ibuprofen - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	ibuprofen	go back to main search page
Accession:	CHEBI:5855	browse the term
Definition:	A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Synonyms:	exact_synonym:	2-[4-(2-methylpropyl)phenyl]propanoic acid
	related_synonym:	(+-)-2-(p-isobutylphenyl)propionic acid; (+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid; (+-)-p-isobutylhydratropic acid; (4-isobutylphenyl)-alpha-methylacetic acid; (RS)-ibuprofen; 2-(4-isobutylphenyl)propanoic acid; 4-isobutylhydratropic acid; Adran; Advil; Amibufen; Anco; Anflagen; Apsifen; Bluton; Brufen; Brufort; Buburone; Butylenin; C13H18O2; CC(C)Cc1ccc(cc1)C(C)C(O)=O; Dolgin; Dolgirid; Dolgit; Dolo-Dolgit; Ebufac; Epobron; Femadon; Haltran; Ibu-Attritin; Ibumetin; Ibuprocin; Ibutid; InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15); InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N; Inabrin; Inoven; Lamidon; Lebrufen; Liptan; Medipren; Motrin; Mynosedin; Nobfen; Nobgen; Nuprin; Nurofen; Pediaprofen; Roidenin; Rufen; Seclodin; Suspren; Tabalon; Trendar; Urem; alpha-(4-isobutylphenyl)propionic acid; alpha-(p-isobutylphenyl)propionic acid
	xref_casrn:	15687-27-1
	xref:	ChEMBL:111674 "ChEMBL COMPOUND"; ChemIDplus:15687-27-1 "CAS Registry Number"; ChemIDplus:2049713 "Beilstein Registry Number"; CiteXplore:11433218 "PubMed citation"; CiteXplore:12723739 "PubMed citation"; CiteXplore:14562167 "PubMed citation"; CiteXplore:15506544 "PubMed citation"; CiteXplore:18335846 "PubMed citation"; CiteXplore:18697608 "PubMed citation"; CiteXplore:21368281 "PubMed citation"; DrugBank:DB01050 "DrugBank"; KEGG COMPOUND:15687-27-1 "CAS Registry Number"; KEGG COMPOUND:C01588 "KEGG COMPOUND"; KEGG DRUG:D00126 "KEGG DRUG"
	xref_mesh:	MESH:D007052
	xref:	NIST Chemistry WebBook:15687-27-1 "CAS Registry Number"; Patent:GB971700 "Patent"; Patent:US3228831 "Patent"; Patent:US3385886 "Patent"; Patent:US5215755 "Patent"; Patent:US6727286 "Patent"; Reaxys:2049713 "Reaxys Registry Number"; Wikipedia:Ibuprofen "Wikipedia"

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ibuprofen
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Acsl1	acyl-CoA synthetase long-chain family member 1		increases metabolic processing	EXP	16	49,036,892	49,081,416	RGD:6480464	CTD
G	Acsl6	acyl-CoA synthetase long-chain family member 6		increases metabolic processing	EXP	10	39,729,805	39,778,106	RGD:6480464	CTD
G	Adamts8	ADAM metallopeptidase with thrombospondin type 1 motif, 8		increases expression	ISO	8	30,732,584	30,743,809	RGD:6480464	CTD
G	Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)		increases expression	EXP	19	54,738,556	54,750,349	RGD:6480464	CTD
G	Akr1c1	aldo-keto reductase family 1, member C1		decreases activity	ISO	17	77,084,306	77,112,994	RGD:6480464	CTD
G	Akr1c2	aldo-keto reductase family 1, member C2		decreases activity	ISO	17	77,034,737	77,081,406	RGD:6480464	CTD
G	Akr1c3	aldo-keto reductase family 1, member C3		decreases activity	ISO	17	77,269,626	77,286,521	RGD:6480464	CTD
G	Alb	albumin		multiple interactions	ISO	14	19,126,935	19,142,214	RGD:6480464	CTD
G	Alox12b	arachidonate 12-lipoxygenase, 12R type		affects expression	ISO	10	55,917,373	55,926,321	RGD:6480464	CTD
G	Aloxe3	arachidonate lipoxygenase 3		affects expression	ISO	10	55,885,573	55,908,641	RGD:6480464	CTD
G	Amacr	alpha-methylacyl-CoA racemase		affects response to substance	ISO	2	60,332,292	60,344,326	RGD:6480464	CTD
G	Amacr	alpha-methylacyl-CoA racemase		multiple interactions	ISO	2	60,332,292	60,344,326	RGD:6480464	CTD
G	Amacr	alpha-methylacyl-CoA racemase		increases metabolic processing	ISO	2	60,332,292	60,344,326	RGD:6480464	CTD
G	Anxa1	annexin A1		affects expression	ISO	1	223,478,436	223,494,455	RGD:6480464	CTD
G	Anxa2	annexin A2		affects expression	ISO	8	73,897,618	73,934,041	RGD:6480464	CTD
