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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:altered extracellular signal-regulated Raf/Mek/Erk signaling pathway
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Accession:PW:0000602 term browser browse the term
Definition:A Raf/Mek/Erk signaling pathway that deviates from what its normal course should be. Aberrant Raf/Mek/Erk signaling has been implicated in many types of cancer.



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altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 PMID:18098337 PMID:20951313 PMID:21277552 RGD:2293882, RGD:2298531, RGD:5133242, RGD:5133243 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Kras KRAS proto-oncogene, GTPase TAS
ISO
RGD PMID:16112461 PMID:19078924 PMID:20951313 PMID:19506583 PMID:18772397 RGD:2306732, RGD:4143515, RGD:5133242, RGD:5490965, RGD:5490966 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO RGD PMID:20951313 PMID:21277552 RGD:5133242, RGD:5133243 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      mitogen activated protein kinase signaling pathway 299
        the extracellular signal-regulated Raf/Mek/Erk signaling pathway 32
          altered extracellular signal-regulated Raf/Mek/Erk signaling pathway 4
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      kinase mediated signaling pathway 601
        serine/threonine-specific kinase mediated signaling pathway 475
          mitogen activated protein kinase signaling pathway 299
            altered mitogen activated protein kinase pathway 6
              altered extracellular signal-regulated Raf/Mek/Erk signaling pathway 4
paths to the root