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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hpgd
Name: 15-hydroxyprostaglandin dehydrogenase
Acc ID: CHEBI:5855
Term: ibuprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.
Chemical ID: MESH:D007052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hpgdaffects expressionISOHPGD (Homo sapiens)6480464CTDIbuprofen affects the expression of HPGD mRNAPMID:17070997
Hpgdincreases activityISOHPGD (Homo sapiens)6480464CTDIbuprofen results in increased activity of HPGD proteinPMID:19501039
Hpgdincreases expressionISOHPGD (Homo sapiens)6480464CTDIbuprofen results in increased expression of HPGD mRNAPMID:19501039
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