G	Anxa3	annexin A3		affects expression	ISO	14	14,245,112	14,297,100	RGD:6480464	CTD
G	Anxa9	annexin A9		decreases expression	ISO	2	190,206,342	190,215,046	RGD:6480464	CTD
G	App	amyloid beta (A4) precursor protein		affects cleavage	ISO	11	24,457,855	24,693,851	RGD:6480464	CTD
G	App	amyloid beta (A4) precursor protein		multiple interactions	ISO	11	24,457,855	24,693,851	RGD:6480464	CTD
G	App	amyloid beta (A4) precursor protein		decreases expression	ISO	11	24,457,855	24,693,851	RGD:6480464	CTD
G	App	amyloid beta (A4) precursor protein		multiple interactions	ISO	11	24,457,855	24,693,851	RGD:6480464	CTD
G	App	amyloid beta (A4) precursor protein		multiple interactions	EXP	11	24,457,855	24,693,851	RGD:6480464	CTD
G	App	amyloid beta (A4) precursor protein		affects cleavage	ISO	11	24,457,855	24,693,851	RGD:6480464	CTD
G	Asic1	acid-sensing (proton-gated) ion channel 1		decreases expression	EXP	7	138,414,656	138,443,272	RGD:6480464	CTD
G	Asic1	acid-sensing (proton-gated) ion channel 1		decreases activity	EXP	7	138,414,656	138,443,272	RGD:6480464	CTD
G	Asic2	acid-sensing (proton-gated) ion channel 2		decreases expression	EXP	10	69,103,244	70,190,305	RGD:6480464	CTD
G	Asic3	acid-sensing (proton-gated) ion channel 3		decreases expression	EXP	4	6,125,614	6,129,660	RGD:6480464	CTD
G	Bace1	beta-site APP cleaving enzyme 1		multiple interactions	ISO	8	48,817,824	48,839,681	RGD:6480464	CTD
G	Bace1	beta-site APP cleaving enzyme 1		decreases activity	ISO	8	48,817,824	48,839,681	RGD:6480464	CTD
G	Bace1	beta-site APP cleaving enzyme 1		decreases expression	ISO	8	48,817,824	48,839,681	RGD:6480464	CTD
G	Bace1	beta-site APP cleaving enzyme 1		multiple interactions	ISO	8	48,817,824	48,839,681	RGD:6480464	CTD
G	Bace1	beta-site APP cleaving enzyme 1		decreases expression	ISO	8	48,817,824	48,839,681	RGD:6480464	CTD
G	Bace1	beta-site APP cleaving enzyme 1		decreases expression	EXP	8	48,817,824	48,839,681	RGD:6480464	CTD
G	Bcl2l1	Bcl2-like 1		multiple interactions	ISO	3	143,129,087	143,180,199	RGD:6480464	CTD
G	C3	complement component 3		affects expression	ISO				RGD:6480464	CTD
G	Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3		affects expression	ISO	16	4,173,412	5,059,574	RGD:6480464	CTD
G	Calca	calcitonin-related polypeptide alpha		decreases expression	EXP	1	172,686,168	172,691,061	RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	EXP	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		increases expression	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl3	chemokine (C-C motif) ligand 3		multiple interactions	ISO	10	71,744,559	71,746,109	RGD:6480464	CTD
G	Ccnd1	cyclin D1		multiple interactions	ISO	1	205,357,235	205,366,757	RGD:6480464	CTD
G	Cd36	CD36 molecule (thrombospondin receptor)		increases expression	ISO	4	13,471,878	13,525,620	RGD:6480464	CTD
G	Cdh3	cadherin 3		affects expression	ISO	19	36,343,823	36,393,819	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		increases expression	EXP	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Cdsn	corneodesmosin		affects expression	ISO				RGD:6480464	CTD
G	Ceacam1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)		affects expression	ISO	1	80,742,540	80,758,943	RGD:6480464	CTD
G	Chuk	conserved helix-loop-helix ubiquitous kinase		decreases activity	ISO	1	249,122,845	249,158,369	RGD:6480464	CTD
G	Chuk	conserved helix-loop-helix ubiquitous kinase		multiple interactions	ISO	1	249,122,845	249,158,369	RGD:6480464	CTD
G	Chuk	conserved helix-loop-helix ubiquitous kinase		multiple interactions	ISO	1	249,122,845	249,158,369	RGD:6480464	CTD
G	Clu	clusterin		affects expression	ISO	15	45,365,779	45,405,314	RGD:6480464	CTD
G	Cnr1	cannabinoid receptor 1 (brain)		multiple interactions	EXP	5	50,427,173	50,445,471	RGD:6480464	CTD
G	Cnr2	cannabinoid receptor 2 (macrophage)		multiple interactions	ISO	5	154,674,754	154,702,552	RGD:6480464	CTD
