GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp9 | multiple interactions | EXP | | 6480464 | CTD | [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in decreased expression of CASP9 mRNA; ABCC8 protein promotes the reaction [Estradiol results in increased activity of CASP9 protein] | PMID:19095654 PMID:20732338 | Casp9 | affects expression | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Estradiol affects the expression of CASP9 mRNA | PMID:24481588 | Casp9 | decreases expression | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of CASP9 mRNA; Estradiol results in decreased expression of CASP9 protein | PMID:23373633 PMID:24481588 PMID:31614463 | Casp9 | increases activity | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Estradiol results in increased activity of CASP9 protein | PMID:19095654 | Casp9 | increases expression | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Estradiol analog results in increased expression of CASP9 mRNA; Estradiol analog results in increased expression of CASP9 protein | PMID:36460128 | Casp9 | multiple interactions | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | [Estradiol co-treated with EGF protein] results in decreased expression of CASP9 mRNA; [Estradiol co-treated with Fulvestrant co-treated with 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] results in increased cleavage of CASP9 protein; [Estradiol co-treated with TGFB1 protein] results in decreased expression of CASP9 mRNA | PMID:24758408 PMID:30165855 PMID:33484789 | | ||||||||||||||||||||||
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