Casp9 (caspase 9) - Rat Genome Database

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Gene: Casp9 (caspase 9) Rattus norvegicus
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Symbol: Casp9 (Ensembl: Casp9_v1)
Name: caspase 9 (Ensembl:caspase-9-carboxyl-terminal divergent)
RGD ID: 61867
Description: Enables cysteine-type peptidase activity. Involved in several processes, including response to anesthetic; response to indole-3-methanol; and response to ischemia. Located in cytoplasm. Used to study pre-malignant neoplasm. Biomarker of several diseases, including alcohol use disorder; brain disease (multiple); heart disease (multiple); kidney disease (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9); PARTICIPATES IN intrinsic apoptotic pathway; endometrial cancer pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-anisomycin; (-)-citrinin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 25 kDa caspase-9 dominant negative protein; Apaf3; apoptotic protease activating factor 3; apoptotic protease Mch-6; Casp-9-CTD; Casp9_v1; caspase 9, apoptosis-related cysteine peptidase; caspase-9; caspase-9 dominant negative form; caspase-9-carboxyl-terminal divergent; Ice-Lap6; Ice-like apoptotic protease 6; Mch6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Casp9_v1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8 Ensembl5159,391,188 - 159,409,648 (+)EnsemblGRCr8
mRatBN7.25154,108,872 - 154,126,628 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5154,109,046 - 154,126,626 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5156,793,940 - 156,811,532 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,567,234 - 158,584,828 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,556,396 - 158,573,978 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05160,356,211 - 160,373,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,355,833 - 160,373,778 (+)Ensemblrn6Rnor6.0
Rnor_5.05164,067,734 - 164,085,297 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,704,234 - 160,721,796 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,461,154 - 152,478,717 (+)NCBICelera
RGSC_v3.15160,714,421 - 160,731,984 (+)NCBI
Cytogenetic Map5q36NCBI



Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (IEP)
alcohol use disorder  (IEP)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (IEP)
bacterial infectious disease  (ISO)
Brain Hypoxia-Ischemia  (IEP)
brain ischemia  (ISO)
breast cancer  (ISO)
bronchopulmonary dysplasia  (IEP)
cataract  (IEP)
Cerebral Hemorrhage  (IEP)
Chemical and Drug Induced Liver Injury  (IEP)
colorectal cancer  (ISO)
Diabetes Complications  (IEP)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (ISO)
dilated cardiomyopathy  (IEP)
Edema  (ISO)
endometritis  (IEP)
Endotoxemia  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (IEP)
Experimental Mammary Neoplasms  (IDA,IEP,ISO)
Experimental Radiation Injuries  (IEP)
focal segmental glomerulosclerosis  (IEP)
heart disease  (IEP)
hepatocellular carcinoma  (IEP)
Huntington's disease  (ISO)
Hypercholesterolemia  (IEP)
hypertension  (IEP)
Intestinal Reperfusion Injury  (IEP)
kidney disease  (IEP)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IEP,ISO)
lung non-small cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
middle cerebral artery infarction  (IEP)
Myocardial Reperfusion Injury  (IEP,ISO)
nervous system disease  (ISO)
NSAID-Enteropathy  (IEP)
osteoarthritis  (IEP)
pancreatic cancer  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (IEP)
peripheral nervous system disease  (ISO)
post-traumatic stress disorder  (IEP)
pre-malignant neoplasm  (IDA)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (IDA)
retinal detachment  (ISO)
scrapie  (ISO)
Sepsis  (IEP)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (IDA,IEP)
stomach cancer  (ISO)
Subarachnoid Hemorrhage  (IDA)
Testis Reperfusion Injury  (IEP)
transient cerebral ischemia  (IEP,ISO)
traumatic brain injury  (IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (IEP)
urinary bladder cancer  (ISO)
varicocele  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(+)-pilocarpine  (ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-anisomycin  (EXP,ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (EXP,ISO)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(-)-matairesinol  (ISO)
(-)-noscapine  (ISO)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(20S)-ginsenoside Rh2  (ISO)
(aminomethyl)phosphonic acid  (ISO)
(R)-carnitine  (EXP,ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
(Z)-3-butylidenephthalide  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1-(4-methoxybenzyl)-3-(5-nitro-1,3-thiazol-2-yl)urea  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-hydroxy-1-norresistomycin  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-pyridylethylamine  (ISO)
25-hydroxycholesterol  (EXP)
28-deoxonimbolide  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3',4'-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-aminobenzamide  (EXP)
3-chloropropane-1,2-diol  (EXP,ISO)
3-hydroxybutyric acid  (ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methyladenine  (EXP,ISO)
3-methylcholanthrene  (EXP)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-phenoxybenzoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-aminopyridine  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-Nerolidylcatechol  (ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP,ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aminolevulinic acid  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxypsoralen  (ISO)
6-(cyclohexylmethoxy)-5-nitrosopyrimidine-2,4-diamine  (ISO)
6-Methoxyflavone  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7-ketocholesterol  (EXP)
8-Br-cAMP  (ISO)
9'-cis-neoxanthin  (ISO)
9,10-anthraquinone  (ISO)
9,10-phenanthroquinone  (ISO)
9-hydroxycanthin-6-one  (ISO)
9-Methoxycamptothecin  (ISO)
[6]-Shogaol  (ISO)
AB-Fubinaca  (ISO)
abexinostat  (ISO)
ABT-737  (ISO)
acadesine  (ISO)
acetochlor  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
adenosine  (EXP,ISO)
aflatoxin B1  (ISO)
afzelechin  (EXP)
AICA ribonucleotide  (EXP)
alantolactone  (ISO)
alborixin  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldicarb  (EXP)
aldrithiol  (EXP)
alendronic acid  (ISO)
alginic acid  (ISO)
all-trans-acitretin  (ISO)
all-trans-neoxanthin  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
alloxan  (EXP)
Aloe emodin  (ISO)
alogliptin  (EXP)
aloxistatin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpinumisoflavone  (ISO)
alternariol  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
alvocidib  (ISO)
amiloride  (ISO)
aminoguanidine  (ISO)
amiodarone  (ISO)
amlodipine  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
amosite asbestos  (EXP,ISO)
amphetamine  (EXP)
andrographolide  (EXP,ISO)
Anemoside B4  (ISO)
anethole  (EXP)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (EXP,ISO)
aristolochic acid A  (EXP,ISO)
arjunolic acid  (ISO)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsanilic acid  (EXP)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
Arsenobetaine  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asbestos  (EXP)
asiatic acid  (EXP)
aspartame  (ISO)
astilbin  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (EXP,ISO)
aucubin  (ISO)
Augmentin  (EXP)
auranofin  (ISO)
Auriculasin  (ISO)
azadirachtin A  (ISO)
azadiradione  (ISO)
azilsartan  (ISO)
