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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2191
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bace1
Name: beta-secretase 1
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bace1decreases activityISOBACE1 (Homo sapiens)6480464CTDpioglitazone results in decreased activity of BACE1 proteinPMID:14586007
Bace1decreases expressionISOBace1 (Mus musculus)6480464CTDpioglitazone results in decreased expression of BACE1 mRNA; pioglitazone results in decreased expression of BACE1 proteinPMID:15817521 PMID:16407166
Bace1decreases expressionISOBACE1 (Homo sapiens)6480464CTDpioglitazone results in decreased expression of BACE1 mRNAPMID:14586007
Bace1multiple interactionsISOBACE1 (Homo sapiens)6480464CTDpioglitazone inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased expression of and results in increased activity of BACE1 protein]PMID:14586007
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