G	Col11a1	collagen, type XI, alpha 1		affects expression	ISO	2	209,996,467	210,193,379	RGD:6480464	CTD
G	Cx3cl1	chemokine (C-X3-C motif) ligand 1		affects expression	ISO	19	10,666,940	10,676,424	RGD:6480464	CTD
G	Cxcl10	chemokine (C-X-C motif) ligand 10		multiple interactions	ISO	14	17,265,986	17,268,183	RGD:6480464	CTD
G	Cxcl2	chemokine (C-X-C motif) ligand 2		multiple interactions	EXP	14	18,677,129	18,679,175	RGD:6480464	CTD
G	Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1		decreases activity	ISO				RGD:6480464	CTD
G	Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1		decreases expression	ISO				RGD:6480464	CTD
G	Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11		decreases metabolic processing	ISO	1	243,281,320	243,320,945	RGD:6480464	CTD
G	Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11		affects binding	ISO	1	243,281,320	243,320,945	RGD:6480464	CTD
G	Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11		affects metabolic processing	ISO	1	243,281,320	243,320,945	RGD:6480464	CTD
G	Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11		increases metabolic processing	ISO	1	243,281,320	243,320,945	RGD:6480464	CTD
G	Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11		multiple interactions	ISO	1	243,281,320	243,320,945	RGD:6480464	CTD
G	Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11		increases metabolic processing	ISO	1	243,281,320	243,320,945	RGD:6480464	CTD
G	Cyp2c11	cytochrome P450, subfamily 2, polypeptide 11		decreases metabolic processing	ISO	1	243,281,320	243,320,945	RGD:6480464	CTD
G	Cyp2c79	cytochrome P450, family 2, subfamily c, polypeptide 79		affects metabolic processing	ISO	1	244,400,004	244,493,624	RGD:6480464	CTD
G	Cyp2c79	cytochrome P450, family 2, subfamily c, polypeptide 79		decreases metabolic processing	ISO	1	244,400,004	244,493,624	RGD:6480464	CTD
G	Cyp2c79	cytochrome P450, family 2, subfamily c, polypeptide 79		increases metabolic processing	ISO	1	244,400,004	244,493,624	RGD:6480464	CTD
G	Ddx1	DEAD (Asp-Glu-Ala-Asp) box helicase 1		affects expression	ISO	6	36,794,602	36,825,473	RGD:6480464	CTD
G	Dsc1	desmocollin 1		affects expression	ISO	18	11,953,172	11,979,048	RGD:6480464	CTD
G	Egf	epidermal growth factor		multiple interactions	ISO	2	227,103,900	227,195,062	RGD:6480464	CTD
G	Eif4e	eukaryotic translation initiation factor 4E		multiple interactions	ISO	2	236,072,748	236,104,714	RGD:6480464	CTD
G	Eif4e	eukaryotic translation initiation factor 4E		increases phosphorylation	ISO	2	236,072,748	236,104,714	RGD:6480464	CTD
G	Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)		multiple interactions	ISO	12	1,459,046	1,500,042	RGD:6480464	CTD
G	Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)		increases expression	ISO	12	1,459,046	1,500,042	RGD:6480464	CTD
G	Eno1	enolase 1, (alpha)		affects expression	ISO	5	167,394,131	167,405,516	RGD:6480464	CTD
G	Epas1	endothelial PAS domain protein 1		decreases expression	ISO	6	10,203,108	10,297,215	RGD:6480464	CTD
G	Ephb6	Eph receptor B6		affects expression	ISO	4	69,316,600	69,331,856	RGD:6480464	CTD
G	Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)		affects cleavage	ISO	9	66,843,898	67,967,970	RGD:6480464	CTD
G	F3	coagulation factor III (thromboplastin, tissue factor)		increases expression	ISO	2	218,371,050	218,382,645	RGD:6480464	CTD
G	Faah	fatty acid amide hydrolase		decreases activity	EXP	5	136,310,965	136,329,817	RGD:6480464	CTD
G	Fabp4	fatty acid binding protein 4, adipocyte		decreases expression	ISO	2	93,536,133	93,540,734	RGD:6480464	CTD
G	Fasn	fatty acid synthase		affects expression	ISO				RGD:6480464	CTD
G	Fasn	fatty acid synthase		decreases expression	ISO				RGD:6480464	CTD
G	Fosb	FBJ osteosarcoma oncogene B		increases expression	ISO	1	78,668,497	78,673,330	RGD:6480464	CTD
G	Frzb	frizzled-related protein		affects expression	ISO	3	63,350,504	63,383,436	RGD:6480464	CTD
