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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:39112
Term: bosutinib
Definition: An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.
Chemical ID: MESH:C471992
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1decreases expressionISOCCND1 (Homo sapiens)6480464CTDbosutinib results in decreased expression of CCND1 proteinPMID:16489032
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTD[SM 164 co-treated with bosutinib] results in decreased expression of CCND1 proteinPMID:22241084
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