bafilomycin A1  (EXP,ISO)
Bavachinin  (ISO)
beauvericin  (ISO)
beclomethasone  (ISO)
belinostat  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
berberine  (EXP,ISO)
Bergenin  (ISO)
beta-carboline  (ISO)
beta-ionone  (ISO)
Beta-Solamarine  (ISO)
betaxolol  (ISO)
betulin  (ISO)
betulinic acid  (ISO)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
brucine  (ISO)
Brusatol  (ISO)
budesonide  (ISO)
bufalin  (ISO)
Bufotalin  (ISO)
bupivacaine  (ISO)
buprofezin  (ISO)
bupropion  (ISO)
buserelin  (ISO)
busulfan  (ISO)
butachlor  (ISO)
butan-1-ol  (EXP)
butein  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium acetate  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium telluride  (ISO)
caffeine  (EXP,ISO)
cajanol  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium dichloride  (EXP)
calcium(0)  (EXP)
camphene  (EXP)
camptothecin  (EXP,ISO)
cannabidiol  (EXP,ISO)
Cannabidivarin  (ISO)
cantharidic acid  (ISO)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
CARBENOXOLONE  (EXP)
carbidopa  (ISO)
carbon atom  (ISO)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carboplatin  (EXP,ISO)
carnosic acid  (ISO)
carvacrol  (EXP)
casticin  (ISO)
catechol  (ISO)
CCCP  (ISO)
celastrol  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
ceritinib  (ISO)
cerivastatin  (ISO)
cerulenin  (ISO)
ceruletide  (EXP)
cetrorelix  (EXP,ISO)
CGP 52608  (ISO)
chalcone  (ISO)
chalcones  (ISO)
chelerythrine  (EXP,ISO)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chloroacetic acid  (ISO)
chlorogenic acid  (EXP)
chloroquine  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (ISO)
chromone  (ISO)
chrysazin  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cilostazol  (ISO)
cimetidine  (ISO)
Cinobufotalin  (ISO)
ciprofloxacin  (EXP,ISO)
Cirsimarin  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clavulone II  (ISO)
Clivoline  (ISO)
clofarabine  (ISO)
clofibrate  (ISO)
clomipramine  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clorgyline  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
codeinone  (ISO)
coenzyme Q10  (EXP)
colistin  (ISO)
concanamycin A  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP)
coptisine  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP,ISO)
crotonaldehyde  (EXP)
Cryptotanshinone  (ISO)
cucurbitacin E  (ISO)
cucurbitacin I  (ISO)
curcumin  (EXP,ISO)
cyclizine  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cytochalasin B  (ISO)
D-glucitol  (EXP)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
D-penicillamine  (EXP)
dactolisib  (ISO)
dantrolene  (ISO)
DAPT  (EXP)
daunorubicin  (ISO)
DDE  (EXP,ISO)
decabromodiphenyl ether  (EXP)
delphinidin  (ISO)
demethoxycurcumin  (ISO)
demethoxyfumitremorgin C  (ISO)
Dendrobine  (ISO)
DENSPM  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP,ISO)
Deoxyshikonin  (ISO)
desferrioxamine B  (EXP,ISO)
desipramine  (EXP)
Destruxin B  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
Di-n-octyl phthalate  (ISO)
Diacetoxyscirpenol  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibenziodolium  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorvos  (EXP)
diclofenac  (EXP,ISO)
Didymin  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
digitoxin  (ISO)
dihydrolipoic acid  (ISO)
dihydrosanguinarine  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioscin  (EXP,ISO)
diosgenin  (ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
diquat  (EXP,ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (ISO)
donepezil hydrochloride  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
drimenol  (ISO)
ebselen  (EXP,ISO)
Echimidine  (ISO)
echinacoside  (ISO)
Echinocystic acid  (ISO)
edaravone  (ISO)
elemental carbon  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (ISO)
ellipticine  (ISO)
embelin  (ISO)
emetine  (ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP)
entinostat  (ISO)
epichlorohydrin  (ISO)
equol  (ISO)
eriocitrin  (ISO)
erythrosin B  (EXP)
esculetin  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (EXP)
ethylene glycol  (EXP)
etodolac  (ISO)
etoposide  (ISO)
eugenol  (ISO)
EUK-134  (ISO)
euscaphic acid  (ISO)
Evodiamine  (ISO)
farrerol  (ISO)
fenbendazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (EXP)
fenpropathrin  (EXP)
fenpyroximate  (ISO)
fenvalerate  (EXP)
ferric oxide  (ISO)
ferrosoferric oxide  (ISO)
fipronil  (ISO)
fisetin  (EXP,ISO)
flavanone  (ISO)
flavones  (ISO)
flavonoids  (EXP,ISO)
flavonols  (ISO)
fluoxetine  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
formononetin  (ISO)
fraxetin  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
furosemide  (EXP)
Fusarenone X  (ISO)
galactose  (EXP,ISO)
gallic acid  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gamma-tocopherol  (ISO)
Ganoderic acid A  (ISO)
Ganoderic acid T  (ISO)
Garcinol  (ISO)
gardenin B  (ISO)
Gastrodin  (ISO)
gedunin  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
geneticin  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
Gentiopicrin  (ISO)
geraniol  (EXP,ISO)
gibberellin A3  (EXP)
gingerol  (ISO)
Ginkgoic acid  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rg1  (EXP,ISO)
Ginsenoside Rg5  (ISO)
glabridin  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyburide  (EXP)
glycochenodeoxycholic acid  (EXP,ISO)
glycyrrhizinic acid  (EXP,ISO)
glyphosate  (EXP,ISO)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
gossypin  (ISO)
gossypol  (EXP,ISO)
graphite  (ISO)
Grifolin  (ISO)
griseofulvin  (ISO)
GSK2656157  (ISO)
guggulsterone  (ISO)
harman  (ISO)
Harpagoside  (ISO)
Heliotrine  (ISO)
hemin  (ISO)
hesperetin  (EXP)
hesperidin  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hispidin  (EXP)
homocysteine  (ISO)
homoeriodictyol  (ISO)
Honokiol  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hydroxamic acid  (EXP)
hydroxyurea  (ISO)
icariin  (EXP)
icariside II  (ISO)
idarubicin  (ISO)
ifosfamide  (EXP,ISO)
indocyanine green  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
insulin  (EXP)
inulin  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
iron(III) nitrilotriacetate  (EXP)
isatin  (ISO)
Isoangustone A  (ISO)
isoflavones  (EXP)
isoflurane  (EXP,ISO)
Isoliensinine  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoprenaline  (EXP)
isorhamnetin  (ISO)
isotretinoin  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
ketamine  (EXP,ISO)
ketoconazole  (ISO)
Kukoamine B  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-cystathionine  (ISO)
L-gamma-glutamyl-L-cysteine  (EXP)
L-glutamic acid  (EXP)
L-methionine  (EXP)
L-mimosine  (ISO)
lanthanum trichloride  (EXP)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
Leonurine  (EXP,ISO)
leuprolide  (ISO)
Licochalcone A  (ISO)
licoricidin  (ISO)
lidocaine  (EXP,ISO)
Liensinine  (ISO)
limonin  (ISO)
linalool  (ISO)
linderalactone  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lithium carbonate  (ISO)
lithium chloride  (ISO)
lithocholic acid  (ISO)
Lobetyolin  (ISO)
loganin  (ISO)
lonafarnib  (ISO)
Longikaurin A  (ISO)
lonidamine  (ISO)
loratadine  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
lupeol  (EXP,ISO)
Lupiwighteone  (ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
magnesium oxide  (ISO)
Magnolol  (ISO)
malathion  (EXP,ISO)
malonic acid  (EXP)
mancozeb  (ISO)
maneb  (ISO)
manganese (III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin  (EXP)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
masoprocol  (ISO)