G	Gata3	GATA binding protein 3		decreases expression	ISO	17	79,991,587	80,011,574	RGD:6480464	CTD
G	Gclc	glutamate-cysteine ligase, catalytic subunit		increases expression	ISO	8	82,724,429	82,762,848	RGD:6480464	CTD
G	Gclm	glutamate cysteine ligase, modifier subunit		increases expression	ISO	2	218,895,434	218,915,491	RGD:6480464	CTD
G	Gdf15	growth differentiation factor 15		increases expression	ISO	16	19,310,882	19,313,465	RGD:6480464	CTD
G	Gdf15	growth differentiation factor 15		increases expression	ISO	16	19,310,882	19,313,465	RGD:6480464	CTD
G	Gdf15	growth differentiation factor 15		multiple interactions	ISO	16	19,310,882	19,313,465	RGD:6480464	CTD
G	Gstt1	glutathione S-transferase theta 1		increases expression	EXP	20	13,604,355	13,621,456	RGD:6480464	CTD
G	Gstt2	glutathione S-transferase, theta 2		increases expression	EXP	20	13,221,696	13,225,367	RGD:6480464	CTD
G	Hif1a	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)		decreases expression	ISO	6	96,419,024	96,463,891	RGD:6480464	CTD
G	Hpgd	hydroxyprostaglandin dehydrogenase 15 (NAD)		affects expression	ISO	16	37,419,901	37,457,896	RGD:6480464	CTD
G	Hpgd	hydroxyprostaglandin dehydrogenase 15 (NAD)		increases expression	ISO	16	37,419,901	37,457,896	RGD:6480464	CTD
G	Hpgd	hydroxyprostaglandin dehydrogenase 15 (NAD)		increases activity	ISO	16	37,419,901	37,457,896	RGD:6480464	CTD
G	Hsf1	heat shock transcription factor 1		increases activity	ISO	7	114,524,211	114,551,166	RGD:6480464	CTD
G	Hspa1a	heat shock protein 1A		affects localization	ISO	20	3,945,716	3,959,552	RGD:6480464	CTD
G	Hspa1a	heat shock protein 1A		increases expression	ISO	20	3,945,716	3,959,552	RGD:6480464	CTD
G	Hspa8	heat shock 70kDa protein 8		affects localization	ISO	8	43,784,035	43,787,760	RGD:6480464	CTD
G	Hspa8	heat shock 70kDa protein 8		affects localization	ISO	8	43,784,035	43,787,760	RGD:6480464	CTD
G	Icam1	intercellular adhesion molecule 1		multiple interactions	ISO	8	20,040,177	20,051,939	RGD:6480464	CTD
G	Icam1	intercellular adhesion molecule 1		decreases expression	ISO	8	20,040,177	20,051,939	RGD:6480464	CTD
G	Ifng	interferon gamma		multiple interactions	ISO	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Ifng	interferon gamma		multiple interactions	ISO	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Ifng	interferon gamma		multiple interactions	ISO	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Ifng	interferon gamma		decreases secretion	ISO	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Igf1	insulin-like growth factor 1		increases expression	EXP	7	24,531,669	24,605,742	RGD:6480464	CTD
G	Il10	interleukin 10		multiple interactions	ISO	13	43,953,900	43,957,766	RGD:6480464	CTD
G	Il1a	interleukin 1 alpha		multiple interactions	ISO	3	116,913,612	116,924,114	RGD:6480464	CTD
G	Il1a	interleukin 1 alpha		increases expression	ISO	3	116,913,612	116,924,114	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		affects expression	EXP	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1rn	interleukin 1 receptor antagonist		decreases secretion	ISO	3	2,607,800	2,613,216	RGD:6480464	CTD
G	Il1rn	interleukin 1 receptor antagonist		multiple interactions	EXP	3	2,607,800	2,613,216	RGD:6480464	CTD
G	Il1rn	interleukin 1 receptor antagonist		increases expression	EXP	3	2,607,800	2,613,216	RGD:6480464	CTD
G	Il4	interleukin 4		multiple interactions	ISO	10	39,074,582	39,080,134	RGD:6480464	CTD
G	Il6	interleukin 6		increases expression	ISO	4	456,799	461,376	RGD:6480464	CTD
G	Il6	interleukin 6		multiple interactions	ISO	4	456,799	461,376	RGD:6480464	CTD
G	Insm1	insulinoma-associated 1		decreases expression	ISO	3	134,845,568	134,847,243	RGD:6480464	CTD
G	Itgbl1	integrin, beta-like 1		affects expression	ISO	15	108,785,509	109,051,028	RGD:6480464	CTD
G	Ldhb	lactate dehydrogenase B		affects expression	ISO	4	180,061,567	180,079,473	RGD:6480464	CTD
