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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ibuprofen
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Accession:CHEBI:5855 term browser browse the term
Definition:A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Synonyms:exact_synonym: 2-[4-(2-methylpropyl)phenyl]propanoic acid
 related_synonym: (+-)-2-(p-isobutylphenyl)propionic acid;   (+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid;   (+-)-p-isobutylhydratropic acid;   (4-isobutylphenyl)-alpha-methylacetic acid;   (RS)-ibuprofen;   2-(4-isobutylphenyl)propanoic acid;   4-isobutylhydratropic acid;   Adran;   Advil;   Amibufen;   Anco;   Anflagen;   Apsifen;   Bluton;   Brufen;   Brufort;   Buburone;   Butylenin;   Dolgin;   Dolgirid;   Dolgit;   Dolo-Dolgit;   Ebufac;   Epobron;   Femadon;   Formula=C13H18O2;   Haltran;   Ibu-Attritin;   Ibumetin;   Ibuprocin;   Ibutid;   InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15);   InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N;   Inabrin;   Inoven;   Lamidon;   Lebrufen;   Liptan;   Medipren;   Motrin;   Mynosedin;   Nobfen;   Nobgen;   Nuprin;   Nurofen;   Pediaprofen;   Roidenin;   Rufen;   SMILES=CC(C)Cc1ccc(cc1)C(C)C(O)=O;   Seclodin;   Suspren;   Tabalon;   Trendar;   Urem;   alpha-(4-isobutylphenyl)propionic acid;   alpha-(p-isobutylphenyl)propionic acid
 xref: Beilstein:2049713;   CAS:15687-27-1;   DrugBank:DB01050;   Drug_Central:1407;   HMDB:HMDB0001925;   KEGG:C01588;   KEGG:D00126;   LINCS:LSM-1354
 xref_mesh: MESH:D007052
 xref: PMID:11433218;   PMID:12723739;   PMID:14562167;   PMID:15506544;   PMID:16176022;   PMID:18335846;   PMID:18697608;   PMID:21368281;   PMID:24168233;   PMID:25521617;   PMID:25708941;   PMID:25915907;   PMID:29756342;   Patent:GB971700;   Patent:US3228831;   Patent:US3385886;   Patent:US5215755;   Patent:US6727286;   Reaxys:2049713;   Wikipedia:Ibuprofen
 cyclic_relationship: is_conjugate_acid_of CHEBI:132922


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ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of ABCB11 mRNA CTD PMID:29222744 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression EXP Ibuprofen results in increased expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 increases expression ISO Ibuprofen results in increased expression of ABCG1 mRNA CTD PMID:25596134 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B increases expression ISO Ibuprofen results in increased expression of ABHD4 mRNA CTD PMID:25596134 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions
increases expression		 ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of ACOX1 mRNA
Ibuprofen results in increased expression of ACOX1 mRNA		 CTD PMID:29222744 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases metabolic processing
increases expression		 EXP
ISO		 ACSL1 protein results in increased metabolism of Ibuprofen
Ibuprofen results in increased expression of ACSL1 mRNA		 CTD PMID:10725307 PMID:25596134 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541 		JBrowse link
G Acsl6 acyl-CoA synthetase long-chain family member 6 increases metabolic processing EXP ACSL6 protein results in increased metabolism of Ibuprofen CTD PMID:10725307 NCBI chr10:38,439,914...38,501,182
Ensembl chr10:38,440,080...38,498,757 		JBrowse link
G Adamts8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 increases expression ISO Ibuprofen results in increased expression of ADAMTS8 mRNA CTD PMID:17070997 NCBI chr 8:29,349,078...29,368,413
Ensembl chr 8:29,349,114...29,368,404 		JBrowse link
G Adcy1 adenylate cyclase 1 decreases expression ISO Ibuprofen results in decreased expression of ADCY1 mRNA CTD PMID:25596134 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Agt angiotensinogen increases expression EXP Ibuprofen results in increased expression of AGT protein CTD PMID:18096423 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor affects activity EXP Ibuprofen affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 increases expression ISO
EXP		 Ibuprofen results in increased expression of AIFM2 mRNA CTD PMID:25596134 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236 		JBrowse link
G Ak4 adenylate kinase 4 decreases expression ISO Ibuprofen results in decreased expression of AK4 mRNA CTD PMID:25596134 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases activity ISO Ibuprofen results in decreased activity of AKR1C1 protein CTD PMID:19010312 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases activity ISO Ibuprofen results in decreased activity of AKR1C2 protein CTD PMID:8573067 PMID:19010312 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases activity ISO Ibuprofen results in decreased activity of AKR1C3 protein CTD PMID:19010312 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Alb albumin multiple interactions ISO Ibuprofen inhibits the reaction [Fenoprofen binds to ALB protein] CTD PMID:9470966 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression ISO Ibuprofen results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Alox12b arachidonate 12-lipoxygenase, 12R type affects expression ISO Ibuprofen affects the expression of ALOX12B mRNA CTD PMID:17070997 NCBI chr10:53,863,060...53,874,938
Ensembl chr10:53,863,060...53,874,938 		JBrowse link
G Aloxe3 arachidonate lipoxygenase 3 affects expression ISO Ibuprofen affects the expression of ALOXE3 mRNA CTD PMID:17070997 NCBI chr10:53,830,219...53,854,328
Ensembl chr10:53,831,264...53,854,328 		JBrowse link
G Amacr alpha-methylacyl-CoA racemase affects response to substance
multiple interactions
increases metabolic processing		 ISO AMACR gene SNP affects the susceptibility to Ibuprofen
AMACR protein results in increased metabolism of and results in increased activity of Ibuprofen
AMACR protein results in increased metabolism of Ibuprofen		 CTD PMID:17680641 PMID:17684125 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression ISO Ibuprofen results in decreased expression of AMBP mRNA CTD PMID:25596134 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO Ibuprofen results in increased expression of ANGPTL4 mRNA CTD PMID:25596134 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519 		JBrowse link
G Anxa1 annexin A1 affects expression ISO Ibuprofen affects the expression of ANXA1 mRNA CTD PMID:17070997 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343 		JBrowse link
G Anxa2 annexin A2 affects expression ISO Ibuprofen affects the expression of ANXA2 protein CTD PMID:18351690 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658 		JBrowse link
G Anxa3 annexin A3 affects expression ISO Ibuprofen affects the expression of ANXA3 mRNA CTD PMID:17070997 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617 		JBrowse link
G Anxa9 annexin A9 decreases expression ISO Ibuprofen results in decreased expression of ANXA9 mRNA CTD PMID:17070997 NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374 		JBrowse link
G App amyloid beta precursor protein affects cleavage
multiple interactions
decreases expression		 ISO
EXP		 Ibuprofen affects the cleavage of APP protein
Ibuprofen inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]
Ibuprofen results in decreased expression of APP protein mutant form
Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]
Ibuprofen inhibits the reaction [APP protein results in increased uptake of Calcium]		 CTD PMID:11080519 PMID:11700559 PMID:12777371 PMID:14586007 PMID:15817521 More... NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 increases expression ISO Ibuprofen results in increased expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856 		JBrowse link
G Asic1 acid sensing ion channel subunit 1 decreases expression
decreases activity		 EXP Ibuprofen results in decreased expression of ASIC1 mRNA
Ibuprofen results in decreased activity of ASIC1 protein		 CTD PMID:11588175 NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541 		JBrowse link
G Asic2 acid sensing ion channel subunit 2 decreases expression EXP Ibuprofen results in decreased expression of ASIC2 mRNA CTD PMID:11588175 NCBI chr10:65,870,592...66,940,577
Ensembl chr10:65,870,594...66,940,424 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 decreases expression EXP Ibuprofen results in decreased expression of ASIC3 mRNA CTD PMID:11588175 NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Ibuprofen results in increased expression of ASNS mRNA CTD PMID:25596134 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Atf4 activating transcription factor 4 affects activity ISO Ibuprofen affects the activity of ATF4 protein CTD PMID:25596134 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Atxn1 ataxin 1 increases expression ISO Ibuprofen results in increased expression of ATXN1 mRNA CTD PMID:25596134 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360 		JBrowse link