mechlorethamine  (ISO)
melamine  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (EXP,ISO)
melphalan  (ISO)
memantine  (ISO)
menadione  (EXP,ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP)
mercury(0)  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (EXP,ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
Methylone  (EXP)
methylphenidate  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP)
metoprolol  (ISO)
mevalonic acid  (EXP,ISO)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (EXP,ISO)
mitomycin C  (ISO)
MitoTEMPO  (ISO)
mitoxantrone  (ISO)
MK-2206  (EXP,ISO)
ML-7  (ISO)
molybdenum atom  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
morin  (EXP)
morphine  (EXP,ISO)
Morroniside  (ISO)
morusin  (ISO)
Muconic dialdehyde  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (ISO)
myristicin  (ISO)
Myrtucommulone A  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylformamide  (ISO)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP,ISO)
N-(p-amylcinnamoyl)anthranilic acid  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetyl-L-tryptophan  (ISO)
N-acylsphinganine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-phenylthiourea  (ISO)
N-phosphocreatine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
naringin  (EXP,ISO)
navitoclax  (ISO)
NCX-4040  (ISO)
nefazodone  (ISO)
Neferine  (EXP,ISO)
nelfinavir  (ISO)
neoastilbin  (ISO)
neomycin  (ISO)
nevadensin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel ferrite  (ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicotinamide  (EXP,ISO)
nicotine  (EXP,ISO)
Niflumic acid  (ISO)
nifuroxazide  (EXP)
nilotinib  (ISO)
nimesulide  (EXP,ISO)
nimodipine  (EXP)
nimustine  (ISO)
nitric oxide  (ISO)
nitroprusside  (ISO)
NMS-873  (ISO)
nobiletin  (EXP,ISO)
nocodazole  (ISO)
Nodularin  (EXP)
NORCANTHARIDIN  (ISO)
notoginsenoside R1  (EXP,ISO)
NS-398  (ISO)
Nutlin-3  (ISO)
O-acetyl-L-carnitine  (EXP)
Obacunone  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
olaparib  (ISO)
oleamide  (ISO)
oleanolic acid  (ISO)
oleic acid  (EXP,ISO)
oligopeptide  (EXP)
omacetaxine mepesuccinate  (ISO)
orlistat  (EXP,ISO)
oroxylin A  (ISO)
osthole  (ISO)
ouabain  (ISO)
oxidopamine  (EXP,ISO)
oxybenzone  (EXP)
oxybuprocaine  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
Pachymic acid  (EXP)
paclitaxel  (ISO)
paeoniflorin  (ISO)
pamidronate  (ISO)
Panduratin A  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
parathion-methyl  (EXP)
paroxetine  (ISO)
Parthenin  (ISO)
patulin  (ISO)
Pendulone  (ISO)
pentachlorophenol  (ISO)
pentetic acid  (ISO)
Pentoxifylline  (ISO)
pepstatin A  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (EXP)
phenanthridone  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phenol  (ISO)
phenylephrine  (ISO)
phloretin  (ISO)
phloroglucinol  (ISO)
phorate  (EXP)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidylcholine  (ISO)
phytol  (ISO)
phytosphingosine  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
Pinacidil  (EXP)
pinostrobin  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
platycodin D  (ISO)
plumbagin  (EXP,ISO)
podophyllotoxin  (ISO)
poly(I:C)  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
Polygodial  (ISO)
ponatinib  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
potassium iodide  (EXP)
Pramanicin  (ISO)
Pranoprofen  (ISO)
pravastatin  (EXP)
prazosin  (ISO)
prednisone  (ISO)
probenecid  (ISO)
procyanidin B2  (ISO)
procymidone  (ISO)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propofol  (EXP,ISO)
propranolol  (EXP,ISO)
propylparaben  (ISO)
prostaglandin E2  (ISO)
protosappanin A  (EXP)
pterostilbene  (ISO)
Pulsatilla saponin D  (ISO)
punicalagin  (ISO)
puromycin  (ISO)
putrescine  (EXP)
pyrethrins  (EXP,ISO)
pyrimethamine  (ISO)
pyrogallol  (ISO)
pyrroles  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrroloquinoline quinone  (ISO)
pyruvic acid  (EXP)
quercetin  (EXP,ISO)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quinacrine  (ISO)
ranitidine  (ISO)
reactive oxygen species  (ISO)
Rebamipide  (EXP)
resveratrol  (EXP,ISO)
retinyl acetate  (EXP)
Rhein  (ISO)
riboflavin  (ISO)
ricolinostat  (ISO)
Riluzole  (ISO)
Risedronate sodium  (EXP)
Ro 31-8220  (EXP)
robinin  (EXP)
romidepsin  (ISO)
ropinirole  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (ISO)
royal jelly  (EXP)
rubimaillin  (ISO)
rubitecan  (ISO)
ruthenium atom  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
safrole  (ISO)
Salinomycin  (ISO)
salubrinal  (ISO)
Sanggenon C  (ISO)
sanguinarine  (ISO)
sappanchalcone  (ISO)
saquinavir  (ISO)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
Schizandrin  (EXP)
sclareol  (ISO)
scopoletin  (EXP)
scutellarin  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
semilicoisoflavone B  (ISO)
senecionine  (ISO)
Senkirkine  (ISO)
sepantronium  (ISO)
serpentine asbestos  (EXP,ISO)
sertraline  (ISO)
Sesamol  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP)
Shikonin  (ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
SM-164  (ISO)
SNX-2112  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (ISO)
sodium cyanate  (ISO)
sodium dichromate  (ISO)
sodium disulfite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
sodium thiosulfate pentahydrate  (EXP)
solasodine  (ISO)
sorafenib  (ISO)
spermine  (EXP,ISO)
spironolactone  (EXP)
staurosporine  (EXP,ISO)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
styrene  (EXP)
Suillin  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
surfactin  (ISO)
surfactin C  (ISO)
swainsonine  (EXP)
syringic acid  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
tangeretin  (ISO)
tannic acid  (EXP)
tapentadol  (ISO)
tartrazine  (EXP)
taurine  (EXP)
taurocholic acid  (EXP)
taurodeoxycholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
temozolomide  (ISO)
TEMPO  (EXP)
tenofovir disoproxil fumarate  (EXP)
Terfenadine  (EXP,ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
tetramethylpyrazine  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thymidine  (ISO)
thymol  (EXP,ISO)
thymol sulfate(1-)  (EXP,ISO)
thymoquinone  (EXP,ISO)
Tiron  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (ISO)
Tormentic acid  (ISO)
Torularhodin  (ISO)
torulene  (ISO)
trametinib  (ISO)
tranexamic acid  (ISO)
trans-anethole  (EXP)
trans-chalcone  (ISO)
triadimefon  (ISO)
triamcinolone  (ISO)
triazoles  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trifluridine  (ISO)
trimethylenediamine  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
tyrphostin B42  (ISO)
urethane  (ISO)
uridine  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (EXP)
usnic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
vandetanib  (ISO)
vanillic acid  (EXP)
venetoclax  (ISO)
venom  (ISO)
verapamil  (ISO)
Vernodalol  (ISO)
verteporfin  (EXP)
violacein  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP,ISO)
WIN 55212-2  (ISO)
withaferin A  (EXP)
wortmannin  (EXP,ISO)
xanthohumol  (ISO)
Xanthorrhizol  (ISO)
XAV939  (ISO)
Y-27632  (EXP)
ytterbium  (ISO)
zearalenone  (EXP,ISO)
zebularine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)
zolmitriptan  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apoptosome  (IEA,ISO)
caspase complex  (IEA,ISO)
cytoplasm  (IBA,IDA)
cytosol  (IBA,IEA,ISO)
mitochondrion  (IEA,ISO)
nucleus  (IEA,ISO)
protein-containing complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Al-Mashat HA, etal., Diabetes. 2006 Feb;55(2):487-95.