G	Ldlr	low density lipoprotein receptor		multiple interactions	ISO	8	20,824,040	20,846,920	RGD:6480464	CTD
G	Lgals1	lectin, galactoside-binding, soluble, 1		affects expression	ISO	7	116,893,662	116,896,768	RGD:6480464	CTD
G	Lta	lymphotoxin alpha (TNF superfamily, member 1)		affects response to substance	ISO	20	3,657,842	3,659,848	RGD:6480464	CTD
G	Ltbr	lymphotoxin beta receptor (TNFR superfamily, member 3)		decreases expression	ISO	4	161,431,864	161,438,265	RGD:6480464	CTD
G	Ly9	lymphocyte antigen 9		decreases expression	ISO	13	87,581,203	87,600,810	RGD:6480464	CTD
G	Mal	mal, T-cell differentiation protein		increases expression	ISO	3	115,166,671	115,190,432	RGD:6480464	CTD
G	Mapk11	mitogen-activated protein kinase 11		multiple interactions	ISO	7	127,444,055	127,449,990	RGD:6480464	CTD
G	Mapk14	mitogen activated protein kinase 14		multiple interactions	ISO	20	6,939,249	7,000,378	RGD:6480464	CTD
G	Mapk14	mitogen activated protein kinase 14		multiple interactions	ISO	20	6,939,249	7,000,378	RGD:6480464	CTD
G	Mapkapk2	mitogen-activated protein kinase-activated protein kinase 2		multiple interactions	ISO	13	43,994,943	44,041,504	RGD:6480464	CTD
G	Mapkapk3	mitogen-activated protein kinase-activated protein kinase 3		multiple interactions	ISO	8	112,497,626	112,531,778	RGD:6480464	CTD
G	Mapre2	microtubule-associated protein, RP/EB family, member 2		affects expression	ISO				RGD:6480464	CTD
G	Mcl1	myeloid cell leukemia sequence 1		multiple interactions	ISO				RGD:6480464	CTD
G	Mmp1	matrix metallopeptidase 1 (interstitial collagenase)		increases expression	ISO	8	4,333,773	4,354,284	RGD:6480464	CTD
G	Mmp3	matrix metallopeptidase 3		increases expression	ISO	8	4,315,601	4,329,146	RGD:6480464	CTD
G	Mmp9	matrix metallopeptidase 9		multiple interactions	ISO	3	155,985,473	155,993,433	RGD:6480464	CTD
G	Mta2	metastasis associated 1 family, member 2		increases expression	ISO	1	211,618,426	211,627,147	RGD:6480464	CTD
G	Mxd1	max dimerization protein 1		increases expression	ISO	4	120,801,932	120,822,346	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		multiple interactions	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		multiple interactions	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		multiple interactions	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		multiple interactions	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		multiple interactions	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		multiple interactions	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha		multiple interactions	ISO	6	75,729,302	75,732,475	RGD:6480464	CTD
G	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha		multiple interactions	ISO	6	75,729,302	75,732,475	RGD:6480464	CTD
G	Ngfr	nerve growth factor receptor		multiple interactions	ISO	10	84,262,804	84,281,006	RGD:6480464	CTD
G	Ngfr	nerve growth factor receptor		increases expression	ISO	10	84,262,804	84,281,006	RGD:6480464	CTD
G	Ngfr	nerve growth factor receptor		increases expression	ISO	10	84,262,804	84,281,006	RGD:6480464	CTD
G	Ngfr	nerve growth factor receptor		increases expression	ISO	10	84,262,804	84,281,006	RGD:6480464	CTD
G	Ngfr	nerve growth factor receptor		increases expression	ISO	10	84,262,804	84,281,006	RGD:6480464	CTD
G	Ngfr	nerve growth factor receptor		increases expression	ISO	10	84,262,804	84,281,006	RGD:6480464	CTD
G	Ngfr	nerve growth factor receptor		increases expression	ISO	10	84,262,804	84,281,006	RGD:6480464	CTD
G	Ngfr	nerve growth factor receptor		multiple interactions	ISO	10	84,262,804	84,281,006	RGD:6480464	CTD
