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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2191
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bace1
Name: beta-secretase 1
Acc ID: CHEBI:15379
Term: dioxygen
Definition: An elemental molecule that has formula O2.
Chemical ID: MESH:D010100
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bace1increases expressionISOBACE1 (Homo sapiens)6480464CTDOxygen deficiency results in increased expression of BACE1 mRNA; Oxygen deficiency results in increased expression of BACE1 proteinPMID:19196431
Bace1multiple interactionsISOBACE1 (Homo sapiens)6480464CTDalpha-Tocopherol inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]; CAT protein inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]; HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]; HIF1A protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 protein]; MAPK8 protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 protein]; MAPK9 protein affects the reaction [Oxygen deficiency results in increased expression of BACE1 protein]; Rotenone inhibits the reaction [Oxygen deficiency results in increased expression of BACE1 mRNA]PMID:19196431
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