2. Bladder cancer SNP panel predicts susceptibility and survival. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
3. Characterization of a novel isoform of caspase-9 that inhibits apoptosis. Angelastro JM, etal., J Biol Chem 2001 Apr 13;276(15):12190-200.
4. Activation of caspase 8 in the pituitaries of streptozotocin-induced diabetic rats: implication in increased apoptosis of lactotrophs. Arroba AI, etal., Endocrinology. 2005 Oct;146(10):4417-24. Epub 2005 Jun 23.
5. Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1. Atkin JD, etal., J Biol Chem. 2006 Oct 6;281(40):30152-65. Epub 2006 Jul 17.
6. Bax and Bid act in synergy to bring about T11TS-mediated glioma apoptosis via the release of mitochondrial cytochrome c and subsequent caspase activation. Bhattacharjee M, etal., Int Immunol. 2008 Dec;20(12):1489-505. Epub 2008 Oct 17.
7. Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. Bishayee A, etal., Nutr Cancer. 2016;68(1):120-30. doi: 10.1080/01635581.2016.1115094. Epub 2015 Dec 23.
8. Peripheral proteasome and caspase activity in Parkinson disease and Alzheimer disease. Blandini F, etal., Neurology. 2006 Feb 28;66(4):529-34. doi: 10.1212/01.wnl.0000198511.09968.b3.
9. Hypothyroidism minimizes the effects of acute hepatic failure caused by endoplasmic reticulum stress and redox environment alterations in rats. Blas-Valdivia V, etal., Acta Histochem. 2015 Oct;117(8):811-9. doi: 10.1016/j.acthis.2015.07.003. Epub 2015 Jul 31.
10. Cloning and characterization of rat caspase-9: implications for a role in mediating caspase-3 activation and hippocampal cell death after transient cerebral ischemia. Cao G, etal., J Cereb Blood Flow Metab 2002 May;22(5):534-46.
11. Role of p97/Valosin-containing protein (VCP) and Jab1/CSN5 in testicular ischaemia-reperfusion injury. Cayli S, etal., J Mol Histol. 2016 Feb;47(1):91-100. doi: 10.1007/s10735-016-9652-9. Epub 2016 Jan 11.
12. 4'-O-ß-D-Glucosyl-5-O-Methylvisamminol, A Natural Histone H3 Phosphorylation Epigenetic Suppressor, Exerts a Neuroprotective Effect Through PI3K/Akt Signaling Pathway on Focal Cerebral Ischemia in Rats. Chang CZ and Wu SC, World Neurosurg. 2016 May;89:474-88. doi: 10.1016/j.wneu.2016.01.061. Epub 2016 Feb 8.
13. A purine antimetabolite attenuates toll-like receptor-2, -4, and subarachnoid hemorrhage-induced brain apoptosis. Chang CZ, etal., J Surg Res. 2015 Dec;199(2):676-87. doi: 10.1016/j.jss.2015.06.011. Epub 2015 Jun 12.
14. Dihydroartemisinin inhibits growth of pancreatic cancer cells in vitro and in vivo. Chen H, etal., Anticancer Drugs. 2009 Feb;20(2):131-40. doi: 10.1097/CAD.0b013e3283212ade.
15. Insulin-like growth factor (IGF)-I/IGF-binding protein-3 complex: therapeutic efficacy and mechanism of protection against type 1 diabetes. Chen W, etal., Endocrinology. 2004 Feb;145(2):627-38. Epub 2003 Nov 14.
16. Apaf-1, Bcl-xL, cytochrome c, and caspase-9 form the critical elements for cerebral vascular protection by erythropoietin. Chong ZZ, etal., J Cereb Blood Flow Metab 2003 Mar;23(3):320-30.
17. Age-related alterations in expression of apoptosis regulatory proteins and heat shock proteins in rat skeletal muscle. Chung L and Ng YC, Biochim Biophys Acta. 2006 Jan;1762(1):103-9. Epub 2005 Aug 24.
18. Time-dependent increases in protease activities for neuronal apoptosis in spinal cords of Lewis rats during development of acute experimental autoimmune encephalomyelitis. Das A, etal., J Neurosci Res. 2008 Oct;86(13):2992-3001.
19. Defective function of the Fas apoptotic pathway in type 1 diabetes mellitus correlates with age at onset. De Franco S, etal., Int J Immunopathol Pharmacol. 2007 Jul-Sep;20(3):567-76.
20. Activation of cell death pathway after a brief period of global ischemia in diabetic and non-diabetic animals. Ding C, etal., Exp Neurol. 2004 Aug;188(2):421-9.
21. [Study of L-NAME treatment on experimental autoimmune myocarditis]. Ding GL, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2013 Mar;29(2):119-23.
22. Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. Dowdy SC, etal., Mol Cancer Ther. 2006 Nov;5(11):2767-76.
23. Effect of maternal diabetes and hypercholesterolemia on fetal liver of albino Wistar rats. El-Sayyad HI, etal., Nutrition. 2014 Mar;30(3):326-36. doi: 10.1016/j.nut.2013.08.016.
24. Renoprotective effect of nifuroxazide in diabetes-induced nephropathy: impact on NF¿B, oxidative stress, and apoptosis. Elsherbiny NM, etal., Toxicol Mech Methods. 2018 Jul;28(6):467-473. doi: 10.1080/15376516.2018.1459995. Epub 2018 Apr 16.
25. Evaluation of the effects of a high dose of erythropoietin-beta on early endotoxemia using a rat model. Eren Z, etal., Adv Clin Exp Med. 2012 May-Jun;21(3):321-9.
26. The role of heme oxygenase-1 (HO-1) in the regulation of inflammatory reaction, neuronal cell proliferation and apoptosis in rats after intracerebral hemorrhage (ICH). Fan X and Mu L, Neuropsychiatr Dis Treat. 2016 Dec 28;13:77-85. doi: 10.2147/NDT.S120496. eCollection 2017.
27. Temporal and spatial profile of Bid cleavage after experimental traumatic brain injury. Franz G, etal., J Cereb Blood Flow Metab 2002 Aug;22(8):951-8.
28. Caspase 9 and caspase 8 gene polymorphisms and susceptibility to bladder cancer in north Indian population. Gangwar R, etal., Ann Surg Oncol. 2009 Jul;16(7):2028-34. Epub 2009 May 2.
29. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
30. Cardiomyocyte apoptosis induced by short-term diabetes requires mitochondrial GSH depletion. Ghosh S, etal., Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H768-76. Epub 2005 Apr 1.
31. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
32. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. Goehe RW, etal., J Clin Invest. 2010 Nov;120(11):3923-39. doi: 10.1172/JCI43552. Epub 2010 Oct 25.
33. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis.PG - 22595-604 Gukovskaya AS, etal., J Biol Chem 2002 Jun 21;277(25):22595-604.
34. Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis. Haidara K, etal., Toxicol Appl Pharmacol. 2008 May 15;229(1):65-76. Epub 2008 Jan 29.
35. Activation of caspase 9 in a rat model of experimental glaucoma. Hanninen VA, etal., Curr Eye Res 2002 Dec;25(6):389-95.
36. Chloroquine upregulates TRAIL/TRAILR2 expression and potentiates doxorubicin anti-tumor activity in thioacetamide-induced hepatocellular carcinoma model. Helmy SA, etal., Chem Biol Interact. 2018 Jan 5;279:84-94. doi: 10.1016/j.cbi.2017.11.009. Epub 2017 Nov 10.
37. MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. Huang YH, etal., Exp Biol Med (Maywood). 2018 Jan;243(1):13-21. doi: 10.1177/1535370217741500. Epub 2017 Nov 6.
38. Fish oil improves learning impairments of diabetic rats by blocking PI3K/AKT/nuclear factor-¿B-mediated inflammatory pathways. Jia D, etal., Neuroscience. 2014 Jan 31;258:228-37. doi: 10.1016/j.neuroscience.2013.11.016. Epub 2013 Nov 16.
39. CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease. Jiao W, etal., Biochem Biophys Res Commun. 2018 Jul 2;501(4):1016-1022. doi: 10.1016/j.bbrc.2018.05.101. Epub 2018 May 18.
40. Estradiol protects PC12 cells against CoCl2-induced apoptosis. Jung JY, etal., Brain Res Bull. 2008 Aug 15;76(6):579-85. Epub 2008 May 16.
41. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
42. Caspase-9: involvement in secondary death of axotomized rat retinal ganglion cells in vivo. Kermer P, etal., Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):144-50.
43. Cytochrome C and caspase-9 expression in Huntington's disease. Kiechle T, etal., Neuromolecular Med. 2002;1(3):183-95.
44. The apoptotic effects of oxidative stress and antiapoptotic effects of caspase inhibitors on rat notochordal cells. Kim KW, etal., Spine (Phila Pa 1976). 2007 Oct 15;32(22):2443-8.
45. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae Kong L, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2007 Dec;29(6):782-6.
46. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
47. p53- and Bax-mediated apoptosis in injured rat spinal cord. Kotipatruni RR, etal., Neurochem Res. 2011 Nov;36(11):2063-74. doi: 10.1007/s11064-011-0530-2. Epub 2011 Jul 7.
48. Expression of apoptosome pathway-related transcripts in non-small cell lung cancer. Krepela E, etal., J Cancer Res Clin Oncol. 2006 Jan;132(1):57-68. Epub 2005 Oct 18.
49. Caspase function in programmed cell death. Kumar S Cell Death Differ. 2007 Jan;14(1):32-43. Epub 2006 Nov 3.
50. Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury. Kumral A, etal., Early Hum Dev. 2013 Mar;89(3):165-73. doi: 10.1016/j.earlhumdev.2012.09.016. Epub 2012 Oct 6.
51. Involved intrinsic apoptotic pathway of testicular tissues in varicocele-induced rats. Lee JD, etal., World J Urol. 2009 Jan 15.
52. Polymorphisms in the caspase genes and the risk of lung cancer. Lee SY, etal., J Thorac Oncol. 2010 Aug;5(8):1152-8. doi: 10.1097/JTO.0b013e3181e04543.
53. Radioprotective effect of a pan-caspase inhibitor in a novel model of radiation injury to the nucleus of the abducens nerve. Li J, etal., Mol Med Rep. 2014 Sep;10(3):1433-7. doi: 10.3892/mmr.2014.2334. Epub 2014 Jun 16.
54. In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. Li T, etal., Exp Neurol. 2006 Feb;197(2):301-8. Epub 2005 Dec 5.
55. Glutamine reduces myocardial cell apoptosis in a rat model of sepsis by promoting expression of heat shock protein 90. Li W, etal., J Surg Res. 2017 Dec;220:247-254. doi: 10.1016/j.jss.2017.06.090. Epub 2017 Aug 5.
56. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae Li Y, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2005 Jun;27(3):274-9.
57. Ginkgolic acid (GA) suppresses gastric cancer growth by inducing apoptosis and suppressing STAT3/JAK2 signaling regulated by ROS. Liang JR and Yang H, Biomed Pharmacother. 2020 May;125:109585. doi: 10.1016/j.biopha.2019.109585. Epub 2020 Feb 25.
58. Isolated mitochondria infusion mitigates ischemia-reperfusion injury of the liver in rats. Lin HC, etal., Shock. 2013 Mar;39(3):304-10. doi: 10.1097/SHK.0b013e318283035f.
59. The Coexistence of Hypertension and Ovariectomy Additively Increases Cardiac Apoptosis. Lin YY, etal., Int J Mol Sci. 2016 Dec 6;17(12). pii: ijms17122036. doi: 10.3390/ijms17122036.
60. Cellular communication network factor 1 (CCN1) knockdown exerts a protective effect for hepatic ischemia/reperfusion injury by deactivating the MEK/ERK pathway. Liu H, etal., Clin Res Hepatol Gastroenterol. 2021 Sep;45(5):101737. doi: 10.1016/j.clinre.2021.101737. Epub 2021 Jun 16.
61. Association of CASP9, CASP10 gene polymorphisms and tea drinking with colorectal cancer risk in the Han Chinese population. Liu H, etal., J Zhejiang Univ Sci B. 2013 Jan;14(1):47-57. doi: 10.1631/jzus.B1200218.
62. Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats. Liu Y, etal., Biol Trace Elem Res. 2016 Oct;173(2):345-53. doi: 10.1007/s12011-016-0659-6. Epub 2016 Feb 26.
63. Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides. Liu ZR, etal., Free Radic Res. 2018 May;52(5):616-628. doi: 10.1080/10715762.2018.1457789.
64. [A study on the expression of CASP9 gene and its polymorphism distribution in non-small cell lung cancer]. Lou Y, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Feb;24(1):59-62.
65. Trichosanthes kirilowii lectin alleviates diabetic nephropathy by inhibiting the LOX1/NF-¿B/caspase-9 signaling pathway. Lu J, etal., Biosci Rep. 2018 Jul 23. pii: BSR20180071. doi: 10.1042/BSR20180071.
66. Pre-administration of BAX-inhibiting peptides decrease the loss of the nigral dopaminergic neurons in rats. Ma C, etal., Life Sci. 2016 Jan 1;144:113-20. doi: 10.1016/j.lfs.2015.11.019. Epub 2015 Dec 2.
67. Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination. Malejka-Giganti D, etal., Eur J Cancer Prev. 2007 Apr;16(2):130-41.
68. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
69. Chaperone peptides of a-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts. Nahomi RB, etal., J Biol Chem. 2013 May 3;288(18):13022-35. doi: 10.1074/jbc.M112.440214. Epub 2013 Mar 18.
70. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
71. cDNA cloning and promoter analysis of rat caspase-9. Nishiyama J, etal., Biochem J 2001 Nov 15;360(Pt 1):49-56.
72. Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats. Niu X, etal., Toxicol In Vitro. 2014 Oct;28(7):1296-305. doi: 10.1016/j.tiv.2014.06.010. Epub 2014 Jul 8.
73. Mitochondria- and caspase-dependent cell death pathway involved in neuronal degeneration in diabetic retinopathy. Oshitari T, etal., Br J Ophthalmol. 2008 Apr;92(4):552-6.
74. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
75. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
76. Caspase gene expression in the brain as a function of the clinical progression of Alzheimer disease. Pompl PN, etal., Arch Neurol. 2003 Mar;60(3):369-76.
77. Neuroprotective effects of microRNA-210 on hypoxic-ischemic encephalopathy. Qiu J, etal., Biomed Res Int. 2013;2013:350419. doi: 10.1155/2013/350419. Epub 2013 Sep 9.
78. Long-term hormonal promotion overcomes genetic resistance to mammary cancer. Rajkumar L, etal., Steroids. 2011 Jan;76(1-2):31-7. doi: 10.1016/j.steroids.2010.08.004. Epub 2010 Aug 21.
79. Effect of saffron (stigma of Crocus sativus L.) aqueous extract on ethanol toxicity in rats: A biochemical, histopathological and molecular study. Rezaee-Khorasany A, etal., J Ethnopharmacol. 2019 Jun 12;237:286-299. doi: 10.1016/j.jep.2019.03.048. Epub 2019 Mar 26.
80. GOA pipeline RGD automated data pipeline
81. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
82. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
83. Effects of injury severity on regional and temporal mRNA expression levels of calpains and caspases after traumatic brain injury in rats. Ringger NC, etal., J Neurotrauma. 2004 Jul;21(7):829-41.
84. Nuclear translocation of X-linked inhibitor of apoptosis (XIAP) determines cell fate after hypoxia ischemia in neonatal brain. Russell JC, etal., J Neurochem. 2008 Aug;106(3):1357-70. Epub 2008 May 13.
85. Different signaling pathways induce apoptosis in endothelial cells and cardiac myocytes during ischemia/reperfusion injury. Scarabelli TM, etal., Circ Res. 2002 Apr 5;90(6):745-8.
86. Involvement of caspases and their upstream regulators in myocardial apoptosis in a rat model of selenium deficiency-induced dilated cardiomyopathy. Shan H, etal., J Trace Elem Med Biol. 2015;31:85-91. doi: 10.1016/j.jtemb.2015.03.005. Epub 2015 Apr 16.
87. Caspase activation in fetal rat brain following experimental intrauterine inflammation. Sharangpani A, etal., Brain Res. 2008 Mar 20;1200C:138-45. Epub 2008 Jan 26.
88. Inhibition of mammary tumor growth by estrogens: is there a specific role for estrogen receptors alpha and beta? Soldati R, etal., Breast Cancer Res Treat. 2009 Dec 11.
89. Stromal Cell-Derived Factor-1a Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps. Song L, etal., Biomed Res Int. 2018 Jan 11;2018:8945850. doi: 10.1155/2018/8945850. eCollection 2018.
90. Expression of Cyt-c-Mediated Mitochondrial Apoptosis-Related Proteins in Rat Renal Proximal Tubules during Development. Song XF, etal., Nephron. 2017;135(1):77-86. doi: 10.1159/000450585. Epub 2016 Sep 24.
91. p,p'-DDE induces mitochondria-mediated apoptosis of cultured rat Sertoli cells. Song Y, etal., Toxicology. 2008 Nov 20;253(1-3):53-61. Epub 2008 Sep 4.
92. Apigetrin inhibits gastric cancer progression through inducing apoptosis and regulating ROS-modulated STAT3/JAK2 pathway. Sun Q, etal., Biochem Biophys Res Commun. 2018 Mar 25;498(1):164-170. doi: 10.1016/j.bbrc.2018.02.009. Epub 2018 Mar 5.
93. Role of inhibitor of apoptosis protein in gentamicin-induced cochlear hair cell damage. Tabuchi K, etal., Neuroscience. 2007 Oct 12;149(1):213-22. Epub 2007 Aug 2.
94. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
95. Polymorphisms of caspase 8 and caspase 9 gene and colorectal cancer susceptibility and prognosis. Theodoropoulos GE, etal., Int J Colorectal Dis. 2011 Sep;26(9):1113-8. doi: 10.1007/s00384-011-1217-5. Epub 2011 May 3.
96. Effects of caspase-9 and survivin gene polymorphisms in pancreatic cancer risk and tumor characteristics. Theodoropoulos GE, etal., Pancreas. 2010 Oct;39(7):976-80. doi: 10.1097/MPA.0b013e3181d705d4.
97. The natural compound n-butylidenephthalide derived from Angelica sinensis inhibits malignant brain tumor growth in vitro and in vivo. Tsai NM, etal., J Neurochem. 2006 Nov;99(4):1251-62. Epub 2006 Sep 20.
98. Immunohistochemical study of the apoptosis process in epidermal epithelial cells of rats under a physiological condition. Udayanga KG, etal., Histol Histopathol. 2011 Jul;26(7):811-20. doi: 10.14670/HH-26.811.
99. Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. Valladares A, etal., Cancer Genet Cytogenet. 2006 Oct 15;170(2):147-51.
100. Differential involvement of initiator caspases in apoptotic volume decrease and potassium efflux during Fas- and UV-induced cell death. Vu CC, etal., J Biol Chem 2001 Oct 5;276(40):37602-11. Epub 2001 Jun 28.
101. Critical role of regulator of calcineurin 1 in spinal cord injury. Wang G, etal., J Physiol Biochem. 2016 Dec;72(4):605-613. doi: 10.1007/s13105-016-0499-z. Epub 2016 Jun 23.
102. Neuroprotective effects of caffeic acid phenethyl ester against sevoflurane‑induced neuronal degeneration in the hippocampus of neonatal rats involve MAPK and PI3K/Akt signaling pathways. Wang LY, etal., Mol Med Rep. 2016 Oct;14(4):3403-12. doi: 10.3892/mmr.2016.5586. Epub 2016 Aug 4.
103. Role of Protease-Activated Receptor 2 in Regulating Focal Segmental Glomerulosclerosis. Wang Y, etal., Cell Physiol Biochem. 2017;41(3):1147-1155. doi: 10.1159/000464121. Epub 2017 Feb 28.
104. Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis. Wei Y, etal., Mol Med Rep. 2018 Jan;17(1):1493-1498. doi: 10.3892/mmr.2017.8036. Epub 2017 Nov 13.
105. XZ-1 regulates cell apoptosis of gastric epithelial dysplasia via NF-¿B/p53/Ki67 signaling pathway. Xu B, etal., Biosci Rep. 2018 Jun 12;38(3). pii: BSR20171529. doi: 10.1042/BSR20171529. Print 2018 Jun 29.