G	Nos1	nitric oxide synthase 1, neuronal		affects expression	ISO	12	39,812,500	39,869,484	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		multiple interactions	ISO	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		increases activity	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		increases expression	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		increases expression	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nqo1	NAD(P)H dehydrogenase, quinone 1		affects expression	ISO	19	37,251,147	37,266,040	RGD:6480464	CTD
G	Nr3c1	nuclear receptor subfamily 3, group C, member 1		increases activity	EXP	18	32,371,496	32,459,145	RGD:6480464	CTD
G	P2ry2	purinergic receptor P2Y, G-protein coupled, 2		multiple interactions	ISO	1	158,440,018	158,454,213	RGD:6480464	CTD
G	Pabpn1	poly(A) binding protein, nuclear 1		multiple interactions	ISO	15	32,994,493	32,999,104	RGD:6480464	CTD
G	Pdgfa	platelet-derived growth factor alpha polypeptide		multiple interactions	ISO	12	16,151,045	16,172,412	RGD:6480464	CTD
G	Pgam1	phosphoglycerate mutase 1 (brain)		affects expression	ISO				RGD:6480464	CTD
G	Pgam1	phosphoglycerate mutase 1 (brain)		increases expression	ISO				RGD:6480464	CTD
G	Pla2g2a	phospholipase A2, group IIA (platelets, synovial fluid)		affects expression	ISO	5	157,654,786	157,657,360	RGD:6480464	CTD
G	Plau	plasminogen activator, urokinase		multiple interactions	ISO	15	3,680,072	3,686,232	RGD:6480464	CTD
G	Plec	plectin		increases expression	ISO	7	114,202,742	114,262,385	RGD:6480464	CTD
G	Plec	plectin		affects expression	ISO	7	114,202,742	114,262,385	RGD:6480464	CTD
G	Pml	promyelocytic leukemia		affects expression	ISO	8	62,020,438	62,051,927	RGD:6480464	CTD
G	Ppara	peroxisome proliferator activated receptor alpha		multiple interactions	ISO	7	123,729,774	123,807,090	RGD:6480464	CTD
G	Ppara	peroxisome proliferator activated receptor alpha		increases activity	EXP	7	123,729,774	123,807,090	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		multiple interactions	ISO	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		multiple interactions	ISO	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		multiple interactions	ISO	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		increases activity	EXP	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		increases expression	ISO	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Ppia	peptidylprolyl isomerase A (cyclophilin A)		affects expression	ISO	14	87,165,998	87,169,995	RGD:6480464	CTD
G	Ppp1ca	protein phosphatase 1, catalytic subunit, alpha isozyme		multiple interactions	ISO	1	206,774,719	206,778,336	RGD:6480464	CTD
G	Prdx2	peroxiredoxin 2		affects expression	ISO	19	24,836,199	24,841,390	RGD:6480464	CTD
G	Prdx2	peroxiredoxin 2		increases expression	ISO	19	24,836,199	24,841,390	RGD:6480464	CTD
G	Prdx6	peroxiredoxin 6		affects expression	ISO	13	76,824,968	76,835,517	RGD:6480464	CTD
G	Ptger3	prostaglandin E receptor 3 (subtype EP3)		affects expression	ISO	2	255,680,691	255,759,202	RGD:6480464	CTD
G	Ptgs1	prostaglandin-endoperoxide synthase 1		decreases activity	ISO	3	15,343,832	15,365,412	RGD:6480464	CTD
G	Ptgs1	prostaglandin-endoperoxide synthase 1		decreases activity	ISO	3	15,343,832	15,365,412	RGD:6480464	CTD
G	Ptgs1	prostaglandin-endoperoxide synthase 1		decreases activity	ISO	3	15,343,832	15,365,412	RGD:6480464	CTD
G	Ptgs1	prostaglandin-endoperoxide synthase 1		decreases expression	EXP	3	15,343,832	15,365,412	RGD:6480464	CTD
G	Ptgs1	prostaglandin-endoperoxide synthase 1		decreases activity	ISO	3	15,343,832	15,365,412	RGD:6480464	CTD
G	Ptgs1	prostaglandin-endoperoxide synthase 1		decreases activity	ISO	3	15,343,832	15,365,412	RGD:6480464	CTD