G Bace1 beta-secretase 1 multiple interactions
decreases activity
decreases expression		 ISO
EXP		 GW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]
Ibuprofen results in decreased activity of BACE1 protein
Ibuprofen results in decreased expression of BACE1 mRNA
GW0072 inhibits the reaction [Ibuprofen results in decreased expression of BACE1 mRNA]		 CTD PMID:14586007 PMID:16407166 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 increases expression ISO Ibuprofen results in increased expression of BCAT2 mRNA CTD PMID:25596134 NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of BCL2L1 mRNA alternative form; [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of BCL2L1 mRNA alternative form; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of BCL2L1 mRNA alternative form]; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of BCL2L1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of BCL2L1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of BCL2L1 mRNA alternative form] CTD PMID:18348186 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Ibuprofen results in increased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359 		JBrowse link
G C3 complement C3 affects expression ISO Ibuprofen affects the expression of C3 mRNA CTD PMID:17070997 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 affects expression ISO Ibuprofen affects the expression of CACNA2D3 mRNA CTD PMID:17070997 NCBI chr16:4,098,439...4,912,498
Ensembl chr16:4,098,445...4,912,351 		JBrowse link
G Calca calcitonin-related polypeptide alpha decreases expression EXP Ibuprofen results in decreased expression of CALCA mRNA CTD PMID:11588175 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein] CTD PMID:24333387 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Casp1 caspase 1 multiple interactions
decreases cleavage		 ISO Ibuprofen inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]
Ibuprofen results in decreased cleavage of CASP1 protein		 CTD PMID:36088791 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Ibuprofen inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA] CTD PMID:11296547 PMID:24333387 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO Ibuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]
Ibuprofen results in increased expression of CCL2 mRNA
Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]		 CTD PMID:11230753 PMID:17070997 PMID:18799549 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein] CTD PMID:15263833 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15489888 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO Ibuprofen results in increased expression of CCNE2 mRNA CTD PMID:25596134 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cd36 CD36 molecule increases expression ISO Ibuprofen results in increased expression of CD36 protein CTD PMID:12664607 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cdh3 cadherin 3 affects expression ISO Ibuprofen affects the expression of CDH3 mRNA CTD PMID:17070997 NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Ibuprofen results in decreased expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Ibuprofen results in increased expression of CDKN1A mRNA; Ibuprofen results in increased expression of CDKN1A protein CTD PMID:15099639 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdsn corneodesmosin affects expression ISO Ibuprofen affects the expression of CDSN mRNA CTD PMID:17070997 NCBI chr20:3,179,432...3,184,252
Ensembl chr20:3,179,438...3,184,250 		JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 affects expression ISO Ibuprofen affects the expression of CEACAM1 mRNA CTD PMID:17070997 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992 		JBrowse link
G Cers5 ceramide synthase 5 decreases expression EXP Ibuprofen results in decreased expression of CERS5 mRNA CTD PMID:25596134 NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases activity
multiple interactions		 ISO Ibuprofen results in decreased activity of CHUK protein
Ibuprofen inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Ibuprofen results in decreased activity of [TNF protein results in increased activity of CHUK protein]		 CTD PMID:10602496 PMID:15489888 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Clu clusterin affects expression ISO Ibuprofen affects the expression of CLU mRNA CTD PMID:17070997 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression
decreases expression		 EXP
ISO		 Ibuprofen results in increased expression of CMBL mRNA
Ibuprofen results in decreased expression of CMBL mRNA		 CTD PMID:25596134 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein] CTD PMID:17397826 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO Ibuprofen analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein] CTD PMID:17397826 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Coch cochlin decreases expression ISO Ibuprofen results in decreased expression of COCH mRNA CTD PMID:25596134 NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109 		JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects expression ISO Ibuprofen affects the expression of COL11A1 mRNA CTD PMID:17070997 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853 		JBrowse link
G Cth cystathionine gamma-lyase multiple interactions ISO Ibuprofen promotes the reaction [Dexamethasone results in decreased activity of CTH protein]; Ibuprofen promotes the reaction [Dexamethasone results in decreased expression of CTH mRNA]; NR3C1 protein affects the reaction [Ibuprofen promotes the reaction [Dexamethasone results in decreased expression of CTH mRNA]] CTD PMID:29222744 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO Ibuprofen results in decreased expression of CTNNB1 mRNA CTD PMID:37453669 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsc cathepsin C decreases expression ISO
EXP		 Ibuprofen results in decreased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects expression ISO Ibuprofen affects the expression of CX3CL1 mRNA CTD PMID:17070997 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 protein] CTD PMID:19020770 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions
increases expression		 EXP
ISO		 Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]
Ibuprofen results in increased expression of CXCL2 mRNA		 CTD PMID:11545620 PMID:24747151 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression		 ISO Ibuprofen results in decreased activity of CYP19A1 protein
Ibuprofen results in decreased expression of CYP19A1 mRNA		 CTD PMID:15964185 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO Ibuprofen results in decreased expression of CYP1A2 mRNA CTD PMID:25596134 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing
decreases metabolic processing
increases metabolic processing		 ISO CYP2C8 gene polymorphism affects the metabolism of Ibuprofen
CYP2C8 gene polymorphism results in decreased metabolism of Ibuprofen
CYP2C8 gene polymorphism results in increased metabolism of Ibuprofen		 CTD PMID:15289789 PMID:15606441 PMID:18694831
G Ddx1 DEAD-box helicase 1 affects expression ISO Ibuprofen affects the expression of DDX1 protein CTD PMID:18351690 NCBI chr 6:35,996,469...36,027,340
Ensembl chr 6:35,996,469...36,027,365 		JBrowse link
G Defb5 defensin beta 5 affects expression ISO Ibuprofen affects the expression of DEFB4 mRNA CTD PMID:17070997 NCBI chr16:70,612,985...70,615,389
Ensembl chr16:70,613,146...70,615,467 		JBrowse link
G Dhx37 DEAH-box helicase 37 increases expression ISO Ibuprofen results in increased expression of DHX37 mRNA CTD PMID:25596134 NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein] CTD PMID:24333387 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dlgap2 DLG associated protein 2 multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA] CTD PMID:24333387 NCBI chr16:74,786,771...75,496,402
Ensembl chr16:74,791,509...75,496,407 		JBrowse link
G Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 increases expression ISO Ibuprofen results in increased expression of DNAJB2 mRNA CTD PMID:25596134 NCBI chr 9:76,731,060...76,739,278
Ensembl chr 9:76,731,065...76,739,277 		JBrowse link
G Dnajc5b DnaJ heat shock protein family (Hsp40) member C5 beta increases expression EXP Ibuprofen results in increased expression of DNAJC5B mRNA CTD PMID:25596134 NCBI chr 2:101,973,726...102,066,275
