RGD Reference Report - Regulatory mechanisms of mitogen-activated kinase signaling. - Rat Genome Database

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Regulatory mechanisms of mitogen-activated kinase signaling.

Authors: Zhang, Y  Dong, C 
Citation: Zhang Y and Dong C, Cell Mol Life Sci. 2007 Nov;64(21):2771-89.
RGD ID: 2293880
Pubmed: PMID:17726577   (View Abstract at PubMed)
DOI: DOI:10.1007/s00018-007-7012-3   (Journal Full-text)

MAP kinases (MAPKs) are evolutionarily conserved regulators that mediate signal transduction and play essential roles in various physiological processes. There are three main families of MAPKs in mammals, whose functions are regulated by activators, inactivators, substrates and scaffolds, which together form delicate signaling cascades in response to different extracellular or intracellular stimulation. MAPK signaling is tightly regulated so that optimal biological activities are achieved and health is maintained. However, how the specificity of the signaling flow along each cascade is achieved is still relatively unclear. In this review, we summarize recent advances in understanding the regulation of MAPK cascades and the roles of MAP kinases and their regulators in development and in immune responses.



Molecular Pathway Annotations    Click to see Annotation Detail View
Objects Annotated

Genes (Rattus norvegicus)
Ksr1  (kinase suppressor of ras 1)
Mapk8ip1  (mitogen-activated protein kinase 8 interacting protein 1)
Mapk8ip2  (mitogen-activated protein kinase 8 interacting protein 2)
Mapk8ip3  (mitogen-activated protein kinase 8 interacting protein 3)

Genes (Mus musculus)
Ksr1  (kinase suppressor of ras 1)
Mapk8ip1  (mitogen-activated protein kinase 8 interacting protein 1)
Mapk8ip2  (mitogen-activated protein kinase 8 interacting protein 2)
Mapk8ip3  (mitogen-activated protein kinase 8 interacting protein 3)

Genes (Homo sapiens)
KSR1  (kinase suppressor of ras 1)
MAPK8IP1  (mitogen-activated protein kinase 8 interacting protein 1)
MAPK8IP2  (mitogen-activated protein kinase 8 interacting protein 2)
MAPK8IP3  (mitogen-activated protein kinase 8 interacting protein 3)


Additional Information