Gene: Bace1 (beta-secretase 1) Rattus norvegicus
Symbol: Bace1
Name: beta-secretase 1
Description: ENCODES a protein that exhibits peptidase activity; aspartic-type endopeptidase activity (ortholog); beta-amyloid binding (ortholog); INVOLVED IN beta-amyloid metabolic process; membrane protein ectodomain proteolysis (ortholog); proteolysis (ortholog); PARTICIPATES IN Alzheimer disease pathway; ASSOCIATED WITH Alzheimer Disease (ortholog); FOUND IN endosome; Golgi apparatus; axon (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrolein; all-trans-retinoic acid
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: asp 2; ASP2; aspartyl protease 2; Bace; beta-secretase 1; beta-site amyloid precursor protein cleaving enzyme 1; beta-site APP cleaving enzyme; beta-site APP cleaving enzyme 1; memapsin-2; membrane-associated aspartic protease 2
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0850,140,092 - 50,162,388 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0848,766,005 - 48,788,272 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4848,817,824 - 48,839,681 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1848,826,589 - 48,848,447 (+)NCBI
Celera845,724,900 - 45,747,208 (+)NCBI
Cytogenetic Map8q22NCBImapview
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Bace1
Entrez Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 2191
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2016-08-09
Status: ACTIVE