BACs was 51.2% (22/43), significantly lower than that in normal pulmonary tissue (12/13), P<0.01. p27kip1 expression level was not associated with sex, age, tobacco-use history, tumor size or histologic subtype (P>0.05), but was negatively correlated with stromal fibrosis, lymph node metastasis and clinical stage (P<0.05); and positively associated with postoperative survival period (P<0.01). The survival rate of p27kip1 positive group was significantly higher than that of p27kip1 negative group (P<0.01). No statistically significant correlation was found between cyclin D1 and p27kip1 expression.
CONCLUSIONS: Increased cyclin D1 expression and decreased p27kip1 expression are related to the pathogenesis of BAC; decreased p27kip1 expression is associated with metastasis progression; immunodetection of p27kip1 is useful for assessment of prognosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bronchiolo-alveolar adenocarcinoma  IEP 13434930protein:increased expression:lungRGD 
bronchiolo-alveolar adenocarcinoma  ISOCCND1 (Homo sapiens)13434930; 13434930protein:increased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnd1  (cyclin D1)

Genes (Mus musculus)
Ccnd1  (cyclin D1)

Genes (Homo sapiens)
CCND1  (cyclin D1)


Additional Information