Ensembl chr 2:101,973,793...102,066,275 		JBrowse link
G Dnmbp dynamin binding protein increases expression EXP Ibuprofen results in increased expression of DNMBP mRNA CTD PMID:25596134 NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO Ibuprofen results in decreased expression of DNMT3A mRNA CTD PMID:29665328 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dpp9 dipeptidyl peptidase 9 increases expression EXP
ISO		 Ibuprofen results in increased expression of DPP9 mRNA CTD PMID:25596134 NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541 		JBrowse link
G Dsc1 desmocollin 1 affects expression ISO Ibuprofen affects the expression of DSC1 mRNA CTD PMID:17070997 NCBI chr18:11,499,936...11,556,801
Ensembl chr18:11,502,003...11,528,494 		JBrowse link
G Dusp22 dual specificity phosphatase 22 increases expression ISO Ibuprofen results in increased expression of DUSP22 mRNA CTD PMID:25596134 NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321 		JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Ibuprofen results in increased expression of DUSP5 mRNA CTD PMID:25596134 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Ibuprofen inhibits the reaction [EGF protein results in increased activity of MMP9 protein]; Ibuprofen inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; Ibuprofen inhibits the reaction [EGF protein results in increased expression of PLAU mRNA] CTD PMID:16340751 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Eif1 eukaryotic translation initiation factor 1 decreases expression EXP Ibuprofen results in decreased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions
increases phosphorylation		 ISO MAPK14 protein promotes the reaction [Ibuprofen results in increased phosphorylation of EIF4E protein] CTD PMID:18056468 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions
increases expression		 ISO ELAVL1 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; Ibuprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]
Ibuprofen results in increased expression of ELAVL1 protein		 CTD PMID:18056468 NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784 		JBrowse link
G Elf4 E74 like ETS transcription factor 4 increases expression ISO Ibuprofen results in increased expression of ELF4 mRNA CTD PMID:25596134 NCBI chr  X:127,587,401...127,639,063
Ensembl chr  X:127,590,650...127,630,200 		JBrowse link
G Elk4 ETS transcription factor ELK4 increases expression ISO Ibuprofen results in increased expression of ELK4 mRNA CTD PMID:25596134 NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035 		JBrowse link
G Eno1 enolase 1 affects expression
increases expression		 ISO Ibuprofen affects the expression of ENO1 protein
Ibuprofen results in increased expression of ENO1 mRNA		 CTD PMID:18351690 PMID:25596134 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336 		JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO Ibuprofen results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G Ephb6 Eph receptor B6 affects expression ISO Ibuprofen affects the expression of EPHB6 mRNA CTD PMID:17070997 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230 		JBrowse link
G Eprs1 glutamyl-prolyl-tRNA synthetase 1 increases expression ISO Ibuprofen results in increased expression of EPRS1 mRNA CTD PMID:25596134 NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 affects cleavage ISO Ibuprofen affects the cleavage of ERBB4 protein CTD PMID:12777371 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Ibuprofen results in decreased expression of ESR1 mRNA CTD PMID:37453669 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 decreases expression ISO Ibuprofen results in decreased expression of ESR2 mRNA CTD PMID:37453669 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit increases expression EXP Ibuprofen results in increased expression of EZH2 mRNA CTD PMID:29665328 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Ibuprofen results in increased expression of F3 mRNA CTD PMID:17070997 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Faah fatty acid amide hydrolase decreases activity EXP Ibuprofen analog results in decreased activity of FAAH protein CTD PMID:17397826 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression
increases expression		 ISO Ibuprofen results in decreased expression of FABP4 mRNA
Ibuprofen results in increased expression of FABP4 mRNA		 CTD PMID:17070997 PMID:25596134 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fam210b family with sequence similarity 210, member B decreases expression ISO Ibuprofen results in decreased expression of FAM210B mRNA CTD PMID:25596134 NCBI chr 3:161,118,228...161,128,400
Ensembl chr 3:161,118,239...161,128,397 		JBrowse link
G Fam89a family with sequence similarity 89, member A increases expression ISO Ibuprofen results in increased expression of FAM89A mRNA CTD PMID:25596134 NCBI chr19:52,710,002...52,722,630
Ensembl chr19:52,710,019...52,722,631 		JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO Ibuprofen results in decreased expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase affects expression
decreases expression		 ISO Ibuprofen affects the expression of FASN protein
Ibuprofen results in decreased expression of FASN mRNA		 CTD PMID:18351690 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression
multiple interactions		 ISO
EXP		 Ibuprofen results in decreased expression of FGF15 mRNA; Ibuprofen results in decreased expression of FGF15 protein
[Ibuprofen co-treated with Dexamethasone] results in decreased expression of FGF15 mRNA
[Dexamethasone co-treated with Ibuprofen] results in decreased expression of FGF15 mRNA; [Dexamethasone co-treated with Ibuprofen] results in decreased expression of FGF15 protein		 CTD PMID:29222744 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Ibuprofen results in increased expression of FOSB mRNA CTD PMID:17070997 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Frzb frizzled-related protein affects expression ISO Ibuprofen affects the expression of FRZB mRNA CTD PMID:17070997 NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208 		JBrowse link
G Gas6 growth arrest specific 6 decreases expression ISO Ibuprofen results in decreased expression of GAS6 mRNA CTD PMID:37453669 NCBI chr16:76,045,430...76,075,904
Ensembl chr16:76,045,426...76,075,904 		JBrowse link
G Gata3 GATA binding protein 3 decreases expression ISO Ibuprofen results in decreased expression of GATA3 mRNA CTD PMID:17630191 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 increases expression ISO Ibuprofen results in increased expression of GBE1 mRNA CTD PMID:25596134 NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO Ibuprofen results in increased expression of GCLC mRNA CTD PMID:11909699 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO Ibuprofen results in increased expression of GCLM mRNA CTD PMID:11909699 PMID:25596134 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO Ibuprofen results in increased expression of GCNT3 mRNA CTD PMID:25596134 NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO Ibuprofen results in increased expression of GDF15 mRNA; Ibuprofen results in increased expression of GDF15 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]; NGFR protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]		 CTD PMID:15555568 PMID:21097678 PMID:25596134 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP protein] CTD PMID:24333387 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Ibuprofen results in increased expression of GOT1 mRNA CTD PMID:25596134 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Ibuprofen results in increased expression of GPAT3 mRNA CTD PMID:25596134 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 increases expression EXP Ibuprofen results in increased expression of GSTT1 protein CTD PMID:9729437 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Gstt2 glutathione S-transferase theta 2 increases expression EXP Ibuprofen results in increased expression of GSTT2 protein CTD PMID:9729437 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288 		JBrowse link
G H1f2 H1.2 linker histone, cluster member decreases expression ISO Ibuprofen results in decreased expression of H1-2 mRNA CTD PMID:25596134 NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
affects activity		 ISO Ibuprofen results in decreased expression of HIF1A protein
Ibuprofen affects the activity of HIF1A protein		 CTD PMID:12912967 PMID:25596134 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 increases expression
multiple interactions		 ISO Ibuprofen results in increased expression of HMGB1 protein