G	Ptgs1	prostaglandin-endoperoxide synthase 1		decreases activity	ISO	3	15,343,832	15,365,412	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		multiple interactions	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		increases expression	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		increases response to substance	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases activity	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases expression	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		multiple interactions	EXP	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		increases expression	EXP	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases expression	EXP	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		multiple interactions	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		multiple interactions	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases activity	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases activity	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases expression	EXP	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases activity	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases activity	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases degradation	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Pxn	paxillin		decreases expression	EXP	12	42,322,193	42,370,507	RGD:6480464	CTD
G	Pyy	peptide YY (mapped)		decreases expression	ISO	10	91,174,365	91,175,488	RGD:6480464	CTD
G	Ran	RAN, member RAS oncogene family		affects expression	ISO	12	28,736,786	28,739,921	RGD:6480464	CTD
G	Rb1	retinoblastoma 1		decreases phosphorylation	EXP	15	53,828,881	53,962,099	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Sat1	spermidine/spermine N1-acetyl transferase 1		increases expression	ISO	X	61,634,964	61,638,247	RGD:6480464	CTD
G	Sele	selectin E		multiple interactions	ISO	13	79,813,455	79,822,845	RGD:6480464	CTD
G	Slc22a1	solute carrier family 22 (organic cation transporter), member 1		decreases activity	ISO	1	42,351,239	42,378,295	RGD:6480464	CTD
G	Slc22a24	solute carrier family 22, member 24		multiple interactions	EXP	1	210,409,224	210,465,549	RGD:6480464	CTD
G	Slc22a6	solute carrier family 22 (organic anion transporter), member 6		decreases activity	ISO	1	211,294,178	211,302,398	RGD:6480464	CTD
G	Slc22a6	solute carrier family 22 (organic anion transporter), member 6		increases uptake	ISO	1	211,294,178	211,302,398	RGD:6480464	CTD
G	Slc22a7	solute carrier family 22 (organic anion transporter), member 7		multiple interactions	ISO	9	9,934,309	9,940,107	RGD:6480464	CTD
G	Slc22a7	solute carrier family 22 (organic anion transporter), member 7		decreases activity	ISO	9	9,934,309	9,940,107	RGD:6480464	CTD
G	Slc22a8	solute carrier family 22 (organic anion transporter), member 8		multiple interactions	ISO	1	211,269,366	211,287,596	RGD:6480464	CTD
G	Slc22a8	solute carrier family 22 (organic anion transporter), member 8		multiple interactions	ISO	1	211,269,366	211,287,596	RGD:6480464	CTD
G	Slc2a1	solute carrier family 2 (facilitated glucose transporter), member 1		decreases expression	ISO	5	139,690,801	139,719,021	RGD:6480464	CTD
G	Slc5a8	solute carrier family 5 (iodide transporter), member 8		decreases activity	ISO	7	25,585,545	25,626,486	RGD:6480464	CTD
G	Slc5a8	solute carrier family 5 (iodide transporter), member 8		decreases activity	ISO	7	25,585,545	25,626,486	RGD:6480464	CTD
G	Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3		multiple interactions	ISO	1	30,516,568	30,557,540	RGD:6480464	CTD
G	Slco1a1	solute carrier organic anion transporter family, member 1a1		decreases activity	EXP				RGD:6480464	CTD
G	Slco1a1	solute carrier organic anion transporter family, member 1a1		multiple interactions	EXP				RGD:6480464	CTD
G	Socs3	suppressor of cytokine signaling 3		affects expression	ISO	10	107,958,468	107,959,330	RGD:6480464	CTD
G	Sod2	superoxide dismutase 2, mitochondrial		increases expression	ISO	1	41,862,997	41,870,327	RGD:6480464	CTD
G	Sult1e1	sulfotransferase family 1E, estrogen-preferring, member 1		decreases activity	ISO	14	21,948,475	21,965,541	RGD:6480464	CTD
G	Tbx21	T-box 21		decreases expression	ISO	10	85,817,743	85,834,178	RGD:6480464	CTD
