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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:28865
Term: taurocholic acid
Definition: A bile acid taurine conjugate of cholic acid that usually occurs as the sodium salt of bile in mammals.
Chemical ID: MESH:D013656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1increases expressionISOCCND1 (Homo sapiens)6480464CTDTaurocholic Acid results in increased expression of CCND1 mRNA; Taurocholic Acid results in increased expression of CCND1 proteinPMID:18512153 PMID:18840136
Ccnd1multiple interactionsISOCCND1 (Homo sapiens)6480464CTDsorafenib inhibits the reaction [Taurocholic Acid results in increased expression of CCND1 mRNA]; sorafenib inhibits the reaction [Taurocholic Acid results in increased expression of CCND1 protein]; U 0126 inhibits the reaction [Taurocholic Acid results in increased expression of CCND1 protein]PMID:18512153 PMID:18840136
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