Ibuprofen inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Ibuprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:24747151 PMID:34755645 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase affects expression
increases expression
increases activity		 ISO Ibuprofen affects the expression of HPGD mRNA
Ibuprofen results in increased expression of HPGD mRNA
Ibuprofen results in increased activity of HPGD protein		 CTD PMID:17070997 PMID:19501039 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Ibuprofen results in increased activity of HSF1 protein CTD PMID:10328874 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A affects localization
increases expression		 ISO Ibuprofen affects the localization of HSPA1A protein
Ibuprofen results in increased expression of HSPA1A protein		 CTD PMID:16239242 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO
EXP		 Ibuprofen results in decreased expression of HSPA5 mRNA CTD PMID:25596134 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 affects localization ISO Ibuprofen affects the localization of HSPA8 protein CTD PMID:14706622 PMID:16239242 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression EXP Ibuprofen results in decreased expression of HTATIP2 mRNA CTD PMID:25596134 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629 		JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression
decreases expression		 ISO
EXP		 Ibuprofen results in increased expression of IARS1 mRNA
Ibuprofen results in decreased expression of IARS1 mRNA		 CTD PMID:25596134 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases expression		 ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
Ibuprofen results in decreased expression of ICAM1 mRNA		 CTD PMID:16769766 PMID:17931847 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ids iduronate 2-sulfatase increases expression ISO Ibuprofen results in increased expression of IDS mRNA CTD PMID:25596134 NCBI chr  X:149,025,976...149,046,641
Ensembl chr  X:149,025,976...149,046,663 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases secretion		 ISO GW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]
Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ibuprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA]
Ibuprofen analog results in decreased secretion of IFNG protein; Ibuprofen results in decreased secretion of IFNG protein		 CTD PMID:11080519 PMID:14586007 PMID:16407166 PMID:17630191 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP Ibuprofen results in increased expression of IGF1 protein CTD PMID:16799050 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Igkc immunoglobulin kappa constant affects expression ISO Ibuprofen affects the expression of IGKC mRNA CTD PMID:17070997
G Iglc1 immunoglobulin lambda constant 1 affects expression ISO Ibuprofen affects the expression of IGLC1 mRNA CTD PMID:17070997 NCBI chr11:81,947,966...81,949,822
Ensembl chr11:81,947,934...81,949,822 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein] CTD PMID:19020770 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17rb interleukin 17 receptor B decreases expression EXP Ibuprofen results in decreased expression of IL17RB mRNA CTD PMID:25596134 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO Ibuprofen inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein]; Ibuprofen results in decreased expression of and results in decreased secretion of IL18 protein CTD PMID:36088791 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
increases expression		 ISO Ibuprofen inhibits the reaction [IL1A protein results in increased secretion of CCL2 protein]
Ibuprofen results in increased expression of IL1A mRNA		 CTD PMID:11230753 PMID:17070997 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
affects expression
increases expression		 ISO
EXP		 Ibuprofen inhibits the reaction [[IFNG protein co-treated with IL1B protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [IL1B protein results in increased abundance of Cyclic AMP]; Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; tert-Butylhydroperoxide inhibits the reaction [Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
Ibuprofen inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 mRNA]; Ibuprofen inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]; Ibuprofen results in decreased expression of and results in decreased secretion of IL1B protein
Ibuprofen affects the expression of IL1B protein
Ibuprofen results in increased expression of IL1B mRNA
[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL1B mRNA]		 CTD PMID:9890559 PMID:14586007 PMID:15705740 PMID:17709599 PMID:18799549 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases secretion
multiple interactions
increases expression		 ISO
EXP		 Ibuprofen results in decreased secretion of IL1RN protein
Ibuprofen results in increased expression of and results in increased secretion of IL1RN protein
Ibuprofen results in increased expression of IL1RN mRNA		 CTD PMID:12169827 PMID:15837124 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Ibuprofen co-treated with Lipopolysaccharides] results in increased expression of IL4 protein CTD PMID:19020770 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO
EXP		 Ibuprofen results in increased expression of IL6 mRNA; Ibuprofen results in increased expression of IL6 protein
Ibuprofen analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
[Ibuprofen co-treated with Eucalyptol] inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]; Ibuprofen inhibits the reaction [ammonium acetate results in increased expression of IL6 mRNA]		 CTD PMID:10903797 PMID:17070997 PMID:36346500 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Ibuprofen results in increased expression of INSIG1 mRNA CTD PMID:25596134 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Insm1 INSM transcriptional repressor 1 decreases expression ISO Ibuprofen results in decreased expression of INSM1 mRNA CTD PMID:17070997 NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP Ibuprofen inhibits the reaction [Streptozocin results in increased expression of ITGAM mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of ITGAM protein] CTD PMID:24333387 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgbl1 integrin subunit beta like 1 affects expression ISO Ibuprofen affects the expression of ITGBL1 mRNA CTD PMID:17070997 NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733 		JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO Ibuprofen results in decreased expression of LAMA3 mRNA CTD PMID:25596134 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Lars1 leucyl-tRNA synthetase 1 increases expression ISO Ibuprofen results in increased expression of LARS1 mRNA CTD PMID:25596134 NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931 		JBrowse link
G Lats1 large tumor suppressor kinase 1 increases expression
multiple interactions		 ISO Ibuprofen results in increased expression of LATS1 mRNA
Ibuprofen results in increased expression of and results in increased phosphorylation of LATS1 protein		 CTD PMID:37453669 NCBI chr 1:2,160,411...2,193,640
Ensembl chr 1:2,160,411...2,193,640 		JBrowse link
G Ldhb lactate dehydrogenase B affects expression ISO Ibuprofen affects the expression of LDHB protein CTD PMID:18351690 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403 		JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO Ibuprofen promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]; Ibuprofen promotes the reaction [Cholesterol, LDL binds to LDLR protein] CTD PMID:10395027 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lgals1 galectin 1 affects expression ISO Ibuprofen affects the expression of LGALS1 protein CTD PMID:18351690 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345 		JBrowse link
G Lta lymphotoxin alpha affects response to substance ISO LTA gene SNP affects the susceptibility to Ibuprofen CTD PMID:16931544 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859 		JBrowse link
G Ltbr lymphotoxin beta receptor decreases expression ISO Ibuprofen results in decreased expression of LTBR mRNA CTD PMID:17070997 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539 		JBrowse link
G Ly9 lymphocyte antigen 9 decreases expression ISO Ibuprofen results in decreased expression of LY9 mRNA CTD PMID:17070997 NCBI chr13:84,079,345...84,100,783
Ensembl chr13:84,079,458...84,100,823 		JBrowse link
G Mafg MAF bZIP transcription factor G decreases expression EXP Ibuprofen results in decreased expression of MAFG mRNA CTD PMID:25596134 NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026 		JBrowse link