106. Activation of caspase-12 at early stage contributes to cardiomyocyte apoptosis in trauma-induced secondary cardiac injury. Yan Z, etal., Sheng Li Xue Bao. 2017 Aug 25;69(4):367-377.
107. Tumor necrosis factor-a mediates JNK activation response to intestinal ischemia-reperfusion injury. Yang Q, etal., World J Gastroenterol. 2013 Aug 14;19(30):4925-34. doi: 10.3748/wjg.v19.i30.4925.
108. MicroRNA-140 attenuates myocardial ischemia-reperfusion injury through suppressing mitochondria-mediated apoptosis by targeting YES1. Yang S, etal., J Cell Biochem. 2019 Mar;120(3):3813-3821. doi: 10.1002/jcb.27663. Epub 2018 Sep 27.
109. Aberrant Alterations of Mitochondrial Factors Drp1 and Opa1 in the Brains of Scrapie Experiment Rodents. Yang X-, etal., J Mol Neurosci. 2017 Mar;61(3):368-378. doi: 10.1007/s12031-016-0866-9. Epub 2016 Dec 6.
110. Time course of apoptosis induced by photodynamic therapy with PsD007 in LT12 acute myeloid leukemia cells. Yin H, etal., Lasers Med Sci. 2016 Jul;31(5):817-24. doi: 10.1007/s10103-016-1887-x. Epub 2016 Feb 9.
111. Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1alpha and p53 pathways. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
112. The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia. Yip KK, etal., Neuroscience. 2011 Sep 8;190:301-6. doi: 10.1016/j.neuroscience.2011.06.022. Epub 2011 Jun 17.
113. Single Prolonged Stress induces ATF6 alpha-dependent Endoplasmic reticulum stress and the apoptotic process in medial Frontal Cortex neurons. Yu B, etal., BMC Neurosci. 2014 Oct 21;15:115. doi: 10.1186/s12868-014-0115-5.
114. Apoptosis and cell proliferation in short-term and long-term effects of radioiodine-131-induced kidney damage: an experimental and immunohistochemical study. Yumusak N, etal., Nucl Med Commun. 2018 Feb;39(2):131-139. doi: 10.1097/MNM.0000000000000788.
115. Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. Zeng C, etal., PLoS One. 2018 Mar 14;13(3):e0193845. doi: 10.1371/journal.pone.0193845. eCollection 2018.
116. H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation. Zhang X, etal., Cell Physiol Biochem. 2017;43(4):1311-1324. doi: 10.1159/000481843. Epub 2017 Oct 9.
Additional References at PubMed
PMID:11092819   PMID:11150333   PMID:11821383   PMID:12847083   PMID:14561754   PMID:14993216   PMID:15069058   PMID:15149850   PMID:15240811   PMID:15271982   PMID:15541731   PMID:15657060  
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PMID:27735993   PMID:27998213   PMID:32633389   PMID:33224431   PMID:33847039   PMID:34304702   PMID:34314869  


Genomics

Comparative Map Data
Casp9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8 Ensembl5159,391,188 - 159,409,648 (+)EnsemblGRCr8
mRatBN7.25154,108,872 - 154,126,628 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5154,109,046 - 154,126,626 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5156,793,940 - 156,811,532 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05158,567,234 - 158,584,828 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05158,556,396 - 158,573,978 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05160,356,211 - 160,373,774 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,355,833 - 160,373,778 (+)Ensemblrn6Rnor6.0
Rnor_5.05164,067,734 - 164,085,297 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45160,704,234 - 160,721,796 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5152,461,154 - 152,478,717 (+)NCBICelera
RGSC_v3.15160,714,421 - 160,731,984 (+)NCBI
Cytogenetic Map5q36NCBI
CASP9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38115,491,401 - 15,524,912 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl115,490,832 - 15,526,534 (-)Ensemblhg38GRCh38
GRCh37115,817,896 - 15,851,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36115,691,378 - 15,723,377 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34115,564,102 - 15,596,096NCBI
Celera114,301,661 - 14,333,662 (-)NCBICelera
Cytogenetic Map1p36.21NCBI
HuRef114,337,387 - 14,370,798 (-)NCBIHuRef
CHM1_1115,616,531 - 15,649,948 (-)NCBICHM1_1
T2T-CHM13v2.0114,936,101 - 14,969,610 (-)NCBIT2T-CHM13v2.0
Casp9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394141,520,923 - 141,543,289 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4141,520,923 - 141,543,287 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384141,793,612 - 141,815,978 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4141,793,612 - 141,815,976 (+)Ensemblmm10GRCm38
MGSCv374141,349,527 - 141,371,890 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364141,065,688 - 141,088,051 (+)NCBIMGSCv36mm8
Celera4143,618,711 - 143,640,921 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map474.75NCBI
Casp9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555272,613,683 - 2,629,738 (+)Ensembl
ChiLan1.0NW_0049555272,613,691 - 2,630,217 (+)NCBIChiLan1.0ChiLan1.0
CASP9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21211,395,731 - 211,430,328 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11210,644,170 - 210,678,765 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0114,630,659 - 14,662,865 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1115,624,666 - 15,656,266 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl115,624,666 - 15,656,266 (-)EnsemblpanPan2panpan1.1
CASP9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1282,033,759 - 82,076,710 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl282,031,563 - 82,090,484 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,571,149 - 78,590,692 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0282,683,018 - 82,723,170 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl282,682,995 - 82,725,574 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1279,435,738 - 79,455,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0280,453,740 - 80,473,245 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0281,519,391 - 81,539,023 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Casp9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505837,353,117 - 37,371,367 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364743,178,097 - 3,196,130 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CASP9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl674,706,516 - 74,730,007 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1674,707,597 - 74,730,033 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2669,087,179 - 69,111,408 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CASP9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120116,772,819 - 116,798,402 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20116,772,155 - 116,798,930 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605420,315,214 - 20,346,777 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Casp9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247641,773,455 - 1,789,423 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247641,769,270 - 1,789,399 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Casp9
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1116,337,170 - 16,355,659 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir133a1rno-miR-133a-3pMirtarbaseexternal_infoWestern blotFunctional MTI17715156
Mir133a1rno-miR-133a-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20056941

