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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:the extracellular signal-regulated Raf/Mek/Erk signaling pathway
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Accession:PW:0000102 term browser browse the term
Definition:The Raf/Mek/Erk signaling pathway - a Ras activated protein kinase cascade - regulates diverse processes such as cell growth, proliferation and differentiation, in response to cytokines, hormones, growth factors.
Synonyms:related_synonym: ERK1 and ERK2 cascade
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the extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Araf A-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:22177953 RGD:5686410 NCBI chr  X:3,780,932...3,845,919
Ensembl chr  X:3,780,932...3,792,611 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase IMP
ISO 		RGD PMID:16508002 PMID:22177953 PMID:17310240 RGD:1580106, RGD:5686410, RGD:1626216 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Dusp6 dual specificity phosphatase 6 ISO RGD PMID:17208316 RGD:2293881 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 IMP RGD PMID:20445128 RGD:4892084 NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO RGD PMID:22177953 RGD:5686410 NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590 		JBrowse link
G Kras KRAS proto-oncogene, GTPase IDA
ISO 		RGD PMID:12388314 PMID:22177953 RGD:628557, RGD:5686410 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Ksr1 kinase suppressor of ras 1 ISO RGD PMID:17726577 PMID:22177953 RGD:2293880, RGD:5686410 NCBI chr10:64,459,786...64,596,083
Ensembl chr10:64,459,786...64,596,082 		JBrowse link
G Ksr2 kinase suppressor of ras 2 ISO RGD PMID:22177953 RGD:5686410 NCBI chr12:44,462,579...44,848,555
Ensembl chr12:44,471,038...44,848,308 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 TAS
IMP 		RGD PMID:9779826 PMID:17310240 RGD:70317, RGD:1626216 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 NAS
IMP 		RGD PMID:8462694 PMID:17310240 RGD:729046, RGD:1626216 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISS
ISO 		RGD PMID:12835716 PMID:9305638 RGD:1357969, RGD:2293879 NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:45,081,889...45,149,897 		JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 NAS RGD PMID:11359865 RGD:724475 NCBI chr18:24,081,444...24,153,940
Ensembl chr18:24,081,444...24,147,323 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IDA
IMP 		RGD PMID:12097495 PMID:16955078 PMID:17310240 RGD:628468, RGD:8553011, RGD:1626216 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IDA
ISO
IMP 		RGD PMID:12097495 PMID:20080775 PMID:16955078 PMID:17310240 RGD:628468, RGD:5508172, RGD:8553011, RGD:1626216 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 ISO
IMP 		RGD PMID:16421520 PMID:16955078 RGD:2315047, RGD:8553011 NCBI chr 5:134,554,881...134,594,392
Ensembl chr 5:134,554,943...134,594,393 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 7:9,690,385...9,701,527
Ensembl chr 7:9,690,421...9,701,529 		JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO RGD PMID:22177953 RGD:5686410 NCBI chr 2:193,271,399...193,282,023
Ensembl chr 2:193,271,430...193,278,543 		JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 TAS
IMP 		RGD PMID:17126425 PMID:10490027 RGD:2293882, RGD:2302807 NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780 		JBrowse link
G Prkcd protein kinase C, delta IMP RGD PMID:12790799 RGD:1642529 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:15096502 RGD:1642630 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase TAS
ISO
IMP 		RGD PMID:9779826 PMID:22177953 PMID:17310240 PMID:16508002 RGD:70317, RGD:5686410, RGD:1626216, RGD:1580106 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:151,362,819...151,476,044 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 1:55,178,988...55,454,271
Ensembl chr 1:55,179,319...55,454,338 		JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 ISO RGD PMID:16421520 RGD:2315047 NCBI chr  X:39,325,926...39,432,017
Ensembl chr  X:39,325,926...39,433,678 		JBrowse link
G Rps6ka4 ribosomal protein S6 kinase A4 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 1:213,451,026...213,461,982
Ensembl chr 1:213,451,027...213,461,982 		JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 ISO RGD PMID:16421520 RGD:2315047 NCBI chr 6:125,558,434...125,736,576
Ensembl chr 6:125,558,434...125,735,856 		JBrowse link
G Rps6ka6 ribosomal protein S6 kinase A6 ISO RGD PMID:16421520 RGD:2315047 NCBI chr  X:80,537,723...80,638,910
Ensembl chr  X:80,537,723...80,692,148 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 IMP RGD PMID:14711826 RGD:1304283 NCBI chr 2:206,309,715...206,314,070
Ensembl chr 2:205,900,836...206,328,689 		JBrowse link
G Shc1 SHC adaptor protein 1 IEP RGD PMID:16699171 RGD:1643182 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:177,135,659...177,147,914 		JBrowse link
G Smad1 SMAD family member 1 IMP RGD PMID:16427075 RGD:1643230 NCBI chr19:45,417,430...45,477,962
Ensembl chr19:45,417,433...45,477,957 		JBrowse link
G Spp1 secreted phosphoprotein 1 ISO RGD PMID:15757900 RGD:1581337 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Tsc2 TSC complex subunit 2 ISO RGD PMID:15150271 RGD:1580097 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:14,125,680...14,160,600 		JBrowse link
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 PMID:18098337 PMID:20951313 PMID:21277552 RGD:2293882, RGD:2298531, RGD:5133242, RGD:5133243 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Kras KRAS proto-oncogene, GTPase TAS
ISO 		RGD PMID:16112461 PMID:19078924 PMID:20951313 PMID:19506583 PMID:18772397 RGD:2306732, RGD:4143515, RGD:5133242, RGD:5490965, RGD:5490966 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO RGD PMID:20951313 PMID:21277552 RGD:5133242, RGD:5133243 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      mitogen activated protein kinase signaling pathway 299
        the extracellular signal-regulated Raf/Mek/Erk signaling pathway 32
          altered extracellular signal-regulated Raf/Mek/Erk signaling pathway 4
Path 2
Term Annotations click to browse term
  pathway 6091
    signaling pathway 2635
      kinase mediated signaling pathway 602
        serine/threonine-specific kinase mediated signaling pathway 476
          mitogen activated protein kinase signaling pathway 299
            the extracellular signal-regulated Raf/Mek/Erk signaling pathway 32
              altered extracellular signal-regulated Raf/Mek/Erk signaling pathway 4
paths to the root