G Mal mal, T-cell differentiation protein increases expression ISO Ibuprofen results in increased expression of MAL mRNA CTD PMID:17070997 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ibuprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:34755645 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 increases expression ISO Ibuprofen results in increased expression of MAPK10 mRNA CTD PMID:37453669 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 multiple interactions ISO MAPK11 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]; MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Ibuprofen results in increased phosphorylation of EIF4E protein] CTD PMID:18056468 PMID:21097678 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ibuprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:34755645 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Ibuprofen results in increased expression of MAPK8 mRNA CTD PMID:37453669 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 increases expression ISO Ibuprofen results in increased expression of MAPK9 mRNA CTD PMID:37453669 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO Ibuprofen results in increased phosphorylation of and results in increased activity of MAPKAPK2 protein; MAPKAPK2 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457 		JBrowse link
G Mapkapk3 MAPK activated protein kinase 3 multiple interactions ISO MAPKAPK3 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein] CTD PMID:18056468 NCBI chr 8:107,929,754...107,963,638
Ensembl chr 8:107,929,762...107,963,568 		JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 affects expression ISO Ibuprofen affects the expression of MAPRE2 mRNA CTD PMID:17070997 NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO [Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form; [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form]; calyculin A inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in decreased expression of MCL1 mRNA alternative form]; tautomycin inhibits the reaction [[Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of MCL1 mRNA alternative form] CTD PMID:18348186 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Me1 malic enzyme 1 increases expression EXP Ibuprofen results in increased expression of ME1 mRNA CTD PMID:25596134 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304 		JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO Ibuprofen results in increased expression of MMP1 mRNA CTD PMID:16580899 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP [Ibuprofen co-treated with Carbon Tetrachloride] results in increased expression of and results in increased cleavage of MMP13 protein CTD PMID:21360558 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [Ibuprofen co-treated with Carbon Tetrachloride] results in increased expression of MMP2 protein CTD PMID:21360558 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Ibuprofen results in increased expression of MMP3 mRNA CTD PMID:16580899 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP		 Ibuprofen inhibits the reaction [EGF protein results in increased activity of MMP9 protein]; Ibuprofen inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]
[Ibuprofen co-treated with Carbon Tetrachloride] results in increased expression of MMP9 protein		 CTD PMID:16340751 PMID:21360558 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Ibuprofen inhibits the reaction [Carrageenan results in increased expression of MPO protein] CTD PMID:25451575 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mta2 metastasis associated 1 family, member 2 increases expression ISO Ibuprofen results in increased expression of MTA2 mRNA CTD PMID:17070997 NCBI chr 1:205,838,181...205,846,903
Ensembl chr 1:205,837,964...205,846,946 		JBrowse link
G Mtfp1 mitochondrial fission process 1 increases expression ISO Ibuprofen results in increased expression of MTFP1 mRNA CTD PMID:25596134 NCBI chr14:78,968,434...78,972,274
Ensembl chr14:78,968,442...78,972,274 		JBrowse link
G Mxd1 max dimerization protein 1 increases expression ISO Ibuprofen results in increased expression of MXD1 mRNA CTD PMID:17070997 NCBI chr 4:119,097,353...119,118,080
Ensembl chr 4:119,097,353...119,117,751 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression ISO Ibuprofen results in increased expression of NAMPT mRNA CTD PMID:25596134 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100 		JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP
ISO		 Ibuprofen results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
affects activity		 ISO Ibuprofen results in increased expression of NFE2L2 mRNA
Ibuprofen affects the activity of NFE2L2 protein		 CTD PMID:25596134 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]
Ibuprofen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Ibuprofen results in decreased activity of [NFKB1 protein binds to RELA protein]		 CTD PMID:9281604 PMID:9890559 PMID:10602496 PMID:15489888 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Ibuprofen inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] CTD PMID:9890559 PMID:15489888 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngfr nerve growth factor receptor multiple interactions
increases expression		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ibuprofen results in increased expression of NGFR mRNA]; ELAVL1 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; Ibuprofen promotes the reaction [ELAVL1 protein binds to NGFR mRNA]; Ibuprofen results in increased stability of and results in increased expression of NGFR mRNA; MAPK11 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; MAPK14 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; MAPKAPK2 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; MAPKAPK3 protein promotes the reaction [Ibuprofen results in increased expression of NGFR protein]; NGFR protein promotes the reaction [Ibuprofen results in increased expression of GDF15 protein]
Ibuprofen results in increased expression of NGFR mRNA; Ibuprofen results in increased expression of NGFR protein		 CTD PMID:17409433 PMID:17447067 PMID:18056468 PMID:21097678 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 decreases expression ISO Ibuprofen results in decreased expression of NLRP3 protein CTD PMID:36088791 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos1 nitric oxide synthase 1 affects expression ISO Ibuprofen affects the expression of NOS1 mRNA CTD PMID:17070997 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
increases activity		 EXP
ISO		 Ibuprofen results in increased expression of NOS2 mRNA
Ibuprofen inhibits the reaction [[APP protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]
Ibuprofen results in increased activity of NOS2 protein		 CTD PMID:11080519 PMID:11545620 PMID:11837731 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 affects expression ISO Ibuprofen affects the expression of NQO1 mRNA CTD PMID:17070997 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 mRNA; [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR0B2 protein CTD PMID:29222744 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR1H4 mRNA; [Dexamethasone co-treated with Ibuprofen] results in decreased expression of NR1H4 protein CTD PMID:29222744 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases activity
decreases expression
multiple interactions		 EXP
ISO		 Ibuprofen results in increased activity of NR3C1 protein
Ibuprofen results in decreased expression of NR3C1 mRNA
NR3C1 protein affects the reaction [Ibuprofen promotes the reaction [Dexamethasone results in decreased expression of CTH mRNA]]		 CTD PMID:15700047 PMID:25596134 PMID:29222744 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nuak1 NUAK family kinase 1 decreases expression ISO Ibuprofen results in decreased expression of NUAK1 mRNA CTD PMID:25596134 NCBI chr 7:19,330,034...19,401,918
Ensembl chr 7:19,329,933...19,401,913 		JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632 		JBrowse link
G Pabpn1 poly(A) binding protein, nuclear 1 multiple interactions ISO Ibuprofen inhibits the reaction [PABPN1 protein mutant form binds to PABPN1 protein mutant form] CTD PMID:16239242 NCBI chr15:28,368,100...28,372,712
Ensembl chr15:28,368,100...28,372,703 		JBrowse link
G Pank1 pantothenate kinase 1 increases expression ISO
EXP		 Ibuprofen results in increased expression of PANK1 mRNA CTD PMID:25596134 NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829 		JBrowse link
G Pclo piccolo (presynaptic cytomatrix protein) increases expression ISO Ibuprofen results in increased expression of PCLO mRNA CTD PMID:25596134 NCBI chr 4:19,691,439...20,050,015