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:103
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000017972
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000017972   ⟹   ENSRNOP00000017972
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,391,984 - 159,409,648 (+)Ensembl
mRatBN7.2 Ensembl5154,109,046 - 154,126,626 (+)Ensembl
Rnor_6.0 Ensembl5160,355,833 - 160,373,778 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080721   ⟹   ENSRNOP00000068713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,392,070 - 159,395,468 (+)Ensembl
mRatBN7.2 Ensembl5154,109,046 - 154,112,444 (+)Ensembl
Rnor_6.0 Ensembl5160,355,833 - 160,359,599 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085378   ⟹   ENSRNOP00000072710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl5160,356,245 - 160,372,829 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088523   ⟹   ENSRNOP00000072787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,391,899 - 159,399,022 (+)Ensembl
mRatBN7.2 Ensembl5154,109,046 - 154,116,001 (+)Ensembl
Rnor_6.0 Ensembl5160,355,833 - 160,373,069 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138358   ⟹   ENSRNOP00000100955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,391,899 - 159,408,841 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138644   ⟹   ENSRNOP00000109391
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5159,391,188 - 159,409,330 (+)Ensembl
RefSeq Acc Id: NM_031632   ⟹   NP_113820
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25154,109,050 - 154,126,628 (+)NCBI
Rnor_6.05160,356,211 - 160,373,774 (+)NCBI
Rnor_5.05164,067,734 - 164,085,297 (+)NCBI
RGSC_v3.45160,704,234 - 160,721,796 (+)RGD
Celera5152,461,154 - 152,478,717 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110693   ⟹   XP_038966621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.25154,108,872 - 154,126,341 (+)NCBI
RefSeq Acc Id: NP_113820   ⟸   NM_031632
- UniProtKB: Q9JHK1 (UniProtKB/TrEMBL),   F1M776 (UniProtKB/TrEMBL),   A0A9K3Y7W8 (UniProtKB/TrEMBL),   A6ITW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068713   ⟸   ENSRNOT00000080721
Ensembl Acc Id: ENSRNOP00000072710   ⟸   ENSRNOT00000085378
Ensembl Acc Id: ENSRNOP00000017972   ⟸   ENSRNOT00000017972
Ensembl Acc Id: ENSRNOP00000072787   ⟸   ENSRNOT00000088523
RefSeq Acc Id: XP_038966621   ⟸   XM_039110693
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000109391   ⟸   ENSRNOT00000138644
Ensembl Acc Id: ENSRNOP00000100955   ⟸   ENSRNOT00000138358
Protein Domains
CARD   Caspase family p10   Caspase family p20

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JHK1-F1-model_v2 AlphaFold Q9JHK1 1-454 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694234
Promoter ID:EPDNEW_R4759
Type:multiple initiation site
Name:Casp9_1
Description:caspase 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05160,356,216 - 160,356,276EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61867 AgrOrtholog
BioCyc Gene G2FUF-39331 BioCyc
Ensembl Genes ENSRNOG00000012944 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017972 ENTREZGENE
  ENSRNOT00000017972.8 UniProtKB/TrEMBL
  ENSRNOT00000080721.3 UniProtKB/TrEMBL
  ENSRNOT00000088523.3 UniProtKB/TrEMBL
  ENSRNOT00000138358.1 UniProtKB/TrEMBL
  ENSRNOT00000138644.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  3.40.50.1460 UniProtKB/TrEMBL
InterPro CARD UniProtKB/TrEMBL
  CARD_CASP9 UniProtKB/TrEMBL
  Caspase-like_dom UniProtKB/TrEMBL
  Caspase_cys_AS UniProtKB/TrEMBL
  CRADD UniProtKB/TrEMBL
  DEATH-like UniProtKB/TrEMBL
  Pept_C14 UniProtKB/TrEMBL
  Pept_C14_caspase UniProtKB/TrEMBL
  Pept_C14_ICE_p20 UniProtKB/TrEMBL
  Pept_C14_ICE_p20_AS UniProtKB/TrEMBL
  Pept_C14_p10 UniProtKB/TrEMBL
  Pept_C14_p45_core UniProtKB/TrEMBL
KEGG Report rno:58918 UniProtKB/TrEMBL
NCBI Gene 58918 ENTREZGENE
PANTHER CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18 UniProtKB/TrEMBL
  CASPASE-3 UniProtKB/TrEMBL
  DEATH DOMAIN-CONTAINING PROTEIN CRADD UniProtKB/TrEMBL
  DEATH DOMAIN-CONTAINING PROTEIN CRADD UniProtKB/TrEMBL
  PTHR10454 UniProtKB/TrEMBL
  PTHR10454:SF157 UniProtKB/TrEMBL
Pfam CARD UniProtKB/TrEMBL
  Peptidase_C14 UniProtKB/TrEMBL
PharmGKB CASP9 RGD
PhenoGen Casp9 PhenoGen
PIRSF Caspase_ICE UniProtKB/TrEMBL
PRINTS IL1BCENZYME UniProtKB/TrEMBL
PROSITE CARD UniProtKB/TrEMBL
  CASPASE_CYS UniProtKB/TrEMBL
  CASPASE_HIS UniProtKB/TrEMBL
  CASPASE_P10 UniProtKB/TrEMBL
  CASPASE_P20 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012944 RatGTEx
SMART CARD UniProtKB/TrEMBL
  CASc UniProtKB/TrEMBL
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
  SSF52129 UniProtKB/TrEMBL
TIGR TC231270
UniProt A0A0G2JTH3_RAT UniProtKB/TrEMBL
  A0A0G2K3V0_RAT UniProtKB/TrEMBL
  A0A9K3Y7W8 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0KZR0_RAT UniProtKB/TrEMBL
  A0ABK0M2Q4_RAT UniProtKB/TrEMBL
  A6ITW3 ENTREZGENE, UniProtKB/TrEMBL
  A6ITW4_RAT UniProtKB/TrEMBL
  A6ITW5_RAT UniProtKB/TrEMBL
  A6ITW6_RAT UniProtKB/TrEMBL
  A6ITW7_RAT UniProtKB/TrEMBL
  F1M776 ENTREZGENE
  Q9JHK1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M776 UniProtKB/TrEMBL
  Q920G4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Casp9  caspase 9      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization inactive full-length Casp9 is present both in cytoplasm and nucleus 62424
gene_cellular_localization inactive full-length Casp9 is present both in cytoplasm and nucleus 70570
gene_domains promoter contains elements binding known transcription factors like Sp-1, Pit-1, CCAAT-enhance-binding protein (C/BP), glucocorticoid receptor, and hypoxia-inducible factor 1 (HIF-1) 62424
gene_domains promoter contains elements binding known transcription factors like Sp-1, Pit-1, CCAAT-enhance-binding protein (C/BP), glucocorticoid receptor, and hypoxia-inducible factor 1 (HIF-1) 70570
gene_domains contains an N-terminus caspase-recuitment domain (CARD) and C-terminal enzymic domains 62424
gene_domains contains an N-terminus caspase-recuitment domain (CARD) and C-terminal enzymic domains 70570
gene_pathway cleaves executioner caspases like caspase-3 at specific sites that activate downstream caspases towards cellular disintegration 62424
gene_pathway cleaves executioner caspases like caspase-3 at specific sites that activate downstream caspases towards cellular disintegration 70570
gene_process initiates cascades in the mitochondrial apoptotic pathway 62424
gene_process initiates cascades in the mitochondrial apoptotic pathway 70570
gene_process may also be involved in apoptosis triggered by death-receptor ligation 62424
gene_process may also be involved in apoptosis triggered by death-receptor ligation 70570
gene_process initiators of cell death cascades in apoptotic paradigms 62424
gene_process initiators of cell death cascades in apoptotic paradigms 70570
gene_product 2054 bp and 2270 bp mRNAs 62424
gene_product 2054 bp and 2270 bp mRNAs 70570
gene_regulation cytochrome c complex in response to stress 62424
gene_regulation cytochrome c complex in response to stress 70570
gene_regulation induced by hypoxia in kidney proximal tubular cells 62424
gene_regulation induced by hypoxia in kidney proximal tubular cells 70570
gene_regulation activated by cholecystokinin (CCK) in pancreatic acinar cells 625521