Gene: Bace1 (beta-secretase 1) Rattus norvegicus
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Symbol: Bace1
Name: beta-secretase 1
Description: ENCODES a protein that exhibits peptidase activity; amyloid-beta binding (ortholog); aspartic-type endopeptidase activity (ortholog); INVOLVED IN amyloid-beta metabolic process; membrane protein ectodomain proteolysis (ortholog); modulation of chemical synaptic transmission (ortholog); PARTICIPATES IN Alzheimer disease pathway; ASSOCIATED WITH Alzheimer Disease (ortholog); Alzheimer's disease (ortholog); FOUND IN endosome; Golgi apparatus; axon (ortholog); INTERACTS WITH 6-propyl-2-thiouracil; acrolein; all-trans-retinoic acid
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: asp 2; ASP2; aspartyl protease 2; Bace; beta-site amyloid precursor protein cleaving enzyme 1; beta-site APP cleaving enzyme; beta-site APP cleaving enzyme 1; memapsin-2; membrane-associated aspartic protease 2
Orthologs:
Homo sapiens (human) : BACE1 (beta-secretase 1)  HGNC  AGR
Mus musculus (house mouse) : Bace1 (beta-site APP cleaving enzyme 1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Bace1 (beta-secretase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BACE1 (beta-secretase 1)
Canis lupus familiaris (dog) : BACE1 (beta-secretase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bace1 (beta-secretase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0850,140,092 - 50,162,388 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0848,766,005 - 48,788,272 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4848,817,824 - 48,839,681 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1848,826,589 - 48,848,447 (+)NCBI
Celera845,724,900 - 45,747,208 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Bace1
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2191
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-11-14
Status: ACTIVE