Ensembl chr 4:19,695,315...20,049,885 		JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions ISO Ibuprofen inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]; Ibuprofen inhibits the reaction [PDGFA results in increased abundance of Epoprostenol] CTD PMID:19201774 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 decreases expression EXP Ibuprofen results in decreased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP
ISO		 Ibuprofen results in increased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Pdlim1 PDZ and LIM domain 1 decreases expression ISO
EXP		 Ibuprofen results in decreased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076 		JBrowse link
G Pgam1 phosphoglycerate mutase 1 affects expression
increases expression		 ISO Ibuprofen affects the expression of PGAM1 protein
Ibuprofen results in increased expression of PGAM1 mRNA		 CTD PMID:18351690 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452 		JBrowse link
G Pla2g2a phospholipase A2 group IIA affects expression ISO Ibuprofen affects the expression of PLA2G2A mRNA CTD PMID:17070997 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions ISO Ibuprofen inhibits the reaction [EGF protein results in increased expression of PLAU mRNA] CTD PMID:16340751 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Plec plectin increases expression
affects expression		 ISO Ibuprofen results in increased expression of PLEC mRNA
Ibuprofen affects the expression of PLEC protein		 CTD PMID:18351690 NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467 		JBrowse link
G Plin2 perilipin 2 increases expression EXP
ISO		 Ibuprofen results in increased expression of PLIN2 mRNA CTD PMID:25596134 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression EXP Ibuprofen results in decreased expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454 		JBrowse link
G Pml PML nuclear body scaffold affects expression ISO Ibuprofen affects the expression of PML mRNA CTD PMID:17070997 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Podxl podocalyxin-like decreases expression EXP Ibuprofen results in decreased expression of PODXL mRNA CTD PMID:25596134 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Ibuprofen results in decreased expression of POU5F1 mRNA CTD PMID:29665328 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases activity
increases expression		 ISO
EXP		 Ibuprofen binds to and results in increased activity of PPARA protein
Ibuprofen analog results in increased activity of PPARA protein
Ibuprofen results in increased expression of PPARA mRNA
[Dexamethasone co-treated with Ibuprofen] results in increased expression of PPARA mRNA; [Dexamethasone co-treated with Ibuprofen] results in increased expression of PPARA protein
Ibuprofen results in increased expression of PPARA mRNA; Ibuprofen results in increased expression of PPARA protein		 CTD PMID:9013583 PMID:11755111 PMID:29222744 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases activity
increases expression
affects activity		 ISO
EXP		 Ibuprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA]; Ibuprofen inhibits the reaction [Methamphetamine results in decreased expression of PPARG protein]
Ibuprofen binds to and results in increased activity of PPARG protein
Ibuprofen analog results in increased activity of PPARG protein
Ibuprofen results in increased expression of PPARG mRNA
Ibuprofen affects the activity of PPARG protein		 CTD PMID:9013583 PMID:11755111 PMID:16407166 PMID:18946735 PMID:25596134 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppia peptidylprolyl isomerase A affects expression ISO Ibuprofen affects the expression of PPIA protein CTD PMID:18351690 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha multiple interactions ISO [Ibuprofen co-treated with epigallocatechin gallate] results in increased expression of PPP1CA protein CTD PMID:18348186 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Ibuprofen results in increased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171 		JBrowse link
G Prdx2 peroxiredoxin 2 affects expression
increases expression		 ISO Ibuprofen affects the expression of PRDX2 protein
Ibuprofen results in increased expression of PRDX2 mRNA		 CTD PMID:18351690 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194 		JBrowse link
G Prdx6 peroxiredoxin 6 affects expression ISO Ibuprofen affects the expression of PRDX6 protein CTD PMID:18351690 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 decreases expression ISO Ibuprofen results in decreased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872 		JBrowse link
G Ptger2 prostaglandin E receptor 2 decreases expression ISO Ibuprofen results in decreased expression of PTGER2 mRNA CTD PMID:37453669 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Ptger3 prostaglandin E receptor 3 affects expression ISO Ibuprofen affects the expression of PTGER3 mRNA CTD PMID:17070997 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434 		JBrowse link
G Ptgr1 prostaglandin reductase 1 affects activity ISO Ibuprofen affects the activity of PTGR1 protein CTD PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity
decreases expression		 ISO
EXP		 Ibuprofen results in decreased activity of PTGS1 protein
Ibuprofen results in decreased expression of PTGS1 mRNA
Ibuprofen analog results in decreased activity of PTGS1 protein; Ibuprofen results in decreased activity of PTGS1 protein		 CTD PMID:10697514 PMID:12242329 PMID:16141368 PMID:17164136 PMID:18848576 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
increases response to substance
decreases activity
decreases expression
decreases degradation		 ISO
EXP		 Ibuprofen inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]; Ibuprofen inhibits the reaction [PTGS2 protein affects the chemical synthesis of and affects the abundance of Dinoprostone]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of Arachidonic Acid]; Ibuprofen inhibits the reaction [PTGS2 protein results in increased metabolism of glyceryl 2-arachidonate]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; tert-Butylhydroperoxide inhibits the reaction [Ibuprofen inhibits the reaction [IL1B protein results in increased activity of PTGS2 protein]]
Ibuprofen results in increased expression of PTGS2 mRNA
PTGS2 gene SNP results in increased susceptibility to Ibuprofen
Ibuprofen results in decreased activity of PTGS2 protein
Ibuprofen results in decreased expression of PTGS2 mRNA; Ibuprofen results in decreased expression of PTGS2 protein
Ibuprofen inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [endotoxin, Escherichia coli promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Ibuprofen inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprostone]]; Ibuprofen inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
Ibuprofen results in decreased activity of PTGS2 protein; Ibuprofen results in decreased activity of PTGS2 protein mutant form
Ibuprofen results in decreased degradation of PTGS2 protein
[Dexamethasone co-treated with Ibuprofen] results in decreased expression of PTGS2 mRNA; [Ibuprofen binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2		 CTD PMID:10697514 PMID:12242329 PMID:15489888 PMID:15705740 PMID:15817521 More... NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pvt1 Pvt1 oncogene decreases expression ISO Ibuprofen results in decreased expression of PVT1 mRNA alternative form CTD PMID:37453669 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Pxn paxillin decreases expression EXP Ibuprofen results in decreased expression of PXN mRNA; Ibuprofen results in decreased expression of PXN protein CTD PMID:16463375 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Pygl glycogen phosphorylase L increases expression EXP Ibuprofen results in increased expression of PYGL mRNA CTD PMID:25596134 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Pyy peptide YY decreases expression ISO Ibuprofen results in decreased expression of PYY mRNA CTD PMID:17070997 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815 		JBrowse link
G Ran RAN, member RAS oncogene family affects expression ISO Ibuprofen affects the expression of RAN protein CTD PMID:18351690 NCBI chr12:27,674,049...27,678,598
Ensembl chr12:27,674,050...27,678,276 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO Ibuprofen results in decreased expression of RARA mRNA CTD PMID:25596134 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation EXP Ibuprofen results in decreased phosphorylation of RB1 protein CTD PMID:15099639 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]; Ibuprofen results in decreased activity of [NFKB1 protein binds to RELA protein]
