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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:46024
Term: trichostatin A
Definition: A trichostatin that has formula 302.36826.
Chemical ID: MESH:C012589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9affects expressionISOCASP9 (Homo sapiens)6480464CTDtrichostatin A affects the expression of CASP9 mRNAPMID:28542535
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTD[Bortezomib co-treated with trichostatin A] results in increased cleavage of and results in increased activity of CASP9 protein; [trichostatin A co-treated with Bortezomib] results in increased cleavage of CASP9 protein; trichostatin A promotes the reaction [CASP9 protein affects the localization of BID protein]; trichostatin A results in increased cleavage of and results in increased activity of CASP9 proteinPMID:12556448 PMID:16010430 PMID:16904634 PMID:21345073
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