G	Thbs1	thrombospondin 1		increases expression	ISO				RGD:6480464	CTD
G	Tmprss4	transmembrane protease, serine 4		affects expression	ISO	8	48,120,501	48,154,809	RGD:6480464	CTD
G	Tnc	tenascin C		increases expression	ISO				RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		decreases secretion	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases expression	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnfrsf21	tumor necrosis factor receptor superfamily, member 21		multiple interactions	ISO	9	13,587,961	13,666,380	RGD:6480464	CTD
G	Tnfrsf21	tumor necrosis factor receptor superfamily, member 21		decreases expression	ISO	9	13,587,961	13,666,380	RGD:6480464	CTD
G	Tpi1	triosephosphate isomerase 1		increases expression	ISO	4	160,933,341	160,936,871	RGD:6480464	CTD
G	Tpi1	triosephosphate isomerase 1		affects expression	ISO	4	160,933,341	160,936,871	RGD:6480464	CTD
G	Ugt1a1	UDP glucuronosyltransferase 1 family, polypeptide A1		increases glucuronidation	ISO	9	87,091,241	87,098,362	RGD:6480464	CTD
G	Ugt1a2	UDP glucuronosyltransferase 1 family, polypeptide A2		increases glucuronidation	ISO	9	87,081,132	87,098,362	RGD:6480464	CTD
G	Ugt1a2	UDP glucuronosyltransferase 1 family, polypeptide A2		increases glucuronidation	ISO	9	87,081,132	87,098,362	RGD:6480464	CTD
G	Ugt1a8	UDP glycosyltransferase 1 family, polypeptide A8		increases glucuronidation	ISO	9	87,017,029	87,098,362	RGD:6480464	CTD
G	Ugt1a9	UDP glucuronosyltransferase 1 family, polypeptide A9		increases glucuronidation	ISO	9	86,986,915	87,098,362	RGD:6480464	CTD
G	Ugt2b15	UDP glucuronosyltransferase 2 family, polypeptide B15		increases glucuronidation	ISO	14	22,346,334	22,366,860	RGD:6480464	CTD
G	Ugt2b17	UDP glucuronosyltransferase 2 family, polypeptide B17		increases glucuronidation	ISO	14	22,639,182	22,650,931	RGD:6480464	CTD
G	Ugt2b35	UDP glucuronosyltransferase 2 family, polypeptide B35		increases glucuronidation	ISO	14	22,454,256	22,493,510	RGD:6480464	CTD
G	Ugt2b7	UDP glucuronosyltransferase 2 family, polypeptide B7		multiple interactions	ISO	14	22,499,152	22,522,842	RGD:6480464	CTD
G	Ugt2b7	UDP glucuronosyltransferase 2 family, polypeptide B7		increases glucuronidation	ISO	14	22,499,152	22,522,842	RGD:6480464	CTD
G	Ugt2b7	UDP glucuronosyltransferase 2 family, polypeptide B7		increases glucuronidation	ISO	14	22,499,152	22,522,842	RGD:6480464	CTD
G	Ugt2b7	UDP glucuronosyltransferase 2 family, polypeptide B7		increases glucuronidation	ISO	14	22,499,152	22,522,842	RGD:6480464	CTD
G	UST4r	integral membrane transport protein UST4r		decreases activity	ISO	1	210,618,706	210,688,125	RGD:6480464	CTD
G	UST4r	integral membrane transport protein UST4r		increases uptake	ISO	1	210,618,706	210,688,125	RGD:6480464	CTD
G	Vcam1	vascular cell adhesion molecule 1		multiple interactions	ISO	2	212,277,654	212,297,376	RGD:6480464	CTD
G	Vegfa	vascular endothelial growth factor A		decreases secretion	ISO	9	10,520,730	10,536,071	RGD:6480464	CTD
G	Vegfa	vascular endothelial growth factor A		decreases expression	EXP	9	10,520,730	10,536,071	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	501881
role	491510
application	249674
anti-inflammatory agent	34449
anti-inflammatory drug	21993
non-steroidal anti-inflammatory drug	17548
ibuprofen	292
dexibuprofen	0
levibuprofen	0
Path 2
Term	Annotations
CHEBI ontology	501881
subatomic particle	500845
composite particle	500845
hadron	500845
baryon	500845
nucleon	500845
atomic nucleus	500845
atom	500845
main group element atom	470301
p-block element atom	467779
carbon group element atom	419149
carbon atom	415667
organic molecular entity	415660
organic group	171184
organic divalent group	169999
organodiyl group	169999
carbonyl group	169689
carbonyl compound	169689
carboxylic acid	122651
monocarboxylic acid	70955
fatty acid	25205
saturated fatty acid	21832
propionic acid	5645
ibuprofen	292
dexibuprofen	0
levibuprofen	0