Ibuprofen inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]		 CTD PMID:9281604 PMID:9890559 PMID:10328874 PMID:10602496 PMID:15489888 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rrp12 ribosomal RNA processing 12 increases expression ISO Ibuprofen results in increased expression of RRP12 mRNA CTD PMID:25596134 NCBI chr 1:240,672,378...240,705,992
Ensembl chr 1:240,672,382...240,706,018 		JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 increases expression ISO Ibuprofen results in increased expression of RSL1D1 mRNA CTD PMID:25596134 NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593 		JBrowse link
G Rsrc2 arginine and serine rich coiled-coil 2 increases expression ISO Ibuprofen results in increased expression of RSRC2 mRNA CTD PMID:25596134 NCBI chr12:32,839,840...32,859,820
Ensembl chr12:32,839,809...32,859,799 		JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO Ibuprofen results in decreased expression of RXRA mRNA CTD PMID:25596134 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Ibuprofen results in increased expression of S100A9 mRNA CTD PMID:24747151 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Sars1 seryl-tRNA synthetase 1 decreases expression EXP Ibuprofen results in decreased expression of SARS1 mRNA CTD PMID:25596134 NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression ISO
EXP		 Ibuprofen results in increased expression of SAT1 mRNA CTD PMID:16262603 PMID:25596134 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813 		JBrowse link
G Sele selectin E multiple interactions ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:16769766 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sesn1 sestrin 1 decreases expression EXP Ibuprofen results in decreased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697 		JBrowse link
G Sfn stratifin increases expression ISO Ibuprofen results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 increases expression ISO Ibuprofen results in increased expression of SH3TC1 mRNA CTD PMID:25596134 NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995 		JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression
increases expression		 EXP
ISO		 Ibuprofen results in decreased expression of SIK1 mRNA
Ibuprofen results in increased expression of SIK1 mRNA		 CTD PMID:25596134 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of SLC10A1 mRNA CTD PMID:29222744 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc10a2 solute carrier family 10 member 2 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of SLC10A2 mRNA CTD PMID:29222744 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475 		JBrowse link
G Slc15a1 solute carrier family 15 member 1 affects binding ISO Ibuprofen analog binds to SLC15A1 protein CTD PMID:21147219 NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545 		JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression ISO Ibuprofen results in increased expression of SLC16A6 mRNA CTD PMID:25596134 NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779 		JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression ISO Ibuprofen results in increased expression of SLC1A4 mRNA CTD PMID:25596134 NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418 		JBrowse link
G Slc1a7 solute carrier family 1 member 7 increases expression ISO Ibuprofen results in increased expression of SLC1A7 mRNA CTD PMID:25596134 NCBI chr 5:122,731,003...122,775,139
Ensembl chr 5:122,731,003...122,775,134 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity ISO Ibuprofen results in decreased activity of SLC22A1 protein CTD PMID:12388633 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a25 solute carrier family 22, member 25 decreases activity
increases uptake
multiple interactions		 ISO
EXP		 Ibuprofen results in decreased activity of SLC22A9 protein
SLC22A9 protein results in increased uptake of Ibuprofen
Ibuprofen inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]		 CTD PMID:12388633 PMID:16079298 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases uptake		 ISO Ibuprofen results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased uptake of Ibuprofen		 CTD PMID:12388633 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions
decreases activity		 ISO Ibuprofen inhibits the reaction [SLC22A7 protein results in increased transport of Tetracycline]
Ibuprofen results in decreased activity of SLC22A7 protein		 CTD PMID:12388633 PMID:15901346 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO Ibuprofen inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
Ibuprofen inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]		 CTD PMID:11306713 PMID:15100168 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 increases expression EXP Ibuprofen results in increased expression of SLC25A20 mRNA CTD PMID:25596134 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression
increases expression		 ISO Ibuprofen results in decreased expression of SLC2A1 protein
Ibuprofen results in increased expression of SLC2A1 mRNA		 CTD PMID:12912967 PMID:25596134 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression ISO Ibuprofen results in increased expression of SLC3A2 mRNA CTD PMID:25596134 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc5a8 solute carrier family 5 member 8 decreases activity ISO Ibuprofen results in decreased activity of SLC5A8 protein CTD PMID:15090606 PMID:16670197 NCBI chr 7:23,272,891...23,313,811
Ensembl chr 7:23,272,427...23,314,642 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Ibuprofen inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein] CTD PMID:18946735 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression ISO Ibuprofen results in increased expression of SLC6A9 mRNA CTD PMID:25596134 NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728 		JBrowse link
G Slc7a1 solute carrier family 7 member 1 increases expression ISO Ibuprofen results in increased expression of SLC7A1 mRNA CTD PMID:25596134 NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Ibuprofen results in increased expression of SLC7A11 mRNA CTD PMID:25596134 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression ISO Ibuprofen results in increased expression of SLC7A5 mRNA CTD PMID:25596134 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO [Dexamethasone co-treated with Ibuprofen] results in increased expression of SLCO1B2 mRNA CTD PMID:29222744 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression ISO Ibuprofen results in decreased expression of SLCO2B1 mRNA CTD PMID:25596134 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 affects expression ISO Ibuprofen affects the expression of SOCS3 mRNA CTD PMID:17070997 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Ibuprofen results in increased expression of SOD2 mRNA CTD PMID:17070997 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression ISO Ibuprofen results in decreased expression of SORL1 mRNA CTD PMID:25596134 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Ibuprofen results in increased expression of SRXN1 mRNA CTD PMID:25596134 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression ISO Ibuprofen results in increased expression of STRBP mRNA CTD PMID:25596134 NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949 		JBrowse link
G Sulf2 sulfatase 2 decreases expression ISO Ibuprofen results in decreased expression of SULF2 mRNA CTD PMID:25596134 NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO Ibuprofen results in decreased activity of SULT1E1 protein CTD PMID:17073578 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Tafazzin tafazzin, phospholipid-lysophospholipid transacylase decreases expression ISO Ibuprofen results in decreased expression of TAFAZZIN mRNA; Ibuprofen results in decreased expression of TAFAZZIN protein CTD PMID:37453669 NCBI chr  X:152,065,539...152,076,178
Ensembl chr  X:152,065,609...152,074,001 		JBrowse link
G Taldo1 transaldolase 1 decreases expression EXP Ibuprofen results in decreased expression of TALDO1 mRNA CTD PMID:25596134 NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974 		JBrowse link
G Tbx21 T-box transcription factor 21 decreases expression ISO Ibuprofen analog results in decreased expression of TBX21 mRNA; Ibuprofen results in decreased expression of TBX21 mRNA CTD PMID:17630191 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tead4 TEA domain transcription factor 4 decreases expression ISO Ibuprofen results in decreased expression of TEAD4 mRNA; Ibuprofen results in decreased expression of TEAD4 protein CTD PMID:37453669 NCBI chr 4:161,474,122...161,572,837
