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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9increases activityISOCasp9 (Mus musculus)6480464CTDCelecoxib results in increased activity of CASP9 proteinPMID:17201140 PMID:17761345
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDCelecoxib results in increased activity of CASP9 proteinPMID:12824303
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDCelecoxib results in increased cleavage of CASP9 proteinPMID:17612393 PMID:19665451 PMID:20104024
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; [ABT-737 co-treated with Celecoxib] results in increased activity of CASP9 protein; [Atorvastatin co-treated with Celecoxib] results in increased cleavage of CASP9 protein; ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; Celecoxib analog results in increased cleavage of and results in increased activity of CASP9 protein; Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]; Celecoxib promotes the reaction [Docetaxel results in increased cleavage of and results in increased activity of CASP9 protein]; Celecoxib promotes the reaction [tetracycline CMT-3 results in increased cleavage of and results in increased activity of CASP9 protein]; Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein; Docetaxel promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; FADD mutant form inhibits the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; MAP1LC3B mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein]; PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP9 protein]; tetracycline CMT-3 promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; TNFSF10 protein promotes the reaction [Celecoxib results in increased cleavage of and results in increased activity of CASP9 protein]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]PMID:15197583 PMID:15499625 PMID:15572759 PMID:15688368 PMID:18172863 PMID:20104024
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