Ensembl chr 4:161,497,851...161,572,323 		JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 increases expression EXP
ISO		 Ibuprofen results in increased expression of TET1 mRNA CTD PMID:29665328 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052 		JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases expression
increases expression		 EXP
ISO		 Ibuprofen results in decreased expression of TFE3 mRNA
Ibuprofen results in increased expression of TFE3 mRNA		 CTD PMID:25596134 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Ibuprofen inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein] CTD PMID:21360558 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Ibuprofen results in increased expression of THBS1 protein CTD PMID:18261746 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP Ibuprofen results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Tmprss4 transmembrane serine protease 4 affects expression ISO Ibuprofen affects the expression of TMPRSS4 mRNA CTD PMID:17070997 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409 		JBrowse link
G Tnc tenascin C increases expression ISO Ibuprofen results in increased expression of TNC mRNA CTD PMID:17070997 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases secretion		 ISO
EXP		 [Oxygen deficiency co-treated with Lipopolysaccharides] promotes the reaction [Ibuprofen results in increased expression of TNF protein]; GW0072 inhibits the reaction [Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of BACE1 mRNA]; Ibuprofen inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased metabolism of and results in increased secretion of APP protein alternative form]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased activity of RELA protein]; Ibuprofen inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of SELE protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein]; Ibuprofen inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Ibuprofen results in decreased activity of [TNF protein results in increased activity of CHUK protein]
Ibuprofen affects the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Ibuprofen analog promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen inhibits the reaction [[TNF protein co-treated with IFNG protein] results in decreased expression of PPARG mRNA]; Ibuprofen inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ibuprofen promotes the reaction [endotoxin, Escherichia coli results in increased secretion of TNF protein]; Ibuprofen promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]
Ibuprofen analog results in decreased secretion of TNF protein; Ibuprofen results in decreased secretion of TNF protein
Ibuprofen inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of TNF protein]		 CTD PMID:9281604 PMID:9890559 PMID:10328874 PMID:10602496 PMID:10903797 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfaip8 TNF alpha induced protein 8 decreases expression ISO Ibuprofen results in decreased expression of TNFAIP8 mRNA CTD PMID:25596134 NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517 		JBrowse link
G Tnfrsf21 TNF receptor superfamily member 21 multiple interactions
decreases expression		 ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of TNFRSF21 protein]
Ibuprofen results in decreased expression of TNFRSF21 mRNA; Ibuprofen results in decreased expression of TNFRSF21 protein		 CTD PMID:11753679 NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Ibuprofen affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 decreases expression ISO Ibuprofen results in decreased expression of TP53INP1 mRNA CTD PMID:25596134 NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968 		JBrowse link
G Tpd52l1 TPD52 like 1 increases expression ISO Ibuprofen results in increased expression of TPD52L1 mRNA CTD PMID:25596134 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression
affects expression		 ISO Ibuprofen results in increased expression of TPI1 mRNA
Ibuprofen affects the expression of TPI1 protein		 CTD PMID:18351690 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
multiple interactions
increases expression		 ISO UGT1A1 protein results in increased glucuronidation of Ibuprofen
[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A1 mRNA
Ibuprofen results in increased expression of UGT1A1 mRNA		 CTD PMID:15843492 PMID:29222744 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Ibuprofen CTD PMID:15117964 PMID:15843492 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions		 ISO Ibuprofen results in increased expression of UGT1A6 mRNA
[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A6 mRNA		 CTD PMID:29222744 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Ibuprofen CTD PMID:15843492 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation EXP UGT2B1 protein results in increased glucuronidation of Ibuprofen CTD PMID:8302279 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions
increases glucuronidation
increases expression		 ISO Ibuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone]
UGT2B7 protein alternative form results in increased glucuronidation of Ibuprofen; UGT2B7 protein results in increased glucuronidation of Ibuprofen
Ibuprofen results in increased expression of UGT2B34 mRNA
[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT2B34 mRNA		 CTD PMID:8423545 PMID:8517101 PMID:15843492 PMID:19740398 PMID:29222744 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G Vars1 valyl-tRNA synthetase 1 increases expression
decreases expression		 ISO
EXP		 Ibuprofen results in increased expression of VARS1 mRNA
Ibuprofen results in decreased expression of VARS1 mRNA		 CTD PMID:25596134 NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Ibuprofen inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:16769766 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases secretion
decreases expression		 ISO
EXP		 Ibuprofen results in decreased secretion of VEGFA protein
Ibuprofen results in decreased expression of VEGFA mRNA alternative form; Ibuprofen results in decreased expression of VEGFA protein		 CTD PMID:12912967 PMID:16799050 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vwce von Willebrand factor C and EGF domains decreases expression ISO Ibuprofen results in decreased expression of VWCE mRNA CTD PMID:25596134 NCBI chr 1:207,280,714...207,327,215
Ensembl chr 1:207,282,356...207,312,986 		JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 decreases expression EXP Ibuprofen results in decreased expression of WARS1 mRNA CTD PMID:25596134 NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269 		JBrowse link
G Wdr81 WD repeat domain 81 increases expression ISO Ibuprofen results in increased expression of WDR81 mRNA CTD PMID:25596134 NCBI chr10:60,281,969...60,295,374
Ensembl chr10:60,281,972...60,295,296 		JBrowse link
G Xbp1 X-box binding protein 1 affects activity ISO Ibuprofen affects the activity of XBP1 protein CTD PMID:25596134 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions
decreases expression		 ISO Ibuprofen results in decreased expression of and results in increased phosphorylation of YAP1 protein
Ibuprofen results in decreased expression of YAP1 mRNA		 CTD PMID:37453669 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 increases expression ISO Ibuprofen results in increased expression of YARS1 mRNA CTD PMID:25596134 NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833 		JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO Ibuprofen results in increased expression of ZMAT3 mRNA CTD PMID:25596134 NCBI chr 2:115,106,046...115,136,888
Ensembl chr 2:115,106,966...115,136,863 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        xenobiotic 18707
          ibuprofen 308
            carboxyibuprofen 0
            dexibuprofen 0
            ibuproxam 0
            levibuprofen 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  carbon oxoacid 18612
                                    carboxylic acid 18609
                                      monocarboxylic acid 17984
                                        fatty acid 16792
                                          saturated fatty acid 16519
                                            propionic acid 3800
                                              ibuprofen 308
                                                carboxyibuprofen 0
                                                dexibuprofen 0
                                                ibuproxam 0
                                                levibuprofen 0
paths to the root